sulprostone and Pulmonary-Edema

Topics: Adult; Dinoprostone; Female; Humans; Intraoperative Complications; Jehovah's Witnesses; Postpartum Hemorrhage; Pulmonary Edema

We report the case of a 31-year-old woman who delivered twins by Caesarean section in whom atonic uterine haemorrhage developed 6 h postoperatively. During conservative treatment with the high-dose prostaglandin analogs sulprostone (PGE(2)) and dinoprost (PGF(2alpha)), acute pulmonary oedema and cardiac decompensation developed and, subsequently, the patient suffered cardiopulmonary arrest. After a 2h-period of cardiopulmonary resuscitation (CPR), it was possible to restore and stabilize circulation under the highest dose of catecholamines. Despite 2h of CPR, the patient was discharged from hospital 3 months later without any major physical or neurocognitive deficit.

Topics: Adult; Cardiopulmonary Resuscitation; Cesarean Section; Dinoprost; Dinoprostone; Female; Heart Arrest; Heart Failure; Heart Massage; Humans; Oxytocics; Postoperative Hemorrhage; Pregnancy; Pulmonary Edema; Uterine Contraction; Uterine Hemorrhage

We encountered a patient with pre-eclampsia who developed pulmonary edema whilst receiving an infusion of sulprostone. Recent evidence suggests that pulmonary hypertension following the administration of prostaglandins may result from stimulation of an EP3 or thromboxane receptor in the pulmonary artery. This has implications for therapeutic use of prostaglandins.

Topics: Abortifacient Agents, Nonsteroidal; Adult; Dinoprostone; Female; Humans; Infusions, Intravenous; Labor, Induced; Pregnancy; Pulmonary Edema

Topics: Adult; Cardiomyopathy, Hypertrophic; Dinoprostone; Female; Humans; Oxytocin; Pregnancy; Pregnancy Complications, Cardiovascular; Puerperal Disorders; Pulmonary Edema