sulprostone and Seizures

We report the case of a 29-year-old female who had developed a postpartum cerebral angiopathy (PCA) complicated by an intracerebral haematoma and convulsions, after a postpartum haemorrhage with sulprostone and norepinephrine infusion. PCA is an under diagnosed neurovascular pathology, responsible of reversible and non-specific symptoms. However, it can be complicated by haemorrhagic or ischemic stroke with vital or functional risks. As PCA is favored by vasoactive treatments, their administration in peripartum period, when it is imperative, should be strictly controlled.

Topics: Adult; Brain; Cerebral Angiography; Cerebrovascular Disorders; Dinoprostone; Female; Humans; Intracranial Hemorrhages; Intracranial Pressure; Norepinephrine; Postpartum Period; Respiration, Artificial; Resuscitation; Seizures; Tomography, X-Ray Computed; Vasoconstrictor Agents

Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Dinoprostone; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Seizures

Prostaglandins are mainly used in clinical medicine for midterm abortion and to terminate pregnancy. Systemic adverse reactions include nausea and vomiting, which occur in approximately half of the patients and, to a lesser extent, diarrhea. Although bronchospasm occurs infrequently, PGF2 should be avoided in asthmatics. Cardiorespiratory failure culminating in prolonged coma and death has been reported. Moreover, convulsions and EEG changes have been observed in a comparatively small number of cases.

Topics: Abortifacient Agents; Abortion, Induced; Bronchial Spasm; Diarrhea; Dinoprost; Dinoprostone; Female; Heart Arrest; Humans; Pregnancy; Prostaglandins; Prostaglandins E; Prostaglandins E, Synthetic; Prostaglandins F; Seizures; Vomiting