Page last updated: 2024-11-04

sulpiride and Weight Gain

sulpiride has been researched along with Weight Gain in 31 studies

Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Weight Gain: Increase in BODY WEIGHT over existing weight.

Research Excerpts

ExcerptRelevanceReference
"We compared the efficacy of ziprasidone and amisulpride in the treatment of negative symptoms and overall psychopathology in subjects who had chronic schizophrenia with predominantly negative symptoms."9.12Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia: results of a 12-week, double-blind study. ( Murray, S; Olié, JP; Spina, E; Yang, R, 2006)
"To compare the efficacy and safety of amisulpride and olanzapine in subjects with schizophrenia and comorbid depression in a randomised double-blind trial."9.12A double-blind randomised comparative trial of amisulpride versus olanzapine for 2 months in the treatment of subjects with schizophrenia and comorbid depression. ( Douki, S; Vanelle, JM, 2006)
"Between 40% and 70% of people with treatment-resistant schizophrenia do not respond to clozapine, despite adequate blood levels."8.95Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia. ( Barber, S; Cipriani, A; Corsi, M; Olotu, U, 2017)
"Sixty outpatients with chronic schizophrenia who had been treated with either amisulpride or olanzapine for at least six months were investigated."7.74Outcomes in schizophrenia outpatients treated with amisulpride or olanzapine. ( Bodner, T; Edlinger, M; Fleischhacker, WW; Hofer, A; Huber, R; Kemmler, G; Rettenbacher, MA; Sachs, G, 2007)
"To assess the role of insulin in the development of obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in 40 female rats during the peak of sulpiride-induced weight gain and in 40 vehicle-treated animals."7.70Glucose tolerance and serum insulin levels in an animal model of obesity induced by the antipsychotic drug, sulpiride. ( Baptista, T; Hernández, L; LaCruz, A, 1998)
"5-16 mg/kg/ip for 21 days) (a) affects body weight and food intake in gonadally-intact and drug-free female rats, (b) prevents obesity, hyperphagia, hyperprolactinemia and vaginal cycle disruption induced by long-term administration of the antipsychotic drug sulpiride (SUL, 20 mg/kg/ip for 21 days), or (c) reverses the acute hyperphagia induced by SUL (15 microg bilaterally), when directly applied in the perifornical lateral hypothalamus (PFLH)."7.70Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats. ( Acosta, A; Baptista, T; Colasante, C; de Mendoza, S; de Quijada, M; Hernández, L; Lacruz, A; Mendoza, JM, 2000)
"Tremor and insomnia were more frequent with amisulpride, while olanzapine caused more weight gain and sedation."6.75Amisulpride versus olanzapine in the treatment of schizophrenia in Indian patients: randomized controlled trial. ( Bhowmick, S; Ghosh, M; Hazra, A, 2010)
"Excessive body weight gain, hyperprolactinemia and low gonadal steroid serum levels are often observed during chronic administration of antipsychotic drugs (AP)."6.69Body weight gain after administration of antipsychotic drugs: correlation with leptin, insulin and reproductive hormones. ( Angeles, F; Baptista, T; de Mendoza, S; Hernández, L; Lacruz, A; Mendoza Guillén, JM; Mendoza, MT; Silvera, R, 2000)
"We compared the efficacy of ziprasidone and amisulpride in the treatment of negative symptoms and overall psychopathology in subjects who had chronic schizophrenia with predominantly negative symptoms."5.12Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia: results of a 12-week, double-blind study. ( Murray, S; Olié, JP; Spina, E; Yang, R, 2006)
"To compare the efficacy and safety of amisulpride and olanzapine in subjects with schizophrenia and comorbid depression in a randomised double-blind trial."5.12A double-blind randomised comparative trial of amisulpride versus olanzapine for 2 months in the treatment of subjects with schizophrenia and comorbid depression. ( Douki, S; Vanelle, JM, 2006)
