sumatriptan has been researched along with Ache in 55 studies
Sumatriptan: A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
sumatriptan : A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Excerpt | Relevance | Reference |
---|---|---|
"Results from The Spectrum Study suggested that early treatment of migraine attacks with sumatriptan 50-mg tablets while the pain is mild might enhance pain-free response and reduce headache recurrence." | 10.19 | Effect of early intervention with sumatriptan on migraine pain: retrospective analyses of data from three clinical trials. ( Cady, RK; Crisp, A; Jones, M; Lipton, RB; McNeal, S; Metz, A; O'Quinn, S; Putnam, DG; Sheftell, F, 2000) |
"Sumatriptan, a drug widely used to alleviate migraine headaches, has several somatosensory adverse effects, including tactile allodynia." | 9.17 | A pharmaco-fMRI study on pain networks induced by electrical stimulation after sumatriptan injection. ( Chenwang, J; Dan, L; Ming, Z; Netra, R; Shaohui, M; Yuan, W, 2013) |
" The present study examined the effectiveness of a 5-HT1A/1B/1D receptor agonist, sumatriptan, on pain relief in patients with trigeminal neuralgia." | 9.12 | Sumatriptan alleviates pain in patients with trigeminal neuralgia. ( Hoka, S; Kanai, A; Osawa, S; Suzuki, A, 2006) |
"In the intention to treat group, two hour pain free rates were 16%, 40%, and 50% in the placebo group, sumatriptan 50 mg group, and the sumatriptan 100 mg group respectively (p < 0." | 9.12 | Pain free efficacy of sumatriptan in the early treatment of migraine. ( Ahmad, FE; Becker, WJ; Christie, SN; Jelinski, SE; Pryse-Phillips, W; Simpson, SD, 2006) |
"Two studies were conducted comparing the time to onset of relief from moderate or severe migraine pain with the fast-disintegrating/rapid-release formulation of sumatriptan tablets 50 and 100 mg and placebo." | 9.11 | Two replicate randomized, double-blind, placebo-controlled trials of the time to onset of pain relief in the acute treatment of migraine with a fast-disintegrating/rapid-release formulation of sumatriptan tablets. ( Agosti, R; Barrett, PS; Brandes, JL; Dahlöf, CG; Jones, MW; Sheftell, FD, 2005) |
"To investigate the hypothesis that early treatment of a migraine attack with sumatriptan, while pain is still mild, results in higher pain free rates in comparison to delayed treatment, when pain is at least moderate, we performed a prospective, controlled and open label study." | 9.11 | Early treatment of a migraine attack while pain is still mild increases the efficacy of sumatriptan. ( Banik, N; Moeckesch, B; Schellenberg, R; Scholpp, J, 2004) |
"To evaluate the efficacy and tolerability of sumatriptan, 50-mg and 100-mg tablets, compared with placebo for treatment of migraine at the first sign of pain." | 9.10 | Pain-free results with sumatriptan taken at the first sign of migraine pain: 2 randomized, double-blind, placebo-controlled studies. ( Kwong, J; Mannix, LK; McNeal, S; O'Quinn, S; Putnam, DG; Richardson, MS; Winner, P, 2003) |
" Nitroglycerin (NTG) administration commonly causes a headache with some features similar to those of a migraine." | 9.09 | The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. ( Forrest, A; Fullerton, T; Gengo, FM; Komorowski-Swiatek, D, 1999) |
"A double-blind, placebo-controlled crossover study was undertaken to assess the efficacy and tolerability of sumatriptan in patients with atypical facial pain." | 9.08 | A double-blind, placebo-controlled, crossover, study to evaluate the efficacy of subcutaneous sumatriptan in the treatment of atypical facial pain. ( al Balawi, S; Feinmann, C; Tariq, M, 1996) |
"The efficacy, safety, and tolerability of subcutaneous sumatriptan in the acute treatment of cluster headache were investigated in a multicenter study over a period of up to 1 year." | 9.08 | Acute therapy for cluster headache with sumatriptan: findings of a one-year long-term study. ( Deuschl, G; Göbel, H; Heinze, A; Lindner, V; Ribbat, M, 1998) |
"To demonstrate that sumatriptan may induce activation or aggravation of pain at sites of inflammation caused by trauma or disease." | 7.72 | Activation of pain by sumatriptan. ( Clark, DW; Coulter, DM; Passier, JL; van Puijenbroek, EP, 2003) |
"Results from The Spectrum Study suggested that early treatment of migraine attacks with sumatriptan 50-mg tablets while the pain is mild might enhance pain-free response and reduce headache recurrence." | 6.19 | Effect of early intervention with sumatriptan on migraine pain: retrospective analyses of data from three clinical trials. ( Cady, RK; Crisp, A; Jones, M; Lipton, RB; McNeal, S; Metz, A; O'Quinn, S; Putnam, DG; Sheftell, F, 2000) |
