sulmazole has been researched along with Heart Failure in 37 studies
sulmazole: structure given in first source
sulmazole : An imidazopyridine that is 1H-imidazo[4,5-b]pyridine which is substituted at position 2 by a 2-methoxy-4-(methylsulfinyl)phenyl group. An A1 adenosine receptor antagonist, it was formerly used as a cardiotonic agent.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cl and milrinone at A1 adenosine receptors and m-cholinoceptors were evaluated in human myocardium from patients with heart failure." | 3.68 | Antagonism of novel inotropic agents at A1 adenosine receptors and m-cholinoceptors in human myocardium. ( Böhm, M; Erdmann, E; Schwinger, RH; Ungerer, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (89.19) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sircar, I | 2 |
| Duell, BL | 1 |
| Bobowski, G | 1 |
| Bristol, JA | 2 |
| Evans, DB | 2 |
| Moos, WH | 1 |
| Weishaar, RE | 1 |
| el Allaf, D | 2 |
| D'Orio, V | 2 |
| Carlier, J | 2 |
| Morita, T | 1 |
| Satoh, K | 1 |
| Taira, N | 1 |
| Scholz, H | 2 |
| Cocco, G | 2 |
| Strozzi, C | 1 |
| Tasini, MT | 1 |
| Padula, A | 1 |
| Urso, L | 1 |
| Rizzo, A | 1 |
| Alfiero, R | 1 |
| Pouleur, H | 1 |
| Detry, JM | 1 |
| Mancia, G | 1 |
| Sfrisi, C | 1 |
| Berkenboom, GM | 1 |
| Sobolski, JC | 1 |
| Depelchin, PE | 1 |
| Contu, E | 1 |
| Dieudonné, PM | 1 |
| Degré, SG | 1 |
| Renard, M | 4 |
| Jacobs, P | 2 |
| Dechamps, P | 1 |
| Dresse, A | 2 |
| Bernard, R | 4 |
| Colle, JP | 1 |
| Ohayon, J | 1 |
| Ledain, L | 1 |
| Besse, P | 1 |
| Drobinski, G | 1 |
| Komajda, M | 1 |
| Lechat, P | 1 |
| Cremers, S | 1 |
| Stauch, M | 1 |
| Sigel, H | 1 |
| Seibold, H | 1 |
| Nechwatal, W | 1 |
| Mols, P | 1 |
| Melot, C | 1 |
| González Maqueda, I | 1 |
| Benito Bartolomé, F | 1 |
| García Fernández, F | 1 |
| Pavón Freire, C | 1 |
| Lomberas Romero, F | 1 |
| Martín Jadraque, L | 1 |
| Pérez Benito, L | 1 |
| Maurer, E | 1 |
| Klein, W | 1 |
| Brandt, D | 1 |
| Mendiola-García, A | 1 |
| Fernández-Fernández, JL | 1 |
| Tello-Arias, A | 1 |
| Camacho-Rivera, B | 1 |
| Hagemeijer, F | 2 |
| Segers, A | 1 |
| Schelling, A | 2 |
| van Mechelen, R | 1 |
| Thormann, J | 1 |
| Kramer, W | 1 |
| Schlepper, M | 1 |
| Gottwick, M | 1 |
| Nebel, W | 1 |
| Sabin, G | 1 |
| Wollschläger, H | 2 |
| Drexler, H | 2 |
| Löllgen, H | 2 |
| Just, H | 2 |
| Hauf, GF | 1 |
| Bubenheimer, P | 1 |
| Roskamm, H | 1 |
| Klein, G | 1 |
| Sauer, E | 1 |
| Bauer, R | 1 |
| Wirtzfeld, A | 1 |
| Sebening, H | 1 |
| Tuininga, YS | 1 |
| van Veldhuisen, DJ | 1 |
| Crijns, HJ | 1 |
| van den Broek, SA | 1 |
| Brouwer, J | 1 |
| Haaksma, J | 1 |
| Man in 't Veld, AJ | 1 |
| Lie, KI | 1 |
| Van der Ent, M | 1 |
| Remme, WJ | 1 |
| Bartels, GL | 1 |
| De Leeuw, PW | 1 |
| Van Hoogenhuyze, DC | 1 |
| Kruijssen, DA | 1 |
| Bethke, T | 1 |
| Klimkiewicz, A | 1 |
| Kohl, C | 1 |
| von der Leyen, H | 1 |
| Mehl, H | 1 |
| Mende, U | 1 |
| Meyer, W | 1 |
| Neumann, J | 1 |
| Schmitz, W | 1 |
| Ungerer, M | 1 |
| Böhm, M | 1 |
| Schwinger, RH | 1 |
| Erdmann, E | 1 |
| Colucci, WS | 1 |
| Wright, RF | 1 |
| Braunwald, E | 1 |
| Andersson, KE | 1 |
| Colombo, F | 1 |
| Libretti, A | 1 |
| Tommaso, CL | 1 |
| Verhoeven, A | 1 |
| Liebens, I | 1 |
| Imai, N | 1 |
| Liang, CS | 1 |
| Stone, CK | 1 |
| Hayes, JS | 1 |
| Hood, WB | 1 |
7 reviews available for sulmazole and Heart Failure
| Article | Year |
|---|---|
The new inotropic phosphodiesterase inhibitors.
