sulpiride has been researched along with Cancer of Pituitary in 35 studies
Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "TRH, arginine, L-dopa, and sulpiride tests for PRL secretion were carried out in 18 control subjects and 20 patients with pituitary PRL-secreting adenomas before and after hypophysectomy." | 7.66 | Persistence of impaired PRL responses to sulpiride in patients with PRL secreting pituitary adenomas after successful hypophysectomy. ( Hanew, K; Kasai, M; Murakami, O; Murata, K; Sasaki, A; Sato, S; Shimizu, Y; Yoshinaga, K, 1983) |
| "TRH, arginine, L-dopa, and sulpiride tests for PRL secretion were carried out in 18 control subjects and 20 patients with pituitary PRL-secreting adenomas before and after hypophysectomy." | 3.66 | Persistence of impaired PRL responses to sulpiride in patients with PRL secreting pituitary adenomas after successful hypophysectomy. ( Hanew, K; Kasai, M; Murakami, O; Murata, K; Sasaki, A; Sato, S; Shimizu, Y; Yoshinaga, K, 1983) |
| "Antipsychotic drugs are the mainstay of treatment in schizophrenia." | 1.35 | Hyperprolactinemia and possibly related development of prolactinoma during amisulpride treatment; three cases. ( Akkaya, C; Ersoy, C; Kaya, B; Kirli, S; Kotan, Z; Sarandol, A, 2009) |
| " Preclinical evidence shows that chronic administration of antipsychotics can cause pituitary adenomas in female mice." | 1.34 | Atypical antipsychotics and pituitary neoplasms in the WHO database. ( Doraiswamy, PM; Edwards, R; Mueller-Oerlinghausen, B; Schott, G; Star, K, 2007) |
| "Although all of 19 prolactinomas tested expressed gp130 and LIFR subunit mRNA and immunoreactive protein, only 3 of 19 prolactinomas expressed LIF mRNA." | 1.32 | Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells. ( Ben-Shlomo, A; Culler, MD; Heaney, AP; Melmed, S; Miklovsky, I; Ren, SG; Yong, WH, 2003) |
| "However, there are prolactinomas that are difficult to treat." | 1.31 | Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas. ( Castro, MG; Lowenstein, PR; Morris, ID; Smith-Arica, JR; Stone, D; Williams, JC, 2001) |
| "The most effective therapy of human prolactinomas is represented by dopamine D-2 receptor agonists; there is, however, a population of nonresponder patients who require surgical intervention." | 1.29 | Nerve growth factor suppresses the transforming phenotype of human prolactinomas. ( Balsari, A; Boroni, F; Dal Toso, R; Giovanelli, M; Losa, M; Missale, C; Spano, P; Zanellato, A, 1993) |
| "When there was a pituitary adenoma or supra-sellar lesion the PRL response to sulpiride was always less than 481%." | 1.28 | [The combined stimulation test sulpiride-TRH in the investigation of prolactin secretion]. ( Claustrat, F; Dechaud, H; Miras-Mirakian, P; Pugeat, M, 1992) |
| "Patients with prolactinoma showed much greater TSH responses than normal subjects on the first day." | 1.28 | Evidence for dopamine-related and TRH-related pituitary TSH and PRL pools in patients with prolactinoma. ( Hanew, K; Shimizu, Y; Sugawara, A; Utsumi, A; Yoshinaga, K, 1991) |
| " A dose-response effect was shown between 40 and 80 mg in control subjects (n = 7); in 4 hyperprolactinemics the higher dose also failed to increase PRL levels." | 1.27 | Effect of fenfluramine oral administration on serum prolactin levels in healthy and hyperprolactinemic women. ( Adelasco, P; Brambilla, G; Cavioni, V; Ferrari, C; Mattei, AM; Scarduelli, C; Zavaglia, C, 1985) |
| "In 61 patients with pituitary adenoma, plasma TSH responses to sulpiride were significantly greater than those of normal controls, and the mean maximal increments were as follows: 1." | 1.26 | [Effect of sulpiride on plasma TSH secretion in various hypothalamo-pituitary disorders (author's transl)]. ( Sasaki, A, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (54.29) | 18.7374 |