"Our data suggest that sumatriptan reduces central sensitization (secondary hyperalgesia) without modulating peripheral sensitization (primary hyperalgesia) in a human pain model of capsaicin-induced sensitization." | 5.51 | Sumatriptan prevents central sensitization specifically in the trigeminal dermatome in humans. ( Basedau, H; Jürgens, T; May, A; Ortlieb, L; Peng, KP, 2022) |
"This review was designated to evaluate the efficacy of parenteral ketorolac in treating acute migraine headache." | 5.22 | Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis. ( Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB, 2022) |
"Sumatriptan, a drug widely used to alleviate migraine headaches, has several somatosensory adverse effects, including tactile allodynia." | 5.17 | A pharmaco-fMRI study on pain networks induced by electrical stimulation after sumatriptan injection. ( Chenwang, J; Dan, L; Ming, Z; Netra, R; Shaohui, M; Yuan, W, 2013) |
" The present study examined the effectiveness of a 5-HT1A/1B/1D receptor agonist, sumatriptan, on pain relief in patients with trigeminal neuralgia." | 5.12 | Sumatriptan alleviates pain in patients with trigeminal neuralgia. ( Hoka, S; Kanai, A; Osawa, S; Suzuki, A, 2006) |
"In the intention to treat group, two hour pain free rates were 16%, 40%, and 50% in the placebo group, sumatriptan 50 mg group, and the sumatriptan 100 mg group respectively (p < 0." | 5.12 | Pain free efficacy of sumatriptan in the early treatment of migraine. ( Ahmad, FE; Becker, WJ; Christie, SN; Jelinski, SE; Pryse-Phillips, W; Simpson, SD, 2006) |
"The aim of this study was to determine whether clinical indicators of cutaneous allodynia predict the success of migraine therapy with sumatriptan using a brief questionnaire." | 5.12 | Clarification of developing and established clinical allodynia and pain-free outcomes. ( Landy, SH; McDonald, SA; McGinnis, JE, 2007) |
"To investigate the hypothesis that early treatment of a migraine attack with sumatriptan, while pain is still mild, results in higher pain free rates in comparison to delayed treatment, when pain is at least moderate, we performed a prospective, controlled and open label study." | 5.11 | Early treatment of a migraine attack while pain is still mild increases the efficacy of sumatriptan. ( Banik, N; Moeckesch, B; Schellenberg, R; Scholpp, J, 2004) |
"Two studies were conducted comparing the time to onset of relief from moderate or severe migraine pain with the fast-disintegrating/rapid-release formulation of sumatriptan tablets 50 and 100 mg and placebo." | 5.11 | Two replicate randomized, double-blind, placebo-controlled trials of the time to onset of pain relief in the acute treatment of migraine with a fast-disintegrating/rapid-release formulation of sumatriptan tablets. ( Agosti, R; Barrett, PS; Brandes, JL; Dahlöf, CG; Jones, MW; Sheftell, FD, 2005) |
"To evaluate the efficacy and tolerability of sumatriptan, 50-mg and 100-mg tablets, compared with placebo for treatment of migraine at the first sign of pain." | 5.10 | Pain-free results with sumatriptan taken at the first sign of migraine pain: 2 randomized, double-blind, placebo-controlled studies. ( Kwong, J; Mannix, LK; McNeal, S; O'Quinn, S; Putnam, DG; Richardson, MS; Winner, P, 2003) |
" Nitroglycerin (NTG) administration commonly causes a headache with some features similar to those of a migraine." | 5.09 | The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. ( Forrest, A; Fullerton, T; Gengo, FM; Komorowski-Swiatek, D, 1999) |
"A double-blind, placebo-controlled crossover study was undertaken to assess the efficacy and tolerability of sumatriptan in patients with atypical facial pain." | 5.08 | A double-blind, placebo-controlled, crossover, study to evaluate the efficacy of subcutaneous sumatriptan in the treatment of atypical facial pain. ( al Balawi, S; Feinmann, C; Tariq, M, 1996) |
"The efficacy, safety, and tolerability of subcutaneous sumatriptan in the acute treatment of cluster headache were investigated in a multicenter study over a period of up to 1 year." | 5.08 | Acute therapy for cluster headache with sumatriptan: findings of a one-year long-term study. ( Deuschl, G; Göbel, H; Heinze, A; Lindner, V; Ribbat, M, 1998) |
"Sumatriptan and the ergot alkaloids are useful tools for deciphering drug mechanisms in migraine and related headaches." | 4.78 | Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine. ( Moskowitz, MA, 1992) |
