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sulpiride and Obesity

sulpiride has been researched along with Obesity in 14 studies

Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"To assess the role of insulin in the development of obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in 40 female rats during the peak of sulpiride-induced weight gain and in 40 vehicle-treated animals."7.70Glucose tolerance and serum insulin levels in an animal model of obesity induced by the antipsychotic drug, sulpiride. ( Baptista, T; Hernández, L; LaCruz, A, 1998)
"5-16 mg/kg/ip for 21 days) (a) affects body weight and food intake in gonadally-intact and drug-free female rats, (b) prevents obesity, hyperphagia, hyperprolactinemia and vaginal cycle disruption induced by long-term administration of the antipsychotic drug sulpiride (SUL, 20 mg/kg/ip for 21 days), or (c) reverses the acute hyperphagia induced by SUL (15 microg bilaterally), when directly applied in the perifornical lateral hypothalamus (PFLH)."7.70Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats. ( Acosta, A; Baptista, T; Colasante, C; de Mendoza, S; de Quijada, M; Hernández, L; Lacruz, A; Mendoza, JM, 2000)
" Similarly, obesity induced by the neuroleptic drug sulpiride (SUL, 20 mg/kg/ip for 21 days) was prevented by AM only at the dose of 100 mg/kg."7.69Amantadine in the treatment of neuroleptic-induced obesity in rats: behavioral, endocrine and neurochemical correlates. ( Alastre, T; Alternus, M; Araujo de Baptista, E; Baptista, T; Contreras, Q; de Quijada, M; Hernández, L; López, ME; Musseo, E; Páez, X; Teneud, L; Weiss, SR, 1997)
" This reveals that the atypical antipsychotics are most likely to induce weight gain, in particular clozapine and olanzapine."4.82[Psychotropics and weight gain]. ( Bryois, Ch; Sahli, Ch, 2004)
" First, in preclinical experiments in female rats the estradiol antagonist/agonist drug tamoxifen or estradiol itself have been shown to completely prevent the obesity provoked by the AP sulpiride, and to induce an endocrine-metabolic milieu that seems to counteract AP-induced obesity."4.80Body weight gain induced by antipsychotic drugs: mechanisms and management. ( Baptista, T, 1999)
"To assess the role of insulin in the development of obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in 40 female rats during the peak of sulpiride-induced weight gain and in 40 vehicle-treated animals."3.70Glucose tolerance and serum insulin levels in an animal model of obesity induced by the antipsychotic drug, sulpiride. ( Baptista, T; Hernández, L; LaCruz, A, 1998)
" To assess the role of insulin in the development of the obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in female rats after 0 or 30 days of sulpiride administration."3.70Glucose tolerance and serum insulin levels in an animal model of obesity induced by sub-acute or chronic administration of antipsychotic drugs. ( Alvarez, L; Baptista, T; de Mendoza, S; Hernández, L; Lacruz, A, 1999)
"5-16 mg/kg/ip for 21 days) (a) affects body weight and food intake in gonadally-intact and drug-free female rats, (b) prevents obesity, hyperphagia, hyperprolactinemia and vaginal cycle disruption induced by long-term administration of the antipsychotic drug sulpiride (SUL, 20 mg/kg/ip for 21 days), or (c) reverses the acute hyperphagia induced by SUL (15 microg bilaterally), when directly applied in the perifornical lateral hypothalamus (PFLH)."3.70Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats. ( Acosta, A; Baptista, T; Colasante, C; de Mendoza, S; de Quijada, M; Hernández, L; Lacruz, A; Mendoza, JM, 2000)
"The weight gain and hyperphagia induced by chronic administration of sulpiride in female rats were not prevented by the concomitant administration of an extra source of sodium."3.69Hyponatremia and neuroleptic-induced obesity in rats. ( Baptista, T; Catalán, M; Hernández, L; Silva, E; Teneud, L, 1994)
" Similarly, obesity induced by the neuroleptic drug sulpiride (SUL, 20 mg/kg/ip for 21 days) was prevented by AM only at the dose of 100 mg/kg."3.69Amantadine in the treatment of neuroleptic-induced obesity in rats: behavioral, endocrine and neurochemical correlates. ( Alastre, T; Alternus, M; Araujo de Baptista, E; Baptista, T; Contreras, Q; de Quijada, M; Hernández, L; López, ME; Musseo, E; Páez, X; Teneud, L; Weiss, SR, 1997)
"3."1.30Mechanism of the neuroleptic-induced obesity in female rats. ( Acosta, A; Albornoz, MA; Baptista, T; Contreras, Q; de Quijada, M; Hernández, L; LaCruz, A; Páez, X; Teneud, L, 1998)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's6 (42.86)18.2507
2000's6 (42.86)29.6817
2010's0 (0.00)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Wei, H1
Zapata, RC1
Lopez-Valencia, M1
Aslanoglou, D1
Farino, ZJ1
Benner, V1
Osborn, O1
Freyberg, Z1
McCarthy, MJ1
Lin, CC1
Bai, YM1
Wang, YC1
Chen, TT1
Lai, IC1
Chen, JY1
Chen, SY1
Gau, SS1
Liou, YJ1
Sahli, Ch1
Bryois, Ch1
Hajnal, A1
Margas, WM1
Covasa, M1
Sannia, A1
Benna, GM1
Silva, E1
Catalán, M1
Hernández, L7
Teneud, L3
Baptista, T9
López, ME1
Contreras, Q2
Alastre, T1
de Quijada, M3
Araujo de Baptista, E1
Alternus, M1
Weiss, SR1
Musseo, E1
Páez, X2
Albornoz, MA1
Acosta, A2
LaCruz, A5
Alvarez, L1
de Mendoza, S3
Mendoza-Guillén, JM1
Colasante, C1
Mendoza, JM1