| 1990's | 8 (22.86) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 2 (5.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lertxundi, U | 1 |
| Erezuma, I | 1 |
| Hernandez, R | 1 |
| Medrano, J | 1 |
| Garcia, M | 1 |
| Aguirre, C | 1 |
| Florio, T | 1 |
| Barbieri, F | 1 |
| Spaziante, R | 1 |
| Zona, G | 1 |
| Hofland, LJ | 1 |
| van Koetsveld, PM | 1 |
| Feelders, RA | 1 |
| Stalla, GK | 1 |
| Theodoropoulou, M | 1 |
| Culler, MD | 2 |
| Dong, J | 1 |
| Taylor, JE | 1 |
| Moreau, JP | 1 |
| Saveanu, A | 1 |
| Gunz, G | 1 |
| Dufour, H | 1 |
| Jaquet, P | 1 |
| Akkaya, C | 1 |
| Kaya, B | 1 |
| Kotan, Z | 1 |
| Sarandol, A | 1 |
| Ersoy, C | 1 |
| Kirli, S | 1 |
| Höfer, P | 1 |
| Friedrich, F | 1 |
| Vyssoki, B | 1 |
| Spindelegger, C | 1 |
| Schmook, M | 1 |
| Barnas, C | 1 |
| Lesch, OM | 1 |
| Walter, H | 1 |
| Ben-Shlomo, A | 1 |
| Miklovsky, I | 1 |
| Ren, SG | 1 |
| Yong, WH | 1 |
| Heaney, AP | 1 |
| Melmed, S | 1 |
| Perroud, N | 1 |
| Huguelet, P | 1 |
| Doraiswamy, PM | 1 |
| Schott, G | 1 |
| Star, K | 1 |
| Edwards, R | 1 |
| Mueller-Oerlinghausen, B | 1 |
| Hanew, K | 3 |
| Sasaki, A | 3 |
| Sato, S | 3 |
| Kasai, M | 1 |
| Murata, K | 2 |
| Shimizu, Y | 3 |
| Murakami, O | 2 |
| Yoshinaga, K | 3 |
| Chihara, K | 1 |
| Iwasaki, J | 1 |
| Minamitani, N | 1 |
| Kaji, H | 1 |
| Kodama, H | 1 |
| Fujita, T | 1 |
| Shirataki, K | 1 |
| Tamaki, N | 1 |
| Matsumoto, S | 1 |
| Arosio, M | 2 |
| Moriondo, P | 2 |
| Travaglini, P | 2 |
| Ambrosi, B | 1 |
| Beck-Peccoz, P | 2 |
| Puglisi, FC | 1 |
| Secchi, F | 1 |
| Faglia, G | 3 |
| Rocco, A | 2 |
| Falaschi, P | 2 |
| D'Urso, R | 2 |
| De Giorgio, G | 1 |
| Toffano, G | 1 |
| Frajese, G | 1 |
| Fukui, M | 1 |
| Koh, K | 1 |
| Ferrari, C | 3 |
| Rampini, P | 1 |
| Benco, R | 1 |
| Caldara, R | 2 |
| Scarduelli, C | 2 |
| Crosignani, PG | 2 |
| Massara, F | 2 |
| Camanni, F | 2 |
| Martra, M | 1 |
| Dolfin, GC | 1 |
| Müller, EE | 1 |
| Molinatti, GM | 2 |
| Gasparoni, P | 1 |
| Fioretti, D | 1 |
| Roncato, F | 1 |
| Rota, G | 1 |
| Conte, N | 1 |
| Belforte, L | 1 |
| Campagnoli, C | 1 |
| Novi, RF | 1 |
| Larson, BT | 1 |
| Samford, MD | 1 |
| Camden, JM | 1 |
| Piper, EL | 1 |
| Kerley, MS | 1 |
| Paterson, JA | 1 |
| Turner, JT | 1 |
| Izenwasser, S | 1 |
| Côté, TE | 1 |
| Spada, A | 2 |
| Bassetti, M | 2 |
| Reza-Elahi, F | 1 |
| Gil-Del-Alamo, P | 1 |
| Vallar, L | 1 |
| Missale, C | 1 |
| Boroni, F | 1 |
| Losa, M | 1 |
| Giovanelli, M | 1 |
| Zanellato, A | 1 |
| Dal Toso, R | 1 |
| Balsari, A | 1 |
| Spano, P | 1 |
| Allard, S | 1 |
| Lapointe, S | 1 |
| Falardeau, P | 1 |
| Williams, JC | 1 |
| Stone, D | 1 |
| Smith-Arica, JR | 1 |
| Morris, ID | 1 |
| Lowenstein, PR | 1 |
| Castro, MG | 1 |
| Vermeulen, A | 1 |
| Ando, S | 1 |
| Mattei, A | 1 |
| Mancini, AM | 1 |
| Aparicio, NJ | 1 |
| Vargas, CA | 1 |
| Debeljuk, L | 1 |
| Guitelman, A | 1 |
| L'Hermite, M | 2 |
| MacLeod, RM | 1 |
| Robyn, C | 2 |
| Degueldre, M | 1 |
| Caufriez, A | 1 |
| Delvoye, P | 1 |
| Barreca, T | 1 |
| Rolandi, E | 1 |
| Masturzo, P | 1 |
| Gianrossi, R | 1 |
| Perria, C | 1 |
| Miras-Mirakian, P | 1 |
| Claustrat, F | 1 |
| Dechaud, H | 1 |
| Pugeat, M | 1 |
| Utsumi, A | 1 |
| Sugawara, A | 1 |
| Rosa, M | 1 |
| Proietti, A | 1 |
| Melis, GB | 1 |
| Piscitelli, G | 1 |
| Amr, S | 1 |
| Ballabio, M | 1 |
| Giannattasio, G | 1 |
| Nissim, M | 1 |
| Weintraub, BD | 1 |
| Mattei, AM | 1 |
| Brambilla, G | 1 |
| Zavaglia, C | 1 |
| Adelasco, P | 1 |
| Cavioni, V | 1 |
1 trial available for sulpiride and Cancer of Pituitary
| Article | Year |
|---|---|
Effect of ritanserin, specific 5HT-2 antagonist, on PRL secretion in normal subjects and in different hyperprolactinaemic conditions.
