sumatriptan has been researched along with Light Sensitivity in 14 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Addition of metoclopramide 10 mg improves relief of nausea and vomiting." | 4.89 | Aspirin with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Kirthi, V; Moore, RA, 2013) |
| " Addition of metoclopramide 10 mg improves relief of nausea and vomiting." | 4.86 | Aspirin with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Kirthi, V; McQuay, HJ; Moore, RA, 2010) |
| "This pooled analysis (N=1773) used data from three randomized, placebo-controlled, phase III trials (studies A, B, and C) to determine the incidence of migraine-associated symptoms (defined as nausea, vomiting, photophobia, and phonophobia) 2 hours after a single oral dose of study medication (almotriptan, sumatriptan, or placebo)." | 4.81 | Almotriptan reduces the incidence of migraine-associated symptoms: a pooled analysis. ( Cady, R, 2002) |
| "6% (89/219) of subjects reported treatment-emergent adverse events (TEAE), the most common of which were associated with the injection site: swelling (12." | 2.87 | Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: an 8-week open-label extension study. ( Brand-Schieber, E; Landy, S; Munjal, S; Rapoport, AM, 2018) |
| "Sumatriptan nasal spray was well tolerated, the incidence of adverse events with each dose of sumatriptan being similar to the placebo (20-27 and 23%, respectively)." | 2.69 | Sumatriptan nasal spray: a dose-ranging study in the acute treatment of migraine. ( Ashford, EA; Becker, WJ; Dahlof, C; Hassani, H; Peikert, A; Salonen, RJ, 1999) |
| "Migraine is a common, disabling condition and a burden for the individual, health services and society." | 2.49 | Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA, 2013) |
| "Diclofenac is an established analgesic, and new formulations using the potassium or epolamine salts, which can be dissolved in water, have been developed for rapid absorption, which may be beneficial in acute migraine." | 2.48 | Diclofenac with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA; Rabbie, R, 2012) |
| "Migraine is a common, disabling condition and a burden for the individual, health services and society." | 2.46 | Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; McQuay, HJ; Moore, RA, 2010) |
| "Photophobia is an abnormal sensitivity to light experienced by migraineurs during attacks." | 1.37 | A PET study of photophobia during spontaneous migraine attacks. ( Boulloche, N; Denuelle, M; Fabre, N; Géraud, G; Payoux, P; Trotter, Y, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 10 (71.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, C | 1 |
| Unekawa, M | 1 |
| Kitagawa, S | 1 |
| Takizawa, T | 1 |
| Kayama, Y | 1 |
| Nakahara, J | 1 |
| Shibata, M | 1 |
| Landy, S | 1 |
| Munjal, S | 1 |
| Brand-Schieber, E | 1 |
| Rapoport, AM | 1 |
| Derry, S | 5 |
| Moore, RA | 5 |
| Kirthi, V | 2 |
| Sufka, KJ | 1 |
| Staszko, SM | 1 |
| Johnson, AP | 1 |
| Davis, ME | 1 |
| Davis, RE | 1 |
| Smitherman, TA | 1 |
| Mason, BN | 1 |
| Kaiser, EA | 1 |
| Kuburas, A | 1 |
| Loomis, MM | 1 |
| Latham, JA | 1 |
| Garcia-Martinez, LF | 1 |
| Russo, AF | 1 |
| McQuay, HJ | 2 |
| Brennan, KC | 1 |
| Denuelle, M | 1 |
| Boulloche, N | 1 |
| Payoux, P | 1 |
| Fabre, N | 1 |
| Trotter, Y | 1 |
| Géraud, G | 1 |
| Rabbie, R | 1 |
| Christoph-Diener, H | 1 |
| Ferrari, M | 1 |
| Mansbach, H | 1 |
| Peikert, A | 1 |
| Becker, WJ | 1 |
| Ashford, EA | 1 |
| Dahlof, C | 1 |
| Hassani, H | 1 |
| Salonen, RJ | 1 |
| Cady, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02569853] | Phase 3 | 268 participants (Actual) | Interventional | 2015-09-21 | Completed | ||
| A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache[NCT03472872] | Phase 4 | 500 participants (Actual) | Interventional | 2017-09-05 | Terminated (stopped due to no longer recruiting or studying) | ||
| Acute Mountain Sickness Treatment: A Double-blind Comparison of Metoclopramide vs. Ibuprofen[NCT01522326] | 300 participants (Anticipated) | Interventional | 2012-03-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT02569853)
Timeframe: 1 hour
| Intervention | Percentage of responders (Number) |
|---|---|
| DFN-11 | 34.6 |
| Placebo | 19.8 |
(NCT02569853)
Timeframe: 2 hours
| Intervention | Percentage of responders (Number) |
|---|---|
| DFN-11 - Double-Blind | 51.0 |
| Placebo - Double-Blind | 30.8 |
6 reviews available for sumatriptan and Light Sensitivity
| Article | Year |
|---|---|
Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Antiemetics; Drug Therapy, Combinatio | 2013 |
Aspirin with or without an antiemetic for acute migraine headaches in adults.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Drug Therapy, Combination; Hum | 2013 |
Aspirin with or without an antiemetic for acute migraine headaches in adults.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Drug Therapy, Combination; Hum | 2010 |
Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antiemetics; Drug Therapy, Combination; Humans; Hype | 2010 |
Diclofenac with or without an antiemetic for acute migraine headaches in adults.
Topics: Acute Disease; Adult; Analgesics; Antiemetics; Diclofenac; Drug Therapy, Combination; Humans; Hypera | 2012 |
Almotriptan reduces the incidence of migraine-associated symptoms: a pooled analysis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials, Phase III as Topic; Female; Humans; | 2002 |
3 trials available for sumatriptan and Light Sensitivity
| Article | Year |
|---|---|
Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: an 8-week open-label extension study.
Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Hyperacusis; Injections, Subcutaneous; Male; | 2018 |
Predicting the response to sumatriptan: the Sumatriptan Naratriptan Aggregate Patient Database.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Clinical Trials as Topic; Databases, Factual; Double-Bl | 2004 |
Sumatriptan nasal spray: a dose-ranging study in the acute treatment of migraine.
Topics: Adult; Aerosols; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart; Humans; Hyper | 1999 |
5 other studies available for sumatriptan and Light Sensitivity
| Article | Year |
|---|---|
Cortical spreading depolarisation-induced facial hyperalgesia, photophobia and hypomotility are ameliorated by sumatriptan and olcegepant.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cere | 2020 |
Clinically relevant behavioral endpoints in a recurrent nitroglycerin migraine model in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Male; Migraine Disorders; Motor Activity; Nitrogl | 2016 |
Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms.
Topics: Animals; Anxiety; Calcitonin Gene-Related Peptide; Darkness; Female; Injections, Intraperitoneal; Li | 2017 |
Turn down the lights!: an irritable occipital cortex in migraine without aura.
Topics: Analgesics; Cerebrovascular Circulation; Humans; Migraine without Aura; Photophobia; Sumatriptan; Ti | 2011 |
A PET study of photophobia during spontaneous migraine attacks.
Topics: Adult; Analgesics; Analysis of Variance; Cerebrovascular Circulation; Female; Humans; Injections, Su | 2011 |