Page last updated: 2024-11-04

sulpiride and Dyspepsia

sulpiride has been researched along with Dyspepsia in 17 studies

Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Dyspepsia: Impaired digestion, especially after eating.

Research Excerpts

ExcerptRelevanceReference
"Sulpiride and itopride are effective in the treatment of dyspepsia in the form of postprandial distress syndrome."9.19[Efficacy of sulpiride and itopride in the treatment of functional dyspepsia in women with emotional and eating disorders]. ( Chojnacki, C; Klupińska, G; Pawłowicz, M; Wachowska-Kelly, P; Walecka-Kapica, E; Wojtkiewicz, P, 2014)
" The aim of the study is to compare the clinical efficacy of levosulpiride and cisapride in patients with dysmotility-like functional dyspepsia."9.11Levosulpiride and cisapride in the treatment of dysmotility-like functional dyspepsia: a randomized, double-masked trial. ( Balboa, A; Jiménez, I; Mearin, F; Patón, C; Pérez-Mota, A; Rodrigo, L; Sebastián, JJ, 2004)
"To compare the effects of chronic oral administration of cisapride and levosulpiride in patients with functional dyspepsia and delayed gastric emptying."9.09Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis. ( Biagini, R; Borro, P; Giacomini, M; Mansi, C; Mele, MR; Pandolfo, N; Savarino, V, 2000)
"Our study first demonstrates that levosulpiride has an accelerating effect on the emptying of solids from the stomach of patients with diabetic gastroparesis."9.08Gastrokinetic effects of levosulpiride in dyspeptic patients with diabetic gastroparesis. ( De Martini, D; Mansi, C; Mela, GS; Melga, P; Perilli, D; Savarino, V; Sciabà, L; Vigneri, S, 1995)
"Levosulpiride is effective and well tolerated in patients with functional dyspepsia accompanied by delayed gastric emptying."9.08Effects of levosulpiride in patients with functional dyspepsia accompanied by delayed gastric emptying. ( Choe, JG; Chun, HJ; Hyun, JH; Kim, CD; Ryu, HS; Song, CW, 1998)
"Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia."9.07The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia. ( Arienti, V; Biagi, F; Boriani, L; Corazza, GR; Gasbarrini, G; Maconi, G; Sorge, M; Sottili, S; Ugenti, F; Van Thiel, DH, 1994)
"Levosulpiride, a dopaminergic antagonist was compared in a double-blind randomized study with domperidone for treatment of functional dyspepsia in 50 patients divided into two groups of 25 subjects each."9.07[Levosulpiride versus domperidone in the treatment of functional dyspepsia]. ( Blasi, A; Brogna, A; Catanzaro, R; Mangiameli, A; Sofia, M, 1994)
"Fifty patients suffering from functional dyspepsia have been treated in a double-blind study either with 1-sulpiride (75 mg die per os) or with metoclopramide (30 mg die per os) for 30 days."9.07[L-sulpiride versus metoclopramide in functional dyspepsia: a randomized double-blind study]. ( Biasi, L; Brunelli, E; Macarri, G; Marucci, L; Svegliati Baroni, G, 1992)
"Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a D(2) dopamine receptor antagonist and 2) as a serotonin 5HT(4) receptor agonist, conferring this drug with a cholinergic effect."6.46[Levosulpiride in the management of functional dyspepsia and delayed gastric emptying]. ( Serra, J, 2010)
"Sulpiride and itopride are effective in the treatment of dyspepsia in the form of postprandial distress syndrome."5.19[Efficacy of sulpiride and itopride in the treatment of functional dyspepsia in women with emotional and eating disorders]. ( Chojnacki, C; Klupińska, G; Pawłowicz, M; Wachowska-Kelly, P; Walecka-Kapica, E; Wojtkiewicz, P, 2014)
" The aim of the study is to compare the clinical efficacy of levosulpiride and cisapride in patients with dysmotility-like functional dyspepsia."5.11Levosulpiride and cisapride in the treatment of dysmotility-like functional dyspepsia: a randomized, double-masked trial. ( Balboa, A; Jiménez, I; Mearin, F; Patón, C; Pérez-Mota, A; Rodrigo, L; Sebastián, JJ, 2004)
"To compare the effects of chronic oral administration of cisapride and levosulpiride in patients with functional dyspepsia and delayed gastric emptying."5.09Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis. ( Biagini, R; Borro, P; Giacomini, M; Mansi, C; Mele, MR; Pandolfo, N; Savarino, V, 2000)