" The study evaluated the efficacy of amisulpride, fluoxetine and clomipramine at the beginning of the re-feeding phase of the treatment of restricting anorexia nervosa according to DSM-IV criteria."5.09A single blind comparison of amisulpride, fluoxetine and clomipramine in the treatment of restricting anorectics. ( Cavagnini, F; Clemente, A; Ferrari, VM; Laini, V; Lugo, F; Mantero, M; Mauri, MC; Redaelli, G; Ruggiero, GM; Zappulli, D, 2001)
"Between 40% and 70% of people with treatment-resistant schizophrenia do not respond to clozapine, despite adequate blood levels."4.95Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia. ( Barber, S; Cipriani, A; Corsi, M; Olotu, U, 2017)
" Olanzapine produced more weight gain than all other second-generation antipsychotics except for clozapine where no difference was found."4.86Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. ( Davis, JM; Hunger, H; Kissling, W; Komossa, K; Leucht, S; Lobos, CA; Rummel-Kluge, C; Schmid, F; Schwarz, S, 2010)
" This reveals that the atypical antipsychotics are most likely to induce weight gain, in particular clozapine and olanzapine."4.82[Psychotropics and weight gain]. ( Bryois, Ch; Sahli, Ch, 2004)
" First, in preclinical experiments in female rats the estradiol antagonist/agonist drug tamoxifen or estradiol itself have been shown to completely prevent the obesity provoked by the AP sulpiride, and to induce an endocrine-metabolic milieu that seems to counteract AP-induced obesity."4.80Body weight gain induced by antipsychotic drugs: mechanisms and management. ( Baptista, T, 1999)
" Clozapine seems to have the highest risk of weight gain, followed by olanzapine and quetiapine."4.80Atypical antipsychotics and weight gain--a systematic review. ( McAskill, R; Taylor, DM, 2000)
"Sixty outpatients with chronic schizophrenia who had been treated with either amisulpride or olanzapine for at least six months were investigated."3.74Outcomes in schizophrenia outpatients treated with amisulpride or olanzapine. ( Bodner, T; Edlinger, M; Fleischhacker, WW; Hofer, A; Huber, R; Kemmler, G; Rettenbacher, MA; Sachs, G, 2007)
"To assess the role of insulin in the development of obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in 40 female rats during the peak of sulpiride-induced weight gain and in 40 vehicle-treated animals."3.70Glucose tolerance and serum insulin levels in an animal model of obesity induced by the antipsychotic drug, sulpiride. ( Baptista, T; Hernández, L; LaCruz, A, 1998)
"During clinical experience with the "atypical" neuroleptic drugs clozapine, risperidone, and zotepine, some patients have shown a marked weight gain."3.70Weight gain: side effect of atypical neuroleptics? ( Müssigbrodt, HE; Wetterling, T, 1999)
"5-16 mg/kg/ip for 21 days) (a) affects body weight and food intake in gonadally-intact and drug-free female rats, (b) prevents obesity, hyperphagia, hyperprolactinemia and vaginal cycle disruption induced by long-term administration of the antipsychotic drug sulpiride (SUL, 20 mg/kg/ip for 21 days), or (c) reverses the acute hyperphagia induced by SUL (15 microg bilaterally), when directly applied in the perifornical lateral hypothalamus (PFLH)."3.70Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats. ( Acosta, A; Baptista, T; Colasante, C; de Mendoza, S; de Quijada, M; Hernández, L; Lacruz, A; Mendoza, JM, 2000)
"The weight gain and hyperphagia induced by chronic administration of sulpiride in female rats were not prevented by the concomitant administration of an extra source of sodium."3.69Hyponatremia and neuroleptic-induced obesity in rats. ( Baptista, T; Catalán, M; Hernández, L; Silva, E; Teneud, L, 1994)
"Tremor and insomnia were more frequent with amisulpride, while olanzapine caused more weight gain and sedation."2.75Amisulpride versus olanzapine in the treatment of schizophrenia in Indian patients: randomized controlled trial. ( Bhowmick, S; Ghosh, M; Hazra, A, 2010)
