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sumatriptan and Seizures

sumatriptan has been researched along with Seizures in 11 studies

Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Serotonin and fluoxetine, but not sumatriptan, alleviated PTZ-induced seizures by prolonging onset times of myoclonic-jerk and generalized tonic-clonic seizures."8.12Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats. ( Kilinc, E; Kılınc, YB; Torun, IE, 2022)
" In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects."8.12Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022)
"Sumatriptan has been among the top choices in the management of migraine headaches."5.48Biphasic effect of sumatriptan on PTZ-induced seizures in mice: Modulation by 5-HT1B/D receptors and NOS/NO pathway. ( Aghamollaii, V; Ahmadi, M; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Rohani, MM; Tafakhori, A, 2018)
"Sumatriptan has been used for the acute treatment of migraine attacks."5.46Sumatriptan, an Antimigraine Drug, Inhibits Pentylenetetrazol-induced Seizures in NMRI Mice. ( Jand, A; Palizvan, MR, 2017)
"Serotonin and fluoxetine, but not sumatriptan, alleviated PTZ-induced seizures by prolonging onset times of myoclonic-jerk and generalized tonic-clonic seizures."4.12Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats. ( Kilinc, E; Kılınc, YB; Torun, IE, 2022)
" In this study, we investigated the possible beneficial effects of lasmiditan and sumatriptan against post-stroke seizures in mice and explored underlying mechanisms in their effects."4.12Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K ( Amanlou, A; Dehpour, AR; Ejtemaei-Mehr, S; Eslami, F; Ghasemi, M; Rahimi, N; Rashidian, A; Shayan, M; Solaimanian, S, 2022)
"Sumatriptan is a specific 5-Hydroxytryptamine 1B/1D receptor agonist and has neuroprotective effects in various neuropsychiatric disorders."1.72Neuroprotective effect of sumatriptan in pentylenetetrazole-induced seizure is mediated through N-methyl-D-aspartate/nitric oxide and cAMP response element-binding protein signaling pathway. ( Abdollahi, A; Alotaibi, G; Dehpour, AR; Ghazi-Khansari, M; Imran Khan, M; Mumtaz, F; Rashki, A; Shadboorestan, A, 2022)
"Sumatriptan has been among the top choices in the management of migraine headaches."1.48Biphasic effect of sumatriptan on PTZ-induced seizures in mice: Modulation by 5-HT1B/D receptors and NOS/NO pathway. ( Aghamollaii, V; Ahmadi, M; Amiri, S; Dehpour, AR; Ghasemi, K; Gooshe, M; Rohani, MM; Tafakhori, A, 2018)
"Sumatriptan has been used for the acute treatment of migraine attacks."1.46Sumatriptan, an Antimigraine Drug, Inhibits Pentylenetetrazol-induced Seizures in NMRI Mice. ( Jand, A; Palizvan, MR, 2017)
"All were treated for that headache with Synacthen and one also received sumatriptan before her seizures."1.31Unexplained fitting in three parturients suffering from postdural puncture headache. ( Oliver, CD; White, SA, 2002)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's2 (18.18)29.6817
2010's4 (36.36)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Mumtaz, F1
Rashki, A1
Imran Khan, M1
Shadboorestan, A1
Abdollahi, A1
Ghazi-Khansari, M1
Alotaibi, G1
Dehpour, AR3
Torun, IE1
Kılınc, YB1
Kilinc, E1
Shayan, M1
Eslami, F1
Amanlou, A1
Solaimanian, S1
Rahimi, N1
Rashidian, A1
Ejtemaei-Mehr, S1
Ghasemi, M1
Gooshe, M1
Ghasemi, K1
Rohani, MM1
Tafakhori, A1
Amiri, S1
Aghamollaii, V1
Ahmadi, M1
Levin, M1
Jand, A1
Palizvan, MR1
Williams, SH1
Kehr, HA1
Oliver, CD1
White, SA1
Iizuka, T1
Sakai, F1
Endo, M1
Suzuki, N1
Chan, WN1
Evans, JM1
Hadley, MS1
Herdon, HJ1
Jerman, JC1
Parsons, AA1
Read, SJ1
Stean, TO1
Thompson, M1
Upton, N1
O'Quinn, S1
Davis, RL1
Gutterman, DL1
Pait, GD1
Fox, AW1

