sultamicillin and Leprosy

sultamicillin has been researched along with Leprosy* in 1 studies

Other Studies

1 other study(ies) available for sultamicillin and Leprosy

ArticleYear
Bactericidal action of oral ampicillin/sulbactam against Mycobacterium leprae.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 44, Issue:2

    We reported previously that an injectable form of ampicillin/sulbactam, Unasyn, was bactericidal to Mycobacterium leprae multiplying in mouse foot pads. In this study, we examined the effect of an orally active form of ampicillin/sulbactam, Sultamicillin, on the growth of M. leprae in mice. Three concentrations of the drug, mixed with the feed, were administered from the start until the mice were killed at 6 months; 0.01% of the drug inhibited bacterial growth by 54%, 0.10% by 74% and 0.20% by 93%. To test whether oral ampicillin/sulbactam was bactericidal, 0.50% of the drug, mixed with the feed, was administered to experimentally infected mice for 3 months during the logarithmic phase of bacterial growth, and then discontinued; multiplication of the bacilli was monitored monthly for the next 8 months. The results showed that orally active ampicillin/sulbactam is bactericidal to M. leprae.

    Topics: Administration, Oral; Ampicillin; Animals; Drug Therapy, Combination; Hindlimb; Leprosy; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Mycobacterium leprae; Sulbactam

1999
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