"Excessive body weight gain, hyperprolactinemia and low gonadal steroid serum levels are often observed during chronic administration of antipsychotic drugs (AP)."2.69Body weight gain after administration of antipsychotic drugs: correlation with leptin, insulin and reproductive hormones. ( Angeles, F; Baptista, T; de Mendoza, S; Hernández, L; Lacruz, A; Mendoza Guillén, JM; Mendoza, MT; Silvera, R, 2000)
"Sulpiride treatment inhibited the incidence of uterine adenocarcinoma and precancerous lesions of atypical endometrial hyperplasia, whereas EGME had no effect on uterine carcinogenesis."1.43Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats. ( Inoue, K; Sakamoto, Y; Takahashi, M; Taketa, Y; Taya, K; Watanabe, G; Yoshida, M, 2016)
"Weight gain was predicted by low mean (SD) baseline reward-related activity in the right-sided putamen (0."1.43Striatal Reward Activity and Antipsychotic-Associated Weight Change in Patients With Schizophrenia Undergoing Initial Treatment. ( Ebdrup, BH; Glenthøj, B; Nielsen, MØ; Rostrup, E; Wulff, S, 2016)
"1."1.30Mechanism of the neuroleptic-induced obesity in female rats. ( Acosta, A; Albornoz, MA; Baptista, T; Contreras, Q; de Quijada, M; Hernández, L; LaCruz, A; Páez, X; Teneud, L, 1998)
" The present experiments extend these findings by investigating: (a) interactions between isolation rearing and repeated handling/testing on presynaptic DA function in the NAC using in vivo microdialysis: (b) the dose-response curve for the effects of d-amphetamine, and the responses elicited by high potassium, using in vivo microdialysis, and (c) postsynaptic function in isolates as indexed by DA receptor-linked cAMP production."1.30Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems. ( Hall, FS; Humby, T; Inglis, W; Kendall, DA; Marsden, CA; Robbins, TW; Wilkinson, LS, 1998)
"Pretreatment with sulpiride (32 mg/kg, p."1.29A screening concept based on a hypothesis led to the development of a putative cognitive enhancer that stimulates penile erection. ( Arakawa, H; Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M, 1994)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (25.81)18.2507
2000's14 (45.16)29.6817
2010's8 (25.81)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Wei, H1
Zapata, RC1
Lopez-Valencia, M1
Aslanoglou, D1
Farino, ZJ1
Benner, V1
Osborn, O1
Freyberg, Z1
McCarthy, MJ1
Barber, S1
Olotu, U1
Corsi, M1
Cipriani, A1
Taketa, Y1
Inoue, K1
Takahashi, M1
Sakamoto, Y1
Watanabe, G1
Taya, K1
Yoshida, M1
Kapur, S1
Marques, TR1
Nielsen, MØ1
Rostrup, E1
Wulff, S1
Glenthøj, B1
Ebdrup, BH1
Bhowmick, S1
Hazra, A1
Ghosh, M1
Rummel-Kluge, C1
Komossa, K1
Schwarz, S1
Hunger, H1
Schmid, F1
Lobos, CA1
Kissling, W2
Davis, JM1
Leucht, S2
Ružić, K1
Dadić-Hero, E1
Grahovac, T1
Sabljić, V1
Kosec, T1
Knez, R1
Lee, SJ1
Lee, JH1
Jung, SW1
Koo, BH1
Choi, TY1
Lee, KH1
Ng, KF1
Innis, SM1
Wagenpfeil, S1
Hamann, J1
Mortimer, AM1
Sahli, Ch1
Bryois, Ch1
Olié, JP1
Spina, E1
Murray, S1
Yang, R1
Papadimitriou, GN1
Theleritis, CG1
Dikeos, DG1
Psarros, CJ1
Soldatos, CR1
Vanelle, JM1
Douki, S1
Hofer, A1
Rettenbacher, MA1
Edlinger, M1
Huber, R1
Bodner, T1
Kemmler, G1
Sachs, G1
Fleischhacker, WW1
Linden, M1
Eich, FX1
Pyrkosch, L1
Silva, E1
Catalán, M1
Hernández, L6
Teneud, L2
Baptista, T7
Maeda, N1
Matsuoka, N1
Yamazaki, M1
Arakawa, H1
Ohkubo, Y1
Yamaguchi, I1
Contreras, Q1
Albornoz, MA1
Acosta, A2
Páez, X1
de Quijada, M2
LaCruz, A4
Hall, FS1
Wilkinson, LS1
Humby, T1
Inglis, W1
Kendall, DA1
Marsden, CA1
Robbins, TW1
Wetterling, T1
Müssigbrodt, HE1
Colasante, C1
de Mendoza, S2
Mendoza, JM1
Mendoza Guillén, JM1
Silvera, R1
Angeles, F1
Mendoza, MT1
Taylor, DM1
McAskill, R1
Ruggiero, GM1
Laini, V1
Mauri, MC1
Ferrari, VM1
Clemente, A1
Lugo, F1
Mantero, M1
Redaelli, G1
Zappulli, D1
Cavagnini, F1
Parada, MA1
Puig de Parada, M1
Murzi, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Add-on Topiramate vs Metformin on Cardio-Metabolic Profile in Patients With Schizophrenia on Atypical Antipsychotics With Metabolic Syndrome: a Randomized Controlled Trial[NCT05663749]Phase 460 participants (Actual)Interventional2022-09-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for sulpiride and Weight Gain

