sulpiride has been researched along with Huntington Disease in 14 studies
Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eleven patients with Huntington's disease and nine patients with tardive dyskinesia participated in a randomised double-blind crossover trial of sulpiride (as sole antidopaminergic therapy) versus placebo." | 2.65 | A double blind trial of sulpiride in Huntington's disease and tardive dyskinesia. ( Marsden, CD; Quinn, N, 1984) |
| "Pretreatment with haloperidol (2 mg intramuscularly) or sulpiride (100 mg intramuscularly) 30 minutes prior to apomorphine treatment, prevented the therapeutic effect of this compound." | 2.64 | Apomorphine hydrochloride-induced improvement in Huntington's chorea: stimulation of dopamine receptor. ( Cianchetti, C; Corsini, GU; Gessa, G; Mangoni, A; Masala, C; Onali, P, 1978) |
| "Huntington's disease is a hereditary and progressive disease of the central nervous system." | 1.32 | [Frontal dysfunctions in Huntington's disease -- neuropsychology and therapy]. ( Braus, DF; Ries, S; Tost, H; Weimer, E, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, ML | 1 |
| Begeti, F | 1 |
| Oh, JH | 1 |
| Lee, SY | 1 |
| O'Keeffe, GC | 1 |
| Clelland, CD | 1 |
| Tyers, P | 1 |
| Cho, ZH | 1 |
| Kim, YB | 1 |
| Barker, RA | 1 |
| Lukács, A | 1 |
| Szabó, A | 1 |
| Papp, A | 1 |
| Vezér, T | 1 |
| Weimer, E | 1 |
| Ries, S | 1 |
| Tost, H | 1 |
| Braus, DF | 1 |
| Saft, C | 1 |
| Andrich, J | 1 |
| Kraus, PH | 1 |
| Przuntek, H | 1 |
| Vieregge, P | 1 |
| Tremolizzo, L | 1 |
| Rodriguez-Menendez, V | 1 |
| DiFrancesco, JC | 1 |
| Sala, G | 1 |
| Galbussera, A | 1 |
| Appollonio, I | 1 |
| Ferrarese, C | 2 |
| Frattola, L | 1 |
| Albizzati, MG | 1 |
| Alemani, A | 1 |
| Bassi, S | 1 |
| Trabucchi, M | 1 |
| Quinn, N | 2 |
| Marsden, CD | 2 |
| Levivier, M | 1 |
| Przedborski, S | 1 |
| Donatelli, L | 1 |
| Müller, EE | 1 |
| Cocchi, D | 1 |
| Mantegazza, P | 1 |
| Parati, EA | 1 |
| Caraceni, T | 1 |
| Corsini, GU | 1 |
| Onali, P | 1 |
| Masala, C | 1 |
| Cianchetti, C | 1 |
| Mangoni, A | 1 |
| Gessa, G | 1 |
| Knowling, MR | 1 |
| Wrench, W | 1 |
3 trials available for sulpiride and Huntington Disease
| Article | Year |
|---|---|
Acute treatment of Huntington's chorea with lisuride.
Topics: Clinical Trials as Topic; Ergolines; Female; Haloperidol; Humans; Huntington Disease; Lisuride; Male | 1983 |
A double blind trial of sulpiride in Huntington's disease and tardive dyskinesia.
Topics: Adult; Aged; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Dyskin | 1984 |
Apomorphine hydrochloride-induced improvement in Huntington's chorea: stimulation of dopamine receptor.
Topics: Adult; Apomorphine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; | 1978 |
11 other studies available for sulpiride and Huntington Disease
| Article | Year |
|---|---|
Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease.
Topics: Animals; Brain; Corpus Striatum; Dentate Gyrus; Dopamine; Dopamine Antagonists; Female; Hippocampus; | 2014 |
Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid: possible glutamatergic and dopaminergic involvement.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agents; Dopamine D2 | 2009 |
[Frontal dysfunctions in Huntington's disease -- neuropsychology and therapy].
Topics: Adult; Amisulpride; Antipsychotic Agents; Attention; Brain; Dose-Response Relationship, Drug; Female | 2003 |
[Amisulpride in Huntington's disease].
Topics: Aged; Amisulpride; Antipsychotic Agents; Delusions; Dose-Response Relationship, Drug; Drug Administr | 2005 |
[Chorea].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Antipsychotic Agents; Athetosis; Child; Chorea; Dia | 2007 |
Huntington's disease and HDACi: would sulpiride and valproate be of therapeutic value?
Topics: Anticonvulsants; Antipsychotic Agents; Histone Deacetylases; Humans; Huntington Disease; Motor Activ | 2007 |
Quinolinic acid-induced lesions of the rat striatum: quantitative autoradiographic binding assessment.
Topics: Animals; Autoradiography; Benzazepines; Binding, Competitive; Cholinergic Agents; Corpus Striatum; D | 1998 |
[The Cools and van Rossum theory and the pharmacology of Huntington's chorea].
Topics: Animals; Apomorphine; Brain; Cats; Dopamine; Dopamine beta-Hydroxylase; Drug Therapy, Combination; E | 1977 |
Prolactin control in Huntington's chorea.
Topics: Adult; Chlorpromazine; Humans; Huntington Disease; Hypothalamus; Middle Aged; Pituitary Gland, Anter | 1977 |
Treatment of Huntington's chorea with sulpiride.
Topics: Female; Humans; Huntington Disease; Middle Aged; Sulpiride | 1991 |
Tiapride in 12 Huntington's disease patients.
Topics: Benzamides; Humans; Huntington Disease; Sulpiride; Tiapamil Hydrochloride | 1985 |