Reviews

2 reviews available for sulpiride and Obesity

ArticleYear
[Psychotropics and weight gain].
    Praxis, 2004, Aug-25, Volume: 93, Issue:35

    Topics: Adolescent; Adult; Amisulpride; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Aripi

2004
Body weight gain induced by antipsychotic drugs: mechanisms and management.
    Acta psychiatrica Scandinavica, 1999, Volume: 100, Issue:1

    Topics: Animals; Antipsychotic Agents; Body Weight; Dose-Response Relationship, Drug; Endocrine System; Estr

1999

Other Studies

12 other studies available for sulpiride and Obesity

ArticleYear
Dopamine D
    Psychoneuroendocrinology, 2020, Volume: 113

    Topics: Animals; Blood Glucose; Bromocriptine; Circadian Rhythm; Diabetes Mellitus, Type 2; Dopamine; Dopami

2020
Improved body weight and metabolic outcomes in overweight or obese psychiatric patients switched to amisulpride from other atypical antipsychotics.
    Journal of clinical psychopharmacology, 2009, Volume: 29, Issue:6

    Topics: Adult; Amisulpride; Antipsychotic Agents; Body Weight; Energy Metabolism; Female; Follow-Up Studies;

2009
Altered dopamine D2 receptor function and binding in obese OLETF rat.
    Brain research bulletin, 2008, Jan-31, Volume: 75, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Conditioning, Operant; Disease Models, Anima

2008
Prolactin response to stimulation in obesity.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:8

    Topics: Adult; Body Weight; Humans; Middle Aged; Obesity; Prolactin; Sulpiride; Thyrotropin-Releasing Hormon

1983
Hyponatremia and neuroleptic-induced obesity in rats.
    Research communications in molecular pathology and pharmacology, 1994, Volume: 85, Issue:2

    Topics: Animals; Drinking; Female; Hyperphagia; Obesity; Potassium; Rats; Rats, Wistar; Sodium; Sulpiride; W

1994
Amantadine in the treatment of neuroleptic-induced obesity in rats: behavioral, endocrine and neurochemical correlates.
    Pharmacopsychiatry, 1997, Volume: 30, Issue:2

    Topics: Amantadine; Animals; Antipsychotic Agents; Body Weight; Dopamine; Eating; Estrus; Female; Hypothalam

1997
Mechanism of the neuroleptic-induced obesity in female rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1998, Volume: 22, Issue:1

    Topics: Animals; Antipsychotic Agents; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Energ

1998
Glucose tolerance and serum insulin levels in an animal model of obesity induced by the antipsychotic drug, sulpiride.
    Pharmacology & toxicology, 1998, Volume: 83, Issue:2

    Topics: Animals; Antipsychotic Agents; Area Under Curve; Blood Glucose; Disease Models, Animal; Eating; Estr

1998
Glucose tolerance and serum insulin levels in an animal model of obesity induced by sub-acute or chronic administration of antipsychotic drugs.
    Progress in neuro-psychopharmacology & biological psychiatry, 1999, Volume: 23, Issue:2

    Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Female; Glucose Tolerance Test; Hyperinsulini

1999
Antipsychotic drug-induced obesity in rats: correlation between leptin, insulin and body weight during sulpiride treatment.
    Molecular psychiatry, 2000, Volume: 5, Issue:1

    Topics: Animals; Antipsychotic Agents; Blood Glucose; Female; Glucose Tolerance Test; Insulin; Leptin; Multi

2000
Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats.
    Appetite, 2000, Volume: 34, Issue:1

    Topics: Animals; Antipsychotic Agents; Diestrus; Eating; Female; Hyperphagia; Naltrexone; Narcotic Antagonis

2000
Mechanisms of weight gain induced by antipsychotic drugs.
    The Journal of clinical psychiatry, 2002, Volume: 63, Issue:3

    Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Appetite; Dopamine Antagoni

2002