"The selective 5-HT₁ receptor agonist sumatriptan is an effective therapeutic for migraine pain yet the antimigraine mechanisms of action remain controversial." | 3.78 | Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. ( Ahn, AH; Baillie, LD; Mulligan, SJ, 2012) |
"Subjects with persistent interictal pain were more likely to have chronic cluster, allodynia, and suboptimal response to sumatriptan, suggesting that interictal pain in cluster headache may predict a more severe disease process." | 3.76 | Interictal pain in cluster headache. ( Marmura, MJ; Pello, SJ; Young, WB, 2010) |
" This analysis examined productivity loss as a result of migraine after treatment with sumatriptan tablets and patients' usual non-triptan therapy when pain was mild (early intervention) versus when pain was moderate/severe." | 3.73 | The effect of early intervention with sumatriptan tablets on migraine-associated productivity loss. ( Adelman, JU; Kwong, WJ; Taylor, FR, 2005) |
"To demonstrate that sumatriptan may induce activation or aggravation of pain at sites of inflammation caused by trauma or disease." | 3.72 | Activation of pain by sumatriptan. ( Clark, DW; Coulter, DM; Passier, JL; van Puijenbroek, EP, 2003) |
"Early treatment of migraine with sumatriptan 50 mg and 100 mg, while pain is mild, has been reported to enhance pain-free response 2 hours and 4 hours postdose and sustained pain-free response 2 to 24 hours postdose compared with treatment when pain has become moderate to severe." | 3.71 | Economic implications of early treatment of migraine with sumatriptan tablets. ( Cady, RK; Kwong, WJ; Lipton, RB; O'Quinn, S; Sheftell, F, 2001) |
" The purpose of our study was to evaluate the impact of sumatriptan on the quality of life of patients with migraine headaches." | 3.69 | Quality of life assessment among migraine patients treated with sumatriptan. ( Genzen, JR; Skobieranda, FG; Solomon, GD, 1995) |
"2hPF rates were higher for attacks treated when pain was mild vs moderate or severe: ubrogepant 50 mg (47." | 3.11 | Efficacy of Ubrogepant in the Acute Treatment of Migraine With Mild Pain vs Moderate or Severe Pain. ( Adams, AM; Burstein, R; Dodick, DW; Finnegan, M; Goadsby, PJ; Kuang, AW; Lai, J; Lipton, RB; Trugman, JM; Yu, SY, 2022) |
"4% (16/119) who received placebo experienced at least 1 treatment-emergent adverse event (TEAE), the most common of which were injection site swelling (7." | 2.87 | Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: a multicenter, randomized, double-blind, placebo-controlled study. ( Brand-Schieber, E; Landy, S; Munjal, S; Rapoport, AM, 2018) |
"In the treatment of migraine attacks with 6 mg subcutaneous sumatriptan the number needed to treat (NNT) is 2." | 2.82 | [Sumatriptan 3 mg subcutaneous : Clinical relevance of acute treatment of migraine despite dose reduction]. ( Förderreuther, S; Gaul, C, 2022) |
"Headache response or headache relief (i." | 2.78 | Efficacy endpoints in migraine clinical trials: the importance of assessing freedom from pain. ( Farr, SJ; Marmura, MJ; Nahas, SJ; Newman, LC; Silberstein, SD, 2013) |
"Sumatriptan was beneficial for 13 out of 14 newly diagnosed CFS migraine subjects." | 2.76 | Migraine headaches in chronic fatigue syndrome (CFS): comparison of two prospective cross-sectional studies. ( Baraniuk, JN; Merck, SJ; Ravindran, MK; Timbol, C; Zheng, Y, 2011) |
"Oral sumatriptan is an effective acute treatment for migraine in adults, but its efficacy in children is still undetermined." | 2.68 | Sumatriptan for migraine attacks in children: a randomized placebo-controlled study. Do children with migraine respond to oral sumatriptan differently from adults? ( Hämäläinen, ML; Hoppu, K; Santavuori, P, 1997) |
"Although headache is among the most common pain complaints seen by physicians, the measurement of health-related quality of life (HRQoL) in headache patients is in its earliest stages." | 2.40 | Evolution of the measurement of quality of life in migraine. ( Solomon, GD, 1997) |
" Cluster headache is not optimally treated and few clinical trials are available to model therapy, especially dosing and administration." | 1.72 | Cluster Headache: Opportunities for Pharmacists to Improve Care. ( Clark, AS; Smith, TR; Wenzel, R, 2022) |
"Pretreatment with propranolol or nor-BNI prior to restraint stress prevented both transient cutaneous allodynia and priming, demonstrated by a lack of umbellulone-induced cutaneous allodynia." | 1.62 | A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain. ( Chessell, IP; Dodick, DW; Kopruszinski, CM; Navratilova, E; Porreca, F; Swiokla, J, 2021) |
