sulpiride has been researched along with Gastroparesis in 7 studies
Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Gastroparesis: Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effects of chronic oral administration of cisapride and levosulpiride in patients with functional dyspepsia and delayed gastric emptying." | 9.09 | Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis. ( Biagini, R; Borro, P; Giacomini, M; Mansi, C; Mele, MR; Pandolfo, N; Savarino, V, 2000) |
| "Our study first demonstrates that levosulpiride has an accelerating effect on the emptying of solids from the stomach of patients with diabetic gastroparesis." | 9.08 | Gastrokinetic effects of levosulpiride in dyspeptic patients with diabetic gastroparesis. ( De Martini, D; Mansi, C; Mela, GS; Melga, P; Perilli, D; Savarino, V; Sciabà, L; Vigneri, S, 1995) |
| "Our results show the importance of gastric emptying in the maintenance of glycemic control and the usefulness of chronic administration of levosulpiride in diabetic subjects with gastroparesis." | 9.08 | Chronic administration of levosulpiride and glycemic control in IDDM patients with gastroparesis. ( Ciuchi, E; Giusti, R; Mansi, C; Melga, P; Prando, R; Sciaba, L, 1997) |
| "Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a D(2) dopamine receptor antagonist and 2) as a serotonin 5HT(4) receptor agonist, conferring this drug with a cholinergic effect." | 6.46 | [Levosulpiride in the management of functional dyspepsia and delayed gastric emptying]. ( Serra, J, 2010) |
| "To compare the effects of chronic oral administration of cisapride and levosulpiride in patients with functional dyspepsia and delayed gastric emptying." | 5.09 | Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis. ( Biagini, R; Borro, P; Giacomini, M; Mansi, C; Mele, MR; Pandolfo, N; Savarino, V, 2000) |
| "Our study first demonstrates that levosulpiride has an accelerating effect on the emptying of solids from the stomach of patients with diabetic gastroparesis." | 5.08 | Gastrokinetic effects of levosulpiride in dyspeptic patients with diabetic gastroparesis. ( De Martini, D; Mansi, C; Mela, GS; Melga, P; Perilli, D; Savarino, V; Sciabà, L; Vigneri, S, 1995) |
| "Our results show the importance of gastric emptying in the maintenance of glycemic control and the usefulness of chronic administration of levosulpiride in diabetic subjects with gastroparesis." | 5.08 | Chronic administration of levosulpiride and glycemic control in IDDM patients with gastroparesis. ( Ciuchi, E; Giusti, R; Mansi, C; Melga, P; Prando, R; Sciaba, L, 1997) |
| "Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a D(2) dopamine receptor antagonist and 2) as a serotonin 5HT(4) receptor agonist, conferring this drug with a cholinergic effect." | 2.46 | [Levosulpiride in the management of functional dyspepsia and delayed gastric emptying]. ( Serra, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janssen, P | 1 |
| Harris, MS | 1 |
| Jones, M | 1 |
| Masaoka, T | 1 |
| Farré, R | 1 |
| Törnblom, H | 1 |
| Van Oudenhove, L | 1 |
| Simrén, M | 1 |
| Tack, J | 1 |
| Ma, HI | 1 |
| Kim, JH | 1 |
| Chu, MK | 1 |
| Oh, MS | 1 |
| Yu, KH | 1 |
| Kim, J | 1 |
| Hahm, W | 1 |
| Kim, YJ | 1 |
| Lee, BC | 1 |
| Serra, J | 1 |
| Melga, P | 3 |
| Mansi, C | 4 |
| Savarino, V | 2 |
| Vigneri, S | 1 |
| Perilli, D | 1 |
| Sciabà, L | 2 |
| De Martini, D | 1 |
| Mela, GS | 1 |
| Ciuchi, E | 1 |
| Giusti, R | 1 |
| Prando, R | 1 |
| Borro, P | 1 |
| Giacomini, M | 1 |
| Biagini, R | 1 |
| Mele, MR | 1 |
| Pandolfo, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622] | Phase 2 | 3 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Lack of recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for sulpiride and Gastroparesis
| Article | Year |
|---|---|
The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis.
Topics: Cisapride; Diabetes Mellitus, Type 2; Domperidone; Erythromycin; Gastric Emptying; Gastrointestinal | 2013 |
[Levosulpiride in the management of functional dyspepsia and delayed gastric emptying].
Topics: Animals; Clinical Trials as Topic; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Eval | 2010 |
4 trials available for sulpiride and Gastroparesis
| Article | Year |
|---|---|
Type 1 (insulin-dependent) diabetes mellitus and gastric emptying: role of blood glucose concentration and dopamine D2 receptors.
Topics: Adult; Blood Glucose; Breath Tests; Cisapride; Cross-Over Studies; Diabetes Mellitus, Type 1; Female | 2004 |
Gastrokinetic effects of levosulpiride in dyspeptic patients with diabetic gastroparesis.
Topics: Cross-Over Studies; Diabetes Mellitus, Type 1; Dopamine Antagonists; Double-Blind Method; Dyspepsia; | 1995 |
Chronic administration of levosulpiride and glycemic control in IDDM patients with gastroparesis.
Topics: Administration, Oral; Adult; Autonomic Nervous System Diseases; Blood Glucose; Diabetes Mellitus, Ty | 1997 |
Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis.
Topics: Activities of Daily Living; Administration, Oral; Adult; Aged; Anti-Ulcer Agents; Cisapride; Cross-O | 2000 |
1 other study available for sulpiride and Gastroparesis
| Article | Year |
|---|---|
Diabetes mellitus and drug-induced Parkinsonism: a case-control study.
Topics: Age of Onset; Aged; Contraindications; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease Sus | 2009 |