Page last updated: 2024-11-04

sulpiride and Idiopathic Parkinson Disease

sulpiride has been researched along with Idiopathic Parkinson Disease in 34 studies

Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Research Excerpts

ExcerptRelevanceReference
"Levosulpiride is a substituted benzamide that is widely used for the management of dyspepsia and emesis."5.35Levosulpiride-induced movement disorders. ( Chung, SJ; Kim, JS; Kim, MJ; Lee, MC; Shin, HW, 2009)
"Levosulpiride is a substituted benzamide that is widely used for the management of dyspepsia and emesis."1.35Levosulpiride-induced movement disorders. ( Chung, SJ; Kim, JS; Kim, MJ; Lee, MC; Shin, HW, 2009)
" Adverse effects were acute dyskinesia (n=2) or parkinsonian syndrome, which occurred after several months or years of treatment (n=15)."1.33[Extrapyramidal adverse effects of veralipride (Agreal), a drug used to treat hot flushes: a propos of 17 cases]. ( Andréjak, M; Geslin, JM; Gras-Champel, V; Lemaire-Hurtel, AS; Masmoudi, K; Masson, H; Munier, A, 2005)
"Levodopa-induced dyskinesias (LID) in Parkinson's disease (PD) may be classified into three main categories: "On" dyskinesias, diphasic dyskinesias (DD), and "off" periods."1.28Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification. ( Gershanik, O; Luquin, MR; Obeso, JA; Scipioni, O; Vaamonde, J, 1992)
"The neuroleptic-induced catalepsy was reversed by the classical anti-parkinsonian agent L-DOPA and by agents that function through dopamine systems such as d- and methamphetamine and the direct D2 receptor agonist quinpirole."1.28Neuroleptic-induced catalepsy as a model of Parkinson's disease. I. Effect of dopaminergic agents. ( Close, SP; Elliott, PJ; Hayes, AG; Marriott, AS; Walsh, DM, 1990)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19909 (26.47)18.7374
1990's14 (41.18)18.2507
2000's7 (20.59)29.6817
2010's3 (8.82)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Zarrindast, MR1
Fazli-Tabaei, S1
Khakpai, F1
Cáceres-Chávez, VA1
Hernández-Martínez, R1
Pérez-Ortega, J1
Herrera-Valdez, MA1
Aceves, JJ1
Galarraga, E1
Bargas, J1
Naguy, A1
AlHumoud, A1
Stopper, H1
Schupp, N1
Fazeli, G1
Dietel, B1
Queisser, N1
Walitza, S1
Gerlach, M1
Shin, HW1
Kim, MJ1
Kim, JS1
Lee, MC1
Chung, SJ1
Martí Massó, JF1
Ruiz-Martínez, J1
Bergareche, A1
López de Munain, A1
Ohye, C1
Shibazaki, T1
Kovoor, A1
Seyffarth, P1
Ebert, J1
Barghshoon, S1
Chen, CK1
Schwarz, S1
Axelrod, JD1
Cheyette, BN1
Simon, MI1
Lester, HA1
Schwarz, J1
Masmoudi, K1
Gras-Champel, V1
Lemaire-Hurtel, AS1
Masson, H1
Munier, A1
Geslin, JM1
Andréjak, M1
Brusa, L1
Petta, F1
Pisani, A1
Miano, R1
Stanzione, P4
Moschella, V1
Galati, S1
Finazzi Agrò, E1
Campbell, DJ1
Mendelsohn, FA1
Adam, WR1
Funder, JW1
Pierantozzi, M3
Semprini, R3
Tagliati, M3
Traversa, R2
Peppe, A2
Pierelli, F1
Bernardi, G4
Liptrot, J1
Holdup, D1
Phillipson, O1
Strange, PG1
Yanagisawa, N1
Bodis-Wollner, I3
Sarre, S1
Ebinger, G1
Michotte, Y1
Mercuri, NB1
Federici, M1
Teive, HA1
Sa, DS1
Lees, AJ1
Lander, CM1
Stern, GM1
Leger, JM1
Dumond, JJ1
Garoux, R1
Lombertie, E1
Dumas, M1
Graux, P1
Durocher, AM1
Corsini, GU1
Zompo, MD1
Cianchetti, C1
Mangoni, A1
Luquin, MR1
Scipioni, O1
Vaamonde, J1
Gershanik, O1
Obeso, JA1
Marciani, MG1
Lawrence, MS1
Redmond, DE1
Elliott, PJ2
Close, SP2
Walsh, DM2
Hayes, AG2
Marriott, AS2
Gershanik, OS1
Rubinstein, M1
Stefano, F1
Joshita, Y1
Yamamoto, K1
Noda, S1
Umezaki, H1
Koller, W1
Herbster, G1
Anderson, D1
Wack, R1
Gordon, J1

