Page last updated: 2024-11-04

sumatriptan and Pregnancy

sumatriptan has been researched along with Pregnancy in 39 studies

Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"We prospectively compared pregnancy outcome after exposure to sumatriptan with that of disease-matched controls and nonteratogen controls."9.08Pregnancy outcome following first trimester exposure to sumatriptan. ( Brochu, J; Koren, G; Matsui, D; Pastuszak, A; Schick, B; Shuhaiber, S; Spivey, G, 1998)
" A systematic review of the medical literature was conducted to identify information regarding the safety of sumatriptan during pregnancy."8.82Safety of sumatriptan in pregnancy: a review of the data so far. ( Loder, E, 2003)
"To review the literature for treatment of migraine headaches with sumatriptan during pregnancy."8.82Treatment of migraine headaches with sumatriptan in pregnancy. ( Cross, LB; Eichner, SF; Hilaire, ML, 2004)
"To evaluate delivery outcome in women who used drugs for migraine during pregnancy with special reference to sumatriptan."7.71Delivery outcome in women who used drugs for migraine during pregnancy with special reference to sumatriptan. ( Källén, B; Lygner, PE, 2001)
"Assessment of best available evidence for tolerability of sumatriptan after inadvertent exposure during pregnancy."7.71Evidence-based assessment of pregnancy outcome after sumatriptan exposure. ( Anderson, PO; Chambers, CD; Diamond, ML; Fox, AW; Spierings, EL, 2002)
"Perinatal and pregnancy outcome did not differ between patients who had and had not used sumatriptan after conception, at the resolution of these sample sizes."7.70Pregnancy and perinatal outcomes in migraineurs using sumatriptan: a prospective study. ( Davis, RL; Ephross, SA; Fox, AW; Gutterman, DL; O'Quinn, S; Williams, V, 1999)
"5% of fertile Danish women use sumatriptan, and the drug is also taken during pregnancy."7.70Pregnancy outcome following prescription for sumatriptan. ( Nielsen, GL; Olesen, C; Olsen, J; Sorensen, HT; Steffensen, FH, 2000)
" A systematic review of the medical literature was conducted to identify information regarding the safety of sumatriptan during pregnancy."4.82Safety of sumatriptan in pregnancy: a review of the data so far. ( Loder, E, 2003)
"To review the literature for treatment of migraine headaches with sumatriptan during pregnancy."4.82Treatment of migraine headaches with sumatriptan in pregnancy. ( Cross, LB; Eichner, SF; Hilaire, ML, 2004)
"Using the Marketscan database, the risk of major birth defects was ascertained in live-born infants whose birth mothers were exposed to sumatriptan, naratriptan, or sumatriptan/naproxen during pregnancy."3.88Use of existing electronic health care databases to evaluate medication safety in pregnancy: Triptan exposure in pregnancy as a case study. ( Bollinger, L; Cangialose, C; Chia, V; Mikol, DD; Xue, F; Yusuf, A, 2018)
"Accumulated data suggest that exposure to sumatriptan during pregnancy does not increase the risk of birth defects above the baseline rate."3.76Safety of triptans for migraine headaches during pregnancy and breastfeeding. ( Bozzo, P; Duong, S; Einarson, A; Nordeng, H, 2010)
" The mother used bisoprolol, naproxen and sumatriptan for migraine until the fifth postmenstrual week of pregnancy."3.72Bilateral cleft lip and palate, hypertelorism and hypoplastic toes. ( Kajantie, E; Somer, M, 2004)
"To evaluate delivery outcome in women who used drugs for migraine during pregnancy with special reference to sumatriptan."3.71Delivery outcome in women who used drugs for migraine during pregnancy with special reference to sumatriptan. ( Källén, B; Lygner, PE, 2001)
"Assessment of best available evidence for tolerability of sumatriptan after inadvertent exposure during pregnancy."3.71Evidence-based assessment of pregnancy outcome after sumatriptan exposure. ( Anderson, PO; Chambers, CD; Diamond, ML; Fox, AW; Spierings, EL, 2002)
