Page last updated: 2024-11-04

sumatriptan and Emesis

sumatriptan has been researched along with Emesis in 34 studies

Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.

Research Excerpts

ExcerptRelevanceReference
" In the present studies, therefore, we used Suncus murinus, a species of insectivore capable of emesis, to investigate if the vanilloid receptor agonist resiniferatoxin is capable of modeling the emesis associated with migraine."7.73Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew). ( Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C, 2005)
"To describe a patient with cyclic vomiting who was treated successfully with sumatriptan, a serotonin, agonist."7.69Sumatriptan in the treatment of cyclic vomiting. ( Benson, JM; Book, LS; Zorn, SL, 1995)
"Sumatriptan was administered either subcutaneously [(age x 4 + 20)/100 x 3 mg] or by nasal spray (NS; 20 mg)."6.76Sumatriptan as a treatment for cyclic vomiting syndrome: a clinical trial. ( Amakata, K; Fujii, Y; Hikita, T; Kaga, F; Kaneko, S; Kikuchi, A; Kodama, H; Mochizuki, D; Nakamoto, N; Ogita, K, 2011)
"Cyclic vomiting syndrome is an increasingly recognized cause of nausea and vomiting in adults."5.36Adult cyclic vomiting syndrome successfully treated with intranasal sumatriptan. ( Kowalczyk, M; Parkman, H; Ward, L, 2010)
"The authors present a 14-year-old girl with 18q- syndrome combined with cyclic vomiting syndrome."5.35Successful treatment with sumatriptan in a case with cyclic vomiting syndrome combined with 18q- syndrome. ( Haginoya, K; Hirose, M; Kakisaka, Y; Munakata, M; Sato, I; Sato, T; Tsuchiya, S; Uematsu, M; Wakusawa, K, 2009)
" Addition of metoclopramide 10 mg improves relief of nausea and vomiting."4.89Aspirin with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Kirthi, V; Moore, RA, 2013)
" Addition of metoclopramide 10 mg improves relief of nausea and vomiting."4.86Aspirin with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Kirthi, V; McQuay, HJ; Moore, RA, 2010)
"Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting."4.81Gastric motor effects of triptans: open questions and future perspectives. ( Cipolla, G; Crema, F; De Ponti, F; Frigo, G; Moro, E; Sacco, S, 2001)
"This pooled analysis (N=1773) used data from three randomized, placebo-controlled, phase III trials (studies A, B, and C) to determine the incidence of migraine-associated symptoms (defined as nausea, vomiting, photophobia, and phonophobia) 2 hours after a single oral dose of study medication (almotriptan, sumatriptan, or placebo)."4.81Almotriptan reduces the incidence of migraine-associated symptoms: a pooled analysis. ( Cady, R, 2002)
"Sumatriptan succinate and prochlorperazine maleate are a clinically proven combination for treating migraine and associated nausea and vomiting."4.12Development of Optimized Sumatriptan-Prochlorperazine Combined Orodispersible Films Without Disintegrant: in vitro, ex vivo and in vivo Characterization. ( Anwer, UU; Bukhari, NI; Hafiz, MA; Hussain, A; Javed, S; Rasool, F; Raza, SA; Shah, PA; Shamim, R, 2022)
" In the present studies, therefore, we used Suncus murinus, a species of insectivore capable of emesis, to investigate if the vanilloid receptor agonist resiniferatoxin is capable of modeling the emesis associated with migraine."3.73Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew). ( Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C, 2005)