Topics: Adenoma; Female; Follicular Phase; Humans; Hyperprolactinemia; Piperidines; Pituitary Neoplasms; Pos | 1991 |
34 other studies available for sulpiride and Cancer of Pituitary
| Article | Year |
|---|---|
Antipsychotics and pituitary tumors: an analysis of the European pharmacovigilance database (EudraVigilance).
Topics: Adolescent; Adult; Aged; Amisulpride; Antipsychotic Agents; Child; Databases, Factual; Female; Halop | 2019 |
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study.
Topics: Adenoma; Adult; Aged; Antineoplastic Agents, Hormonal; Cabergoline; Cell Division; Dopamine; Dopamin | 2008 |
Hyperprolactinemia and possibly related development of prolactinoma during amisulpride treatment; three cases.
Topics: Adult; Amisulpride; Antipsychotic Agents; Brain; Female; Humans; Hyperprolactinemia; Magnetic Resona | 2009 |
Hyperprolactinaemia and acute psychosis: prolactinoma or medication-induced phenomenon?
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Female; Follow-Up Studies; Humans; Hyperprolacti | 2010 |
Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells.
Topics: Adenoma; Animals; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Gene Expression; Growth In | 2003 |
A possible effect of amisulpride on a prolactinoma growth in a woman with borderline personality disorder.
Topics: Adult; Amisulpride; Borderline Personality Disorder; Female; Humans; Pituitary Neoplasms; Prolactin; | 2004 |
Atypical antipsychotics and pituitary neoplasms in the WHO database.
Topics: Adenoma; Adult; Adverse Drug Reaction Reporting Systems; Amisulpride; Antipsychotic Agents; Causalit | 2007 |
Persistence of impaired PRL responses to sulpiride in patients with PRL secreting pituitary adenomas after successful hypophysectomy.
Topics: Adenoma; Adolescent; Adult; Arginine; Female; Humans; Hypophysectomy; Levodopa; Male; Middle Aged; P | 1983 |
Prolactin secretion from human prolactinomas perifused in vitro: effect of TRH, prostaglandin E1, theophylline, dopamine and dopamine receptor blockers.
Topics: Adult; Alprostadil; Benzamides; Dopamine; Female; Humans; Male; Perfusion; Pituitary Neoplasms; Prol | 1984 |
Modifications in serum growth hormone concentration induced by sulpiride in acromegalic patients pretreated with dopamine, bromocriptine, and metergoline.
Topics: Acromegaly; Adenoma; Adult; Aged; Bromocriptine; Dopamine; Female; Gonadotropin-Releasing Hormone; G | 1980 |
[Clinical and experimental studies of the mechanism of neuroendocrine action of cerebral phospholipids: the behavior of prolactin as a marker of such action].
Topics: Adenoma; Adult; Female; Humans; Liposomes; Male; Metoclopramide; Middle Aged; Phospholipids; Pituita | 1981 |
The autonomy of prolactin secretion in patients with prolactin producing tumor.
Topics: Adult; Arginine; Female; Humans; Kinetics; Male; Middle Aged; Pituitary Neoplasms; Prolactin; Sulpir | 1982 |
Functional characterization of hypothalamic hyperprolactinemia.
Topics: Adult; Aged; Carbidopa; Child; Dopamine; Female; Humans; Hypothalamic Diseases; Levodopa; Male; Meni | 1982 |
Reciprocal pattern of the TSH and PRL responses to dopamine receptor blockade in women with physiological or pathological hyperprolactinaemia.