" The proportions of outcomes with birth defects are as follows: in the Acyclovir (antiviral medication) Pregnancy Registry (1984-1998) (19/581), 3."3.70Monitoring pregnancy outcomes after prenatal drug exposure through prospective pregnancy registries: a pharmaceutical company commitment. ( Andrews, EB; Ephross, SA; Heffner, CR; Reiff-Eldridge, R; Tennis, PS; White, AD, 2000)
"Perinatal and pregnancy outcome did not differ between patients who had and had not used sumatriptan after conception, at the resolution of these sample sizes."3.70Pregnancy and perinatal outcomes in migraineurs using sumatriptan: a prospective study. ( Davis, RL; Ephross, SA; Fox, AW; Gutterman, DL; O'Quinn, S; Williams, V, 1999)
"5% of fertile Danish women use sumatriptan, and the drug is also taken during pregnancy."3.70Pregnancy outcome following prescription for sumatriptan. ( Nielsen, GL; Olesen, C; Olsen, J; Sorensen, HT; Steffensen, FH, 2000)
"Sumatriptan is a potent and selective serotonin1D receptor agonist, which can be administered orally and via the subcutaneous or intranasal route."2.39Acute treatment of migraine attacks. ( Ferrari, MD; Haan, J, 1995)
"Sumatriptan is a serotonin agonist that has been studied for the acute treatment of migraine and cluster headache."2.38Sumatriptan: a selective 5-hydroxytryptamine receptor agonist for the acute treatment of migraine. ( Fullerton, T; Gengo, FM, 1992)
"Allometric scaling is an empirical examination of the relationships between the pharmacokinetic parameters and size (usually body weight), but it can also involve brain weight for metabolized drug."1.30Mixed effect modeling of sumatriptan pharmacokinetics during drug development. I: Interspecies allometric scaling. ( Bye, A; Cosson, VF; Efthymiopoulos, C; Fuseau, E, 1997)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (33.33)18.2507
2000's16 (41.03)29.6817
2010's10 (25.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Weinshank, RL1
Zgombick, JM1
Macchi, MJ1
Branchek, TA1
Hartig, PR1
Jarvis, S1
Dassan, P1
Piercy, CN1
Yusuf, A1
Chia, V1
Xue, F1
Mikol, DD1
Bollinger, L1
Cangialose, C1
Cady, RK1
Diener, HC1
Bejan-Angoulvant, T1
Beau-Salinas, F1
Lengellé, C1
Cissoko, H1
Jonville-Béra, AP1
Hultzsch, S1
Schaefer, C1
Duong, S1
Bozzo, P1
Nordeng, H1
Einarson, A1
Williams, SH1
Kehr, HA1
Loder, E1
Nappi, G1
Sandrini, G1
Sances, G1
Veselá, J1
Rehák, P1
Mihalik, J1
Czikková, S1
Pokorný, J1
Koppel, J1
Fox, AW4
Kajantie, E1
Somer, M1
Sato, S1
Shimizu, M1
Endo, K1
Homma, M1
Yamamoto, T1
Rousso, P1
Hilaire, ML1
Cross, LB1
Eichner, SF1
Gupta, S2
Hanff, LM2
Visser, W2
Steegers, EA2
Saxena, PR2
Vulto, AG2
MaassenVanDenBrink, A2
Stallard, N1
Barry, P1
Ferrari, MD1
Haan, J1
Carp, H1
Singh, PJ1
Vadhera, R1
Jayaram, A1
Schenker, S1
Yang, Y1
Perez, A1
Henderson, GI1
Lee, MP1
Freiherr Von Hornstein, W1
Reich, A1
Cosson, VF1
Fuseau, E1
Efthymiopoulos, C1
Bye, A1
Shuhaiber, S1
Pastuszak, A1
Schick, B1
Matsui, D1
Spivey, G1
Brochu, J1
Koren, G1
Karlsson, C1
Bodelsson, G1
Bodelsson, M1
Stjernquist, M1
Sprigge, JS1
Granier, I1
Garcia, E1
Geissler, A1
Boespflug, MD1
Durand-Gasselin, J1
Reiff-Eldridge, R1
Heffner, CR1
Ephross, SA2
Tennis, PS1
White, AD1
Andrews, EB1
O'Quinn, S1
Williams, V1
Davis, RL1
Gutterman, DL1
Olesen, C2
Steffensen, FH1
Sorensen, HT1
Nielsen, GL1
Olsen, J2
Källén, B1
Lygner, PE1
Chambers, CD1
Anderson, PO1
Diamond, ML1
Spierings, EL1
Fullerton, T1
Gengo, FM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Sumatriptan and Naratriptan Pregnancy Registry[NCT01059604]868 participants (Actual)Observational [Patient Registry]2001-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for sumatriptan and Pregnancy