Topics: Aminopyridines; Amrinone; Calcium; Carbamates; Cardiotonic Agents; Cardiovascular Agents; Enoximone; | 1984 |
[Old and new positive inotropic drugs: problems and controversies].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiotonic Agents; G | 1984 |
[Positive inotropic therapy of cardiac failure: old and new drugs, controversies and tests].
Topics: Aminopyridines; Amrinone; Cardiac Glycosides; Cardiotonic Agents; Glucagon; Heart Failure; Histamine | 1984 |
New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Some new positive inotropic agents.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiotonic Agents; D | 1986 |
[Rational and irrational approach to the inotropic agent therapy of heart failure].
Topics: Amrinone; Cardiotonic Agents; Digitalis Glycosides; Heart Failure; Humans; Imidazoles; Milrinone; Py | 1988 |
Non-glycoside, non-catecholamine inotropic agents in the treatment of congestive heart failure.
Topics: Administration, Oral; Aminopyridines; Amrinone; Arrhythmias, Cardiac; Calcium; Cardiac Output; Cardi | 1986 |
2 trials available for sulmazole and Heart Failure
| Article | Year |
|---|---|
Clinical and hemodynamic observations on orally administered sulmazol (ARL115BS) in refractory heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Clinical Trials as Topic; Female; Heart Failure; Hemodynamics; Huma | 1984 |
Exploratory study of the effects of single doses of isomazole on hemodynamics and heart rate variability parameters in chronic heart failure.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Blood Pressure; Cardiac Output; Cardiotonic Ag | 1995 |
28 other studies available for sulmazole and Heart Failure
| Article | Year |
|---|---|
Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Chemical Phenomena; Chemistry, Physical; D | 1985 |
Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.
Topics: Animals; Cardiotonic Agents; Dogs; Guinea Pigs; Heart Failure; Myocardial Contraction; Phosphodieste | 1984 |
Improvement of cardiac performance by AR-L 115 BS, a new cardiotonic drug, in the experimental failing dog heart.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Do | 1984 |
Inotropic drugs in the treatment of heart failure.
Topics: Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiac Glycosides; Cardiotonic Agents; Cyclic A | 1984 |
Inotropic drugs of the future.
Topics: Aminopyridines; Amrinone; Cardiotonic Agents; Heart Failure; Humans; Imidazoles; Practolol; Prenalte | 1982 |
Hemodynamic and clinical response to three-day infusion of sulmazol (AR-L 115 BS) in severe congestive heart failure.
Topics: Aged; Carbon Dioxide; Diuresis; Drug Tolerance; Female; Heart Failure; Hemodynamics; Humans; Imidazo | 1983 |
[Hemodynamic effects of a new positive inotropic agent (AR-L 115 BS) in ischemic and nonischemic myocardiopathies].
Topics: Adult; Aged; Cardiac Catheterization; Cardiotonic Agents; Coronary Disease; Female; Heart Failure; H | 1984 |
[Hemodynamic effects of ARL 115 in left ventricular insufficiency].
Topics: Adult; Aged; Cardiotonic Agents; Female; Heart Failure; Heart Ventricles; Hemodynamics; Humans; Imid | 1984 |
Acute clinical benefits of a new inotropic agent AR-L 115 BS after i.v. and oral administration.
