sultamicillin and Fever-of-Unknown-Origin

To evaluate efficacy of ampicilline/sulbactame and fluconasole in the regimen of empirical antibiotic therapy in patients with acute leukemia.. The trial covered 14 hematological departments of Russia and 1 of Ukraine. Acute myeloid leukemia patients were included. 92 cases of fever in 56 patients with analysis of efficacy in 66 cases were considered. At the first stage of empirical antibiotic therapy, cefoperason (4 g/day) and gentamycin (240 mg/day) were administered. If no response was reached, ampicilline/sulbactam (7.5 g/day) was added. This was the second stage. If no response occurred for 5 days the three drugs were joined by fluconasol (400 mg followed by 200 mg).. Fever of unclear genesis was cured in 82% (28 of 34), clinical infection--in 80% (20 of 25), microbiologically confirmed infection--in 4 of 7 cases. A complete response to the empirical antibiotic therapy was registered in 52 of 66 cases (79%). 7(10.5%) patients died of infectious complications. 7(10.5%) received other antibiotics.

Topics: Acute Disease; Adult; Ampicillin; Anti-Bacterial Agents; Cefoperazone; Cephalosporins; Drug Therapy, Combination; Fever of Unknown Origin; Fluconazole; Gentamicins; Humans; Leukemia; Russia; Sulbactam; Time Factors; Ukraine

Persistent fever and unspecific general symptoms need a complete and detailed medical history and search for infection. We report on a case of amebiasis with liver abscesses of a 26-year-old man. He had stayed several weeks in India and South America. After being free of complaints for 4 months, unspecific general symptoms and fever appeared. Due to proven liver abscesses, a combination treatment was given. Within 12 days, he was free of symptoms and could be discharged.

Topics: Abdominal Pain; Adult; Amebicides; Ampicillin; Drug Therapy, Combination; Entamoeba histolytica; Fever of Unknown Origin; Humans; Liver Abscess, Amebic; Male; Metronidazole; Paromomycin; Sulbactam; Travel; Treatment Outcome