Page last updated: 2024-11-04

sulthiame and Aura

sulthiame has been researched along with Aura in 42 studies

sulthiame: was heading 1964-94 (see under THIAZINES 1964-90); use THIAZINES to search SULTHIAME 1966-94

Research Excerpts

ExcerptRelevanceReference
"To show non-inferiority of levetiracetam to sulthiame with respect to efficacy, tolerability and safety in benign epilepsy with centrotemporal spikes in a prospective, double-blinded randomized controlled trial."9.17Levetiracetam vs. sulthiame in benign epilepsy with centrotemporal spikes in childhood: a double-blinded, randomized, controlled trial (German HEAD Study). ( Bast, T; Bonfert, M; Borggraefe, I; Heinen, F; Maßmann, K; May, TW; Neubauer, BA; Noachtar, S; Schotten, KJ; Tuxhorn, I, 2013)
" Small sample sizes, poor methodological quality, and lack of data on important outcome measures precluded any meaningful conclusions regarding the efficacy and tolerability of sulthiame as monotherapy in epilepsy."9.12Sulthiame monotherapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Panebianco, M, 2021)
"This prospective uncontrolled open study explored the efficacy and long-term tolerability of sulthiame (STM) in 52 patients with refractory epilepsy and learning disability."9.10Sulthiame in adults with refractory epilepsy and learning disability: an open trial. ( Koepp, MJ; Patsalos, PN; Sander, JW, 2002)
"To assess the efficacy and tolerability of sulthiame as add-on therapy for people with epilepsy of any aetiology compared with placebo or another antiepileptic drug."9.01Sulthiame add-on therapy for epilepsy. ( Bresnahan, R; Marson, AG; Martin-McGill, KJ; Milburn-McNulty, P; Powell, G; Sills, GJ, 2019)
"Randomised controlled add-on trials of sulthiame in people of any age with epilepsy of any aetiology."8.91Sulthiame add-on therapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2015)
"Small sample size, poor methodological quality and lack of data on important outcome measures prevent any meaningful conclusions regarding the efficacy and safety of sulthiame as monotherapy in epilepsy."8.90Sulthiame monotherapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2014)
"Randomised placebo-controlled add-on trials of sulthiame in people of any age with epilepsy of any aetiology."8.89Sulthiame add-on therapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2013)
"The charts of 125 consecutive epilepsy patients treated with sulthiame as monotherapy or add-on therapy were reviewed."7.72Sulthiame in childhood epilepsy. ( Barash, I; Ben-Zeev, B; Brand, N; Lerman, P; Lerman-Sagie, T; Watemberg, N, 2004)
"Sulthiame is effectively used in the treatment of benign and symptomatic focal epilepsy in children."7.69Sulthiame-associated mild compensated metabolic acidosis. ( Darius, J; Fritzsch, C; Gedschold, J; Meyer, FP; Tröger, U, 1996)
"9%) seizure frequency was reduced by more than 50% (mean FBM dosage 3211 mg), and 13 patients (31."5.34[Treatment of epilepsy with third-line antiepileptic drugs: felbamate, tiagabine, and sulthiame]. ( Bauer, J; Chahem, J, 2007)
"To show non-inferiority of levetiracetam to sulthiame with respect to efficacy, tolerability and safety in benign epilepsy with centrotemporal spikes in a prospective, double-blinded randomized controlled trial."5.17Levetiracetam vs. sulthiame in benign epilepsy with centrotemporal spikes in childhood: a double-blinded, randomized, controlled trial (German HEAD Study). ( Bast, T; Bonfert, M; Borggraefe, I; Heinen, F; Maßmann, K; May, TW; Neubauer, BA; Noachtar, S; Schotten, KJ; Tuxhorn, I, 2013)
