suloctidil and Arteriosclerosis

Topics: Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Blood Coagulation Disorders; Blood Platelets; Catheterization; Cerebrovascular Disorders; Coronary Disease; Dipyridamole; Glomerulonephritis; Humans; Sulfinpyrazone; Suloctidil; Thiophenes; Thrombophlebitis; Thrombosis; Ticlopidine; Vascular Diseases; Vascular Surgical Procedures

Topics: Anticoagulants; Arteriosclerosis; beta-Thromboglobulin; Blood Platelets; Clinical Trials as Topic; Humans; Intermittent Claudication; Leg; Platelet Aggregation; Platelet Factor 4; Suloctidil; Thiophenes; Thrombosis; Thromboxane A2; Ticlopidine

The prevalence of symptomatic arterial disease of the lower limbs is 2 per cent of the population aged 45-60, but it has a relatively benign course, with 70 per cent of patients requiring no therapy. Of the numerous drugs used in the treatment of the disease, there is no evidence to suggest that antilipaemic drugs, anticoagulants, vasodilators or rheological agents confer any benefit to the patient. The initial use of antiplatelet drugs and prostaglandins has been disappointing despite the undoubted importance of the platelet/endothelial interaction in the aetiology of atherosclerosis. As it is unlikely that we can reverse advanced disease, this is hardly surprising. Long term use of these drugs may prevent deterioration in those patients with progressive disease, and controlled trials on this aspect of treatment are now required. Symptomatic relief in the claudicant may perhaps be obtained with naftidrofuryl and suloctodil and with the former in more severe ischaemia, but their use should not replace the beneficial effects of exercise and cessation of smoking.

Topics: Aged; Arteriosclerosis; Aspirin; Cholesterol; Collateral Circulation; Female; Hemodynamics; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Ischemia; Leg; Male; Middle Aged; Nafronyl; Physical Exertion; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Sex Factors; Smoking; Suloctidil

15 aged patients with clinical and laboratory evidence of cerebrovascular insufficiency and/or myocardial sclerosis were given suloctidil (Locton) at the daily dose of 200 mg X 3, for 180 days, under the conditions of an open trial. Blood and plasma viscosity, red cell deformability, total lipids, cholesterol, triglycerides, fibrinolysis (plasminogen, antiplasmin, euglobulins with and without activator, fibrinogen), and capillaroscopic parameters in the small conjunctival vessels (artery, vein, and capillary diameter, appearance of collaterals, red cell aggregation and flow homogeneity) were evaluated. After 30 days of treatment and particularly at the end of the trial a significant improvement of almost all these parameters was observed. Tolerance was always excellent.

Topics: Aged; Arteriosclerosis; Blood Viscosity; Cerebrovascular Disorders; Clinical Trials as Topic; Erythrocyte Deformability; Female; Fibrinolysis; Humans; Lipids; Male; Microcirculation; Middle Aged; Propanolamines; Suloctidil; Time Factors

Topics: Anticoagulants; Arteriosclerosis; beta-Thromboglobulin; Blood Platelets; Clinical Trials as Topic; Humans; Intermittent Claudication; Leg; Platelet Aggregation; Platelet Factor 4; Suloctidil; Thiophenes; Thrombosis; Thromboxane A2; Ticlopidine

The involvement of arterial smooth muscle cells in the development of atherogenic lesions following de-endothelialization and platelet-vessel wall interaction was described in detail by Ross et al. (1977). Bourgain & Six (1974) described a method for local de-endothelialization over a small area in a branch of the mesenteric artery of the male white Wistar rat. The vessel wall reaction to the endothelial cell loss was investigated in detail by Potvliege & Bourgain (1976). The reactive pattern following de-endothelialization includes both a marked hypertrophy of the smooth muscle cells, and, if induced at the site of bifurcation, is further accompanied by migration of smooth muscle cells into the subintimal layer (Potvliege & Bourgain 1980). Administration of a fat- and cholesteral-rich diet markedly increased these phenomena (Potvliege & Bourgain 1982).

Topics: Animals; Arteriosclerosis; Blood Platelets; Cholesterol, Dietary; Dietary Fats; Endothelium; Male; Mesenteric Arteries; Microscopy, Electron, Scanning; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Suloctidil

Topics: Aged; Arteriosclerosis; Humans; Middle Aged; Neurocirculatory Asthenia; Propanolamines; Suloctidil; Syndrome

Topics: Adult; Arteriosclerosis; Female; Humans; Male; Platelet Aggregation; Propanolamines; Suloctidil