"To describe a patient with cyclic vomiting who was treated successfully with sumatriptan, a serotonin, agonist."3.69Sumatriptan in the treatment of cyclic vomiting. ( Benson, JM; Book, LS; Zorn, SL, 1995)
"Sumatriptan was administered either subcutaneously [(age x 4 + 20)/100 x 3 mg] or by nasal spray (NS; 20 mg)."2.76Sumatriptan as a treatment for cyclic vomiting syndrome: a clinical trial. ( Amakata, K; Fujii, Y; Hikita, T; Kaga, F; Kaneko, S; Kikuchi, A; Kodama, H; Mochizuki, D; Nakamoto, N; Ogita, K, 2011)
"In some cases photo- and/or phonophobia (hyperexcitability) were not experienced at all, despite severe pain and nausea."2.72The natural course of migraine attacks. A prospective analysis of untreated attacks compared with attacks treated with a triptan. ( Dahlöf, C; Linde, M; Mellberg, A, 2006)
"The sumatriptan dose was 10 mg for a body weight of 20 to 39 kg and 20 mg for those with a body weight of >/==" BORDER="0">40 kg."2.71Nasal sumatriptan is effective in treatment of migraine attacks in children: A randomized trial. ( Ahonen, K; Hämäläinen, ML; Hoppu, K; Rantala, H, 2004)
"The incidence of headache recurrence was also assessed."2.69Sumatriptan nasal spray: a dose-ranging study in the acute treatment of migraine. ( Ashford, EA; Becker, WJ; Dahlof, C; Hassani, H; Peikert, A; Salonen, RJ, 1999)
"Three-hundred-and-twenty-eight migraine sufferers treated a first migraine attack with a nontriptan standard care medication: a mixture containing phenazone, butalbital and caffeine (optalidon) or indomethacin plus prochlorperazine plus caffeine (difmetre) or paracetamol 100 mg (tachipirine), depending on their habits."2.69Efficacy and safety of sumatriptan 50 mg in patients not responding to standard care, in the treatment of mild to moderate migraine. The Sumatriptan 50 mg Italian Study Group. ( Cavazzuti, L; Fabbri, L; Pini, LA, 1999)
"Oral sumatriptan 100 mg was well tolerated, and repeated administration did not alter the pattern or severity of adverse events."2.68Oral sumatriptan for the long-term treatment of migraine: clinical findings. ( Cutler, N; Hazelrigg, R; Jamerson, B; Rapoport, A; Rederich, G, 1995)
"Patients treated up to three migraine attacks at home over a 3-month period and recorded the results on a diary card."2.67Sumatriptan--an oral dose-defining study. The Oral Sumatriptan Dose-Defining Study Group. ( , 1991)
"Sumatriptan was significantly more effective than placebo in relieving headache (moderate/severe reduced to mild/none) at 2 h (50 vs."2.67Evaluation of a multiple-dose regimen of oral sumatriptan for the acute treatment of migraine. The Oral Sumatriptan International Multiple-Dose Study Group. ( , 1991)
"Sumatriptan was significantly more effective than Cafergot at reducing the intensity of headache from severe or moderate to mild or none; 66% (145/220) of those treated with sumatriptan improved in this way by 2 h, compared with 48% (118/246) of those treated with Cafergot (p less than 0."2.67A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. ( , 1991)
"If the migraine had not improved at 1 h, patients had the option of taking a second identical injection."2.67Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device. The Sumatriptan Auto-Injector Study Group. ( , 1991)
