sultamicillin and Fusobacterium-Infections

An invasive Fusobacterium infection may originate from an apparent routine pharyngitis and lead to significant distant septic complications. Even without internal jugular thrombosis, the same mechanism of disease exists, and therefore, the same morbidity, prognosis, and treatments are applicable, hence the suitable term incomplete Lemierre syndrome. We present a case of invasive Fusobacterium infection that meets all criteria for Lemierre syndrome except lacking internal jugular thrombosis. A review of the literature that forms the diagnostic criteria for this syndrome and the rationale for our creating this novel term is presented.

Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Female; Fusobacterium Infections; Fusobacterium nucleatum; Humans; Lemierre Syndrome; Metronidazole; Sulbactam; Tomography, X-Ray Computed

We report an unusual case of septic arthritis in a 4-year-old child caused by Fusobacterium necrophorum. In spite of aggressive parenteral antibiotic therapy with ampicillin-sulbactam after surgical drainage, disease recurred, requiring additional arthrotomies. The infection was eventually eradicated with parenteral meropenem and clindamycin, and additional surgical drainage.

Topics: Ampicillin; Anti-Bacterial Agents; Arthritis, Infectious; Arthroscopy; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Pain Measurement; Recovery of Function; Risk Assessment; Severity of Illness Index; Sulbactam; Treatment Outcome

Topics: Ampicillin; Anti-Bacterial Agents; Bronchial Fistula; Campylobacter Infections; Campylobacter rectus; Clindamycin; Diagnosis, Differential; Drainage; Empyema, Pleural; Fusobacterium Infections; Fusobacterium nucleatum; Humans; Lung Abscess; Male; Middle Aged; Pleural Diseases; Sulbactam; Thoracostomy

Topics: Abducens Nerve Diseases; Actinomycosis; Ampicillin; Anti-Bacterial Agents; Child, Preschool; Coinfection; Diagnosis, Differential; Fatigue; Fusobacterium Infections; Fusobacterium nucleatum; Gram-Positive Bacterial Infections; Humans; Male; Mastoiditis; Otitis Media; Peptostreptococcus; Pneumonia, Bacterial; Recurrence; Sulbactam; Syndrome; Trigeminal Neuralgia; Weight Loss

Here, we report brain abscess due to Fusobacterium necrophorum (F. necrophorum) in a 78-year-old healthy man. He developed convulsion and did not have any signs of meningitis. Although the brain magnetic resonance imaging findings of the left occipital lobe were typical of a brain abscess, his cerebrospinal fluid examination revealed only slight pleocytosis and mild increase in protein levels. Thus, it was difficult to rule out the possibility of metastatic brain tumor; the patient's condition was provisionally diagnosed as symptomatic epilepsy secondary to brain abscess. His convulsion disappeared soon after administration of antiepileptic, antibacterial, and steroid agents. A craniotomy was performed to evacuate the abscess, and F. necrophorum was identified by culturing the abscess contents. After the operation, he was treated with appropriate antibacterial agents, which resulted in resolution of the brain abscess. Although Fusobacterium species are gram-negative anaerobic bacilli commensal of the human oropharynx, we need to recognize that Fusobacterium species can be a primary pathogen causing brain abscesses and may leave residual neurological sequelae without early appropriate treatment.

Topics: Aged; Ampicillin; Anti-Bacterial Agents; Brain Abscess; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Male; Meningitis, Bacterial; Seizures; Sulbactam; Therapeutics; Tomography, X-Ray Computed