" Small sample sizes, poor methodological quality, and lack of data on important outcome measures precluded any meaningful conclusions regarding the efficacy and tolerability of sulthiame as monotherapy in epilepsy."5.12Sulthiame monotherapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Panebianco, M, 2021)
"This prospective uncontrolled open study explored the efficacy and long-term tolerability of sulthiame (STM) in 52 patients with refractory epilepsy and learning disability."5.10Sulthiame in adults with refractory epilepsy and learning disability: an open trial. ( Koepp, MJ; Patsalos, PN; Sander, JW, 2002)
"To assess the efficacy and tolerability of sulthiame as add-on therapy for people with epilepsy of any aetiology compared with placebo or another antiepileptic drug."5.01Sulthiame add-on therapy for epilepsy. ( Bresnahan, R; Marson, AG; Martin-McGill, KJ; Milburn-McNulty, P; Powell, G; Sills, GJ, 2019)
"Randomised controlled add-on trials of sulthiame in people of any age with epilepsy of any aetiology."4.91Sulthiame add-on therapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2015)
"Small sample size, poor methodological quality and lack of data on important outcome measures prevent any meaningful conclusions regarding the efficacy and safety of sulthiame as monotherapy in epilepsy."4.90Sulthiame monotherapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2014)
"Randomised placebo-controlled add-on trials of sulthiame in people of any age with epilepsy of any aetiology."4.89Sulthiame add-on therapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2013)
"The introduction of these new antiepileptic drugs, from felbamate to levetiracetam, raised hope of control of epilepsy with fewer adverse effects and improved quality of life."4.81New antiepileptic drug therapies. ( Bergin, AM; Connolly, M, 2002)
"Sulthiame is an old antiepileptic drug primarily used in a few European countries for the treatment of benign epilepsy of childhood with central temporal spikes."3.77Sulthiame in refractory paediatric epilepsies: an experience of an 'old' antiepileptic drug in a tertiary paediatric neurology unit. ( Appleton, R; Eaton, V; Hawcutt, D; Kneen, R; Kumar, R; Stockton, F; Swiderska, N, 2011)
"The charts of 125 consecutive epilepsy patients treated with sulthiame as monotherapy or add-on therapy were reviewed."3.72Sulthiame in childhood epilepsy. ( Barash, I; Ben-Zeev, B; Brand, N; Lerman, P; Lerman-Sagie, T; Watemberg, N, 2004)
"Sulthiame is a carbonic anhydrase (CA) inhibitor with an anticonvulsant effect in the treatment of benign and symptomatic focal epilepsy in children."3.71Carbonic anhydrase inhibitor sulthiame reduces intracellular pH and epileptiform activity of hippocampal CA3 neurons. ( Bingmann, D; Bonnet, U; Hufnagel, A; Leniger, T; Widman, G; Wiemann, M, 2002)
"Sulthiame is effectively used in the treatment of benign and symptomatic focal epilepsy in children."3.69Sulthiame-associated mild compensated metabolic acidosis. ( Darius, J; Fritzsch, C; Gedschold, J; Meyer, FP; Tröger, U, 1996)
"9%) seizure frequency was reduced by more than 50% (mean FBM dosage 3211 mg), and 13 patients (31."1.34[Treatment of epilepsy with third-line antiepileptic drugs: felbamate, tiagabine, and sulthiame]. ( Bauer, J; Chahem, J, 2007)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199022 (52.38)18.7374
1990's1 (2.38)18.2507
2000's7 (16.67)29.6817
2010's9 (21.43)24.3611
2020's3 (7.14)2.80

