sulpiride has been researched along with Aging in 35 studies
Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objectives of this study were to determine the safety and the pharmacokinetic profile of 50 mg of amisulpride administered orally as a single dose to elderly volunteers." | 2.69 | Safety and pharmacokinetics of a single oral dose of amisulpride in healthy elderly volunteers. ( Ahtoy, P; Canal, M; Chaufour, S; Chretien, P; Deschamps, C; Hamon-Vilcot, B; Nasr, A; Piette, F; Rosenzweig, P; Zieleniuk, I, 1998) |
| "The morphine-treated group showed a significant increase in mu receptor binding on P1 and P7." | 1.33 | Effects of prenatal cocaine, morphine, or both on postnatal opioid (mu) receptor development. ( Bhat, R; Chari, G; Rao, R, 2006) |
| "[3H]sulpiride binding was significantly different only in the ventral tegmental area (VTA), where binding was approximately 20% lower in the periadolescent P rats compared with the NP rat pups." | 1.32 | Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups. ( Li, TK; Lumeng, L; McBride, WJ; Strother, WN, 2003) |
| "A within-subject dose-response analysis was conducted by locally perfusing increasing concentrations (0." | 1.29 | The development of D2 autoreceptor-mediated modulation of K(+)-evoked dopamine release in the neostriatum. ( Andersen, SL; Gazzara, RA, 1994) |
| " No significant differences between young/adult and elderly patients for the various pharmacokinetic parameters (t1/2, AUC, Cmax, Tmax, Vd and Cl), after acute and multiple dosing, were observed." | 1.29 | L-sulpiride in young and elderly negative schizophrenics: clinical and pharmacokinetic variables. ( Altamura, CA; Coppola, MT; Leva, P; Mauri, MC, 1994) |
| "Similarly, catalepsy induced by (-)-sulpiride (40 mg/kg, i." | 1.27 | Influence of (-)-sulpiride and YM-09151-2 on stereotyped behavior in chicks and catalepsy in rats. ( Wambebe, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (34.29) | 18.7374 |
| 1990's | 14 (40.00) | 18.2507 |
| 2000's | 5 (14.29) | 29.6817 |
| 2010's | 4 (11.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdulrahman, H | 1 |
| Fletcher, PC | 1 |
| Bullmore, E | 1 |
| Morcom, AM | 1 |
| Lesovaya, EA | 1 |
| Kirsanov, KI | 1 |
| Antoshina, EE | 1 |
| Trukhanova, LS | 1 |
| Gorkova, TG | 1 |
| Shipaeva, EV | 1 |
| Salimov, RM | 1 |
| Belitsky, GA | 1 |
| Blagosklonny, MV | 1 |
| Yakubovskaya, MG | 1 |
| Chernova, OB | 1 |
| Darvish-Ghane, S | 1 |
| Yamanaka, M | 1 |
| Zhuo, M | 1 |
| Korosue, K | 1 |
| Murase, H | 1 |
| Sato, F | 1 |
| Ishimaru, M | 1 |
| Harada, T | 1 |
| Watanabe, G | 1 |
| Taya, K | 1 |
| Nambo, Y | 1 |
| Strother, WN | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| McBride, WJ | 1 |
| Ng, KF | 1 |
| Innis, SM | 1 |
| Alonso, G | 1 |
| Runquist, M | 1 |
| Hussy, N | 1 |
| Duvoid, A | 1 |
| Moos, F | 1 |
| Bhat, R | 1 |
| Chari, G | 1 |
| Rao, R | 1 |
| Cassel, JC | 1 |
| Lazaris, A | 1 |
| Birthelmer, A | 1 |
| Jackisch, R | 1 |
| Oki, K | 1 |
| Nomura, Y | 1 |
| Moguilevsky, JA | 1 |
| Faigón, MR | 1 |
| Scacchi, P | 1 |
| Scwarcfarb, B | 1 |
| Memo, M | 1 |
| Lucchi, L | 1 |
| Spano, PF | 1 |
| Trabucchi, M | 1 |
| von Euler, G | 1 |
| Hedlund, PB | 1 |
| McDougall, SA | 2 |
| Crawford, CA | 1 |
| Nonneman, AJ | 2 |
| Andersen, SL | 2 |
| Gazzara, RA | 2 |
| Zsilla, G | 1 |
| Zelles, T | 1 |
| Mike, A | 1 |
| Kékes-Szabó, A | 1 |
| Milusheva, E | 1 |
| Vizi, ES | 1 |
| Soghomonian, JJ | 1 |
| Donzanti, BA | 1 |
| Hite, JF | 1 |
| Yamamoto, BK | 1 |
| Mauri, MC | 1 |
| Leva, P | 1 |
