Page last updated: 2024-11-04

sulpiride and Anxiety

sulpiride has been researched along with Anxiety in 43 studies

Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to explore effects on anxiety-like behavior of the D2 dopamine receptor agonist, quinpirole and of the D2 dopamine receptor antagonist, sulpiride given alone or in combination with a low dose of 17β-estradiol (17β-E2) to ovariectomized (OVX) rats."3.79Anxiolytic-like effect of quinpirole in combination with a low dose of 17β-estradiol in ovariectomized rats. ( Fedotova, J, 2013)
"Anxiety-related behaviors increase histamine and dopamine release in the brain."3.79Involvement of the dorsal hippocampal dopamine D2 receptors in histamine-induced anxiogenic-like effects in mice. ( Ayazi, E; Piri, M; Zarrindast, MR, 2013)
"Involvement of the dopamine receptors in the basolateral amygdala (BLA) in the effects of histamine on anxiety-like behaviors of the elevated plus maze in male Wistar rats was investigated."3.78D1 and D2 dopaminergic systems in the rat basolateral amygdala are involved in anxiogenic-like effects induced by histamine. ( Ahmadi, S; Bananej, M; Karimi-Sori, A; Zarrindast, MR, 2012)
"Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it."3.71The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats. ( Gordienko, DV; Krivobok, GK; Pankrat'ev, DV; Talalaenko, AN; Zinkovich, II, 2001)
"The pharmacological treatment of fibromyalgia is limited to a few drugs that have been demonstrated to be moderately effective in some but not all dimensions of the disease."2.50Current status of atypical antipsychotics for the treatment of fibromyalgia. ( Calandre, EP; Rico-Villademoros, F; Slim, M, 2014)
"Treatment with sulpiride further probed the pharmacological basis of long-term behavioural changes."1.40The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD. ( d'Angelo, LS; Day, JO; Dongelmans, ML; Eagle, DM; Mar, AC; Morein-Zamir, S; Noble, CA; Noschang, C; Robbins, TW; Theobald, DE; Urcelay, GP, 2014)
"Cholestasis was induced by ligation of the main bile duct."1.39Differential mechanisms of opioidergic and dopaminergic systems of the ventral hippocampus (CA₃) in anxiolytic-like behaviors induced by cholestasis in mice. ( Kafi, F; Nasehi, M; Zarrindast, MR, 2013)
"Results of a comparative study of the effects of chronic administration of the D2-receptor agonist quinperole (0."1.38[D2-type dopaminergic receptors and anxiety-depression-like behavior in female rats]. ( Fedotova, IuO, 2012)
"The objective of this study was to investigate the effects of chronic administration of a semi-purified extract (Purified Extract A--PEA; 4, 8, or 16 mg/kg) of PAULLINIA CUPANA (guaraná) seeds on rats submitted to the elevated T-maze (ETM) model of generalized anxiety and panic disorders."1.37Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test. ( Audi, EA; Biesdorf de Almeida, C; de Mello, JC; Klein, T; Roncon, CM, 2011)
"Pretreatment with diazepam (0."1.31Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. ( Cazala, P; David, V; Gold, LH; Koob, GF, 2001)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19907 (16.28)18.7374
1990's4 (9.30)18.2507
2000's8 (18.60)29.6817
2010's21 (48.84)24.3611
2020's3 (6.98)2.80

