sumatriptan has been researched along with Obsessive-Compulsive Disorder in 9 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Symptoms of obsessive-compulsive disorder (OCD) may be acutely exacerbated by administration of certain serotonin agonists Exacerbation of OCD symptoms by sumatriptan, a 5HT1D agonist (Zohar, 1993), is consistent with pre-clinical data suggesting that the serotonin auto-receptor plays an important role in this disorder (El Mansari et al, 1995)." | 9.09 | Single photon emission computed tomography of the brain with Tc-99m HMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor. ( Stein, DJ; Van Heerden, B; Van Kradenburg, J; Warwick, J; Wasserman, HJ; Wessels, CJ, 1999) |
| " Symptoms of obsessive-compulsive disorder (OCD) may be acutely exacerbated by administration of certain serotonin agonists Exacerbation of OCD symptoms by sumatriptan, a 5HT1D agonist (Zohar, 1993), is consistent with pre-clinical data suggesting that the serotonin auto-receptor plays an important role in this disorder (El Mansari et al, 1995)." | 5.09 | Single photon emission computed tomography of the brain with Tc-99m HMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor. ( Stein, DJ; Van Heerden, B; Van Kradenburg, J; Warwick, J; Wasserman, HJ; Wessels, CJ, 1999) |
| "Sumatriptan is an antimigraine agent, which interacts most potently with 5HT1D receptors." | 1.30 | Treatment of severe, drug resistant obsessive compulsive disorder with the 5HT1D agonist sumatriptan. ( Cohen, R; Sasson, Y; Stern, L; Zohar, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pathak, S | 1 |
| Cottingham, EM | 1 |
| McConville, BJ | 1 |
| Gross-Isseroff, R | 1 |
| Cohen, R | 2 |
| Sasson, Y | 3 |
| Voet, H | 1 |
| Zohar, J | 4 |
| Kennedy, JL | 2 |
| Hollander, E | 2 |
| Koran, LM | 3 |
| Pian, KL | 1 |
| Westenberg, HG | 1 |
| van Megen, HJ | 1 |
| den Boer, JA | 1 |
| Stern, L | 1 |
| Stein, DJ | 1 |
| Van Heerden, B | 1 |
| Wessels, CJ | 1 |
| Van Kradenburg, J | 1 |
| Warwick, J | 1 |
| Wasserman, HJ | 1 |
| Mundo, E | 1 |
| Richter, MA | 1 |
| Sam, F | 1 |
| Macciardi, F | 1 |
| Pallanti, S | 2 |
| Quercioli, L | 1 |
| Bienstock, CA | 1 |
| Marazziti, D | 1 |
| Rasmussen, SA | 1 |
| Ravizza, L | 1 |
| Benkelfat, C | 1 |
| Saxena, S | 1 |
| Greenberg, BD | 1 |
2 reviews available for sumatriptan and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.
Topics: Humans; Obsessive-Compulsive Disorder; Receptor, Serotonin, 5-HT1D; Serotonin Receptor Agonists; Sum | 2004 |
Refractory obsessive-compulsive disorder: state-of-the-art treatment.
Topics: Antipsychotic Agents; Benzodiazepines; Cognitive Behavioral Therapy; Combined Modality Therapy; Drug | 2002 |
4 trials available for sumatriptan and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan.
Topics: Adult; Female; Humans; Hydrocortisone; Male; Middle Aged; Obsessive-Compulsive Disorder; Piperazines | 2004 |
Sumatriptan (5-HT1D receptor agonist) does not exacerbate symptoms in obsessive compulsive disorder.
Topics: Adolescent; Adult; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Female; Humans; Ma | 1998 |
Single photon emission computed tomography of the brain with Tc-99m HMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor.
Topics: Adult; Algorithms; Autoreceptors; Brain; Brain Chemistry; Cerebrovascular Circulation; Double-Blind | 1999 |
Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder.
Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Diso | 2001 |
3 other studies available for sumatriptan and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
The use of sumatriptan in the treatment of obsessive-compulsive disorder in an adolescent.
Topics: Adolescent; Antipsychotic Agents; Fluvoxamine; Humans; Male; Obsessive-Compulsive Disorder; Risperid | 2003 |
Treatment of severe, drug resistant obsessive compulsive disorder with the 5HT1D agonist sumatriptan.
Topics: Adult; Drug Resistance; Female; Humans; Male; Obsessive-Compulsive Disorder; Serotonin Receptor Agon | 1998 |
Is the 5-HT(1Dbeta) receptor gene implicated in the pathogenesis of obsessive-compulsive disorder?
Topics: Adult; Autoreceptors; Female; Genetic Variation; Genotype; Humans; Linkage Disequilibrium; Male; Obs | 2000 |