"Characterization of headache and pain related behaviours included assessment of cutaneous tactile pain sensitivity, using von Frey monofilaments, and ongoing pain using the conditioned place preference or aversion (CPP/CPA) paradigms." | 1.48 | Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache. ( Bree, D; Levy, D, 2018) |
"Most pharmacological trials deal with migraine as if it were a clinically homogeneous disease, and when detailing its characteristics, they usually report only the presence, or absence, of aura and attack frequency but provide no information on pain location, a non-trivial clinical detail." | 1.42 | Pharmacological trials in migraine: it's time to reappraise where the headache is and what the pain is like. ( Barbanti, P; Egeo, G, 2015) |
"Migraine is a common neurological disorder often treated with triptans." | 1.36 | Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. ( Andrews, JS; Chichorro, J; De Felice, M; Dodick, D; Dussor, G; Lai, J; Maddaford, S; Meng, ID; Ossipov, MH; Porreca, F; Rakhit, S; Wang, R, 2010) |
"There was no difference in the treatments used or pain relief achieved between migraine, migrainous, and tension-type headaches." | 1.35 | Pain treatment and relief among patients with primary headache subtypes in the ED. ( Miner, J; Trainor, A, 2008) |
"This may lead to misdiagnosis as migraine and delayed appropriate diagnosis and treatment." | 1.33 | The risks of sumatriptan administration in patients with unrecognized subarachnoid haemorrhage (SAH). ( Keller, H; Pfadenhauer, K; Schönsteiner, T, 2006) |
"For many migraine patients, triptan therapy provides complete pain relief in some attacks but not in others." | 1.32 | Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. ( Burstein, R; Collins, B; Jakubowski, M, 2004) |
"The other two had migraine without aura." | 1.30 | Recurrent neck pain as a variant of migraine: description of four cases. ( Accornero, N; De Marinis, M, 1997) |
"Zolmitriptan is a newly developed 5HT1B/1D receptor agonist with both peripheral and central sites of action in the trigeminovascular system due to greater lipophilicity relative to the more hydrophilic antimigraine compound sumatriptan." | 1.30 | Comparison of more and less lipophilic serotonin (5HT1B/1D) agonists in a model of trigeminovascular nociception in cat. ( Goadsby, PJ; Hoskin, KL, 1998) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 12 (21.82) | 18.2507 |
2000's | 22 (40.00) | 29.6817 |
2010's | 14 (25.45) | 24.3611 |
2020's | 7 (12.73) | 2.80 |
Authors | Studies |
---|---|
Gaul, C | 1 |
Förderreuther, S | 1 |
Nurathirah, MN | 1 |
Yazid, MB | 1 |
Norhayati, MN | 1 |
Baharuddin, KA | 1 |
Abu Bakar, MA | 1 |
Lipton, RB | 3 |
Dodick, DW | 2 |
Goadsby, PJ | 3 |
Burstein, R | 3 |
Adams, AM | 1 |
Lai, J | 2 |
Yu, SY | 1 |
Finnegan, M | 1 |
Kuang, AW | 1 |
Trugman, JM | 1 |
Peng, KP | 1 |
Jürgens, T | 1 |
Basedau, H | 1 |
Ortlieb, L | 1 |
May, A | 1 |
Tfelt-Hansen, P | 1 |
Diener, HC | 1 |
Kopruszinski, CM | 1 |
Navratilova, E | 1 |
Swiokla, J | 1 |
Chessell, IP | 1 |
Porreca, F | 2 |
Wenzel, R | 1 |
Smith, TR | 1 |
Clark, AS | 1 |
Rea, BJ | 1 |
Wattiez, AS | 1 |
Waite, JS | 1 |
Castonguay, WC | 1 |
Schmidt, CM | 1 |
Fairbanks, AM | 1 |
Robertson, BR | 1 |
Brown, CJ | 1 |
Mason, BN | 1 |
Moldovan-Loomis, MC | 1 |
Garcia-Martinez, LF | 1 |
Poolman, P | 1 |
Ledolter, J | 1 |
Kardon, RH | 1 |
Sowers, LP | 1 |
Russo, AF | 1 |
Landy, S | 1 |
Munjal, S | 1 |
Brand-Schieber, E | 1 |
Rapoport, AM | 1 |
Silberstein, SD | 1 |
Newman, LC | 1 |
Marmura, MJ | 2 |
Nahas, SJ | 1 |
Farr, SJ | 1 |
Yang, LP | 1 |
Barbanti, P | 1 |
Egeo, G | 1 |
Bree, D | 1 |
Levy, D | 1 |
Nikai, T | 1 |
Basbaum, AI | 1 |
Ahn, AH | 2 |
Trainor, A | 1 |
Miner, J | 1 |
De Felice, M | 1 |
Ossipov, MH | 1 |
Wang, R | 1 |
Dussor, G | 1 |
Meng, ID | 1 |
Chichorro, J | 1 |
Andrews, JS | 1 |
Rakhit, S | 1 |
Maddaford, S | 1 |
Dodick, D | 1 |
Watanabe, Y | 1 |
Tanaka, H | 1 |
Dan, I | 1 |
Sakurai, K | 1 |
Kimoto, K | 1 |
Takashima, R | 1 |
Hirata, K | 1 |
Pello, SJ | 1 |
Young, WB | 1 |
Agrawal, V | 1 |
Gupta, V | 1 |
Ramteke, S | 1 |
Trivedi, P | 1 |
Ravindran, MK | 1 |
Zheng, Y | 1 |
Timbol, C | 1 |
Merck, SJ | 1 |
Baraniuk, JN | 1 |
Mitsikostas, DD | 2 |
Knight, YE | 1 |
Lasalandra, M | 1 |
Kavantzas, N | 1 |
Baillie, LD | 1 |
Mulligan, SJ | 1 |
Yuan, W | 1 |
Dan, L | 1 |
Netra, R | 1 |
Shaohui, M | 1 |
Chenwang, J | 1 |
Ming, Z | 1 |
Sanchez del Rio, M | 1 |
Waeber, C | 1 |
Kayser, V | 1 |
Aubel, B | 1 |
Hamon, M | 1 |
Bourgoin, S | 1 |
Benedetti, F | 1 |
Pollo, A | 1 |