"A similar number of patients reported migraine recurrence, within 24 h in both treatment groups."2.67A placebo-controlled study of intranasal sumatriptan for the acute treatment of migraine. The Finnish Sumatriptan Group and the Cardiovascular Clinical Research Group. ( , 1991)
"Migraine is a common, disabling condition and a burden for the individual, health services, and society."2.49Naproxen with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Law, S; Moore, RA, 2013)
"Migraine is a disabling, painful primary headache disorder that is associated with various combinations of neurological, gastrointestinal, autonomic and pain symptoms."2.46Innovative delivery systems for migraine: the clinical utility of a transdermal patch for the acute treatment of migraine. ( Freitag, F; Pearlman, SH; Rapoport, AM, 2010)
" Safety was evaluated based on the frequency of reported adverse events, and treatment with eASA was associated with lower incidence of adverse events than was with sumatriptan."2.44Efficacy and safety of 1,000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms. ( Diener, HC; Lampl, C; Voelker, M, 2007)
"Cyclic vomiting syndrome is an increasingly recognized cause of nausea and vomiting in adults."1.36Adult cyclic vomiting syndrome successfully treated with intranasal sumatriptan. ( Kowalczyk, M; Parkman, H; Ward, L, 2010)
"The authors present a 14-year-old girl with 18q- syndrome combined with cyclic vomiting syndrome."1.35Successful treatment with sumatriptan in a case with cyclic vomiting syndrome combined with 18q- syndrome. ( Haginoya, K; Hirose, M; Kakisaka, Y; Munakata, M; Sato, I; Sato, T; Tsuchiya, S; Uematsu, M; Wakusawa, K, 2009)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (38.24)18.2507
2000's11 (32.35)29.6817
2010's9 (26.47)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Javed, S1
Hussain, A1
Shah, PA1
Raza, SA1
Anwer, UU1
Shamim, R1
Rasool, F1
Hafiz, MA1
Bukhari, NI1
Kirthi, V2
Derry, S3
Moore, RA3
Law, S1
Okumura, T1
Ohhira, M1
Kumei, S1
Nozu, T1
Calhoun, AH1
Pruitt, AP1
Kakisaka, Y1
Wakusawa, K1
Sato, I1
Haginoya, K1
Uematsu, M1
Hirose, M1
Munakata, M1
Sato, T1
Tsuchiya, S1
Kowalczyk, M1
Parkman, H1
Ward, L1
McQuay, HJ1
Rapoport, AM1
Freitag, F1
Pearlman, SH1
Hikita, T1
Kodama, H1
Kaneko, S1
Amakata, K1
Ogita, K1
Mochizuki, D1
Kaga, F1
Nakamoto, N1
Fujii, Y1
Kikuchi, A1
Lee, LY1
Abbott, L1
Mahlangu, B1
Moodie, SJ1
Anderson, S1
Ahonen, K1
Hämäläinen, ML1
Rantala, H1
Hoppu, K1
Christoph-Diener, H1
Ferrari, M1
Mansbach, H1
Igarashi, H1
Cheng, FH1
Andrews, PL1
Moreaux, B1
Ngan, MP1
Rudd, JA1
Sam, TS1
Wai, MK1
Wan, C1
Winner, P1
Rothner, AD1
Wooten, JD1
Webster, C1
Ames, M1
Linde, M1
Mellberg, A1
Dahlöf, C2
Lampl, C1
Voelker, M1
Diener, HC1
Nakazato, Y1
Tamura, N1
Shimazu, K1
Rederich, G1
Rapoport, A1
Cutler, N1
Hazelrigg, R1
Jamerson, B1
Hannington-Kiff, JG1
Benson, JM1
Zorn, SL1
Book, LS1
Pascual, J1
del Arco, C1
Romón, T1
del Olmo, E1
Castro, E1
Pazos, A1
Shane, R1
Peikert, A1
Becker, WJ1
Ashford, EA1
Hassani, H1
Salonen, RJ1
Pini, LA1
Fabbri, L1
Cavazzuti, L1
Cipolla, G1
Sacco, S1
Crema, F1
Moro, E1
De Ponti, F1
Frigo, G1
Cady, R1
Houghton, LA1
Fowler, P1
Keene, ON1
Read, NW1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acute Mountain Sickness Treatment: A Double-blind Comparison of Metoclopramide vs. Ibuprofen[NCT01522326]300 participants (Anticipated)Interventional2012-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for sumatriptan and Emesis