| Coppola, MT | 1 |
| Altamura, CA | 1 |
| Sugawa, M | 1 |
| Giardino, L | 2 |
| Zanni, M | 1 |
| Pignataro, O | 1 |
| Hamon-Vilcot, B | 1 |
| Chaufour, S | 1 |
| Deschamps, C | 1 |
| Canal, M | 1 |
| Zieleniuk, I | 1 |
| Ahtoy, P | 1 |
| Chretien, P | 1 |
| Rosenzweig, P | 1 |
| Nasr, A | 1 |
| Piette, F | 1 |
| Kalbermann, LE | 1 |
| Szijan, I | 1 |
| Jahn, GA | 1 |
| Krawiec, L | 1 |
| Burdman, JA | 1 |
| Arnold, TF | 1 |
| Morelli, M | 1 |
| Mennini, T | 1 |
| Cagnotto, A | 1 |
| Toffano, G | 1 |
| Di Chiara, G | 1 |
| Mongioi, A | 1 |
| Vicari, E | 1 |
| D'Agata, R | 1 |
| Sales, N | 1 |
| Martres, MP | 1 |
| Bouthenet, ML | 1 |
| Schwartz, JC | 1 |
| Wambebe, C | 1 |
| Burchill, SA | 1 |
| Thody, AJ | 1 |
| Joshita, Y | 1 |
| Baptista, T | 1 |
| Parada, MA | 1 |
| Murzi, E | 1 |
| Ferrara, N | 1 |
| Bernardini, R | 1 |
| Nicoletti, F | 1 |
| Drago, F | 1 |
| Matera, M | 1 |
| Ceravolo, A | 1 |
| Scapagnini, U | 1 |
| Nair, NP | 1 |
| Lal, S | 1 |
| Thavundayil, JX | 1 |
| Isaac, I | 1 |
| Eugenio, H | 1 |
| Achim, A | 1 |
| Schwartz, G | 1 |
| Guyda, H | 1 |
3 trials available for sulpiride and Aging
| Article | Year |
|---|---|
Dopamine and memory dedifferentiation in aging.
Topics: Adult; Aged; Aging; Brain; Brain Mapping; Bromocriptine; Carrier Proteins; Dopamine; Dopamine Agonis | 2017 |
Safety and pharmacokinetics of a single oral dose of amisulpride in healthy elderly volunteers.
Topics: Administration, Oral; Adult; Aged; Aging; Amisulpride; Antipsychotic Agents; Drug Administration Sch | 1998 |
Effect of normal aging on the prolactin response to graded doses of sulpiride and to arginine.
Topics: Adolescent; Adult; Aged; Aging; Arginine; Humans; Male; Prolactin; Stimulation, Chemical; Sulpiride; | 1985 |
32 other studies available for sulpiride and Aging
| Article | Year |
|---|---|
Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Drug Administration Schedule; F | 2015 |
Dopaminergic Modulation of Excitatory Transmission in the Anterior Cingulate Cortex of Adult Mice.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzazepines; Dopamine; Ex | 2016 |
Successful induction of lactation in a barren Thoroughbred mare: growth of a foal raised on induced lactation and the corresponding maternal hormone profiles.
Topics: Aging; Animals; Body Weight; Estradiol; Female; Horses; Insemination, Artificial; Lactation; Pregnan | 2012 |
Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Alcohol Drinking; Animals; Autoradiography; Central N | 2003 |
Behavioral responses are altered in piglets with decreased frontal cortex docosahexaenoic acid.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Diet; Dietary Fats, Unsaturated; Docosahe | 2003 |
Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Afferent Pathways; Aging; Animals; Astro | 2003 |
Effects of prenatal cocaine, morphine, or both on postnatal opioid (mu) receptor development.
Topics: Aging; Animals; Brain; Cocaine; Dopamine Antagonists; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; M | 2006 |
Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices.
Topics: Acetylcholine; Age Factors; Aging; Animals; Behavior, Animal; Cholinesterase Inhibitors; Corpus Stri | 2007 |
Development of inhibitory activity of sulpiride for synaptic [3H]-spiperone binding in the rat striatum.
Topics: Aging; Animals; Binding, Competitive; Butyrophenones; Corpus Striatum; Female; Guanosine Triphosphat | 1982 |
Hyperprolactinaemia does not affect the development of the stimulatory mechanism of oestrogen-progesterone on LH secretion.