"Our study first demonstrates that levosulpiride has an accelerating effect on the emptying of solids from the stomach of patients with diabetic gastroparesis."5.08Gastrokinetic effects of levosulpiride in dyspeptic patients with diabetic gastroparesis. ( De Martini, D; Mansi, C; Mela, GS; Melga, P; Perilli, D; Savarino, V; Sciabà, L; Vigneri, S, 1995)
"Levosulpiride is effective and well tolerated in patients with functional dyspepsia accompanied by delayed gastric emptying."5.08Effects of levosulpiride in patients with functional dyspepsia accompanied by delayed gastric emptying. ( Choe, JG; Chun, HJ; Hyun, JH; Kim, CD; Ryu, HS; Song, CW, 1998)
"Our results showed that levosulpiride can be usefully employed in patients affected by functional dyspepsia."5.07The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia. ( Arienti, V; Biagi, F; Boriani, L; Corazza, GR; Gasbarrini, G; Maconi, G; Sorge, M; Sottili, S; Ugenti, F; Van Thiel, DH, 1994)
"Levosulpiride, a dopaminergic antagonist was compared in a double-blind randomized study with domperidone for treatment of functional dyspepsia in 50 patients divided into two groups of 25 subjects each."5.07[Levosulpiride versus domperidone in the treatment of functional dyspepsia]. ( Blasi, A; Brogna, A; Catanzaro, R; Mangiameli, A; Sofia, M, 1994)
"Fifty patients suffering from functional dyspepsia have been treated in a double-blind study either with 1-sulpiride (75 mg die per os) or with metoclopramide (30 mg die per os) for 30 days."5.07[L-sulpiride versus metoclopramide in functional dyspepsia: a randomized double-blind study]. ( Biasi, L; Brunelli, E; Macarri, G; Marucci, L; Svegliati Baroni, G, 1992)
" Evaluation revealed levosulpiride, a dopamine receptor blocker commonly used for dyspepsia, to be the culprit."3.91An Unusual Cause of Camptocormia. ( Kumar, R; Lal, V; Mehta, S, 2019)
"Cisapride was significantly more effective than lansoprazole (OR 0."2.82Comparative Efficacy of Various Pharmacological Interventions in the Treatment of Functional Dyspepsia: A Network Meta-Analysis. ( Liang, L; Wang, G; Xiao, L; Yu, J, 2022)
"Functional dyspepsia is defined as a group of symptoms, whether related or unrelated to intake, localized in the upper abdomen, that manifest in the form of discomfort or epigastric pain, postprandial fullness and early satiety, in the absence of any demonstrable organic or structural anomaly."2.50[Integrative medicine in the management of functional dyspepsia. Role of the herbal preparation STW5]. ( Sebastián-Domingo, JJ, 2014)
"Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a D(2) dopamine receptor antagonist and 2) as a serotonin 5HT(4) receptor agonist, conferring this drug with a cholinergic effect."2.46[Levosulpiride in the management of functional dyspepsia and delayed gastric emptying]. ( Serra, J, 2010)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's5 (29.41)18.2507
2000's4 (23.53)29.6817
2010's6 (35.29)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Liang, L1
Yu, J1
Xiao, L1
Wang, G1
Pathania, M1
Malik, P1
Sharma, S1
Mehta, S1
Kumar, R1
Lal, V1
Sebastián-Domingo, JJ1
Wachowska-Kelly, P1
Walecka-Kapica, E1
Wojtkiewicz, P1
Pawłowicz, M1
Klupińska, G1
Chojnacki, C1
Kim, HJ1
Cho, JY1
Cho, YJ1
Hong, KS1
Serra, J1
Lim, HC1
Lee, SI1
Chen, JD1
Park, H1
Mearin, F1
Rodrigo, L1
Pérez-Mota, A1
Balboa, A1
Jiménez, I1
Sebastián, JJ1
Patón, C1
Morini, A1
Mauceri, P1
Pallotta, P1
Pelliccia, G1
Mansi, C2
Savarino, V2
Vigneri, S1
Perilli, D1
Melga, P1
Sciabà, L1
De Martini, D1
Mela, GS1
Arienti, V1
Corazza, GR1
Sorge, M1
Boriani, L1
Ugenti, F1
Biagi, F1
Maconi, G1
Sottili, S1
Van Thiel, DH1
Gasbarrini, G1
Mangiameli, A1
Brogna, A1
Catanzaro, R1
Sofia, M1
Blasi, A1
Song, CW1
Chun, HJ1
Kim, CD1
Ryu, HS1
Choe, JG1
Hyun, JH1
Borro, P1
Giacomini, M1
Biagini, R1
Mele, MR1
Pandolfo, N1
Distrutti, E1
Fiorucci, S1
Hauer, SK1
Pensi, MO1
Vanasia, M1
Morelli, A1
Macarri, G1
Biasi, L1
Brunelli, E1
Marucci, L1
Svegliati Baroni, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multi-dimensional Clinical and Pathophysiological Profiles of Patients With Functional Dyspepsia and Effect of Gut Microbiota Manipulation Using Rifaximin for Its Treatment: A Randomized Controlled Trial[NCT04302402]Phase 2132 participants (Anticipated)Interventional2020-03-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for sulpiride and Dyspepsia