Authors

AuthorsStudies
Milburn-McNulty, P5
Panebianco, M1
Marson, AG5
Bresnahan, R1
Martin-McGill, KJ1
Powell, G4
Sills, GJ4
Madej, K1
Paprotny, Ł1
Wianowska, D1
Kasprzyk, J1
Herman, M1
Piekoszewski, W1
Liguori, S1
Borggraefe, I1
Bonfert, M1
Bast, T1
Neubauer, BA1
Schotten, KJ1
Maßmann, K1
Noachtar, S1
Tuxhorn, I1
May, TW1
Heinen, F1
Yamamoto, Y1
Takahashi, Y1
Imai, K1
Mogami, Y1
Matsuda, K1
Nakai, M1
Kagawa, Y1
Inoue, Y1
Tan, HJ1
Singh, J1
Gupta, R1
de Goede, C1
Rauchenzauner, M1
Griesmacher, A1
Tatarczyk, T1
Haberlandt, E1
Strasak, A1
Zimmerhackl, LB1
Falkensammer, G1
Luef, G1
Högler, W1
Swiderska, N1
Hawcutt, D1
Eaton, V1
Stockton, F1
Kumar, R1
Kneen, R1
Appleton, R1
Koepp, MJ1
Patsalos, PN1
Sander, JW1
Bergin, AM1
Connolly, M1
ENGELMEIER, MP1
FLUEGEL, F1
BENTE, D1
ITIL, T1
RAFFAUF, HJ1
HAJNSEK, F1
BOHACEK, N1
OVERVAD, E1
HARAN, T2
INGRAM, TT1
RATCLIFFE, SG1
TAEN, S1
GOTO, Y1
ARAI, S1
TOKUDA, Y1
ODAWARA, K1
HIRAI, M1
BRAY, CA1
BOWER, BD1
SUTHERLAND, JM1
BOWMAN, DA1
GARLAND, H1
SUMNER, D1
GRIFFITHS, AW1
SYLVESTER, PE1
DOOSE, H1
KLUGE, D1
EHMSEN, U1
GORDON, N2
FENTON, G1
SERAFETINIDES, EA1
POND, DA1
MELIN, KA1
GAYLOR, JB1
SMYTH, VO1
SONNENREICH, C1
RABE, F1
PENIN, H1
MATTHES, A1
Go, T1
Ben-Zeev, B1
Watemberg, N1
Lerman, P1
Barash, I1
Brand, N1
Lerman-Sagie, T1
Huppke, P1
Kallenberg, K1
Gärtner, J1
Chahem, J1
Bauer, J1
Tröger, U1
Fritzsch, C1
Darius, J1
Gedschold, J1
Meyer, FP1
Leniger, T1
Wiemann, M1
Bingmann, D1
Widman, G1
Hufnagel, A1
Bonnet, U1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
HEAD-TO-HEAD Evaluation of the Antiepileptic Drugs Levetiracetam (LEV) vs. Sulthiame (STM) in a German Multi-Centre, Doubleblind Controlled Trial in Children With Benign Epilepsy With Centro-Temporal Spikes[NCT00471744]Phase 344 participants (Actual)Interventional2006-06-30Terminated (stopped due to low patient number after 2 years recruiting)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for sulthiame and Aura

ArticleYear
Sulthiame monotherapy for epilepsy.
    The Cochrane database of systematic reviews, 2021, 09-23, Volume: 9

    Topics: Anticonvulsants; Epilepsy; Humans; Quality of Life; Randomized Controlled Trials as Topic; Thiazines

2021
Sulthiame add-on therapy for epilepsy.
    The Cochrane database of systematic reviews, 2019, 08-27, Volume: 8

    Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Quality of Life;

2019
Sulthiame add-on therapy for epilepsy.
    The Cochrane database of systematic reviews, 2013, Mar-28, Issue:3

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Male; Randomized Controlled Trials as Topic; Spas

2013
Sulthiame monotherapy for epilepsy.
    The Cochrane database of systematic reviews, 2014, Mar-09, Issue:3

    Topics: Adult; Anticonvulsants; Child; Child, Preschool; Early Termination of Clinical Trials; Epilepsy; Epi

2014
Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes.
    The Cochrane database of systematic reviews, 2014, Sep-05, Issue:9

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Clobazam; Epilepsy; Fructose; Humans; Induct

2014
Sulthiame add-on therapy for epilepsy.
    The Cochrane database of systematic reviews, 2015, Oct-28, Issue:10

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Male; Pyridoxine; Randomized Controlled Trials as

2015
New antiepileptic drug therapies.
    Neurologic clinics, 2002, Volume: 20, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Ep

2002
ADVANCES IN NEUROLOGY.
    The Practitioner, 1964, Volume: 193

    Topics: Drug Therapy; Epilepsy; Headache; Methysergide; Migraine Disorders; Multiple Sclerosis; Nervous Syst

1964

Trials

2 trials available for sulthiame and Aura

ArticleYear
Levetiracetam vs. sulthiame in benign epilepsy with centrotemporal spikes in childhood: a double-blinded, randomized, controlled trial (German HEAD Study).
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2013, Volume: 17, Issue:5

    Topics: Anticonvulsants; Child; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Female; Humans; Le

2013
Sulthiame in adults with refractory epilepsy and learning disability: an open trial.
    Epilepsy research, 2002, Volume: 50, Issue:3

    Topics: Adult; Epilepsy; Female; Follow-Up Studies; Humans; Learning Disabilities; Male; Middle Aged; Neutro