Lopiano, L | 1 |
Lanotte, M | 1 |
Vighetti, S | 1 |
Rainero, I | 1 |
Coulter, DM | 1 |
Passier, JL | 1 |
Clark, DW | 1 |
van Puijenbroek, EP | 1 |
Winner, P | 1 |
Mannix, LK | 1 |
Putnam, DG | 2 |
McNeal, S | 2 |
Kwong, J | 1 |
O'Quinn, S | 3 |
Richardson, MS | 1 |
Jakubowski, M | 2 |
Collins, B | 1 |
Iizuka, T | 1 |
Sakai, F | 1 |
Scholpp, J | 1 |
Schellenberg, R | 1 |
Moeckesch, B | 1 |
Banik, N | 1 |
Sheftell, FD | 1 |
Dahlöf, CG | 1 |
Brandes, JL | 1 |
Agosti, R | 1 |
Jones, MW | 1 |
Barrett, PS | 1 |
Kwong, WJ | 2 |
Taylor, FR | 1 |
Adelman, JU | 1 |
Pfadenhauer, K | 1 |
Schönsteiner, T | 1 |
Keller, H | 1 |
Jelinski, SE | 1 |
Becker, WJ | 1 |
Christie, SN | 1 |
Ahmad, FE | 1 |
Pryse-Phillips, W | 1 |
Simpson, SD | 1 |
Kanai, A | 1 |
Suzuki, A | 1 |
Osawa, S | 1 |
Hoka, S | 1 |
Landy, SH | 1 |
McGinnis, JE | 1 |
McDonald, SA | 1 |
Anisimov, VV | 1 |
Maas, HJ | 1 |
Danhof, M | 1 |
Della Pasqua, O | 1 |
Krämer, HH | 1 |
Lundblad, L | 1 |
Birklein, F | 1 |
Linde, M | 1 |
Karlsson, T | 1 |
Elam, M | 1 |
Olausson, H | 1 |
Solomon, GD | 2 |
Skobieranda, FG | 1 |
Genzen, JR | 1 |
al Balawi, S | 1 |
Tariq, M | 1 |
Feinmann, C | 1 |
Roberts-Thomson, I | 1 |
Argyrides, J | 1 |
Pannall, P | 1 |
Frewin, D | 1 |
Hämäläinen, ML | 1 |
Hoppu, K | 1 |
Santavuori, P | 1 |
De Marinis, M | 1 |
Accornero, N | 1 |
Hoskin, KL | 1 |
Göbel, H | 1 |
Lindner, V | 1 |
Heinze, A | 1 |
Ribbat, M | 1 |
Deuschl, G | 1 |
Fullerton, T | 1 |
Komorowski-Swiatek, D | 1 |
Forrest, A | 1 |
Gengo, FM | 1 |
Jain, NK | 2 |
Kulkarni, SK | 2 |
Cady, RK | 2 |
Sheftell, F | 2 |
Jones, M | 1 |
Crisp, A | 1 |
Metz, A | 1 |
Miyazaki, T | 1 |
Moskowitz, MA | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Multicenter, Randomized, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine With or Without Aura[NCT02873221] | Phase 3 | 1,254 participants (Actual) | Interventional | 2016-09-13 | Completed | ||
[NCT02569853] | Phase 3 | 268 participants (Actual) | Interventional | 2015-09-21 | Completed | ||
A Randomized, Single-Center, Double-Blind, Parallel, Sham-Controlled Study of Gammacore Sapphire (Non-Invasive Vagus Nerve Stimulator) for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)[NCT04071743] | 0 participants (Actual) | Interventional | 2020-01-01 | Withdrawn (stopped due to Primary Investigator left UT Southwestern and was not replaced.) | |||
Identify Unique Set of Proteins in Cerebrospinal Fluid, Which Are Believed to be Found in Chronic Fatigue Syndrome Participants, But Not in Healthy Controls.[NCT00810329] | 160 participants (Actual) | Observational | 2007-07-31 | Completed | |||
Placebo Effect in Children With Attention Deficit Disorder and/or Hyperactivity Disorder[NCT04766580] | 44 participants (Anticipated) | Interventional | 2021-02-17 | Recruiting | |||
A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura[NCT00877838] | Phase 2 | 40 participants (Anticipated) | Interventional | 2009-05-31 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
An adverse event (AE) is any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product. TEAEs are AEs with an onset that occurs after receiving study drug. (NCT02873221)
Timeframe: 56 Weeks
Intervention | Percentage of Participants (Number) |
---|---|
Usual Care | 65 |
Ubrogepant 50 mg | 66.3 |
Ubrogepant 100 mg | 72.6 |
"On the C-SSRS, the 5 types of suicidal ideation are:~Type 1: Wish to be dead Type 2: Non-specific active suicidal thoughts Type 3: Active suicidal ideation with any methods (not plan) without intent to act Type 4: Active suicidal ideation with some intent to act, without specific plan Type 5: Active suicidal ideation with specific plan and intent" (NCT02873221)
Timeframe: 56 Weeks
Intervention | Participants (Count of Participants) | |
---|---|---|
Suicidal Ideation | Suicidal Behavior | |
Ubrogepant 100 mg | 2 | 0 |
Ubrogepant 50 mg | 3 | 0 |
Usual Care | 5 | 0 |
ECG findings considered potentially clinically significant (PCS) meeting either the lower-limit or higher-limit PCS criteria. (NCT02873221)
Timeframe: 56 Weeks
Intervention | Participants (Count of Participants) | |||||
---|---|---|---|---|---|---|
PR interval (msec) PR >= 250 | QRS interval (msec) QRS >= 150 | QTc Bazett (msec) QTcB > 500 | QTc Bazett (msec) Increase > 60 (msec) | QTc Fridericia (msec) QTcF > 500 | QTc Fridericia (msec) Increase > 60 (msec) | |
Ubrogepant 100 mg | 0 | 0 | 0 | 5 | 0 | 0 |
Ubrogepant 50 mg | 0 | 1 | 0 | 1 | 0 | 0 |
Usual Care | 0 | 1 | 0 | 0 | 0 | 1 |
Hematology, Chemistry and Urinalysis results considered potentially clinically significant (PCS) meeting either the lower-limit or higher-limit PCS criteria. (NCT02873221)