Reviews

4 reviews available for sulpiride and Idiopathic Parkinson Disease

ArticleYear
Is aldosterone secretion under dopaminergic control?
    Circulation research, 1981, Volume: 49, Issue:6

    Topics: Aldosterone; Bromocriptine; Chlorpromazine; Dopamine; Dopamine Antagonists; Edema; Humans; Levodopa;

1981
Dopamine receptors in the basal ganglia: relevance to Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 1993, Volume: 8, Issue:3

    Topics: Basal Ganglia; Basal Ganglia Diseases; Brain; Clozapine; Dopamine Agents; Dopamine D2 Receptor Antag

1993
Electrophysiological assessment of retinal dopaminergic deficiency.
    Electroencephalography and clinical neurophysiology. Supplement, 1996, Volume: 46

    Topics: Animals; Aphakia; Dopamine; Dopamine Antagonists; Electrodiagnosis; Electroretinography; Evoked Pote

1996
[Psychiatric manifestations induced by dopamine precursors or antagonists].
    Annales medico-psychologiques, 1979, Volume: 137, Issue:9

    Topics: Anxiety; Bromocriptine; Confusion; Dopamine Antagonists; Dreams; Female; Hallucinations; Humans; Lev

1979

Other Studies

30 other studies available for sulpiride and Idiopathic Parkinson Disease

ArticleYear
Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.
    Neurobiology of learning and memory, 2021, Volume: 186

    Topics: Adrenergic Agents; Animals; Anxiety; Arginine; Disease Models, Animal; Dopamine Agonists; Dopamine A

2021
Acute dopamine receptor blockade in substantia nigra pars reticulata: a possible model for drug-induced Parkinsonism.
    Journal of neurophysiology, 2018, 12-01, Volume: 120, Issue:6

    Topics: Action Potentials; Animals; Benzazepines; Disease Models, Animal; Dopamine Antagonists; Dopaminergic

2018
An octogenarian with Parkinson's disease psychosis that has responded favourably to low-dose sulpiride with facilitated motoric agility.
    Asian journal of psychiatry, 2019, Volume: 43

    Topics: Aged, 80 and over; Antipsychotic Agents; Humans; Male; Parkinson Disease; Psychotic Disorders; Sulpi

2019
Genotoxicity of the neurotransmitter dopamine in vitro.
    Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:4

    Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Dopamine; Humans; Micronucleus Tests; Mutagenicit

2009
Levosulpiride-induced movement disorders.
    Movement disorders : official journal of the Movement Disorder Society, 2009, Nov-15, Volume: 24, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Brain; Female; Humans; Magnetic Resonance Imag

2009
[Parkinsonism induced by sulpiride and veralipride: two different stories].
    Medicina clinica, 2011, Oct-15, Volume: 137, Issue:10

    Topics: Adult; Aged; Brain Damage, Chronic; Contraindications; Dyskinesia, Drug-Induced; Europe; Female; Hum

2011
Lesioning the thalamus for dyskinesia.
    Stereotactic and functional neurosurgery, 2001, Volume: 77, Issue:1-4

    Topics: Antiparkinson Agents; Antipsychotic Agents; Dyskinesia, Drug-Induced; Dyskinesias; Electrocoagulatio

2001
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Feb-23, Volume: 25, Issue:8

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Antipsych

2005
[Extrapyramidal adverse effects of veralipride (Agreal), a drug used to treat hot flushes: a propos of 17 cases].
    La Revue de medecine interne, 2005, Volume: 26, Issue:6

    Topics: Aged; Akathisia, Drug-Induced; Basal Ganglia Diseases; Dopamine Antagonists; Female; Humans; Male; M

2005
Central acute D2 stimulation worsens bladder function in patients with mild Parkinson's disease.
    The Journal of urology, 2006, Volume: 175, Issue:1

    Topics: Domperidone; Dopamine Antagonists; Female; Humans; Male; Middle Aged; Parkinson Disease; Severity of

2006
Increasing doses of l-sulpiride reveal dose- and spatial frequency-dependent effects of D2 selective blockade in the human electroretinogram.
    Vision research, 1995, Volume: 35, Issue:18

    Topics: Adult; Dose-Response Relationship, Drug; Electroretinography; Female; Humans; Male; Parkinson Diseas

1995
1,2,3,4-Tetrahydro-2-methyl-4,6,7-isoquinolinetriol inhibits tyrosine hydroxylase activity in rat striatal synaptosomes.
    Journal of neural transmission. General section, 1994, Volume: 96, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Chromatography, High Pressure Liq

1994
[Diagnosis and treatment of Parkinson's disease in the elderly].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1993, Volume: 30, Issue:12

    Topics: Aged; Brain; Bromocriptine; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Sulpirid

1993
The visual system in Parkinson's disease.
    Advances in neurology, 1993, Volume: 60

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Contrast Sensitivity; Dopamine; Electroenceph

