sumatriptan has been researched along with Auditory Hyperesthesia in 7 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
| Excerpt | Relevance | Reference |
|---|---|---|
| "6% (89/219) of subjects reported treatment-emergent adverse events (TEAE), the most common of which were associated with the injection site: swelling (12." | 2.87 | Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: an 8-week open-label extension study. ( Brand-Schieber, E; Landy, S; Munjal, S; Rapoport, AM, 2018) |
| "In some cases photo- and/or phonophobia (hyperexcitability) were not experienced at all, despite severe pain and nausea." | 2.72 | The natural course of migraine attacks. A prospective analysis of untreated attacks compared with attacks treated with a triptan. ( Dahlöf, C; Linde, M; Mellberg, A, 2006) |
| "Sumatriptan nasal spray was well tolerated, the incidence of adverse events with each dose of sumatriptan being similar to the placebo (20-27 and 23%, respectively)." | 2.69 | Sumatriptan nasal spray: a dose-ranging study in the acute treatment of migraine. ( Ashford, EA; Becker, WJ; Dahlof, C; Hassani, H; Peikert, A; Salonen, RJ, 1999) |
| "Migraine is a common, disabling condition and a burden for the individual, health services and society." | 2.49 | Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA, 2013) |
| "Diclofenac is an established analgesic, and new formulations using the potassium or epolamine salts, which can be dissolved in water, have been developed for rapid absorption, which may be beneficial in acute migraine." | 2.48 | Diclofenac with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA; Rabbie, R, 2012) |
| "Migraine is a common, disabling condition and a burden for the individual, health services and society." | 2.46 | Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; McQuay, HJ; Moore, RA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Landy, S | 1 |
| Munjal, S | 1 |
| Brand-Schieber, E | 1 |
| Rapoport, AM | 1 |
| Derry, S | 3 |
| Moore, RA | 3 |
| McQuay, HJ | 1 |
| Rabbie, R | 1 |
| Christoph-Diener, H | 1 |
| Ferrari, M | 1 |
| Mansbach, H | 1 |
| Linde, M | 1 |
| Mellberg, A | 1 |
| Dahlöf, C | 2 |
| Peikert, A | 1 |
| Becker, WJ | 1 |
| Ashford, EA | 1 |
| Hassani, H | 1 |
| Salonen, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02569853] | Phase 3 | 268 participants (Actual) | Interventional | 2015-09-21 | Completed | ||
| A Randomized Double-blind Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache[NCT03472872] | Phase 4 | 500 participants (Actual) | Interventional | 2017-09-05 | Terminated (stopped due to no longer recruiting or studying) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT02569853)
Timeframe: 1 hour
| Intervention | Percentage of responders (Number) |
|---|---|
| DFN-11 | 34.6 |
| Placebo | 19.8 |
(NCT02569853)
Timeframe: 2 hours
| Intervention | Percentage of responders (Number) |
|---|---|
| DFN-11 - Double-Blind | 51.0 |
| Placebo - Double-Blind | 30.8 |
3 reviews available for sumatriptan and Auditory Hyperesthesia
| Article | Year |
|---|---|
Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Antiemetics; Drug Therapy, Combinatio | 2013 |
Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antiemetics; Drug Therapy, Combination; Humans; Hype | 2010 |
Diclofenac with or without an antiemetic for acute migraine headaches in adults.
Topics: Acute Disease; Adult; Analgesics; Antiemetics; Diclofenac; Drug Therapy, Combination; Humans; Hypera | 2012 |
4 trials available for sumatriptan and Auditory Hyperesthesia
| Article | Year |
|---|---|
Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: an 8-week open-label extension study.
Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Hyperacusis; Injections, Subcutaneous; Male; | 2018 |
Predicting the response to sumatriptan: the Sumatriptan Naratriptan Aggregate Patient Database.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Clinical Trials as Topic; Databases, Factual; Double-Bl | 2004 |
The natural course of migraine attacks. A prospective analysis of untreated attacks compared with attacks treated with a triptan.
Topics: Adult; Aged; Comorbidity; Cross-Over Studies; Disease Progression; Female; Humans; Hyperacusis; Inci | 2006 |
Sumatriptan nasal spray: a dose-ranging study in the acute treatment of migraine.
Topics: Adult; Aerosols; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart; Humans; Hyper | 1999 |