Timeframe: 56 Weeks
Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Basophils Absolute Cell Count (10**9/L) >2×ULN | Eosinophils Absolute Cell Count (10**9/L) >2×ULN | Hematocrit (RATIO) <0.9×LLN | Hematocrit (RATIO) >1.1×ULN | Hemoglobin (g/L) <0.9×LLN | Hemoglobin (g/L) >1.1×ULN | Lymphocytes Absolute Cell Count (10**9/L) <0.7×LLN | Lymphocytes Absolute Cell Count (10**9/L) >1.3×ULN | Monocytes Absolute Cell Count (10**9/L) <0.5×LLN | Monocytes Absolute Cell Count (10**9/L) >2×ULN | Neutrophils Absolute Cell Count (10**9/L) <0.7×LLN | Neutrophils Absolute Cell Count (10**9/L) >1.3×ULN | Platelet Count (Thrombocytes) (10**9/L) <0.5×LLN | Platelet Count (Thrombocytes) (10**9/L) >1.5×ULN | Red Blood Cell Count (10**12/L) <0.9×LLN | Red Blood Cell Count (10**12/L) >1.1×ULN | White Blood Cell Count (10**9/L) <0.9×LLN | White Blood Cell Count (10**9/L) >1.5×ULN | Alanine Aminotransferase (SGPT) (U/L) >3×ULN | Albumin (g/L) <0.8×LLN | Albumin (g/L) >1.2×ULN | Alkaline Phosphatase (U/L) >3×ULN | Aspartate Aminotransferase (SGOT) (U/L) >3×ULN | Bicarbonate (HCO3) (mmol/L) <0.9×LLN | Bicarbonate (HCO3) (mmol/L) >1.1×ULN | Bilirubin, Total (umol/L) >1.5×ULN | Blood Urea Nitrogen (mmol/L) >1.5×ULN | Calcium (mmol/L) <0.9×LLN | Calcium (mmol/L) >1.1×ULN | Chloride (mmol/L) <0.9×LLN | Chloride (mmol/L) >1.1×UL | Cholesterol, Total (mmol/L) >1.6×ULN | Creatine Kinase (U/L) >2×ULN | Creatinine (umol/L) >1.5×ULN | Glucose, Non-fasting (mmol/L) <0.8×LLN | Glucose, Non-fasting (mmol/L) >2×ULN | Lactate Dehydrogenase (U/L) >3×ULN | Phosphorus (mmol/L) <0.9×LLN | Phosphorus (mmol/L) >1.1×ULN | Potassium (mmol/L) <0.9×LLN | Potassium (mmol/L) >1.1×ULN | Protein, Total (g/L) <0.9×LLN | Protein, Total (g/L) >1.1×ULN | Sodium (mmol/L) <0.9×LLN | Sodium (mmol/L) >1.1×ULN | Triglycerides (mmol/L) >2×ULN | Uric Acid (Urate) (umol/L) >1.2×ULN | Glucose Positive | pH (pH) <0.9×LLN | pH (pH) >1.1×ULN | Protein (g/L) Positive | Specific Gravity >1.1×ULN | |
Ubrogepant 100 mg | 0 | 1 | 6 | 1 | 6 | 1 | 5 | 8 | 0 | 0 | 6 | 17 | 0 | 1 | 3 | 2 | 17 | 4 | 8 | 0 | 0 | 0 | 9 | 37 | 0 | 2 | 1 | 3 | 0 | 1 | 0 | 2 | 57 | 1 | 0 | 1 | 0 | 42 | 21 | 3 | 33 | 4 | 0 | 0 | 2 | 17 | 22 | 23 | 0 | 0 | 0 | 0 |
Ubrogepant 50 mg | 0 | 0 | 2 | 0 | 3 | 0 | 5 | 6 | 0 | 0 | 5 | 14 | 0 | 2 | 5 | 2 | 9 | 2 | 4 | 1 | 0 | 0 | 2 | 22 | 0 | 4 | 3 | 1 | 0 | 0 | 0 | 1 | 43 | 1 | 0 | 1 | 0 | 38 | 15 | 1 | 32 | 2 | 0 | 0 | 0 | 20 | 27 | 17 | 0 | 0 | 0 | 0 |
Usual Care | 0 | 1 | 3 | 2 | 7 | 2 | 11 | 8 | 0 | 0 | 6 | 22 | 0 | 2 | 1 | 2 | 17 | 5 | 4 | 0 | 0 | 0 | 2 | 25 | 0 | 3 | 6 | 2 | 0 | 0 | 0 | 4 | 56 | 1 | 0 | 1 | 0 | 45 | 21 | 0 | 28 | 3 | 0 | 0 | 0 | 30 | 26 | 21 | 0 | 0 | 0 | 0 |
Vital sign measurements considered potentially clinically significant (PCS) meeting either the lower-limit or higher-limit PCS criteria. (NCT02873221)
Timeframe: 56 Weeks
Intervention | Participants (Count of Participants) | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SBP (mmHg) (Sitting) <= 90 and Decrease of >= 20 | SBP (mmHg) (Sitting) >= 180 and Increase of >= 20 | SBP (mmHg) (Standing) <= 90 and Decrease of >= 20 | SBP (mmHg) (Standing) >= 180 and Increase of >= 20 | Standing - Sitting SBP (mmHg) <= -20 | DBP (mmHg) (Sitting) <= 50 and Decrease of >= 15 | DBP (mmHg) (Sitting) >= 105 and Increase of >= 15 | DBP (mmHg) (Standing) <= 50 and Decrease of >= 15 | DBP (mmHg) (Standing) >= 105 and Increase of >= 15 | Standing - Sitting DBP (mmHg) <= -15 | PR (beats/min) (Sitting) <= 50, Decrease of >= 15 | PR (beats/min) (Sitting) >= 120, Increase of >= 15 | PR (beats/min) (Standing) <= 50, Decrease of >= 15 | PR (beats/min)(Standing) >= 120, Increase of >= 15 | Standing - Sitting Pulse Rate (beats/min) >= 25 | Weight (kg) Decrease of >= 7% | Weight (kg) Increase of >= 7% | |
Ubrogepant 100 mg | 12 | 1 | 11 | 1 | 49 | 4 | 6 | 4 | 11 | 36 | 7 | 1 | 3 | 13 | 35 | 53 | 61 |
Ubrogepant 50 mg | 20 | 0 | 11 | 0 | 40 | 5 | 3 | 4 | 14 | 42 | 5 | 2 | 3 | 9 | 37 | 48 | 69 |
Usual Care | 11 | 0 | 12 | 0 | 58 | 6 | 6 | 5 | 12 | 38 | 4 | 1 | 2 | 14 | 42 | 58 | 73 |
(NCT02569853)
Timeframe: 1 hour
Intervention | Percentage of responders (Number) |
---|---|
DFN-11 | 34.6 |
Placebo | 19.8 |
(NCT02569853)
Timeframe: 2 hours
Intervention | Percentage of responders (Number) |
---|---|
DFN-11 - Double-Blind | 51.0 |
Placebo - Double-Blind | 30.8 |
9 reviews available for sumatriptan and Ache
Article | Year |
---|---|
[Sumatriptan 3 mg subcutaneous : Clinical relevance of acute treatment of migraine despite dose reduction].