Reviews

1 review available for sumatriptan and Seizures

ArticleYear
An update in the treatment of neurologic disorders during pregnancy--focus on migraines and seizures.
    Journal of pharmacy practice, 2012, Volume: 25, Issue:3

    Topics: Animals; Anticonvulsants; Female; Humans; Migraine Disorders; Nervous System Diseases; Pregnancy; Pr

2012

Trials

1 trial available for sumatriptan and Seizures

ArticleYear
Prospective large-scale study of the tolerability of subcutaneous sumatriptan injection for acute treatment of migraine.
    Cephalalgia : an international journal of headache, 1999, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Cardiovascular Diseases; Cerebrovascul

1999

Other Studies

9 other studies available for sumatriptan and Seizures

ArticleYear
Neuroprotective effect of sumatriptan in pentylenetetrazole-induced seizure is mediated through N-methyl-D-aspartate/nitric oxide and cAMP response element-binding protein signaling pathway.
    Fundamental & clinical pharmacology, 2022, Volume: 36, Issue:2

    Topics: Animals; Cyclic AMP Response Element-Binding Protein; Mice; N-Methylaspartate; Neuroprotective Agent

2022
Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats.
    Arquivos de neuro-psiquiatria, 2022, Volume: 80, Issue:1

    Topics: Animals; Anticonvulsants; Epilepsy; Fluoxetine; Humans; Interleukin-6; Male; Neuroinflammatory Disea

2022
Neuroprotective effects of Lasmiditan and Sumatriptan in an experimental model of post-stroke seizure in mice: Higher effects with concurrent opioid receptors or K
    Toxicology and applied pharmacology, 2022, 11-01, Volume: 454

    Topics: Adenosine Triphosphate; Animals; Anticonvulsants; bcl-2-Associated X Protein; Benzamides; Disease Mo

2022
Biphasic effect of sumatriptan on PTZ-induced seizures in mice: Modulation by 5-HT1B/D receptors and NOS/NO pathway.
    European journal of pharmacology, 2018, Apr-05, Volume: 824

    Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Nitric Oxide; N

2018
Teaching case: hypertensiveheadache.
    Headache, 2013, Volume: 53, Issue:4

    Topics: Brain Diseases; Cerebral Hemorrhage; Female; Headache; Humans; Hypertension; Middle Aged; Seizures;

2013
Sumatriptan, an Antimigraine Drug, Inhibits Pentylenetetrazol-induced Seizures in NMRI Mice.
    Drug research, 2017, Volume: 67, Issue:3

    Topics: Animals; Anticonvulsants; Male; Mice; Migraine Disorders; Pentylenetetrazole; Seizures; Sumatriptan;

2017
Unexplained fitting in three parturients suffering from postdural puncture headache.
    British journal of anaesthesia, 2002, Volume: 89, Issue:5

    Topics: Adult; Analgesia, Epidural; Anesthesia, Obstetrical; Cosyntropin; Female; Headache; Humans; Seizures

2002
Response to sumatriptan in headache of MELAS syndrome.
    Neurology, 2003, Aug-26, Volume: 61, Issue:4

    Topics: Adult; Drug Evaluation; Female; Headache; Humans; Hyperemia; MELAS Syndrome; Parietal Lobe; Phenotyp

2003
Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent.
    Bioorganic & medicinal chemistry letters, 1999, Jan-18, Volume: 9, Issue:2

    Topics: Animals; Benzamides; Benzopyrans; Dose-Response Relationship, Drug; Methylcellulose; Mice; Migraine

1999