Page last updated: 2024-11-04

sumatriptan and Tinnitus

sumatriptan has been researched along with Tinnitus in 1 studies

Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.

Tinnitus: A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"The pathogenesis of migraine involves multiple peripheral and central neural mechanisms that individually have been successful targets for acute (abortive) and preventive treatment."2.71Sumatriptan and naproxen sodium for the acute treatment of migraine. ( Alexander, WJ; Littlefield, DE; Smith, TR; Spruill, SE; Stark, SR; Sunshine, A, 2005)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smith, TR1
Sunshine, A1
Stark, SR1
Littlefield, DE1
Spruill, SE1
Alexander, WJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"An Open-label Study to Evaluate Completeness of Response Following Treatment With Treximetâ„¢ for Migraine"[NCT00893737]Phase 4147 participants (Actual)Interventional2009-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Scores From Completeness of Response Survey (CORS)

"CORS scores for Pain (0-4), Associated Symptoms (0-4), Limbic/Affective Symptoms (0-5), and Speed of Return to Functionality (1-5), represent outcome measures that are relevant to patients. Higher scores represent better treatment efficacy.~The analysis compares CORS scores for usual triptan (pre-study) versus (vs.) Treximet (study medication)." (NCT00893737)
Timeframe: Visit 1 (screening) and Visit 2 (study completion following 2-month treatment period)

InterventionUnits on a scale (Mean)
Pain ScoreAssociated Symptoms ScoreLimbic Symptoms ScoreFunctionality Score
Treximet0.170.070.030.10

Paired T-test Indicating Greater Subject Satisfaction With Treximet Over Usual Pre-study Triptan as Determined by the Revised Patient Perception of Migraine Questionnaire (PPMQ-R)

Scores calculated for (1) Efficacy (2) Functionality (3) Ease of use (4) Cost. Higher score represents better treatment satisfaction. (NCT00893737)
Timeframe: Visit 1 (screening) and Visit 2 (study completion following 2-month treatment period)

InterventionUnits on a scale (Mean)
EfficacyFunctionalityEase of UseCost
Treximet8.6113.862.767.28

Percent of Participants Reporting Treximet Provides Therapeutic Advantage Over Usual Pre-study Triptan

CORS completed at Visit 1 regarding participant pre-study triptan and at Visit 2 regarding Treximet taken in study. Areas of therapeutic advantage evaluated: How often does 1 dose completely relieve (1) headache pain (2) neck/shoulder pain (3) nausea (4) light sensitivity (5) sound sensitivity (6) irritability. How quickly can/do you (1) concentrate or think clearly (2) resume normal activities (3) function normally (4) feel completely normal. How confident are you that (1) one dose will completely relieve migraine within 2 hours (2) once relieved, migraine will not return within 24 hours. (NCT00893737)
Timeframe: Visit 1 (screening) and Visit 2 (study completion following 2-month treatment period)

InterventionPercent of Participants (Number)
How often 1 dose relieves headache painHow often 1 dose relieves neck/shoulder painHow often 1 dose relieves nauseaHow often 1 dose relieves light sensitivityHow often 1 dose relieves sound sensitivityHow often 1 dose relieves irritabilityHow quickly can you concentrate or think clearlyHow quickly can you resume normal activitiesHow quickly can you function normallyHow quickly do you feel completely normalConfidence 1 dose will relieve migraine in 2 hoursConfidence migraine will not return in 24 hours
Treximet425243424536313232363338

Trials

1 trial available for sumatriptan and Tinnitus

ArticleYear
Sumatriptan and naproxen sodium for the acute treatment of migraine.
    Headache, 2005, Volume: 45, Issue:8

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Synergism;

2005