sumatriptan has been researched along with Brain Edema in 2 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The alniditan response was blocked by the 5-HT(1B/D) receptor antagonist, GR 127935 (2'-methyl-4'-(5-methyl-[1,2, 4]oxadiazol-3-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide), but not by ketanserin, indicating that the effect is mediated through 5-HT(1B/D) receptors." | 1.30 | Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. ( Bischoff, A; Diener, H; Fetscher, C; Limmroth, V; Michel, MC; Wermelskirchen, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tradtrantip, L | 1 |
| Jin, BJ | 1 |
| Yao, X | 1 |
| Anderson, MO | 1 |
| Verkman, AS | 1 |
| Limmroth, V | 1 |
| Bischoff, A | 1 |
| Fetscher, C | 1 |
| Wermelskirchen, D | 1 |
| Diener, H | 1 |
| Michel, MC | 1 |
1 review available for sumatriptan and Brain Edema
| Article | Year |
|---|---|
Aquaporin-Targeted Therapeutics: State-of-the-Field.
Topics: Animals; Aquaporin 4; Biological Transport; Brain Edema; Gene Expression Regulation; Humans; Molecul | 2017 |
1 other study available for sumatriptan and Brain Edema
| Article | Year |
|---|---|
Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Brain Edema; Capillary Permeability; Dose-Response Relationshi | 1999 |