sumatriptan has been researched along with Alcoholism in 3 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the possible influence of alcoholism on serotonergic control of growth hormone (GH) secretion, 6 mg of the 5-HT1D serotonergic receptor agonist, sumatriptan, was injected subcutaneously in a group of nine normal controls (aged 32 to 49 years) and in nine age-matched nondepressed male alcoholic subjects after 10 to 25 days of abstinence from alcohol." | 7.69 | Alcoholism abolishes the growth hormone response to sumatriptan administration in man. ( Coiro, V; Vescovi, PP, 1995) |
| "The general lack of efficacy of sumatriptan in producing alcohol-like symptoms or a desire to drink alcohol may suggest that the 5HT1D receptor plays little role in the pathophysiology of alcoholism." | 3.73 | Pharmacological challenge with a serotonin 1D agonist in alcohol dependence. ( Hugo, CJ; Maritz, JS; Pienaar, W; Stein, DJ; Vythilingum, B, 2005) |
| "To assess the possible influence of alcoholism on serotonergic control of growth hormone (GH) secretion, 6 mg of the 5-HT1D serotonergic receptor agonist, sumatriptan, was injected subcutaneously in a group of nine normal controls (aged 32 to 49 years) and in nine age-matched nondepressed male alcoholic subjects after 10 to 25 days of abstinence from alcohol." | 3.69 | Alcoholism abolishes the growth hormone response to sumatriptan administration in man. ( Coiro, V; Vescovi, PP, 1995) |
| "Some studies have associated alcohol dependence (AD) with the human serotonin (5-HT)(1B) receptor (HTR1B)." | 1.34 | Diplotypes of the human serotonin 1B receptor promoter predict growth hormone responses to sumatriptan in abstinent alcohol-dependent men. ( Berrettini, W; Dahl, JP; Hardie, TL; Moss, HB; Xu, K, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vythilingum, B | 1 |
| Hugo, CJ | 1 |
| Maritz, JS | 1 |
| Pienaar, W | 1 |
| Stein, DJ | 1 |
| Moss, HB | 1 |
| Hardie, TL | 1 |
| Dahl, JP | 1 |
| Berrettini, W | 1 |
| Xu, K | 1 |
| Coiro, V | 1 |
| Vescovi, PP | 1 |
3 other studies available for sumatriptan and Alcoholism
| Article | Year |
|---|---|
Pharmacological challenge with a serotonin 1D agonist in alcohol dependence.
Topics: Alcohol Drinking; Alcoholism; Behavior, Addictive; Cross-Over Studies; Emotions; Female; Humans; Mal | 2005 |
Diplotypes of the human serotonin 1B receptor promoter predict growth hormone responses to sumatriptan in abstinent alcohol-dependent men.
Topics: Adult; Alcoholism; Chi-Square Distribution; Ethnicity; Genotype; Growth Hormone; Humans; Male; Polym | 2007 |
Alcoholism abolishes the growth hormone response to sumatriptan administration in man.
Topics: Adult; Alcoholism; Growth Hormone; Humans; Male; Middle Aged; Reference Values; Serotonin Receptor A | 1995 |