ArticleYear
Aspirin with or without an antiemetic for acute migraine headaches in adults.
    The Cochrane database of systematic reviews, 2013, Apr-30, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Drug Therapy, Combination; Hum

2013
Naproxen with or without an antiemetic for acute migraine headaches in adults.
    The Cochrane database of systematic reviews, 2013, Oct-20, Issue:10

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Drug Therapy, Combination; Humans; Migr

2013
Injectable sumatriptan for cyclic vomiting syndrome in adults: a case series.
    Headache, 2014, Volume: 54, Issue:9

    Topics: Adult; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Serotonin 5-HT1 Receptor Agonis

2014
Aspirin with or without an antiemetic for acute migraine headaches in adults.
    The Cochrane database of systematic reviews, 2010, Apr-14, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Drug Therapy, Combination; Hum

2010
Innovative delivery systems for migraine: the clinical utility of a transdermal patch for the acute treatment of migraine.
    CNS drugs, 2010, Volume: 24, Issue:11

    Topics: Clinical Trials as Topic; Drug Administration Routes; Female; Gastroparesis; Humans; Iontophoresis;

2010
The management of cyclic vomiting syndrome: a systematic review.
    European journal of gastroenterology & hepatology, 2012, Volume: 24, Issue:9

    Topics: Adrenergic beta-Antagonists; Age of Onset; Antidepressive Agents, Tricyclic; Depression; Female; Hea

2012
[Side effects of triptans].
    No to shinkei = Brain and nerve, 2004, Volume: 56, Issue:9

    Topics: Central Nervous System; Dose-Response Relationship, Drug; Humans; Indoles; Migraine Disorders; Nause

2004
Efficacy and safety of 1,000 mg effervescent aspirin: individual patient data meta-analysis of three trials in migraine headache and migraine accompanying symptoms.
    Journal of neurology, 2007, Volume: 254, Issue:6

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relatio

2007
Gastric motor effects of triptans: open questions and future perspectives.
    Pharmacological research, 2001, Volume: 43, Issue:3

    Topics: Forecasting; Gastrointestinal Motility; Humans; Indoles; Nausea; Piperidines; Serotonin Receptor Ago

2001
Almotriptan reduces the incidence of migraine-associated symptoms: a pooled analysis.
    Headache, 2002, Volume: 42 Suppl 1

    Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials, Phase III as Topic; Female; Humans;

2002

Trials

14 trials available for sumatriptan and Emesis

ArticleYear
Sumatriptan as a treatment for cyclic vomiting syndrome: a clinical trial.
    Cephalalgia : an international journal of headache, 2011, Volume: 31, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Male; Sumatriptan; Treatment Outcome; Vomiting;

2011
Nasal sumatriptan is effective in treatment of migraine attacks in children: A randomized trial.
    Neurology, 2004, Mar-23, Volume: 62, Issue:6

    Topics: Administration, Intranasal; Adolescent; Child; Cross-Over Studies; Dose-Response Relationship, Drug;

2004
Predicting the response to sumatriptan: the Sumatriptan Naratriptan Aggregate Patient Database.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Clinical Trials as Topic; Databases, Factual; Double-Bl

2004
Sumatriptan nasal spray in adolescent migraineurs: a randomized, double-blind, placebo-controlled, acute study.
    Headache, 2006, Volume: 46, Issue:2

    Topics: Acute Disease; Administration, Inhalation; Administration, Intranasal; Adolescent; Dose-Response Rel

2006
The natural course of migraine attacks. A prospective analysis of untreated attacks compared with attacks treated with a triptan.
    Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:6

    Topics: Adult; Aged; Comorbidity; Cross-Over Studies; Disease Progression; Female; Humans; Hyperacusis; Inci

2006
Oral sumatriptan for the long-term treatment of migraine: clinical findings.
    Neurology, 1995, Volume: 45, Issue:8 Suppl 7

    Topics: Administration, Oral; Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Lo

1995
Sumatriptan nasal spray: a dose-ranging study in the acute treatment of migraine.
    European journal of neurology, 1999, Volume: 6, Issue:1

    Topics: Adult; Aerosols; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart; Humans; Hyper

1999
Efficacy and safety of sumatriptan 50 mg in patients not responding to standard care, in the treatment of mild to moderate migraine. The Sumatriptan 50 mg Italian Study Group.
    International journal of clinical pharmacology research, 1999, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Analgesics; Double-Blind Method; Drug Resistance; Humans; Italy; Middle Age

1999
Effect of sumatriptan, a new selective 5HT1-like agonist, on liquid gastric emptying in man.
    Alimentary pharmacology & therapeutics, 1992, Volume: 6, Issue:6

    Topics: Adult; Double-Blind Method; Fats; Gamma Cameras; Gastric Emptying; Half-Life; Humans; Indoles; Infus

1992
Sumatriptan--an oral dose-defining study. The Oral Sumatriptan Dose-Defining Study Group.
    European neurology, 1991, Volume: 31, Issue:5

