sumatriptan has been researched along with Muscle Relaxation in 13 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sumatriptan prevents the natural decay in rate of transient LES relaxations that occurs after a meal and favors the occurrence of gastroesophageal reflux despite increasing LES pressure." | 9.09 | Effect of sumatriptan, a 5HT1 agonist, on the frequency of transient lower esophageal sphincter relaxations and gastroesophageal reflux in healthy subjects. ( Coulie, B; Holloway, RH; Janssens, J; Missotten, T; Sifrim, D; Tack, J; Zelter, A, 1999) |
| "Sumatriptan prevents the natural decay in rate of transient LES relaxations that occurs after a meal and favors the occurrence of gastroesophageal reflux despite increasing LES pressure." | 5.09 | Effect of sumatriptan, a 5HT1 agonist, on the frequency of transient lower esophageal sphincter relaxations and gastroesophageal reflux in healthy subjects. ( Coulie, B; Holloway, RH; Janssens, J; Missotten, T; Sifrim, D; Tack, J; Zelter, A, 1999) |
| "Donitriptan is a potent, high efficacy agonist at 5-HT(1B/1D) receptors." | 1.31 | Comparison of contractile responses to donitriptan and sumatriptan in the human middle meningeal and coronary arteries. ( Avezaat, CJ; Bogers, AJ; John, GW; MaassenVanDenBrink, A; Mulder, PG; Saxena, PR; van den Broek, RW, 2002) |
| "Sumatriptan did not cause relaxation." | 1.28 | Sumatriptan contracts large coronary arteries of beagle dogs through 5-HT1-like receptors. ( Kaumann, AJ; Parsons, AA; Raval, P; Stutchbury, C, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malatesta, MG | 1 |
| Fascetti, E | 1 |
| Ciccaglione, AF | 1 |
| Cappello, G | 1 |
| Grossi, L | 1 |
| Ferri, A | 1 |
| Marzio, L | 1 |
| Janssen, P | 1 |
| Tack, J | 4 |
| Sifrim, D | 3 |
| Meulemans, AL | 1 |
| Lefebvre, RA | 1 |
| Butler, A | 1 |
| Worton, SP | 1 |
| O'Shaughnessy, CT | 1 |
| Connor, HE | 2 |
| Carter, D | 1 |
| Champney, M | 1 |
| Hwang, B | 1 |
| Eglen, RM | 1 |
| Coulie, B | 3 |
| Andrioli, A | 2 |
| Janssens, J | 3 |
| Terrón, JA | 1 |
| Falcón-Neri, A | 1 |
| Holloway, RH | 1 |
| Zelter, A | 1 |
| Missotten, T | 1 |
| Wilmer, A | 1 |
| Emre-Aydíngöz, S | 1 |
| Erdem, SR | 1 |
| Tuncer, M | 1 |
| van den Broek, RW | 1 |
| MaassenVanDenBrink, A | 1 |
| Mulder, PG | 1 |
| Bogers, AJ | 1 |
| Avezaat, CJ | 1 |
| John, GW | 1 |
| Saxena, PR | 1 |
| Parsons, AA | 1 |
| Stutchbury, C | 1 |
| Raval, P | 1 |
| Kaumann, AJ | 1 |
| Schoeffter, P | 1 |
| Hoyer, D | 1 |
| Humphrey, PP | 1 |
| Feniuk, W | 1 |
| Perren, MJ | 1 |
| Oxford, AW | 1 |
| Coates, LH | 1 |
| Butina, D | 1 |
3 trials available for sumatriptan and Muscle Relaxation
| Article | Year |
|---|---|
5-HT1-receptor agonist sumatriptan modifies gastric size after 500 ml of water in dyspeptic patients and normal subjects.
Topics: Adult; Dyspepsia; Female; Humans; Male; Middle Aged; Muscle Relaxation; Muscle, Smooth; Radiography; | 2002 |
Effect of sumatriptan, a 5HT1 agonist, on the frequency of transient lower esophageal sphincter relaxations and gastroesophageal reflux in healthy subjects.
Topics: Adolescent; Adult; Eating; Esophagogastric Junction; Female; Gastric Emptying; Gastric Fundus; Gastr | 1999 |
Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man.
Topics: Adult; Female; Gastric Fundus; Gastrointestinal Motility; Humans; Male; Manometry; Muscle Relaxation | 2000 |
10 other studies available for sumatriptan and Muscle Relaxation
| Article | Year |
|---|---|
Influence of 5-HT1 receptor agonists on feline stomach relaxation.
Topics: Animals; Cats; Cell Line; Dose-Response Relationship, Drug; Humans; Male; Muscle Relaxation; Muscle, | 2004 |
Sensory nerve-mediated relaxation of guinea-pig isolated pulmonary artery: prejunctional modulation by alpha 2-adrenoceptor agonists but not sumatriptan.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Electric | 1993 |
Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cloning, Molecular; Drug Inter | 1995 |
Role of nitric oxide in fasting gastric fundus tone and in 5-HT1 receptor-mediated relaxation of gastric fundus.
Topics: Animals; Cats; Enzyme Inhibitors; Fasting; Female; Gastric Fundus; Male; Muscle Relaxation; Muscle T | 1999 |
Pharmacological evidence for the 5-HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries.
Topics: Animals; Basilar Artery; Cerebral Arteries; Dinoprost; Dogs; Endothelium, Vascular; Female; In Vitro | 1999 |
Relaxation induced by serotonin and sumatriptan in isolated guinea pig gallbladder strips.
Topics: Adrenergic beta-Antagonists; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Free Rad | 2001 |
Comparison of contractile responses to donitriptan and sumatriptan in the human middle meningeal and coronary arteries.
Topics: Adult; Aged; Coronary Vessels; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques | 2002 |
Sumatriptan contracts large coronary arteries of beagle dogs through 5-HT1-like receptors.
Topics: Animals; Arteries; Coronary Vessels; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Indol | 1992 |
Is the sumatriptan (GR 43175)-induced endothelium-dependent relaxation of pig coronary arteries mediated by 5-HT1D receptors?
Topics: Animals; Coronary Vessels; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Indoles; Muscle | 1989 |
GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein.
Topics: Animals; Cats; Dogs; Female; In Vitro Techniques; Indoles; Male; Methiothepin; Muscle Contraction; M | 1988 |