suloctidil and Chemical-and-Drug-Induced-Liver-Injury

Suloctidil is a new drug that is currently being evaluated in many clinical trials for use in dementia and thrombotic disorders. Hepatotoxicity has to date been reported exclusively in the European literature, and the few available histologic descriptions have been reported in the French language. We report a case of suloctidil-induced hepatotoxicity documented by serum liver biochemical tests and liver biopsy. Histologic features included focal necrosis of hepatocytes, mild hyperplasia of Kupffer cells, and other features suggestive of mild acute hepatitis.

Topics: Aged; Alzheimer Disease; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Function Tests; Male; Propanolamines; Suloctidil

Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Propanolamines; Raynaud Disease; Suloctidil

The effect of suloctidil (120 mg/kg body weight PO for 3 weeks) on rat liver was investigated using biochemical and morphological methods: enzymatic activities characteristic of the main cellular compartments were used as biochemical markers of hepatocyte function and morphometry was applied to investigate morphological changes. No sign of hepatotoxicity was evidenced after suloctidil treatment (liver weight; cytochrome c oxidase; glucose 6-phosphatase; NADPH-cytochrome c reductase; D-amino acid oxidase; urate oxidase; fatty acid oxidation; peroxisomal number, volume and size distribution). Suloctidil increased catalase activity by 22% without morphologically detectable changes in the peroxisomes. After suloctidil treatment, slightly increased mitochondrial volume fraction and slightly decreased mitochondrial number were noted without significant changes in cytochrome c oxidase. Clofibrate, at the same dose, increased NADPH-cytochrome c reductase, catalase, acylCoA oxidase, mitochondrial and peroxisomal number and volume fraction, and decreased urate oxidase activity.

Topics: Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Liver; Male; Mitochondria, Liver; Propanolamines; Rats; Rats, Inbred Strains; Suloctidil

Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Propanolamines; Suloctidil

Topics: Chemical and Drug Induced Liver Injury; Humans; Liver Function Tests; Male; Middle Aged; Propanolamines; Suloctidil; Vasodilator Agents

Topics: Antibodies, Antinuclear; Chemical and Drug Induced Liver Injury; Female; Humans; Middle Aged; Propanolamines; Suloctidil

Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Propanolamines; Suloctidil

Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Propanolamines; Suloctidil

Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Male; Propanolamines; Suloctidil

Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Male; Propanolamines; Suloctidil