sumatriptan has been researched along with Myocardial Ischemia in 12 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Sumatriptan, a medication usually prescribed for acute migraine and cluster headaches has been documented as potentially causing coronary vasospasm, thereby leading to MI." | 3.96 | Vasospasm induced myocardial ischaemia secondary to sumatriptan use. ( Ojha, U; Okonkwo, K, 2020) |
| " Forty-five patients (88%) reported at least one adverse event and 23 (45%) experienced pressure, tightness, and/or pain in the chest, neck, and/or throat after administration of avitriptan." | 2.69 | Safety trial with the 5HT1B/1D agonist avitriptan (BMS-180048) in patients with migraine who have experienced pressure, tightness, and/or pain in the chest, neck, and/or throat following sumatriptan. ( Dahlöf, CG; Falk, L; Lewis, CP; Risenfors, M, 1998) |
| "Part 1 discusses the risks for Torsade de Pointes, vasospasm, and ischemia, with a review and discussion of case reports of triptan-associated cardiovascular events in migraineurs with and without CAD risk factors or documented CAD; of the epidemiology and studies of triptans, vasospasm, and cardiovascular morbidity; and of the relationship of variant angina, migraine, and vasospastic disease." | 2.49 | QT prolongation, Torsade de Pointes, myocardial ischemia from coronary vasospasm, and headache medications. Part 1: review of serotonergic cardiac adverse events with a triptan case. ( Cho, L; Stillman, MJ; Tepper, DE; Tepper, S, 2013) |
| "Migraine is a common disorder with a prevalence of 9-10% in Hungary." | 2.41 | [Treatment of migraine in patients with hypertension and ischemic heart disease]. ( Csiba, L; Ficzere, A, 2002) |
| "Their clinical diagnoses were migraine with aura, migraine without aura, cluster headache, and others." | 1.31 | Evidence against strong correlation between chest symptoms and ischemic coronary changes after subcutaneous sumatriptan injection. ( Endo, M; Igarashi, H; Sakai, F; Suzuki, N; Tomita, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Okonkwo, K | 1 |
| Ojha, U | 1 |
| Lynch, JJ | 1 |
| Stump, GL | 1 |
| Kane, SA | 1 |
| Regan, CP | 1 |
| Stillman, MJ | 1 |
| Tepper, S | 1 |
| Tepper, DE | 1 |
| Cho, L | 1 |
| Ficzere, A | 1 |
| Csiba, L | 1 |
| Hirata, K | 1 |
| Tomita, M | 1 |
| Suzuki, N | 1 |
| Igarashi, H | 1 |
| Endo, M | 1 |
| Sakai, F | 1 |
| Kaumann, AJ | 1 |
| Frenken, M | 1 |
| Posival, H | 1 |
| Brown, AM | 1 |
| Hillis, WS | 1 |
| MacIntyre, PD | 1 |
| Ferrari, MD | 2 |
| Haan, J | 1 |
| Visser, WH | 1 |
| Saxena, PR | 2 |
| Bax, WA | 2 |
| Mulder, LJ | 1 |
| Dahlöf, CG | 2 |
| Mathew, N | 1 |
| Falk, L | 1 |
| Risenfors, M | 1 |
| Lewis, CP | 1 |
| Maassen VanDenBrink, A | 1 |
| Ramrattan, NN | 1 |
4 reviews available for sumatriptan and Myocardial Ischemia
| Article | Year |
|---|---|
QT prolongation, Torsade de Pointes, myocardial ischemia from coronary vasospasm, and headache medications. Part 1: review of serotonergic cardiac adverse events with a triptan case.
Topics: Coronary Vasospasm; Electrocardiography; Female; Humans; Middle Aged; Migraine Disorders; Myocardial | 2013 |
[Treatment of migraine in patients with hypertension and ischemic heart disease].
Topics: Adjuvants, Pharmaceutic; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Carbazol | 2002 |
[Sumatriptan in clinical practice].
Topics: Adolescent; Adult; Child; Cluster Headache; Humans; Indoles; Migraine Disorders; Myocardial Ischemia | 1993 |
Cardiovascular safety of 5HT1B/1D agonists--is there a cause for concern?
Topics: Aged; Chest Pain; Contraindications; Coronary Circulation; Death, Sudden, Cardiac; Diagnosis, Differ | 1998 |
1 trial available for sumatriptan and Myocardial Ischemia
| Article | Year |
|---|---|
Safety trial with the 5HT1B/1D agonist avitriptan (BMS-180048) in patients with migraine who have experienced pressure, tightness, and/or pain in the chest, neck, and/or throat following sumatriptan.
Topics: Adult; Chest Pain; Diagnosis, Differential; Electrocardiography; Electrocardiography, Ambulatory; Fe | 1998 |
7 other studies available for sumatriptan and Myocardial Ischemia
| Article | Year |
|---|---|
Vasospasm induced myocardial ischaemia secondary to sumatriptan use.
Topics: Coronary Angiography; Coronary Vasospasm; Electrocardiography; Humans; Male; Middle Aged; Migraine D | 2020 |
The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
Topics: Animals; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Stenosis; Disease Models, Animal | 2009 |
Sumatriptan-induced chest symptoms in Japanese.
Topics: Chest Pain; Humans; Japan; Migraine Disorders; Myocardial Ischemia; Serotonin Receptor Agonists; Sum | 2002 |
Evidence against strong correlation between chest symptoms and ischemic coronary changes after subcutaneous sumatriptan injection.
Topics: Adolescent; Adult; Chest Pain; Female; Humans; Injections, Subcutaneous; Japan; Male; Middle Aged; M | 2002 |
Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors.
Topics: Adult; Arteriosclerosis; Binding, Competitive; Cardiomyopathy, Dilated; Cloning, Molecular; Coronary | 1994 |
Sumatriptan and chest pain.
Topics: Chest Pain; Electrocardiography; Hemodynamics; Humans; Indoles; Myocardial Infarction; Myocardial Is | 1993 |
Human isolated coronary artery contraction to sumatriptan: a post hoc analysis.
Topics: Adult; Aged; Cause of Death; Chest Pain; Contraindications; Coronary Disease; Coronary Vessels; Dise | 1999 |