ArticleYear
Red flags and comfort signs for ominous secondary headaches.
    Otolaryngologic clinics of North America, 2014, Volume: 47, Issue:2

    Topics: Adult; Cooperative Behavior; Diagnosis, Differential; Diagnostic Imaging; Female; Headache Disorders

2014
Migraine and pregnancy. Choice of treatment.
    Prescrire international, 2014, Volume: 23, Issue:153

    Topics: Abnormalities, Drug-Induced; Female; Fetus; Gestational Age; Humans; Migraine Disorders; Patient Sel

2014
[Analgesic drugs during pregnancy].
    Schmerz (Berlin, Germany), 2016, Volume: 30, Issue:6

    Topics: Abnormalities, Drug-Induced; Acetaminophen; Acute Pain; Analgesics; Analgesics, Opioid; Anticonvulsa

2016
An update in the treatment of neurologic disorders during pregnancy--focus on migraines and seizures.
    Journal of pharmacy practice, 2012, Volume: 25, Issue:3

    Topics: Animals; Anticonvulsants; Female; Humans; Migraine Disorders; Nervous System Diseases; Pregnancy; Pr

2012
Safety of sumatriptan in pregnancy: a review of the data so far.
    CNS drugs, 2003, Volume: 17, Issue:1

    Topics: Animals; Female; Humans; Migraine Disorders; Pregnancy; Pregnancy Complications; Pregnancy Outcome;

2003
Tolerability of the triptans: clinical implications.
    Drug safety, 2003, Volume: 26, Issue:2

    Topics: Brain; Cardiovascular System; Drug Interactions; Female; Fetus; Humans; Migraine Disorders; Pregnanc

2003
Treatment of migraine headaches with sumatriptan in pregnancy.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:10

    Topics: Abnormalities, Drug-Induced; Clinical Trials as Topic; Female; Humans; Migraine Disorders; Pregnancy

2004
Acute treatment of migraine attacks.
    Current opinion in neurology, 1995, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Analgesics; Child; Dihydroergotamine; Female; Humans; Male; Migraine Disorders; P

1995
Sumatriptan: a selective 5-hydroxytryptamine receptor agonist for the acute treatment of migraine.
    The Annals of pharmacotherapy, 1992, Volume: 26, Issue:6

    Topics: Clinical Trials as Topic; Drug Interactions; Female; Humans; Indoles; Migraine Disorders; Pregnancy;

1992

Trials

1 trial available for sumatriptan and Pregnancy

ArticleYear
Pregnancy outcome following first trimester exposure to sumatriptan.
    Neurology, 1998, Volume: 51, Issue:2

    Topics: Adult; Embryonic and Fetal Development; Female; Humans; Pregnancy; Pregnancy Outcome; Pregnancy Trim

1998

Other Studies

29 other studies available for sumatriptan and Pregnancy

ArticleYear
Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Apr-15, Volume: 89, Issue:8

    Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Membrane; Cloning, Molecular; DNA Probes; Female;

1992
Managing migraine in pregnancy.
    BMJ (Clinical research ed.), 2018, 01-25, Volume: 360

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antiemetics; Female; Humans; Migraine with Aura; Pre

2018
Use of existing electronic health care databases to evaluate medication safety in pregnancy: Triptan exposure in pregnancy as a case study.
    Pharmacoepidemiology and drug safety, 2018, Volume: 27, Issue:12

    Topics: Abnormalities, Drug-Induced; Administrative Claims, Healthcare; Adolescent; Adult; Databases, Factua

2018
[Pregnant women can take triptans].
    MMW Fortschritte der Medizin, 2014, Oct-23, Volume: 156, Issue:18

    Topics: Congenital Abnormalities; Female; Humans; Naproxen; Piperidines; Pregnancy; Sumatriptan; Tryptamines

2014
[Drugs news].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2015, Volume: 22, Issue:2

    Topics: Abnormalities, Drug-Induced; Anti-Retroviral Agents; Azathioprine; Female; Humans; Infant, Newborn;

2015
Triptans: beware of vasoconstrictive effects.
    Prescrire international, 2014, Volume: 23, Issue:153

    Topics: Adult; Female; Humans; Male; Migraine Disorders; Patient Selection; Pregnancy; Risk Assessment; Risk

2014
Safety of triptans for migraine headaches during pregnancy and breastfeeding.
    Canadian family physician Medecin de famille canadien, 2010, Volume: 56, Issue:6

    Topics: Breast Feeding; Female; Humans; Migraine Disorders; Piperidines; Pregnancy; Pregnancy Complications;

2010
Expression of serotonin receptors in mouse oocytes and preimplantation embryos.
    Physiological research, 2003, Volume: 52, Issue:2

    Topics: Animals; Blastocyst; Cells, Cultured; Culture Techniques; Female; Gene Expression Regulation, Develo

2003
Revised estimates for probability of successful outcome of pregnancy after sumatriptan exposure.
    Headache, 2004, Volume: 44, Issue:3

    Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Migraine Disorders; Pregnancy; Pregnan

2004
Bilateral cleft lip and palate, hypertelorism and hypoplastic toes.
    Clinical dysmorphology, 2004, Volume: 13, Issue:3

    Topics: Abnormalities, Multiple; Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Bisop

2004
[Postpartum cerebral angiopathy--a case report the vasculopathy associated with co-administration of two vasoconstrictives, methylergometrine maleate and sumatriptan].
    Rinsho shinkeigaku = Clinical neurology, 2004, Volume: 44, Issue:2

    Topics: Adult; Cerebrovascular Disorders; Female; Humans; Hypertension; Magnetic Resonance Imaging; Methyler

