sultamicillin and Tonsillitis

Acute tonsillitis is one of the most common reasons for application to otorhinolaryngology clinics. In the treatment of acute tonsillitis, supportive therapies are mostly used. As antibiotic therapy, penicillin or erythromycin can be used. The aim of this study is to decrease the clinical recovery time of acute tonsillitis by providing parenteral treatment and daily cleaning of tonsillar lesions.. Patients with an age range of 15-60 years were included in the study. The patients were divided into two groups. The first group used an i.v. combination of ampicillin + sulbactam and the tonsillar membranes of patients were cleaned daily. The second group used only the i.v. combination of ampicillin + sulbactam.. Patients who received antibiotherapy and debridement had a clinical improvement of 90% on the 2nd treatment day and 95% on the 5th treatment day. The patients receiving only antibiotics had a clinical improvement of 65% on the 5th treatment day and 75% on the 7th treatment day. The recovery time of both groups was significantly different (p < 0.05).. The solution and technique used in this clinical study showed that patients with acute tonsillitis could recover in a very short time without any complications.

Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Ampicillin; Anti-Bacterial Agents; Combined Modality Therapy; Debridement; Female; Humans; Male; Middle Aged; Sulbactam; Time Factors; Tonsillitis; Treatment Outcome; Young Adult

This study aims to evaluate the effectiveness of Tualang honey in reducing post-tonsillectomy pain.. The study included 63 patients (31 males, 32 females; mean age 10±4.16 years; range 3 to 18 years) who were planned to undergo tonsillectomy. Patients were randomized into two groups. Treatment group received topical Tualang honey intraoperatively followed by oral consumption of Tualang honey three times daily for seven days with intravenous sultamicillin three times daily for first and second day followed by oral sultamicillin twice daily for five days. Control group received intravenous sultamicillin for two days followed by oral sultamicillin twice daily for five days. Patients' pain was assessed according to visual analog scale, frequency of waking up at night due to pain, and additional use of analgesic from postoperative first to seventh day. Results from each group were statistically compared.. Early postoperative pain was relieved slightly faster in Tualang honey + antibiotic group; however, the difference between groups was not statistically significant. On postoperative seventh day, all of patients (100%) in Tualang honey + antibiotic group experienced no pain compared to the antibiotic only group. Frequencies of waking up at night and use of analgesic were lower in the Tualang honey + antibiotic group compared to antibiotic only group.. Early postoperative pain was relieved slightly faster in Tualang honey + antibiotic group, which may be attributed to the soothing effect of honey.

Topics: Adolescent; Ampicillin; Child; Child, Preschool; Female; Honey; Humans; Male; Pain Measurement; Pain, Postoperative; Sulbactam; Tonsillectomy; Tonsillitis; Treatment Outcome

Tonsillectomy is a common operative procedure performed for tonsillar hypertrophy complicates with recurrent tonsillitis. Among the post tonsillectomy morbidities, post operative wound healing is of utmost importance to be effectively managed as it will interfere with patient recuperation from surgery. Tualang honey has been shown to accelerate wound healing in postoperative patients.. The aim of this study was to investigate the effect of Tualang honey in enhancing healing process in post tonsillectomy patients.. In this open labelled prospective study, the selected paediatric patients were randomized into two groups. The 35 subjects in the Tualang honey-antibiotic group received 3 mls of Tualang honey intraoperatively followed by 4 mls of oral Tualang honey three times daily for seven days. Concurrently, 25mg/kg of intravenous Sultamicillin was given three times daily for two days followed by oral Sultamicillin twice daily for five days. The 28 subjects in the antibiotic only group received intravenous at 25mg/kg Sultamicillin kg for two days followed by oral Sultamicillin twice daily for five days. The healing process was assessed at day 1, day 3, day 7 and day 14 postoperatively by semiquantitative endoscopic photograph examination of both tonsillar fossae.. The average ages for the treatment group and the control groups were 9 and 11 years old respectively. Wound healing was significantly faster in the treatment group in both tonsillar fossae compared to the control group (left: p-value = <0.001; right: p-value = <0.001).. Tualang honey has positive effect in enhancing healing process in post tonsillectomy patient. It is easy to use topically, safe to consume orally and available at low cost locally. Overall it can be used as an excellent adjunct therapy for post operative patients.

Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Child; Child, Preschool; Female; Honey; Humans; Male; Postoperative Period; Prospective Studies; Sulbactam; Tonsillectomy; Tonsillitis; Treatment Outcome; Wound Healing

A total of 110 adults with acute ear, nose and throat infections were treated orally with 750 mg/day (n = 9) or 1500 mg/day (n = 46) sultamicillin, or 500 mg/day (n = 51) or 1000 mg/day (n = 4) cefuroxime axetil for a minimum of 5 days. Variations in dose and duration of treatment were due to severity of symptoms. After treatment with sultamicillin for 8.1 +/- 1.5 days or with cefuroxime axetil for 7.9 +/- 1.6 days, local pain, erythema, exudate, oedema and adenopathies were improved in both treatment groups and all sultamicillin-treated patients were apyretic. All sultamicillin-treated and all but three cefuroxime axetil-treated patients experienced cure or improvement; only one cefuroxime axetil-treated patient discontinued treatment due to treatment failure. Gastrointestinal adverse events occurred in both treatment groups (eight sultamicillin-treated patients and three cefuroxime axetil-treated patients); one patient receiving cefuroxime axetil discontinued treatment due to nausea. Pruritus was reported by one sultamicillin-treated patient.

Topics: Adult; Ampicillin; Bacterial Infections; Cefuroxime; Drug Therapy, Combination; Humans; Otitis Media; Pharyngitis; Respiratory Tract Diseases; Rhinitis; Sinusitis; Sulbactam; Tonsillitis

In this multicenter open, comparative study, 135 patients were treated with sultamicillin (67 subjects; 500 mg every 12 h) or amoxicillin (68 subjects; 500 mg every 8 h) for 10 d. Of the pathogens isolated pre-treatment, 24 of 29 (including 4 of 6 resistant strains) in the sultamicillin group were eradicated at the end of treatment, as were 17 of 22 in the amoxicillin group. At follow-up, the figures were 17 of 25 and 16 of 19, respectively. Clinical success was achieved in 55 of 55 sultamicillin and 40 of 43 amoxicillin patients at the end of treatment, and in 40 of 42 and 29 of 31, respectively, at follow-up. Overall success was recorded in 20 of 25 and 15 of 23 sultamicillin, and 14 of 19 and 13 of 17 amoxicillin patients at the two assessments. Side effects were reported for 21 sultamicillin patients, 1 of whom withdrew because of diarrhea, and 15 amoxicillin patients, 4 of whom withdrew because of rash. One sultamicillin and 4 amoxicillin patients developed minor abnormalities in laboratory safety parameters.

Topics: Adolescent; Adult; Aged; Amoxicillin; Ampicillin; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Pharyngitis; Safety; Sulbactam; Tonsillitis

The concurrence of acute coronary syndrome with allergy or hypersensitivity as well as with anaphylactic or anaphylactoid reactions is increasingly encountered in daily clinical practice. There are several reports associating mast cell activation with acute cardiovascular events in adults. This was first described by Kounis as 'allergic angina syndrome',progressing to 'allergic myocardial infarction'. The main mechanism proposed is the vasospasm of coronary arteries. We present a case of a 28-year-old man who was admitted to our hospital with thoracic pain and dyspnoea. The symptoms recurred after simultaneous use of 1 g amoxicillin/clavulanic acid orally and 1 g ampicillin/sulbactam parenterally for tonsillitis the night before presentation and on the morning of admission.

Topics: Acute Coronary Syndrome; Administration, Oral; Adult; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Angina Pectoris; Anti-Bacterial Agents; Coronary Angiography; Coronary Vasospasm; Drug Hypersensitivity; Electrocardiography; Humans; Injections, Intramuscular; Intradermal Tests; Male; Sulbactam; Tonsillitis