2002

Other Studies

32 other studies available for sulthiame and Aura

ArticleYear
A fully validated HPLC-UV method for determination of sulthiame in human serum/plasma samples.
    Biomedical chromatography : BMC, 2021, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chromatography, High Pressure Liquid; D

2021
Is sulthiame effective and tolerated as add-on therapy for infants with epilepsy? A Cochrane Review summary with commentary.
    Developmental medicine and child neurology, 2021, Volume: 63, Issue:6

    Topics: Epilepsy; Humans; Infant; Thiazines

2021
Interaction between sulthiame and clobazam: sulthiame inhibits the metabolism of clobazam, possibly via an action on CYP2C19.
    Epilepsy & behavior : E&B, 2014, Volume: 34

    Topics: Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19

2014
Chronic antiepileptic monotherapy, bone metabolism, and body composition in non-institutionalized children.
    Developmental medicine and child neurology, 2010, Volume: 52, Issue:3

    Topics: Anthropometry; Anticonvulsants; Body Composition; Body Height; Body Mass Index; Body Weight; Carbama

2010
Sulthiame in refractory paediatric epilepsies: an experience of an 'old' antiepileptic drug in a tertiary paediatric neurology unit.
    Seizure, 2011, Volume: 20, Issue:10

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Hospital Units; Humans; Male

2011
[On the clinical evaluation of anti-epileptic medications with special reference to Ospolot].
    Deutsche medizinische Wochenschrift (1946), 1960, Dec-09, Volume: 85

    Topics: Anticonvulsants; Epilepsy; Heterocyclic Compounds; Thiazines

1960
[On the role of the butanesultam derivative Ospolot in the treatment of cerebral epilepsy].
    Deutsche medizinische Wochenschrift (1946), 1960, Dec-09, Volume: 85

    Topics: Anticonvulsants; Epilepsy; Heterocyclic Compounds; Thiazines

1960
[The treatment of cerebral epilepsy with Ospolot].
    Deutsche medizinische Wochenschrift (1946), 1960, Dec-09, Volume: 85

    Topics: Anticonvulsants; Epilepsy; Heterocyclic Compounds; Thiazines

1960
[Our experience in the therapy of some refractory forms of epilepsy with Ospolot].
    Neuropsihijatrija, 1961, Volume: 9

    Topics: Cardiovascular Agents; Epilepsy; Heterocyclic Compounds; Muscle Relaxants, Central; Thiazines

1961
[Ospolot, a new preparation for the treatment of epilepsy].
    Ugeskrift for laeger, 1962, Sep-21, Volume: 124

    Topics: Epilepsy; Heterocyclic Compounds; Thiazines

1962
OSPOLOT: a preliminary communication.
    Irish journal of medical science, 1962, Volume: 441

    Topics: Anticonvulsants; Communication; Epilepsy; Heterocyclic Compounds; Thiazines

1962
Clinical trial of Ospolot in epilepsy.
    Developmental medicine and child neurology, 1963, Volume: 5

    Topics: Anticonvulsants; Epilepsy; Humans; Thiazines

1963
[Therapeutic effect of N-(4-sulfamoylphenyl)-1,4-butanesultam (Ospolot) on epilepsy].
    No to shinkei = Brain and nerve, 1962, Volume: 14

    Topics: Anticonvulsants; Epilepsy; Thiazines

1962
OSPOLOT IN EPILEPSY.
    Developmental medicine and child neurology, 1963, Volume: 5

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Infant; Thiazines; Toxicology

1963
SULTHIAMINE ("OSPOLOT") IN THE TREATMENT OF TEMPORAL LOBE EPILEPSY.
    The Medical journal of Australia, 1963, Sep-28, Volume: 2

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Epilepsy, Temporal Lobe; Humans; Infant; Temporal Lobe

1963
SULTHIAME IN TREATMENT OF EPILEPSY.
    British medical journal, 1964, Feb-22, Volume: 1, Issue:5381

    Topics: Adolescent; Anticonvulsants; Epilepsy; Pharmacology; Statistics as Topic; Sulfanilamide; Sulfanilami