Authors

AuthorsStudies
Zarrindast, MR10
Fazli-Tabaei, S1
Khakpai, F1
László, K1
Péczely, L1
Géczi, F1
Kovács, A1
Zagoracz, O1
Ollmann, T1
Kertes, E1
Kállai, V1
László, B1
Berta, B1
Karádi, Z1
Lénárd, L1
Peng, B1
Xu, Q1
Liu, J1
Guo, S1
Borgland, SL1
Liu, S1
Ebrahimi-Ghiri, M1
Nasehi, M4
Nguyen, D1
Alushaj, E1
Erb, S1
Ito, R1
Magdaleno-Madrigal, VM1
Morales-Mulia, S1
Nicolini, H1
Genis-Mendoza, A1
Cázares-Martínez Claudia, E1
Pérez-Luna José, M1
Morales-Mulia, M1
Fedotova, J1
Piri, M1
Ayazi, E1
Kafi, F1
Becker, S1
Ceko, M1
Louis-Foster, M1
Elfassy, NM1
Leyton, M1
Shir, Y1
Schweinhardt, P1
Eagle, DM1
Noschang, C1
d'Angelo, LS1
Noble, CA1
Day, JO1
Dongelmans, ML1
Theobald, DE1
Mar, AC1
Urcelay, GP1
Morein-Zamir, S1
Robbins, TW1
Rico-Villademoros, F2
Calandre, EP2
Slim, M1
Ishola, IO1
Awodele, O1
Eluogu, CO1
Rezayof, A2
Hosseini, SS1
Hwang, SS1
Jung, DC1
Ahn, YM1
Kim, SH1
Kim, YS1
Naghdi-Sedeh, N1
Sahraei, H1
Bahrami, F1
Asadi, F1
Mahboobi, S1
Sadat-Shirazi, MS1
Ahmadi, S2
Roncon, CM1
Biesdorf de Almeida, C1
Klein, T1
de Mello, JC1
Audi, EA1
Bananej, M1
Karimi-Sori, A1
Savio, LE1
Vuaden, FC1
Piato, AL1
Bonan, CD1
Wyse, AT1
Rickards, H1
Cavanna, AE1
Worrall, R1
Fedotova, IuO1
Rodriguez-Lopez, CM1
Morillas-Arques, P1
Vilchez, JS1
Hidalgo, J1
Pournaghshband, M1
Yekta, BG1
Eslahi, N1
Rostami, P1
Zahmatkesh, M1
Wall, PM1
Blanchard, RJ1
Yang, M1
Blanchard, DC1
Talalaenko, AN2
Pankrat'ev, DV2
Goncharenko, NV1
Kotler, M1
Strous, RD1
Reznik, I1
Shwartz, S1
Weizman, A1
Spivak, B1
Grandi, M1
Sighinolfi, R1
Cagarelli, R1
Ferretti, G1
Borghi, A1
Greco, M1
Della Casa, L1
Maier, W1
Benkert, O1
Rodgers, RJ1
Nikulina, EM1
Cole, JC1
Mizuki, Y1
Suetsugi, M1
Ushijima, I1
Yamada, M1
Paoletti, AM1
Floris, S1
Mannias, M1
Orrù, M1
Crippa, D1
Orlandi, R1
Del Zompo M, M1
Melis, GB1
David, V1
Gold, LH1
Koob, GF1
Cazala, P1
Gordienko, DV1
Zinkovich, II1
Krivobok, GK1
Cancela, LM1
Basso, AM1
Martijena, ID1
Capriles, NR1
Molina, VA1
Sizaret, P1
Moreau, C1
Leger, JM1
Dumond, JJ1
Garoux, R1
Lombertie, E1
Dumas, M1
Pelc, I1
Maurel, H1
Pujol, B1
Planche, S1
Simon, P1
Panissaud, C1
Costentin, J1
Masciocchi, A1
Reitano, S1
Vanini, M1
Cicchetti, V1

Reviews

2 reviews available for sulpiride and Anxiety

ArticleYear
Current status of atypical antipsychotics for the treatment of fibromyalgia.
    Drugs of today (Barcelona, Spain : 1998), 2014, Volume: 50, Issue:6

    Topics: Amisulpride; Antipsychotic Agents; Anxiety; Benzodiazepines; Comorbidity; Depression; Dibenzothiazep

2014
[Psychiatric manifestations induced by dopamine precursors or antagonists].
    Annales medico-psychologiques, 1979, Volume: 137, Issue:9

    Topics: Anxiety; Bromocriptine; Confusion; Dopamine Antagonists; Dreams; Female; Hallucinations; Humans; Lev

1979

Trials

7 trials available for sulpiride and Anxiety

ArticleYear
Sulpiride augmentation of olanzapine in the management of treatment-resistant chronic schizophrenia: evidence for improvement of mood symptomatology.
    International clinical psychopharmacology, 2004, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Affect; Antipsychotic Agents; Anxiety; Basal Ganglia Diseases; Benzodiazepines; C

2004
Treatment of chronic depression with sulpiride: evidence of efficacy in placebo-controlled single case studies.
    Psychopharmacology, 1994, Volume: 115, Issue:4

    Topics: Adult; Anxiety; Case-Control Studies; Chronic Disease; Cross-Over Studies; Depressive Disorder; Doub

1994
Differential effects of dopaminergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety.
    Progress in neuro-psychopharmacology & biological psychiatry, 1997, Volume: 21, Issue:4

    Topics: Adult; Anxiety; Arousal; Bromocriptine; Double-Blind Method; Electroencephalography; Humans; Male; S

1997
Evidence that cyproterone acetate improves psychological symptoms and enhances the activity of the dopaminergic system in postmenopause.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:2

    Topics: Adult; Androgen Antagonists; Anxiety; Area Under Curve; Cyproterone Acetate; Depression; Dopamine; E

2001
[Comparative study using double-blind method of sultopride and thioproperazine].
    L'Encephale, 1977, Volume: 3, Issue:2

    Topics: Antipsychotic Agents; Anxiety; Benzamides; Brief Psychiatric Rating Scale; Clinical Trials as Topic;