Topics: Aging; Animals; Estradiol; Female; Luteinizing Hormone; Progesterone; Prolactin; Rats; Sulpiride | 1981 |
Aging process affects a single class of dopamine receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Aging; Animals; Corpus Striatum; Haloperidol; Hum | 1980 |
Regional and age-dependent differences in the affinity of dopamine D2 agonist binding in the rat brain.
Topics: Aging; Analysis of Variance; Animals; Autoradiography; Brain; Iodine Radioisotopes; Male; Radioligan | 1995 |
Behavioral effects of selective and nonselective dopamine agonists on young rats after irreversible antagonism of D1 and/or D2 receptors.
Topics: Aging; Animals; Behavior, Animal; Benzazepines; Dopamine D2 Receptor Antagonists; Ergolines; Female; | 1993 |
The development of D2 autoreceptor-mediated modulation of K(+)-evoked dopamine release in the neostriatum.
Topics: Aging; Animals; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dose-Response Relations | 1994 |
Differential changes in presynaptic modulation of transmitter release during aging.
Topics: Acetylcholine; Aging; Animals; Berberine; Dopamine; Feedback; Female; Frontal Lobe; Hippocampus; Mal | 1994 |
Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Dopamine; Enkephalins; Female; Glutamate Decarbox | 1994 |
Extracellular glutamate levels increase with age in the lateral striatum: potential involvement of presynaptic D-2 receptors.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dopamine Agents; El | 1993 |
L-sulpiride in young and elderly negative schizophrenics: clinical and pharmacokinetic variables.
Topics: Adult; Aged; Aging; Blood Pressure; Electrocardiography; Female; Half-Life; Heart Rate; Humans; Male | 1994 |
Alterations of inositol phosphate turnover in striatum of aged rats.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Female; Inositol 1,4,5-Trisphosphate; Rats; Rats, Wistar; | 1993 |
Right-left asymmetry of D1- and D2-receptor density is lost in the basal ganglia of old rats.
Topics: Aging; Animals; Autoradiography; Basal Ganglia; Benzazepines; Caudate Nucleus; Dopamine Antagonists; | 1996 |
Effects of (-)-sulpiride on dopamine release in striatum of developing rats: degree of depolarization influences responsiveness.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Kinetics; Male; Mic | 1996 |
DA1 and DA2 receptor regulation in the striatum of young and old rats after peripheral vestibular lesion.
Topics: Aging; Analysis of Variance; Animals; Autoradiography; Benzazepines; Corpus Striatum; Locomotion; Ma | 1996 |
DNA synthesis in the pituitary gland of the rat. Effect of sulpiride and postnatal maturation.
Topics: Aging; Animals; Deoxyribonucleases; DNA; DNA Replication; DNA-Directed DNA Polymerase; Endonucleases | 1979 |
Ontogeny of locomotor activity and grooming in the young rat: role of dopamine D1 and D2 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Dopamine A | 1990 |
Quantitative autoradiographical analysis of the age-related modulation of central dopamine D1 and D2 receptors.
Topics: Aging; Animals; Autoradiography; Benzazepines; Brain; Brain Chemistry; In Vitro Techniques; Male; Ra | 1990 |
The prolactin-secreting system in relation to aging.
Topics: Aged; Aging; Humans; Male; Middle Aged; Prolactin; Prostatic Hyperplasia; Reference Values; Sulpirid | 1985 |
Ontogeny of dopaminergic D-2 receptors in the rat nervous system: characterization and detailed autoradiographic mapping with [125I]iodosulpride.
Topics: Aging; Animals; Autoradiography; Binding, Competitive; Embryonic and Fetal Development; Female; Nerv | 1989 |
Influence of (-)-sulpiride and YM-09151-2 on stereotyped behavior in chicks and catalepsy in rats.
Topics: Aging; Animals; Antipsychotic Agents; Benzamides; Catalepsy; Chickens; Dextroamphetamine; Fenclonine | 1987 |
Dopaminergic inhibition of tyrosinase activity in hair follicular melanocytes of the mouse.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Bromocript | 1986 |
[Studies on the hypothalamic-pituitary dopaminergic system in Parkinson's disease and spinocerebellar degeneration. Response to TRH and sulpiride].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Dopamine; Female; Humans; Hypothalamo-Hypo | 1987 |
Puberty modifies sulpiride effects on body weight in rats.
Topics: Aging; Animals; Body Weight; Feeding Behavior; Female; Male; Rats; Rats, Inbred Strains; Sex Factors | 1988 |
Prolactin influences sexual behavior during aging.
Topics: Aging; Animals; Bromocriptine; Copulation; Corpus Striatum; Glutamate Decarboxylase; Male; Pituitary | 1985 |