Topics: Drug Tapering; Humans; Migraine Disorders; Pain; Quality of Life; Sumatriptan; Tryptamines | 2022 |
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Ph | 2022 |
Onset of action in placebo-controlled migraine attacks trials: A literature review and recommendation.
Topics: Humans; Migraine Disorders; Pain; Pharmaceutical Preparations; Randomized Controlled Trials as Topic | 2021 |
Sumatriptan/naproxen sodium: a review of its use in adult patients with migraine.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Drug The | 2013 |
[Recent progress in therapy for migraine headache].
Topics: Anticonvulsants; Botulinum Toxins; Calcitonin Gene-Related Peptide; Central Nervous System; Clinical | 2004 |
Evolution of the measurement of quality of life in migraine.
Topics: Attitude to Health; Emotions; Headache; Health Status; Humans; Mental Health; Migraine Disorders; Pa | 1997 |
Effect of early intervention with sumatriptan on migraine pain: retrospective analyses of data from three clinical trials.
Topics: Dose-Response Relationship, Drug; Double-Blind Method; Humans; Migraine Disorders; Pain; Placebos; R | 2000 |
[The present situation and the prospect of pain control in this country and other countries].
Topics: Americas; Analgesics, Opioid; Anesthesiology; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsan | 2001 |
Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine.
Topics: Ergot Alkaloids; Humans; Indoles; Migraine Disorders; Pain; Proto-Oncogene Proteins c-fos; Serotonin | 1992 |
19 trials available for sumatriptan and Ache
Article | Year |
---|---|
Efficacy of Ubrogepant in the Acute Treatment of Migraine With Mild Pain vs Moderate or Severe Pain.
Topics: Adult; Double-Blind Method; Humans; Migraine Disorders; Pain; Pyridines; Sumatriptan; Treatment Outc | 2022 |
Sumatriptan prevents central sensitization specifically in the trigeminal dermatome in humans.
Topics: Capsaicin; Central Nervous System Sensitization; Headache; Humans; Hyperalgesia; Migraine Disorders; | 2022 |
Efficacy and safety of DFN-11 (sumatriptan injection, 3 mg) in adults with episodic migraine: a multicenter, randomized, double-blind, placebo-controlled study.
Topics: Adult; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Migraine Di | 2018 |
Efficacy endpoints in migraine clinical trials: the importance of assessing freedom from pain.
Topics: Humans; Migraine Disorders; Pain; Pain Management; Pain Measurement; Patient Satisfaction; Research | 2013 |
Migraine headaches in chronic fatigue syndrome (CFS): comparison of two prospective cross-sectional studies.
Topics: Adult; Comorbidity; Cross-Sectional Studies; Fatigue Syndrome, Chronic; Female; Fibromyalgia; Humans | 2011 |
A pharmaco-fMRI study on pain networks induced by electrical stimulation after sumatriptan injection.
Topics: Adult; Brain; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Female; Humans; Injecti | 2013 |
Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses.
Topics: Aged; Analgesia; Attitude to Health; Cognition; Conditioning, Operant; Consciousness; Female; Human | 2003 |
Pain-free results with sumatriptan taken at the first sign of migraine pain: 2 randomized, double-blind, placebo-controlled studies.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; M | 2003 |
Early treatment of a migraine attack while pain is still mild increases the efficacy of sumatriptan.
Topics: Adolescent; Adult; Aged; Chi-Square Distribution; Confidence Intervals; Drug Administration Schedule | 2004 |
Two replicate randomized, double-blind, placebo-controlled trials of the time to onset of pain relief in the acute treatment of migraine with a fast-disintegrating/rapid-release formulation of sumatriptan tablets.
Topics: Adult; Area Under Curve; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Double-Blind M | 2005 |
Pain free efficacy of sumatriptan in the early treatment of migraine.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Migraine Disorders; Pain; Serotonin R | 2006 |
Sumatriptan alleviates pain in patients with trigeminal neuralgia.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Female; Humans; Male; Middle Aged; Pain; Pain Measuremen | 2006 |
Clarification of developing and established clinical allodynia and pain-free outcomes.
Topics: Adolescent; Adult; Aged; Cross-Over Studies; Female; Health Surveys; Humans; Hyperalgesia; Male; Mid | 2007 |
Activation of the cortical pain network by soft tactile stimulation after injection of sumatriptan.
Topics: Adult; Brain Mapping; Cerebral Cortex; Cross-Over Studies; Double-Blind Method; Female; Humans; Imag | 2007 |
A double-blind, placebo-controlled, crossover, study to evaluate the efficacy of subcutaneous sumatriptan in the treatment of atypical facial pain.
Topics: Adolescent; Adult; Aged; Cross-Over Studies; Double-Blind Method; Face; Female; Humans; Male; Middle | 1996 |
Sumatriptan for migraine attacks in children: a randomized placebo-controlled study. Do children with migraine respond to oral sumatriptan differently from adults?
Topics: Administration, Oral; Adolescent; Child; Cross-Over Studies; Double-Blind Method; Female; Humans; Ma | 1997 |
Acute therapy for cluster headache with sumatriptan: findings of a one-year long-term study.
Topics: Adult; Cluster Headache; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Pain; Prospect | 1998 |
The pharmacodynamics of sumatriptan in nitroglycerin-induced headache.