2004
[Drug exposure during pregnancy: a differentiated approach].
    Praxis, 2004, May-26, Volume: 93, Issue:22

    Topics: Abnormalities, Drug-Induced; Abortion, Eugenic; Alcohol Drinking; Benzodiazepines; Drug Therapy; Fem

2004
Revised estimates for probability of successful outcome of pregnancy after sumatriptan exposure.
    Headache, 2004, Volume: 44, Issue:8

    Topics: Female; Humans; Pregnancy; Pregnancy Outcome; Risk Assessment; Serotonin Receptor Agonists; Sumatrip

2004
Functional reactivity of 5-HT receptors in human umbilical cord and maternal subcutaneous fat arteries after normotensive or pre-eclamptic pregnancy.
    Journal of hypertension, 2006, Volume: 24, Issue:7

    Topics: Adult; Arteries; Blood Pressure; Data Interpretation, Statistical; Female; Fetus; Humans; Ketanserin

2006
The effect of maternal ketanserin treatment on foetal 5-HT receptor function in umbilical cord artery of pre-eclamptic patients.
    Neonatology, 2007, Volume: 92, Issue:4

    Topics: Adolescent; Adult; Antihypertensive Agents; Benzamides; Case-Control Studies; Dose-Response Relation

2007
Another complication of the combined extradural-subarachnoid technique.
    British journal of anaesthesia, 1995, Volume: 75, Issue:3

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Cesarean Section; Female;

1995
Effects of the serotonin-receptor agonist sumatriptan on postdural puncture headache: report of six cases.
    Anesthesia and analgesia, 1994, Volume: 79, Issue:1

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Female; Headache; Humans; Male; Pregnancy; Spinal P

1994
Sumatriptan (Imitrex) transport by the human placenta.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1995, Volume: 210, Issue:3

    Topics: Biological Transport; Female; Humans; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Serot

1995
[Limits of sumatriptan in the treatment of headache after dura mater puncture].
    Annales francaises d'anesthesie et de reanimation, 1996, Volume: 15, Issue:2

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Blood Patch, Epidural; Dura Mater; Female; Hea

1996
Mixed effect modeling of sumatriptan pharmacokinetics during drug development. I: Interspecies allometric scaling.
    Journal of pharmacokinetics and biopharmaceutics, 1997, Volume: 25, Issue:2

    Topics: Animals; Biological Availability; Dogs; Dose-Response Relationship, Drug; Drug Design; Female; Human

1997
Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery.
    Gynecologic and obstetric investigation, 1999, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Female; Humans; Ketanserin; Methiothepin; Muscle Contraction; Muscle, Smooth; Pre

1999
The use of sumatriptan in the treatment of postdural puncture headache after accidental lumbar puncture complicated a blood patch procedure.
    Anaesthesia, 1999, Volume: 54, Issue:1

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Blood Patch, Epidural; Female; Headache; Humans;

1999
Postpartum cerebral angiopathy associated with the administration of sumatriptan and dihydroergotamine--a case report.
    Intensive care medicine, 1999, Volume: 25, Issue:5

    Topics: Adult; Cerebral Angiography; Cerebrovascular Disorders; Ergonovine; Female; Humans; Obstetric Labor

1999
Monitoring pregnancy outcomes after prenatal drug exposure through prospective pregnancy registries: a pharmaceutical company commitment.
    American journal of obstetrics and gynecology, 2000, Volume: 182, Issue:1 Pt 1

    Topics: Abnormalities, Drug-Induced; Acyclovir; Anticonvulsants; Antiviral Agents; Drug Industry; Epilepsy;

2000
Pregnancy and perinatal outcomes in migraineurs using sumatriptan: a prospective study.
    Archives of gynecology and obstetrics, 1999, Volume: 263, Issue:1-2

    Topics: Abortion, Spontaneous; Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Middle Aged; Migr

1999
Pregnancy outcome following prescription for sumatriptan.
    Headache, 2000, Volume: 40, Issue:1

    Topics: Adult; Drug Prescriptions; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Maternal Expos

2000
Sumatriptan: what do we know about fetal risks?
    Headache, 2001, Volume: 41, Issue:2

    Topics: Denmark; Female; Humans; Infant, Newborn; Infant, Premature; Maternal Exposure; Migraine Disorders;

2001
Delivery outcome in women who used drugs for migraine during pregnancy with special reference to sumatriptan.
    Headache, 2001, Volume: 41, Issue:4

    Topics: Adult; Congenital Abnormalities; Delivery, Obstetric; Female; Humans; Infant, Newborn; Middle Aged;

2001
Evidence-based assessment of pregnancy outcome after sumatriptan exposure.
    Headache, 2002, Volume: 42, Issue:1

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Evidence-Based Medicine; Female; Humans; Infant,

2002