1977
[Situation of sultopride among present-day neuroleptics].
    L'Encephale, 1975, Volume: 1, Issue:1

    Topics: Anxiety; Asthenia; Basal Ganglia Diseases; Benzamides; Bipolar Disorder; Clinical Trials as Topic; D

1975
[Sulpiride and drug addiction].
    L'Encephale, 1975, Volume: 1, Issue:1

    Topics: Adolescent; Adult; Anxiety; Clinical Trials as Topic; Delusions; Female; Hallucinations; Humans; Lys

1975

Other Studies

34 other studies available for sulpiride and Anxiety

ArticleYear
Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.
    Neurobiology of learning and memory, 2021, Volume: 186

    Topics: Adrenergic Agents; Animals; Anxiety; Arginine; Disease Models, Animal; Dopamine Agonists; Dopamine A

2021
The role of D2 dopamine receptors in oxytocin induced place preference and anxiolytic effect.
    Hormones and behavior, 2020, Volume: 124

    Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conditioning, Classical; Dopamine

2020
Corticosterone Attenuates Reward-Seeking Behavior and Increases Anxiety via D2 Receptor Signaling in Ventral Tegmental Area Dopamine Neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021, 02-17, Volume: 41, Issue:7

    Topics: Animals; Anxiety; Behavior, Animal; Conditioning, Operant; Corticosterone; Dopamine D2 Receptor Anta

2021
The modulatory role of accumbens and hippocampus D2 receptors in anxiety and memory.
    Naunyn-Schmiedeberg's archives of pharmacology, 2018, Volume: 391, Issue:10

    Topics: Animals; Anxiety; Avoidance Learning; Dopamine Agonists; Dopamine Antagonists; Exploratory Behavior;

2018
Dissociative effects of dorsomedial striatum D1 and D2 receptor antagonism in the regulation of anxiety and learned approach-avoidance conflict decision-making.
    Neuropharmacology, 2019, 03-01, Volume: 146

    Topics: Animals; Anxiety; Benzazepines; Choice Behavior; Cues; Decision Making; Dopamine Antagonists; Dopami

2019
Orexin-A promotes EEG changes but fails to induce anxiety in rats.
    Behavioural brain research, 2019, 04-01, Volume: 361

    Topics: Animals; Anxiety; Anxiety Disorders; Arousal; Behavior, Animal; Dopamine D2 Receptor Antagonists; El

2019
Anxiolytic-like effect of quinpirole in combination with a low dose of 17β-estradiol in ovariectomized rats.
    Acta physiologica Hungarica, 2013, Volume: 100, Issue:2

    Topics: Animals; Anxiety; Anxiety Disorders; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor A

2013
Involvement of the dorsal hippocampal dopamine D2 receptors in histamine-induced anxiogenic-like effects in mice.
    Neuroscience letters, 2013, Aug-29, Volume: 550

    Topics: Animals; Anxiety; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor An

2013
Differential mechanisms of opioidergic and dopaminergic systems of the ventral hippocampus (CA₃) in anxiolytic-like behaviors induced by cholestasis in mice.
    European journal of pharmacology, 2013, Aug-15, Volume: 714, Issue:1-3

    Topics: Animals; Anxiety; Behavior, Animal; Benzazepines; CA3 Region, Hippocampal; Cholestasis; Exploratory

2013
Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosine depletion have effects on thermal pain sensations in healthy volunteers.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Adolescent; Adult; Affect; Anxiety; Dopamine; Dopamine D2 Receptor Antagonists; Female; Healthy Volu

2013
The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD.
    Behavioural brain research, 2014, May-01, Volume: 264

    Topics: Animals; Anxiety; Compulsive Behavior; Conditioning, Operant; Disease Models, Animal; Dopamine Agoni

2014
Potentials of Mangifera indica in the treatment of depressive-anxiety disorders: possible mechanisms of action.
    Journal of complementary & integrative medicine, 2016, Sep-01, Volume: 13, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Anxiety Disorders; Depression; Depress

2016
Effects of morphine on rat behaviour in the elevated plus maze: the role of central amygdala dopamine receptors.
    Behavioural brain research, 2009, Sep-14, Volume: 202, Issue:2

    Topics: Amygdala; Animals; Anxiety; Apomorphine; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Dopa

2009
The effects of psychopathology on subjective experience of side effects of antipsychotics in patients with schizophrenia.
    International clinical psychopharmacology, 2010, Volume: 25, Issue:2

    Topics: Adult; Amisulpride; Antipsychotic Agents; Anxiety; Benzodiazepines; Cognition Disorders; Depressive

2010
The effects of dopaminergic drugs in the ventral hippocampus of rats in the nicotine-induced anxiogenic-like response.
    Neuroscience letters, 2010, May-21, Volume: 475, Issue:3

