sumatriptan has been researched along with Hypothermia, Accidental in 3 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 23% bioavailability following oral drug administration." | 1.31 | The effect of SB-236057-A, a selective 5-HT1B receptor inverse agonist, on in vivo extracellular 5-HT levels in the freely-moving guinea-pig. ( Austin, NE; Gaster, LM; Hagan, JJ; Hatcher, P; Jeffrey, P; Middlemiss, DN; Roberts, C; Routledge, C; Wyman, P, 2000) |
| "Sumatriptan failed to produce either of these effects due to a poor brain penetration." | 1.29 | 5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates. ( Barf, TA; de Boer, P; Ennis, MD; Ghazal, NB; McGuire, JC; Peroutka, SJ; Smith, MW; Swensson, K; Wikström, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barf, TA | 1 |
| de Boer, P | 1 |
| Wikström, H | 1 |
| Peroutka, SJ | 1 |
| Swensson, K | 1 |
| Ennis, MD | 2 |
| Ghazal, NB | 2 |
| McGuire, JC | 1 |
| Smith, MW | 2 |
| Hoffman, RL | 1 |
| Schlachter, SK | 1 |
| Lawson, CF | 1 |
| Im, WB | 1 |
| Pregenzer, JF | 1 |
| Svensson, KA | 1 |
| Lewis, RA | 1 |
| Hall, ED | 1 |
| Sutter, DM | 1 |
| Harris, LT | 1 |
| McCall, RB | 1 |
| Roberts, C | 1 |
| Hatcher, P | 1 |
| Hagan, JJ | 1 |
| Austin, NE | 1 |
| Jeffrey, P | 1 |
| Wyman, P | 1 |
| Gaster, LM | 1 |
| Routledge, C | 1 |
| Middlemiss, DN | 1 |
3 other studies available for sumatriptan and Hypothermia, Accidental
| Article | Year |
|---|---|
5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.
Topics: 5-Hydroxytryptophan; Acrylamides; Animals; Brain; CHO Cells; Cricetinae; Cyclic AMP; Ethylamines; Gu | 1996 |
Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.
Topics: Animals; Benzopyrans; Biological Availability; Blood Pressure; Brain; Capillary Permeability; Caroti | 1998 |
The effect of SB-236057-A, a selective 5-HT1B receptor inverse agonist, on in vivo extracellular 5-HT levels in the freely-moving guinea-pig.
Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Extracellular Space; Guinea | 2000 |