1964
SULTHIAME TREATMENT OF EPILEPSY.
    British medical journal, 1964, Mar-21, Volume: 1, Issue:5385

    Topics: Anticonvulsants; Dysmenorrhea; Epilepsy; Female; Humans; Thiazines; Toxicology

1964
OSPOLOT--A CLINICAL TRIAL OF A NEW ANTICONVULSANT.
    The British journal of psychiatry : the journal of mental science, 1964, Volume: 110

    Topics: Anticonvulsants; Electroencephalography; Epilepsy; Humans; Intellectual Disability; Pathology; Pharm

1964
[EXPERIENCES WITH OSPOLOT IN THE TREATMENT OF INFANTILE EPILEPSY].
    Medizinische Klinik, 1964, Feb-14, Volume: 59

    Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic

1964
SULTHIAME (OSPOLOT) IN THE TREATMENT OF EPILEPSY.
    Developmental medicine and child neurology, 1964, Volume: 6

    Topics: Anticonvulsants; Child; Child Behavior Disorders; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic

1964
THE USE OF OSPOLOT IN THE TREATMENT OF EPILEPSY.
    Epilepsia, 1964, Volume: 5

    Topics: Anticonvulsants; Biomedical Research; Child; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy, Te

1964
THE EFFECT OF SULTHIAME, A NEW ANTICONVULSANT DRUG IN THE TREATMENT OF TEMPORAL LOBE EPILEPSY.
    Epilepsia, 1964, Volume: 5

    Topics: Adolescent; Anticonvulsants; Drug Therapy; Dyspnea; Epilepsy; Epilepsy, Temporal Lobe; Humans; Paran

1964
[OSPOLOT, A NEW ANTICONVULSANT. REPORT SUMMING UP 2 YEARS OF CLINICAL TRIALS].
    Hospital (Rio de Janeiro, Brazil), 1964, Volume: 65

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Heterocyclic Compounds; Humans; Thiazines

1964
THE USE OF OSPOLOT IN TEMPORAL LOBE EPILEPSY. A PRELIMINARY COMMUNICATION.
    Epilepsia, 1964, Volume: 5

    Topics: Anticonvulsants; Drug Therapy; Epilepsy; Epilepsy, Temporal Lobe; Heterocyclic Compounds; Humans; Te

1964
[OSPOLOT IN EPILEPSY TREATMENT].
    Revista brasileira de medicina, 1965, Volume: 22

    Topics: Anticonvulsants; Drug Therapy; Epilepsy; Thiazines

1965
[Experiences with Ospolot in the treatment of epilepsy].
    Deutsche medizinische Wochenschrift (1946), 1962, May-04, Volume: 87

    Topics: Epilepsy; Heterocyclic Compounds; Thiazines

1962
Effect of antiepileptic drug monotherapy on crystalluria in children and young adults.
    Journal of neurology, 2003, Volume: 250, Issue:10

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Female; Humans; Isoxazoles; Male; Retrospective Studie

2003
Sulthiame in childhood epilepsy.
    Pediatrics international : official journal of the Japan Pediatric Society, 2004, Volume: 46, Issue:5

    Topics: Adolescent; Australia; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female;

2004
Perisylvian polymicrogyria in Landau-Kleffner syndrome.
    Neurology, 2005, May-10, Volume: 64, Issue:9

    Topics: Cerebral Arteries; Cerebral Cortex; Child; Electroencephalography; Epilepsy; Humans; Landau-Kleffner

2005
[Treatment of epilepsy with third-line antiepileptic drugs: felbamate, tiagabine, and sulthiame].
    Der Nervenarzt, 2007, Volume: 78, Issue:12

    Topics: Adult; Anticonvulsants; Epilepsy; Felbamate; Humans; Nipecotic Acids; Phenylcarbamates; Propylene Gl

2007
Sulthiame-associated mild compensated metabolic acidosis.
    International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:12

    Topics: Acidosis; Anticonvulsants; Blood Gas Analysis; Child, Preschool; Epilepsy; Humans; Male; Thiazines

1996
Carbonic anhydrase inhibitor sulthiame reduces intracellular pH and epileptiform activity of hippocampal CA3 neurons.
    Epilepsia, 2002, Volume: 43, Issue:5

    Topics: Acetazolamide; Animals; Anticonvulsants; Benzolamide; Carbonic Anhydrase Inhibitors; Epilepsy; Guine

2002