ArticleYear
Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia.
    The Cochrane database of systematic reviews, 2017, 03-23, Volume: 3

    Topics: Adult; Amisulpride; Antipsychotic Agents; Aripiprazole; Clozapine; Dibenzothiazepines; Drug Resistan

2017
Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis.
    Schizophrenia research, 2010, Volume: 123, Issue:2-3

    Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Blood Glucose; Cholesterol; Clinic

2010
How do we choose between atypical antipsychotics? The advantages of amisulpride.
    The international journal of neuropsychopharmacology, 2004, Volume: 7 Suppl 1

    Topics: Adverse Drug Reaction Reporting Systems; Amisulpride; Antipsychotic Agents; Clinical Trials as Topic

2004
[Psychotropics and weight gain].
    Praxis, 2004, Aug-25, Volume: 93, Issue:35

    Topics: Adolescent; Adult; Amisulpride; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Aripi

2004
Body weight gain induced by antipsychotic drugs: mechanisms and management.
    Acta psychiatrica Scandinavica, 1999, Volume: 100, Issue:1

    Topics: Animals; Antipsychotic Agents; Body Weight; Dose-Response Relationship, Drug; Endocrine System; Estr

1999
Atypical antipsychotics and weight gain--a systematic review.
    Acta psychiatrica Scandinavica, 2000, Volume: 101, Issue:6

    Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Dibenzothiepins;

2000

Trials

7 trials available for sulpiride and Weight Gain

ArticleYear
Amisulpride versus olanzapine in the treatment of schizophrenia in Indian patients: randomized controlled trial.
    The Australian and New Zealand journal of psychiatry, 2010, Volume: 44, Issue:3

    Topics: Adult; Amisulpride; Antipsychotic Agents; Benzodiazepines; Brief Psychiatric Rating Scale; Drug Admi

2010
A 6-week, randomized, multicentre, open-label study comparing efficacy and tolerability of amisulpride at a starting dose of 400 mg/day versus 800 mg/day in patients with acute exacerbations of schizophrenia.
    Clinical drug investigation, 2012, Volume: 32, Issue:11

    Topics: Adult; Aged; Amisulpride; Analysis of Variance; Antipsychotic Agents; Chi-Square Distribution; Disea

2012
Amisulpride is an "atypical" antipsychotic associated with low weight gain.
    Psychopharmacology, 2004, Volume: 173, Issue:1-2

    Topics: Amisulpride; Antipsychotic Agents; Databases as Topic; Dose-Response Relationship, Drug; Humans; Mal

2004
Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia: results of a 12-week, double-blind study.
    International clinical psychopharmacology, 2006, Volume: 21, Issue:3

    Topics: Adult; Adverse Drug Reaction Reporting Systems; Amisulpride; Antipsychotic Agents; Behavioral Sympto

2006
A double-blind randomised comparative trial of amisulpride versus olanzapine for 2 months in the treatment of subjects with schizophrenia and comorbid depression.
    European psychiatry : the journal of the Association of European Psychiatrists, 2006, Volume: 21, Issue:8

    Topics: Adult; Amisulpride; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Comorbidity; Depres

2006
Body weight gain after administration of antipsychotic drugs: correlation with leptin, insulin and reproductive hormones.
    Pharmacopsychiatry, 2000, Volume: 33, Issue:3

    Topics: Adult; Antipsychotic Agents; Estradiol; Female; Follicle Stimulating Hormone; Hormones; Humans; Insu

2000
A single blind comparison of amisulpride, fluoxetine and clomipramine in the treatment of restricting anorectics.
    Progress in neuro-psychopharmacology & biological psychiatry, 2001, Volume: 25, Issue:5

    Topics: Adult; Amenorrhea; Amisulpride; Anorexia Nervosa; Antidepressive Agents, Second-Generation; Antidepr

2001

Other Studies

18 other studies available for sulpiride and Weight Gain

ArticleYear
Dopamine D
    Psychoneuroendocrinology, 2020, Volume: 113

    Topics: Animals; Blood Glucose; Bromocriptine; Circadian Rhythm; Diabetes Mellitus, Type 2; Dopamine; Dopami