Topics: Administration, Oral; Blood Pressure; Cardiotonic Agents; Female; Heart; Heart Failure; Heart Rate; | 1984 |
The effect of AR-L 115 BS on left ventricular function in patients with coronary heart disease and dilated cardiomyopathy.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Cardiac Catheterization; Cardiac Volume; Cardiomyopath | 1983 |
The effective plasma concentrations of sulmazol (AR-L 115 BS) on haemodynamics in chronic heart failure.
Topics: Aged; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart Failure; Hemodynamics; Humans; Imi | 1983 |
[Hemodynamic effect of ARL-115 in congestive heart failure following acute myocardial infarction].
Topics: Aged; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Myocardial Infarct | 1983 |
[Heart failure and acute myocardial infarct. Current treatment].
Topics: Cardiotonic Agents; Dobutamine; Heart Failure; Humans; Imidazoles; Labetalol; Myocardial Infarction; | 1983 |
[Effect of sulmazol on left ventricular function in congestive cardiomyopathy].
Topics: Adult; Blood Pressure; Cardiotonic Agents; Female; Heart; Heart Failure; Heart Rate; Humans; Imidazo | 1983 |
Hemodynamic activity of different doses of sulmazole by infusion.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Cardiotonic Agents; Dose-Response Relationship, Drug; F | 1983 |
Cardiovascular effects of sulmazol administered intravenously to patients with severe heart failure.
Topics: Acute Disease; Adult; Aged; Cardiotonic Agents; Coronary Circulation; Female; Heart Failure; Hemodyn | 1984 |
Hemodynamic effects of the new inotropic agent sulmazol (AR-L115 BS) administered intravenously to patients with severe heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Child; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Inf | 1983 |
AR-L115BS in the treatment of heart failure.
Topics: Adult; Coronary Disease; Heart Failure; Hemodynamics; Humans; Imidazoles; Middle Aged; Myocardial Co | 1982 |
[Changes in hemodynamic parameters after parenteral administration of ARL-115 in patients with severe heart insufficiency (NYHA III-IV)].
Topics: Cardiotonic Agents; Heart Failure; Hemodynamics; Humans; Imidazoles | 1982 |
The hemodynamic effect of AR-L 115 BS, a new positive-inotropic agent, in patients with left ventricular failure.
Topics: Aged; Blood Pressure; Cardiac Output; Cardiotonic Agents; Female; Heart Failure; Heart Rate; Hemodyn | 1981 |
The acute effect of a new positive inotropic agent (AR-L 115 BS) on cardiac hemodynamics and contractility in patients with severe chronic congestive heart failure.
Topics: Adult; Cardiotonic Agents; Chronic Disease; Coronary Circulation; Dose-Response Relationship, Drug; | 1981 |
The comparison of the effects of AR-L 115 BS and dobutamine in patients with severe cardiac failure.
Topics: Blood Pressure; Cardiotonic Agents; Catecholamines; Dobutamine; Female; Heart Failure; Heart Rate; H | 1981 |
Study of the acute effect of AR-L 115 BS, a new positive-inotropic agent in patients with exercise-induced heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Male; Midd | 1981 |
Contrasting preload-dependent hemodynamic and neurohumoral effects of isomazole, a partial phosphodiesterase inhibitor and calcium sensitizer.
Topics: Adult; Aged; Cardiotonic Agents; Coronary Circulation; Female; Heart; Heart Failure; Hemodynamics; H | 1997 |
Effects of isomazole on force of contraction and phosphodiesterase isoenzymes I-IV in nonfailing and failing human hearts.
Topics: Adult; Calcium; Chromatography, DEAE-Cellulose; Electric Stimulation; Female; Heart; Heart Failure; | 1991 |
Antagonism of novel inotropic agents at A1 adenosine receptors and m-cholinoceptors in human myocardium.
Topics: Adult; Binding, Competitive; Cardiotonic Agents; Electric Stimulation; Guanylyl Imidodiphosphate; He | 1990 |
Blood gas and hemodynamic changes induced by the treatment of pulmonary congestion with vasodilators in the acute phase of myocardial infarction.
Topics: Adult; Aged; Carbon Dioxide; Female; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; I | 1986 |
Systemic and regional hemodynamic effects of isomazole in awake dogs with congestive heart failure.
Topics: Angiotensin II; Animals; Cardiac Output; Catecholamines; Dogs; Heart Failure; Heart Rate; Hemodynami | 1987 |