    Topics: Administration, Oral; Adult; Consumer Behavior; Double-Blind Method; Female; Humans; Indoles; Male;

1991
Evaluation of a multiple-dose regimen of oral sumatriptan for the acute treatment of migraine. The Oral Sumatriptan International Multiple-Dose Study Group.
    European neurology, 1991, Volume: 31, Issue:5

    Topics: Adult; Aged; Consumer Behavior; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up

1991
A randomized, double-blind comparison of sumatriptan and Cafergot in the acute treatment of migraine. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group.
    European neurology, 1991, Volume: 31, Issue:5

    Topics: Administration, Oral; Adult; Aged; Caffeine; Double-Blind Method; Drug Combinations; Electrocardiogr

1991
Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device. The Sumatriptan Auto-Injector Study Group.
    European neurology, 1991, Volume: 31, Issue:5

    Topics: Adult; Aged; Consumer Behavior; Double-Blind Method; Female; Humans; Indoles; Injections, Subcutaneo

1991
A placebo-controlled study of intranasal sumatriptan for the acute treatment of migraine. The Finnish Sumatriptan Group and the Cardiovascular Clinical Research Group.
    European neurology, 1991, Volume: 31, Issue:5

    Topics: Absorption; Administration, Intranasal; Adult; Disability Evaluation; Double-Blind Method; Female; H

1991

Other Studies

10 other studies available for sumatriptan and Emesis

ArticleYear
Development of Optimized Sumatriptan-Prochlorperazine Combined Orodispersible Films Without Disintegrant: in vitro, ex vivo and in vivo Characterization.
    AAPS PharmSciTech, 2022, Jun-02, Volume: 23, Issue:5

    Topics: Excipients; Humans; Migraine Disorders; Nausea; Prochlorperazine; Sumatriptan; Vomiting

2022
An adult patient with cyclic vomiting syndrome successfully treated with oral sumatriptan.
    The American journal of gastroenterology, 2014, Volume: 109, Issue:2

    Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female;

2014
Successful treatment with sumatriptan in a case with cyclic vomiting syndrome combined with 18q- syndrome.
    Journal of child neurology, 2009, Volume: 24, Issue:12

    Topics: Administration, Intranasal; Adolescent; Adrenal Cortex; Brain; Chromosome Disorders; Chromosomes, Hu

2009
Adult cyclic vomiting syndrome successfully treated with intranasal sumatriptan.
    Journal of general internal medicine, 2010, Volume: 25, Issue:1

    Topics: Administration, Intranasal; Age Factors; Humans; Male; Middle Aged; Periodicity; Sumatriptan; Syndro

2010
Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).
    European journal of pharmacology, 2005, Jan-31, Volume: 508, Issue:1-3

    Topics: Animals; Antiemetics; Butanols; Capsaicin; Cyclooxygenase Inhibitors; Dihydroergotamine; Diphenhydra

2005
An adult case of cyclic vomiting syndrome successfully responding to valproic acid.
    Journal of neurology, 2008, Volume: 255, Issue:6

    Topics: Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Consciousness Disorders; Diazepam; Female; Humans

2008
Sumatriptan relieves and prevents peri-operative migraine attacks.
    Anaesthesia, 1993, Volume: 48, Issue:2

    Topics: Adult; Anesthesia, General; Female; Humans; Indoles; Middle Aged; Migraine Disorders; Postoperative

1993
Sumatriptan in the treatment of cyclic vomiting.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:10

    Topics: Abdominal Pain; Adult; Humans; Male; Nausea; Recurrence; Serotonin Receptor Agonists; Sumatriptan; V

1995
Autoradiographic distribution of [3H]sumatriptan-binding sites in post-mortem human brain.
    Cephalalgia : an international journal of headache, 1996, Volume: 16, Issue:5

    Topics: Adult; Animals; Antiemetics; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Mapping; Guinea Pigs

1996
Development and implementation of practice guidelines (Part 1).
    Hospital formulary, 1994, Volume: 29, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Colony-Stimulating Factors; Drug Utilization; Hospital Bed Capac

1994