sulprostone and Vomiting

Topics: Abdomen; Animals; Behavior, Animal; Defecation; Dinoprostone; Ferrets; Male; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Vagotomy; Vomiting

Therapeutic interruption of the pregnancies of the 2nd and 3-rd quarter is often badly accepted by the patients and it is original that his realization is easy, effective and the less traumatic possible. In this indication, the sulprostone (Nalador) is a big contribution.. The purpose of our study is to review this product, to describe our experience concerning its use in the therapeutic interruptions of pregnancies and to study alternatives in case of failure or of against indication in its use.. It is about a forward-looking study opened from the 01-07-02 led in the service "A" of the CMNT. We brought together 30 women where a therapeutic interruption of the pregnancy was put and who did'nt present of against indications to the sulprostone.. The average age was of 27 years with extremes from 18 to 39 years 50% of our patients were nullipares. The terms of pregnancy varied from 16 to 28 LIMITED COMPANIES with an average of 20 LIMITED COMPANIES. The indications of these terminations of pregnancy were maternal in 33.33% of cases and foetal in 66.66% of cases. The average number of light bulbs of Nalador used by the women was of 2.25 with extremes going from 1 to 4. The delay of eviction from the beginning of the induction was on average of 21 hours, with a rate of success of 90%. We did not regret any break uterine Delivery was incomplete requiring a uterine revision under general anesthetic in 5 cases. Tolerance was good in general In case of failure alternatives were: the misoprostol (cytotec *), the Probe extra amniotic dries and the wet Probe.. The sulprostone by intravenous way constitutes an effective method of medical interruption of the pregnancy in the 2-nd and 3-rd quarter with a satisfactory tolerance and a rate of success of 90 %.

Topics: Abortifacient Agents, Nonsteroidal; Abortion, Therapeutic; Adolescent; Adult; Congenital Abnormalities; Diarrhea; Dinoprostone; Female; Fetal Death; Gestational Age; Humans; Misoprostol; Parity; Pelvic Pain; Pregnancy; Prospective Studies; Time Factors; Treatment Outcome; Vomiting

We have reviewed a hundred terminations of pregnancy in the second trimester carried out in Geneva, using repeated intra-muscular injections of prostaglandin analogues. We have compared the efficacy and the importance of the side effects of two of these analogues, namely Dinoproston ( Prostin F2 alpha) and Sulproston ( Nalador 500). The induction-delivery interval was identically the same. On the other hand Sulproston provoked fewer cases of diarrhoea (18%) than Dinoproston (69%).

Topics: Abortifacient Agents; Abortion, Induced; Adult; Diarrhea; Dinoprostone; Female; Humans; Pregnancy; Pregnancy Trimester, Second; Prostaglandins E; Prostaglandins E, Synthetic; Retrospective Studies; Vomiting

Prostaglandins are mainly used in clinical medicine for midterm abortion and to terminate pregnancy. Systemic adverse reactions include nausea and vomiting, which occur in approximately half of the patients and, to a lesser extent, diarrhea. Although bronchospasm occurs infrequently, PGF2 should be avoided in asthmatics. Cardiorespiratory failure culminating in prolonged coma and death has been reported. Moreover, convulsions and EEG changes have been observed in a comparatively small number of cases.

Topics: Abortifacient Agents; Abortion, Induced; Bronchial Spasm; Diarrhea; Dinoprost; Dinoprostone; Female; Heart Arrest; Humans; Pregnancy; Prostaglandins; Prostaglandins E; Prostaglandins E, Synthetic; Prostaglandins F; Seizures; Vomiting

Midtrimester abortion was succesfully induced within 30 hours in 62 out of 90 patients by intraamniotic administration of 16-phenoxy-omega-17,18,19, 20-tetranor-prostaglandine-E2-methylsulfonamide. The Pg-analogue was tested in 5 groups of patients which received 1,2 or 3 mg. In group IV, 2 mg of the analogue was combined with oxytocin. In group V, 3 mg of the analogue was combined with 2.75 grams of calcium gluconate. The success rate was significantly influenced by the amount of the drug administered. Side effects were minimal. Multiparous women respond better to the therapy than nulliparous patients. The combination with oxytocin was more effective than the Pg-analogue alone and the combination of sulprostone with calcium gluconate was 87% succesful within 30 hours and 100% succesful within 36 hours.. A prostaglandin analog, 16-phenoxy-delta-17,18,19,20-tetranor-prostaglandin-E2-methylsulfonamide, was tested in 5 groups of patients which received 1, 2, or 3 mg of the analog intraamniotically. 29/46 (Groups 1-3) patients receiving only the analog expelled the fetus within 30 hours. In Group 4, 2 mg of the analog was combined with oxytocin. 22/28 expelled the fetus within 30 hours. In Group 5, 15 nulliparous and 1 multiparous woman received 3 mg of the analog together with calcium gluconate, injected intraamniotically. Although the mean induction-abortion time was not significantly influenced, the success rate was higher: 87% aborted within 30 hours and 100% within 36 hours. Clinically, the contractions in this group (5) started earlier and were stronger than in other groups. In all groups, side effects were minimal. Multiparous women responded better to therapy than nulliparous patients. Since the amount of drug influenced both the success rate and the induction-abortion interval considerably and the side effects were few, a new study using 4-mg doses is in progress.

Topics: Abortion, Induced; Adolescent; Adult; Amnion; Calcium Gluconate; Chemical Phenomena; Chemistry; Dinoprostone; Drug Therapy, Combination; Female; Gluconates; Humans; Injections; Oxytocin; Parity; Pregnancy; Pregnancy Trimester, Second; Prostaglandins E, Synthetic; Time Factors; Vomiting