ArticleYear
Comparative Efficacy of Various Pharmacological Interventions in the Treatment of Functional Dyspepsia: A Network Meta-Analysis.
    Digestive diseases and sciences, 2022, Volume: 67, Issue:1

    Topics: Cisapride; Comparative Effectiveness Research; Dyspepsia; Gastrointestinal Agents; Humans; Network M

2022
[Integrative medicine in the management of functional dyspepsia. Role of the herbal preparation STW5].
    Gastroenterologia y hepatologia, 2014, Volume: 37, Issue:4

    Topics: Algorithms; Anti-Anxiety Agents; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antidepressive Age

2014
[Levosulpiride in the management of functional dyspepsia and delayed gastric emptying].
    Gastroenterologia y hepatologia, 2010, Volume: 33, Issue:8

    Topics: Animals; Clinical Trials as Topic; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Eval

2010

Trials

10 trials available for sulpiride and Dyspepsia

ArticleYear
[Efficacy of sulpiride and itopride in the treatment of functional dyspepsia in women with emotional and eating disorders].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2014, Volume: 37, Issue:217

    Topics: Aged; Anxiety Disorders; Benzamides; Benzyl Compounds; Depression; Dopamine Antagonists; Dyspepsia;

2014
Electrogastrography associated with symptomatic changes after prokinetic drug treatment for functional dyspepsia.
    World journal of gastroenterology, 2012, Nov-07, Volume: 18, Issue:41

    Topics: Adult; Aged; Benzamides; Benzyl Compounds; Dyspepsia; Electrodiagnosis; Female; Gastrointestinal Age

2012
Levosulpiride and cisapride in the treatment of dysmotility-like functional dyspepsia: a randomized, double-masked trial.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2004, Volume: 2, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Cisapride; Dose-Response Relationship, Drug; Double-B

2004
Gastrokinetic effects of levosulpiride in dyspeptic patients with diabetic gastroparesis.
    The American journal of gastroenterology, 1995, Volume: 90, Issue:11

    Topics: Cross-Over Studies; Diabetes Mellitus, Type 1; Dopamine Antagonists; Double-Blind Method; Dyspepsia;

1995
The effects of levosulpiride on gastric and gall-bladder emptying in functional dyspepsia.
    Alimentary pharmacology & therapeutics, 1994, Volume: 8, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Dyspepsia; Female; Gallbladder Emptying; Gastri

1994
[Levosulpiride versus domperidone in the treatment of functional dyspepsia].
    La Clinica terapeutica, 1994, Volume: 144, Issue:2

    Topics: Adult; Benzamides; Domperidone; Dopamine Agents; Double-Blind Method; Dyspepsia; Female; Gastric Emp

1994
Effects of levosulpiride in patients with functional dyspepsia accompanied by delayed gastric emptying.
    The Korean journal of internal medicine, 1998, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Double-Blind Method; Dyspepsia; Female; Gastric Emptying; Gastrointestinal Agents

1998
Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis.
    Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:5

    Topics: Activities of Daily Living; Administration, Oral; Adult; Aged; Anti-Ulcer Agents; Cisapride; Cross-O

2000
Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsia.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:3

    Topics: Adult; Double-Blind Method; Drug Administration Schedule; Dyspepsia; Female; Gastric Emptying; Gastr

2002
[L-sulpiride versus metoclopramide in functional dyspepsia: a randomized double-blind study].
    Minerva medica, 1992, Volume: 83, Issue:5

    Topics: Adult; Aged; Double-Blind Method; Dyspepsia; Female; Humans; Male; Metoclopramide; Middle Aged; Sulp

1992

Other Studies

4 other studies available for sulpiride and Dyspepsia

ArticleYear
Good clinical history scores over extensive workup in unmasking a case of galactorrhoea.
    BMJ case reports, 2018, Apr-07, Volume: 2018

    Topics: Depression; Dyspepsia; Female; Galactorrhea; Helicobacter Infections; Humans; Pituitary Gland; Proto

2018
An Unusual Cause of Camptocormia.
    Tremor and other hyperkinetic movements (New York, N.Y.), 2019, Volume: 9

    Topics: Aged; Brain; Diabetes Complications; Diagnosis, Differential; Dopamine Antagonists; Dyspepsia; Femal

2019
Levosulpiride-induced resting orolingual tremor.
    Movement disorders : official journal of the Movement Disorder Society, 2009, Aug-15, Volume: 24, Issue:11

    Topics: Dopamine Antagonists; Dyskinesia, Drug-Induced; Dyspepsia; Facial Muscles; Female; Humans; Middle Ag

2009
[Irritable colon and psychosomatic disease].
    Minerva medica, 1984, Aug-25, Volume: 75, Issue:32-33

    Topics: Antidepressive Agents, Tricyclic; Benzodiazepines; Colitis; Colonic Diseases, Functional; Dyspepsia;

1984