2020
Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats.
    Journal of applied toxicology : JAT, 2016, Volume: 36, Issue:6

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinogens; Endometrial Hyperplas

2016
Dopamine, Striatum, Antipsychotics, and Questions About Weight Gain.
    JAMA psychiatry, 2016, Volume: 73, Issue:2

    Topics: Antipsychotic Agents; Dopamine D2 Receptor Antagonists; Female; Humans; Male; Putamen; Reward; Schiz

2016
Striatal Reward Activity and Antipsychotic-Associated Weight Change in Patients With Schizophrenia Undergoing Initial Treatment.
    JAMA psychiatry, 2016, Volume: 73, Issue:2

    Topics: Adolescent; Adult; Amisulpride; Anticipation, Psychological; Antipsychotic Agents; Dopamine D2 Recep

2016
Switching among antipsychotics--focus on side effects.
    Psychiatria Danubina, 2011, Volume: 23, Issue:1

    Topics: Affective Disorders, Psychotic; Antipsychotic Agents; Benzodiazepines; Depressive Disorder, Major; D

2011
Behavioral responses are altered in piglets with decreased frontal cortex docosahexaenoic acid.
    The Journal of nutrition, 2003, Volume: 133, Issue:10

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Diet; Dietary Fats, Unsaturated; Docosahe

2003
Acute weight gain induced by amisulpride monotherapy in a first-episode schizophrenic patient.
    International clinical psychopharmacology, 2006, Volume: 21, Issue:3

    Topics: Adult; Amisulpride; Antipsychotic Agents; Female; Humans; Schizophrenia; Sulpiride; Time Factors; We

2006
Outcomes in schizophrenia outpatients treated with amisulpride or olanzapine.
    Pharmacopsychiatry, 2007, Volume: 40, Issue:1

    Topics: Adult; Amisulpride; Antipsychotic Agents; Benzodiazepines; Cross-Sectional Studies; Female; Humans;

2007
Do differences in atypical antipsychotics matter in routine practice? Medication switch from olanzapine and risperidone to amisulpride.
    International clinical psychopharmacology, 2007, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Amisulpride; Antipsychotic Agents; Benzodiazepines; Drug Utilization; Dyskinesia,

2007
Hyponatremia and neuroleptic-induced obesity in rats.
    Research communications in molecular pathology and pharmacology, 1994, Volume: 85, Issue:2

    Topics: Animals; Drinking; Female; Hyperphagia; Obesity; Potassium; Rats; Rats, Wistar; Sodium; Sulpiride; W

1994
A screening concept based on a hypothesis led to the development of a putative cognitive enhancer that stimulates penile erection.
    Japanese journal of pharmacology, 1994, Volume: 64, Issue:3

    Topics: Animals; Anorexia; Avoidance Learning; Behavior, Animal; Cognition; Cysteamine; Drug Evaluation, Pre

1994
Mechanism of the neuroleptic-induced obesity in female rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1998, Volume: 22, Issue:1

    Topics: Animals; Antipsychotic Agents; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Energ

1998
Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:4

    Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Dextroamphetamine; Dopamine; Dopami

1998
Glucose tolerance and serum insulin levels in an animal model of obesity induced by the antipsychotic drug, sulpiride.
    Pharmacology & toxicology, 1998, Volume: 83, Issue:2

    Topics: Animals; Antipsychotic Agents; Area Under Curve; Blood Glucose; Disease Models, Animal; Eating; Estr

1998
Weight gain: side effect of atypical neuroleptics?
    Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Body Mass Index; C

1999
Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats.
    Appetite, 2000, Volume: 34, Issue:1

    Topics: Animals; Antipsychotic Agents; Diestrus; Eating; Female; Hyperphagia; Naltrexone; Narcotic Antagonis

2000
Mechanisms of weight gain induced by antipsychotic drugs.
    The Journal of clinical psychiatry, 2002, Volume: 63, Issue:3

    Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Appetite; Dopamine Antagoni

2002
Ventromedial hypothalamus vs. lateral hypothalamic D2 satiety receptors in the body weight increase induced by systemic sulpiride.
    Physiology & behavior, 1991, Volume: 50, Issue:6

    Topics: Amphetamine; Animals; Eating; Female; Hypothalamic Area, Lateral; Injections; Injections, Intraperit

1991