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sulpiride and Hypothermia

sulpiride has been researched along with Hypothermia in 9 studies

Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.

Research Excerpts

ExcerptRelevanceReference
"A single high dose of apomorphine (10 mg x kg(-1)) produced not only contextual sensitization to and conditioning of climbing behavior, but also context-independent tolerance to hypothermia."7.71Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine. ( Jang, CG; Kim, HS; Lee, MK; Lee, SC; Oh, KW; Oh, SK; Park, WK; Seong, YH; Yun, JS, 2001)
"A single high dose of apomorphine (10 mg x kg(-1)) produced not only contextual sensitization to and conditioning of climbing behavior, but also context-independent tolerance to hypothermia."3.71Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine. ( Jang, CG; Kim, HS; Lee, MK; Lee, SC; Oh, KW; Oh, SK; Park, WK; Seong, YH; Yun, JS, 2001)
"0 mg/kg, ip) hypothermia was reversed by the central and peripheral administration of the D2 antagonists S-(-)-sulpiride (3."3.68Dopamine D2-receptors mediate hypothermia in mice: ICV and IP effects of agonists and antagonists. ( Michel, AD; Nunes, JL; Sharif, NA; Whiting, RL, 1991)
"The nonselective dopamine (DA) receptor agonists R(-)apomorphine (APO) and R(-)-N-n-propylnorapomorphine (NPA) elicited dose- and time-dependent hypothermia in mice with ED50 values of 300 and 18 micrograms/kg, respectively."3.67Hypothermia in mice: D2 dopamine receptor mediation and absence of spare receptors. ( Hizami, R; Kreuter, L; Meller, E, 1989)
"The hypothermia induced by apomorphine, a mixed dopamine (DA) agonist in male Swiss-Webster mice, was not blocked by the selective D-1 antagonist SCH 23390 but was completely blocked by the selective D-2 antagonists haloperidol, sulpiride and YM-09151-2."3.67Influence of D-1 receptor system on the D-2 receptor-mediated hypothermic response in mice. ( Fitten, J; Gordon, LI; Kodama, CK; Menon, MK, 1988)
"A new benzamide, cis-N-(1-benzyl-2-methylpyrrolidin - 3 - yl) - 5 - chloro - 2 - methoxy - 4 - methylaminobenzamide (YM-09151-2) exhibited more potent and longer-lasting inhibitory effects on apomorphine-induced behaviours (stereotyped behaviour, emesis and hypothermia), and methamphetamine-induced stereotyped behaviour, conditioned avoidance response and open field behaviour, conditioned avoidance response and open field behaviour than either structurally similar benzamides (YM-0850 and sulpiride) or classical neuroleptics [chlorpromazine (CPZ) and haloperidol(HPD)]."3.66Neuroleptic properties of cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide (YM-09151-2) with selective antidopaminergic activity. ( Maeno, H; Nishikori, K; Noshiro, O; Usuda, S, 1981)
" This variation for fluphenazine may be explained by the fact that its pKa value is closer to that of piracetam, thus preventing better bioavailability of the neuroleptic, or its better affinity for DA-1 dopaminergic receptors."1.27Piracetam interactions with neuroleptics in psychopharmacological tests. ( Bourin, M; Larousse, C; Poisson, L, 1986)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19905 (55.56)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Usuda, S1
Nishikori, K1
Noshiro, O1
Maeno, H1
Buvat, J1
Buvat-Herbaut, M1
Parada, MA1
de Parada, MP1
Rada, P1
Hernandez, L1
Cryan, JF1
Harkin, A1
Naughton, M1
Kelly, JP1
Leonard, BE1
Yun, JS1
Kim, HS1
Lee, MK1
Oh, KW1
Jang, CG1
Park, WK1
Seong, YH1
Lee, SC1
Oh, SK1
Nunes, JL1
Sharif, NA1
Michel, AD1
Whiting, RL1
Meller, E1
Hizami, R1
Kreuter, L1
Bourin, M1
Poisson, L1
Larousse, C1
Menon, MK1
Gordon, LI1
Kodama, CK1
Fitten, J1

Reviews

1 review available for sulpiride and Hypothermia

ArticleYear
[New data on the physiology and treatment of vasomotor menopausal flushing].
    LARC medical, 1983, Volume: 3, Issue:4

    Topics: Animals; Climacteric; Clonidine; Estrogens; Female; Haplorhini; Humans; Hypothalamic Hormones; Hypot

1983

Other Studies

8 other studies available for sulpiride and Hypothermia

ArticleYear
Neuroleptic properties of cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide (YM-09151-2) with selective antidopaminergic activity.
    Psychopharmacology, 1981, Volume: 73, Issue:2

    Topics: Animals; Antipsychotic Agents; Apomorphine; Benzamides; Chlorpropamide; Dogs; Drug Evaluation, Precl

1981
Sulpiride increases and dopamine decreases intracranial temperature in rats when injected in the lateral hypothalamus: an animal model for the neuroleptic malignant syndrome?
    Brain research, 1995, Mar-13, Volume: 674, Issue:1

    Topics: Animals; Body Temperature; Brain; Disease Models, Animal; Dopamine; Fever; Hypothalamic Area, Latera

1995
Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action.
    European journal of pharmacology, 2000, Mar-03, Volume: 390, Issue:3

    Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzofurans; Body Temperature; Cerebral

2000
Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine.
    Pharmacological research, 2001, Volume: 44, Issue:6

    Topics: Animals; Apomorphine; Benzazepines; Conditioning, Psychological; Depression, Chemical; Dizocilpine M

2001
Dopamine D2-receptors mediate hypothermia in mice: ICV and IP effects of agonists and antagonists.
    Neurochemical research, 1991, Volume: 16, Issue:10

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Body Temperature

1991
Hypothermia in mice: D2 dopamine receptor mediation and absence of spare receptors.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Antagonists; Animals; A

1989
Piracetam interactions with neuroleptics in psychopharmacological tests.
    Neuropsychobiology, 1986, Volume: 16, Issue:2-3

    Topics: Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Drug Interactions; Fluph

1986
Influence of D-1 receptor system on the D-2 receptor-mediated hypothermic response in mice.
    Life sciences, 1988, Volume: 43, Issue:10

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anti-Anxiety Agents; Apomorphin

1988