Page last updated: 2024-11-04
sumatriptan and Pulsatile Tinnitus
sumatriptan has been researched along with Pulsatile Tinnitus in 1 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Smith, TR | 1 |
| Sunshine, A | 1 |
| Stark, SR | 1 |
| Littlefield, DE | 1 |
| Spruill, SE | 1 |
| Alexander, WJ | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| "An Open-label Study to Evaluate Completeness of Response Following Treatment With Treximet™ for Migraine"[NCT00893737] | Phase 4 | 147 participants (Actual) | Interventional | 2009-06-30 | Completed |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Change in Scores From Completeness of Response Survey (CORS)
"CORS scores for Pain (0-4), Associated Symptoms (0-4), Limbic/Affective Symptoms (0-5), and Speed of Return to Functionality (1-5), represent outcome measures that are relevant to patients. Higher scores represent better treatment efficacy.~The analysis compares CORS scores for usual triptan (pre-study) versus (vs.) Treximet (study medication)." (NCT00893737)
Timeframe: Visit 1 (screening) and Visit 2 (study completion following 2-month treatment period)
| Intervention | Units on a scale (Mean) |
|---|
| Pain Score | Associated Symptoms Score | Limbic Symptoms Score | Functionality Score |
|---|
| Treximet | 0.17 | 0.07 | 0.03 | 0.10 |
Paired T-test Indicating Greater Subject Satisfaction With Treximet Over Usual Pre-study Triptan as Determined by the Revised Patient Perception of Migraine Questionnaire (PPMQ-R)
Scores calculated for (1) Efficacy (2) Functionality (3) Ease of use (4) Cost. Higher score represents better treatment satisfaction. (NCT00893737)
Timeframe: Visit 1 (screening) and Visit 2 (study completion following 2-month treatment period)
| Intervention | Units on a scale (Mean) |
|---|
| Efficacy | Functionality | Ease of Use | Cost |
|---|
| Treximet | 8.61 | 13.86 | 2.76 | 7.28 |
Percent of Participants Reporting Treximet Provides Therapeutic Advantage Over Usual Pre-study Triptan
CORS completed at Visit 1 regarding participant pre-study triptan and at Visit 2 regarding Treximet taken in study. Areas of therapeutic advantage evaluated: How often does 1 dose completely relieve (1) headache pain (2) neck/shoulder pain (3) nausea (4) light sensitivity (5) sound sensitivity (6) irritability. How quickly can/do you (1) concentrate or think clearly (2) resume normal activities (3) function normally (4) feel completely normal. How confident are you that (1) one dose will completely relieve migraine within 2 hours (2) once relieved, migraine will not return within 24 hours. (NCT00893737)
Timeframe: Visit 1 (screening) and Visit 2 (study completion following 2-month treatment period)
| Intervention | Percent of Participants (Number) |
|---|
| How often 1 dose relieves headache pain | How often 1 dose relieves neck/shoulder pain | How often 1 dose relieves nausea | How often 1 dose relieves light sensitivity | How often 1 dose relieves sound sensitivity | How often 1 dose relieves irritability | How quickly can you concentrate or think clearly | How quickly can you resume normal activities | How quickly can you function normally | How quickly do you feel completely normal | Confidence 1 dose will relieve migraine in 2 hours | Confidence migraine will not return in 24 hours |
|---|
| Treximet | 42 | 52 | 43 | 42 | 45 | 36 | 31 | 32 | 32 | 36 | 33 | 38 |
Trials
1 trial available for sumatriptan and Pulsatile Tinnitus