    Topics: Animals; Anxiety; Apomorphine; Benzazepines; Dopamine Agents; Dopamine D2 Receptor Antagonists; Hipp

2010
Anxiolytic-like effect induced by the cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA), in the rat amygdala is mediated through the D1 and D2 dopaminergic systems.
    Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:1

    Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Apomorphine; Arachidonic Acids; Benzazepines; Dopam

2011
Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test.
    Planta medica, 2011, Volume: 77, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Dopamine Agents; Es

2011
D1 and D2 dopaminergic systems in the rat basolateral amygdala are involved in anxiogenic-like effects induced by histamine.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:4

    Topics: Amygdala; Animals; Anxiety; Benzazepines; Histamine; Male; Maze Learning; Quinpirole; Rats; Rats, Wi

2012
Behavioral changes induced by long-term proline exposure are reversed by antipsychotics in zebrafish.
    Progress in neuro-psychopharmacology & biological psychiatry, 2012, Mar-30, Volume: 36, Issue:2

    Topics: 1-Pyrroline-5-Carboxylate Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Animals; Antipsychoti

2012
Treatment practices in Tourette syndrome: the European perspective.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:4

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Atomoxetine Hydrochloride

2012
[D2-type dopaminergic receptors and anxiety-depression-like behavior in female rats].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:2

    Topics: Adult; Animals; Antidepressive Agents; Anxiety; Depression; Diestrus; Dopamine; Dopamine Agonists; D

2012
Amisulpride in the treatment of fibromyalgia: an uncontrolled study.
    Clinical rheumatology, 2012, Volume: 31, Issue:9

    Topics: Adult; Amisulpride; Antipsychotic Agents; Anxiety; Comorbidity; Dopamine Antagonists; Female; Fibrom

2012
Dopaminergic system in CA1 modulates MK-801 induced anxiolytic-like responses.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 103, Issue:1

    Topics: Animals; Anxiety; Benzazepines; CA1 Region, Hippocampal; Dizocilpine Maleate; Dopamine; Dopamine D2

2012
Modulation of ventral tegmental area dopamine receptors inhibit nicotine-induced anxiogenic-like behavior in the central amygdala.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Mar-05, Volume: 41

    Topics: Amygdala; Animals; Anxiety; Benzazepines; Dopamine Antagonists; Injections, Intraventricular; Male;

2013
Infralimbic D2 receptor influences on anxiety-like behavior and active memory/attention in CD-1 mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:3

    Topics: Animals; Anxiety; Attention; Dopamine D2 Receptor Antagonists; Limbic System; Male; Memory; Mice; Pr

2003
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
    Neuroscience and behavioral physiology, 2003, Volume: 33, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-

2003
[Liposomes of hypothalamic phospholipids: evaluation of their efficacy in subjects pretreated with sulpiride].
    La Clinica terapeutica, 1984, Oct-31, Volume: 111, Issue:2

    Topics: Adolescent; Adult; Aged; Anxiety; Depression; Double-Blind Method; Drug Therapy, Combination; Follic

1984
Dopamine D1 and D2 receptor ligands modulate the behaviour of mice in the elevated plus-maze.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anti-Anxiety Agents; Anxiety; B

1994
Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Caudate Nucleus; Cocaine; Conditioning, Operant; Diaze

2001
The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats.
    Bulletin of experimental biology and medicine, 2001, Volume: 131, Issue:1

    Topics: Adrenergic Agents; Animals; Anxiety; Apomorphine; Avoidance Learning; Disease Models, Animal; Dopami

2001
A dopaminergic mechanism is involved in the 'anxiogenic-like' response induced by chronic amphetamine treatment: a behavioral and neurochemical study.
    Brain research, 2001, Aug-03, Volume: 909, Issue:1-2

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Anxiety; Behavior, Animal; Benzazepines; Brain;

2001
[Sulpiride and psychic decompensation].
    L'Encephale, 1976, Volume: 2, Issue:4

    Topics: Anxiety; Autistic Disorder; Cognition Disorders; Depression; Humans; Psychotic Disorders; Sulpiride

1976
Sulpiride anxiogenic-like effect inhibition by a D1 dopamine receptor antagonist.
    Neuroreport, 1992, Volume: 3, Issue:10

    Topics: Animals; Anxiety; Behavior, Animal; Benzazepines; Dopamine D2 Receptor Antagonists; Male; Mice; Moto

1992
[Preliminary results of a controlled trial with sulpiride versus chlorimipramine in chronic schizophrenic patients with marked ideo-emotional poverty (author's transl)].
    Rivista di patologia nervosa e mentale, 1974, Volume: 95, Issue:1

    Topics: Affect; Anxiety; Chronic Disease; Clomipramine; Depression; Dibenzazepines; Humans; Mental Processes

1974