1993
Levodopa biotransformation in hemi-Parkinson rats: effect of dopamine receptor agonists and antagonists.
    European journal of pharmacology, 1996, Feb-05, Volume: 296, Issue:3

    Topics: Animals; Antiparkinson Agents; Benzazepines; Biotransformation; Corpus Striatum; Denervation; Dopami

1996
A mixed D1 and D2 antagonist does not replay pattern electroretinogram alterations observed with a selective D2 antagonist in normal humans: relationship with Parkinson's disease pattern electroretinogram alterations.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 1999, Volume: 110, Issue:1

    Topics: Adult; Brain; Electroencephalography; Electroretinography; Haloperidol; Humans; Parkinson Disease; R

1999
Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons.
    Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:11-12

    Topics: Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Cells, Cultured; Dopamine; Dopamine

1999
Worsening of Parkinsonism after the use of veralipride for treatment of menopause: case report.
    Arquivos de neuro-psiquiatria, 2001, Volume: 59, Issue:1

    Topics: Dopamine Antagonists; Female; Humans; Menopause; Middle Aged; Parkinson Disease; Parkinson Disease,

2001
Tiapride and sulpiride in Parkinson's disease.
    Lancet (London, England), 1978, Dec-02, Volume: 2, Issue:8101

    Topics: Benzamides; Drug Evaluation; Dyskinesia, Drug-Induced; Humans; Parkinson Disease; Sulpiride

1978
[Value of sulpiride and tiapride in geriatrics. Antagonism between Parkinson disease and chorea].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1979, Nov-17, Volume: Suppl 1

    Topics: Aged; Benzamides; Chorea; Dyskinesia, Drug-Induced; Humans; Levodopa; Parkinson Disease; Sulpiride;

1979
Therapeutical efficacy of a combination of apomorphine with sulpiride or metoclopramide in Parkinsonism.
    Psychopharmacologia, 1976, May-28, Volume: 47, Issue:2

    Topics: Adult; Apomorphine; Drug Therapy, Combination; Haloperidol; Humans; Male; Metoclopramide; Parkinson

1976
Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification.
    Movement disorders : official journal of the Movement Disorder Society, 1992, Volume: 7, Issue:2

    Topics: Aged; Apomorphine; Chlorpromazine; Dopamine Agents; Dose-Response Relationship, Drug; Dyskinesia, Dr

1992
An electrophysiological study of D2 dopaminergic actions in normal human retina: a tool in Parkinson's disease.
    Neuroscience letters, 1992, Jun-08, Volume: 140, Issue:1

    Topics: Adult; Dopamine D2 Receptor Antagonists; Humans; Parkinson Disease; Receptors, Dopamine D2; Referenc

1992
MPTP lesions and dopaminergic drugs alter eye blink rate in African green monkeys.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:4

    Topics: Animals; Apomorphine; Blinking; Chlorocebus aethiops; Dopamine Agents; Haloperidol; Male; MPTP Poiso

1991
Neuroleptic-induced catalepsy as a model of Parkinson's disease. I. Effect of dopaminergic agents.
    Journal of neural transmission. Parkinson's disease and dementia section, 1990, Volume: 2, Issue:2

    Topics: Animals; Antipsychotic Agents; Catalepsy; Disease Models, Animal; Dopamine; Dose-Response Relationsh

1990
Neuroleptic-induced catalepsy as a model of Parkinson's disease. II. Effect of glutamate antagonists.
    Journal of neural transmission. Parkinson's disease and dementia section, 1990, Volume: 2, Issue:2

    Topics: Animals; Antipsychotic Agents; Catalepsy; Disease Models, Animal; Dizocilpine Maleate; Fluphenazine;

1990
Inhibitory action of L-dopa.
    Neurology, 1989, Volume: 39, Issue:8

    Topics: Animals; Humans; Levodopa; Mice; Parkinson Disease; Receptors, Dopamine; Receptors, Dopamine D2; Sul

1989
[Studies on the hypothalamic-pituitary dopaminergic system in Parkinson's disease and spinocerebellar degeneration. Response to TRH and sulpiride].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1987, Volume: 76, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Dopamine; Female; Humans; Hypothalamo-Hypo

1987
[Parkinson's disease associated with trihexyphenidyl (THP) induced dysphonia plicae ventricularis].
    Rinsho shinkeigaku = Clinical neurology, 1988, Volume: 28, Issue:4

    Topics: Aged; Female; Humans; Movement Disorders; Parkinson Disease; Sulpiride; Tongue Diseases; Trihexyphen

1988
Quinpirole hydrochloride, a potential anti-parkinsonism drug.
    Neuropharmacology, 1987, Volume: 26, Issue:8

    Topics: Animals; Benzazepines; Corpus Striatum; Dogs; Dose-Response Relationship, Drug; Ergolines; Grooming;

1987