Topics: Adolescent; Adult; Domperidone; Female; Humans; Pituitary Neoplasms; Postpartum Period; Pregnancy; P | 1983 |
[Effect of sulpiride on plasma TSH secretion in various hypothalamo-pituitary disorders (author's transl)].
Topics: Adenoma; Adult; Aged; Female; Humans; Hypothalamic Diseases; Male; Middle Aged; Pituitary Diseases; | 1982 |
[Effect of bromopride on prolactin secretion].
Topics: Adenoma; Adolescent; Adult; Female; Humans; Male; Metoclopramide; Middle Aged; Pituitary Gland; Pitu | 1982 |
Effect of sulpiride on plasma prolactin levels in women with puerperal or pathological hyperprolactinaemia.
Topics: Adult; Amenorrhea; Female; Galactorrhea; Humans; Lactation Disorders; Pituitary Neoplasms; Pregnancy | 1980 |
Ergovaline binding and activation of D2 dopamine receptors in GH4ZR7 cells.
Topics: Adenosine Monophosphate; Animals; Cell Membrane; Ergotamines; Pituitary Neoplasms; Radioligand Assay | 1995 |
Inhibition of adenylyl cyclase activity by a homogeneous population of dopamine receptors: selective blockade by antisera directed against Gi1 and/or Gi2.
Topics: Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; Dopamine; Dopamine Agonists; Electrophor | 1995 |
Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas.
Topics: Adenoma; Adenylyl Cyclases; Calcium; Cytosol; Dopamine; Dose-Response Relationship, Drug; Female; Gr | 1994 |
Nerve growth factor suppresses the transforming phenotype of human prolactinomas.
Topics: Animals; Binding, Competitive; Bromocriptine; Cell Division; Cell Membrane; Humans; Kinetics; Mice; | 1993 |
Specific induction of a functional endogenous D2 short dopamine receptor in GH4C1 cells.
Topics: Animals; Apomorphine; Base Sequence; Colforsin; Cyclic AMP; Dopamine; Dose-Response Relationship, Dr | 1993 |
Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas.
Topics: Adenoviridae; Animals; Dopamine; Estrogens; Flow Cytometry; Gene Transfer Techniques; Genetic Therap | 2001 |
Prolactin and adrenal androgen secretion.
Topics: Adolescent; Adrenal Glands; Adult; Bromocriptine; Dehydroepiandrosterone; Female; Humans; Hydrocorti | 1978 |
Restoration of the prolactin response to sulpiride by metergoline administration in hyperprolactinemic patients.
Topics: Adenoma; Adult; Amenorrhea; Bromocriptine; Dopamine; Ergolines; Female; Humans; Metergoline; Pituita | 1979 |
Serum levels of prolactin under basal conditions and after administration of sulpiride in normal and galactorrheic women.
Topics: Adenoma, Chromophobe; Adolescent; Adult; Amenorrhea; Female; Galactorrhea; Humans; Lactation Disorde | 1978 |
Effects of two substituted benzamides, tiapride and sultopride, on gonadotrophins and prolactin.
Topics: Adolescent; Adult; Animals; Benzamides; Female; Follicle Stimulating Hormone; Humans; Luteinizing Ho | 1978 |
[Secretion of prolactin: the value of dynamic studies].
Topics: Breast Feeding; Circadian Rhythm; Female; Humans; Hypothalamo-Hypophyseal System; Lactation Disorder | 1975 |
[Studies of the prolactin functional response to the sulpiride test in patients with pituitary adenoma].
Topics: Adenoma, Chromophobe; Female; Humans; Hypophysectomy; Male; Pituitary Gland; Pituitary Gland, Anteri | 1975 |
[The combined stimulation test sulpiride-TRH in the investigation of prolactin secretion].
Topics: Adenoma; Amenorrhea; Clinical Protocols; Diagnosis, Differential; Evaluation Studies as Topic; Femal | 1992 |
Evidence for dopamine-related and TRH-related pituitary TSH and PRL pools in patients with prolactinoma.
Topics: Adolescent; Adult; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Combinatio | 1991 |
Endocrine, biochemical, and morphological studies of a pituitary adenoma secreting growth hormone, thyrotropin (TSH), and alpha-subunit: evidence for secretion of TSH with increased bioactivity.
Topics: Adenoma; Adult; Chromatography, Gel; Dopamine; Glycoprotein Hormones, alpha Subunit; Growth Hormone; | 1986 |
[The properties of prolactin secretion in patients with prolactin secreting pituitary adenomas].
Topics: Adenoma; Adolescent; Adult; Arginine; Dopamine; Female; Humans; Levodopa; Male; Middle Aged; Pituita | 1987 |
Effect of fenfluramine oral administration on serum prolactin levels in healthy and hyperprolactinemic women.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Pituita | 1985 |