Topics: Adult; Analysis of Variance; Area Under Curve; Brain; Cerebral Arteries; Electrocardiography; Headac | 1999 |
Effect of early intervention with sumatriptan on migraine pain: retrospective analyses of data from three clinical trials.
Topics: Dose-Response Relationship, Drug; Double-Blind Method; Humans; Migraine Disorders; Pain; Placebos; R | 2000 |
28 other studies available for sumatriptan and Ache
Article | Year |
---|---|
A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; | 2021 |
Cluster Headache: Opportunities for Pharmacists to Improve Care.
Topics: Cluster Headache; Humans; Oxygen; Pain; Pharmacists; Sumatriptan | 2022 |
Peripherally administered calcitonin gene-related peptide induces spontaneous pain in mice: implications for migraine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Calcitonin Gene-Related Peptide; Disea | 2018 |
Pharmacological trials in migraine: it's time to reappraise where the headache is and what the pain is like.
Topics: Acetylcholine Release Inhibitors; Botulinum Toxins; Humans; Migraine Disorders; Pain; Serotonin 5-HT | 2015 |
Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.
Topics: Analgesics; Animals; Antibodies, Monoclonal; Behavior, Animal; Brain Concussion; Disease Models, Ani | 2018 |
Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Blood-Brain Barrier; Carrageenan; Drug Evaluation, P | 2008 |
Pain treatment and relief among patients with primary headache subtypes in the ED.
Topics: Adolescent; Adult; Aged; Droperidol; Emergency Service, Hospital; Headache; Humans; Middle Aged; Pai | 2008 |
Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers.
Topics: Animals; Calcitonin Gene-Related Peptide; Dura Mater; Enzyme Inhibitors; Male; Migraine Disorders; N | 2010 |
Monitoring cortical hemodynamic changes after sumatriptan injection during migraine attack by near-infrared spectroscopy.
Topics: Adult; Case-Control Studies; Cerebral Cortex; Cerebrovascular Circulation; Female; Hemodynamics; Hum | 2011 |
Interictal pain in cluster headache.
Topics: Adult; Aged; Cluster Headache; Female; Humans; Male; Middle Aged; Pain; Sumatriptan; Surveys and Que | 2010 |
Preparation and evaluation of tubular micelles of pluronic lecithin organogel for transdermal delivery of sumatriptan.
Topics: Administration, Cutaneous; Animals; Drug Compounding; Drug Delivery Systems; Drug Stability; Gels; H | 2010 |
Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?
Topics: Animals; Capsaicin; Cyclic AMP Response Element-Binding Protein; Hyperalgesia; Immunohistochemistry; | 2011 |
Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Calcium Chann | 2012 |
5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
Topics: Anesthetics, General; Animals; Area Postrema; Brain Stem; Capsaicin; Carbazoles; Chloralose; Cistern | 2002 |
The antimigraine 5-HT 1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.
Topics: Animals; Dihydroergotamine; Disease Models, Animal; Male; Migraine Disorders; Oxazolidinones; Pain; | 2002 |
Activation of pain by sumatriptan.
Topics: Adult; Female; Humans; Inflammation; Injections, Subcutaneous; Male; Middle Aged; Pain; Prospective | 2003 |
Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization.
Topics: Animals; Brain Mapping; Disease Models, Animal; Electrophysiology; Male; Migraine Disorders; Neurons | 2004 |
Defeating migraine pain with triptans: a race against the development of cutaneous allodynia.
Topics: Administration, Oral; Adolescent; Adult; Humans; Injections; Middle Aged; Migraine Disorders; Oxazol | 2004 |
The effect of early intervention with sumatriptan tablets on migraine-associated productivity loss.
Topics: Adult; Clinical Trials as Topic; Female; Humans; Male; Migraine Disorders; Pain; Retrospective Studi | 2005 |
The risks of sumatriptan administration in patients with unrecognized subarachnoid haemorrhage (SAH).
Topics: Adult; Diagnostic Errors; Female; Humans; Male; Migraine Disorders; Pain; Serotonin Receptor Agonist | 2006 |
Analysis of responses in migraine modelling using hidden Markov models.
Topics: Biometry; Clinical Trials as Topic; Confidence Intervals; Humans; Markov Chains; Migraine Disorders; | 2007 |
Quality of life assessment among migraine patients treated with sumatriptan.
Topics: Health Status; Humans; Migraine Disorders; Pain; Pain Measurement; Quality of Life; Serotonin Recept | 1995 |
Sumatriptan and episodic pain syndromes other than migraine.
Topics: Humans; Migraine Disorders; Pain; Palliative Care; Periodicity; Sumatriptan; Syndrome | 1996 |
Recurrent neck pain as a variant of migraine: description of four cases.
Topics: Adult; Carotid Arteries; Female; Humans; Magnetic Resonance Imaging; Migraine Disorders; Neck; Pain; | 1997 |
Comparison of more and less lipophilic serotonin (5HT1B/1D) agonists in a model of trigeminovascular nociception in cat.
Topics: Animals; Cats; Cerebrovascular Circulation; Cranial Sinuses; Electric Stimulation; Gene Expression R | 1998 |
Antinociceptive effect of sumatriptan in mice.
Topics: Animals; Female; Male; Mice; Pain; Serotonin Receptor Agonists; Sumatriptan | 1998 |
L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception.
Topics: Acetic Acid; Analgesics; Animals; Buspirone; Cholinergic Agents; Drug Synergism; Enzyme Inhibitors; | 1999 |
Economic implications of early treatment of migraine with sumatriptan tablets.
Topics: Cost Control; Drug Costs; Migraine Disorders; Pain; Retrospective Studies; Sumatriptan; Vasoconstric | 2001 |