sulmazole has been researched along with Cardiac Failure in 37 studies
sulmazole: structure given in first source
sulmazole : An imidazopyridine that is 1H-imidazo[4,5-b]pyridine which is substituted at position 2 by a 2-methoxy-4-(methylsulfinyl)phenyl group. An A1 adenosine receptor antagonist, it was formerly used as a cardiotonic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cl and milrinone at A1 adenosine receptors and m-cholinoceptors were evaluated in human myocardium from patients with heart failure." | 3.68 | Antagonism of novel inotropic agents at A1 adenosine receptors and m-cholinoceptors in human myocardium. ( Böhm, M; Erdmann, E; Schwinger, RH; Ungerer, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (89.19) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sircar, I | 2 |
| Duell, BL | 1 |
| Bobowski, G | 1 |
| Bristol, JA | 2 |
| Evans, DB | 2 |
| Moos, WH | 1 |
| Weishaar, RE | 1 |
| el Allaf, D | 2 |
| D'Orio, V | 2 |
| Carlier, J | 2 |
| Morita, T | 1 |
| Satoh, K | 1 |
| Taira, N | 1 |
| Scholz, H | 2 |
| Cocco, G | 2 |
| Strozzi, C | 1 |
| Tasini, MT | 1 |
| Padula, A | 1 |
| Urso, L | 1 |
| Rizzo, A | 1 |
| Alfiero, R | 1 |
| Pouleur, H | 1 |
| Detry, JM | 1 |
| Mancia, G | 1 |
| Sfrisi, C | 1 |
| Berkenboom, GM | 1 |
| Sobolski, JC | 1 |
| Depelchin, PE | 1 |
| Contu, E | 1 |
| Dieudonné, PM | 1 |
| Degré, SG | 1 |
| Renard, M | 4 |
| Jacobs, P | 2 |
| Dechamps, P | 1 |
| Dresse, A | 2 |
| Bernard, R | 4 |
| Colle, JP | 1 |
| Ohayon, J | 1 |
| Ledain, L | 1 |
| Besse, P | 1 |
| Drobinski, G | 1 |
| Komajda, M | 1 |
| Lechat, P | 1 |
| Cremers, S | 1 |
| Stauch, M | 1 |
| Sigel, H | 1 |
| Seibold, H | 1 |
| Nechwatal, W | 1 |
| Mols, P | 1 |
| Melot, C | 1 |
| González Maqueda, I | 1 |
| Benito Bartolomé, F | 1 |
| García Fernández, F | 1 |
| Pavón Freire, C | 1 |
| Lomberas Romero, F | 1 |
| Martín Jadraque, L | 1 |
| Pérez Benito, L | 1 |
| Maurer, E | 1 |
| Klein, W | 1 |
| Brandt, D | 1 |
| Mendiola-García, A | 1 |
| Fernández-Fernández, JL | 1 |
| Tello-Arias, A | 1 |
| Camacho-Rivera, B | 1 |
| Hagemeijer, F | 2 |
| Segers, A | 1 |
| Schelling, A | 2 |
| van Mechelen, R | 1 |
| Thormann, J | 1 |
| Kramer, W | 1 |
| Schlepper, M | 1 |
| Gottwick, M | 1 |
| Nebel, W | 1 |
| Sabin, G | 1 |
| Wollschläger, H | 2 |
| Drexler, H | 2 |
| Löllgen, H | 2 |
| Just, H | 2 |
| Hauf, GF | 1 |
| Bubenheimer, P | 1 |
| Roskamm, H | 1 |
| Klein, G | 1 |
| Sauer, E | 1 |
| Bauer, R | 1 |
| Wirtzfeld, A | 1 |
| Sebening, H | 1 |
| Tuininga, YS | 1 |
| van Veldhuisen, DJ | 1 |
| Crijns, HJ | 1 |
| van den Broek, SA | 1 |
| Brouwer, J | 1 |
| Haaksma, J | 1 |
| Man in 't Veld, AJ | 1 |
| Lie, KI | 1 |
| Van der Ent, M | 1 |
| Remme, WJ | 1 |
| Bartels, GL | 1 |
| De Leeuw, PW | 1 |
| Van Hoogenhuyze, DC | 1 |
| Kruijssen, DA | 1 |
| Bethke, T | 1 |
| Klimkiewicz, A | 1 |
| Kohl, C | 1 |
| von der Leyen, H | 1 |
| Mehl, H | 1 |
| Mende, U | 1 |
| Meyer, W | 1 |
| Neumann, J | 1 |
| Schmitz, W | 1 |
| Ungerer, M | 1 |
| Böhm, M | 1 |
| Schwinger, RH | 1 |
| Erdmann, E | 1 |
| Colucci, WS | 1 |
| Wright, RF | 1 |
| Braunwald, E | 1 |
| Andersson, KE | 1 |
| Colombo, F | 1 |
| Libretti, A | 1 |
| Tommaso, CL | 1 |
| Verhoeven, A | 1 |
| Liebens, I | 1 |
| Imai, N | 1 |
| Liang, CS | 1 |
| Stone, CK | 1 |
| Hayes, JS | 1 |
| Hood, WB | 1 |
7 reviews available for sulmazole and Cardiac Failure
| Article | Year |
|---|---|
The new inotropic phosphodiesterase inhibitors.
Topics: Aminopyridines; Amrinone; Calcium; Carbamates; Cardiotonic Agents; Cardiovascular Agents; Enoximone; | 1984 |
[Old and new positive inotropic drugs: problems and controversies].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiotonic Agents; G | 1984 |
[Positive inotropic therapy of cardiac failure: old and new drugs, controversies and tests].
Topics: Aminopyridines; Amrinone; Cardiac Glycosides; Cardiotonic Agents; Glucagon; Heart Failure; Histamine | 1984 |
New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Some new positive inotropic agents.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiotonic Agents; D | 1986 |
[Rational and irrational approach to the inotropic agent therapy of heart failure].
Topics: Amrinone; Cardiotonic Agents; Digitalis Glycosides; Heart Failure; Humans; Imidazoles; Milrinone; Py | 1988 |
Non-glycoside, non-catecholamine inotropic agents in the treatment of congestive heart failure.
Topics: Administration, Oral; Aminopyridines; Amrinone; Arrhythmias, Cardiac; Calcium; Cardiac Output; Cardi | 1986 |
2 trials available for sulmazole and Cardiac Failure
| Article | Year |
|---|---|
Clinical and hemodynamic observations on orally administered sulmazol (ARL115BS) in refractory heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Clinical Trials as Topic; Female; Heart Failure; Hemodynamics; Huma | 1984 |
Exploratory study of the effects of single doses of isomazole on hemodynamics and heart rate variability parameters in chronic heart failure.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Blood Pressure; Cardiac Output; Cardiotonic Ag | 1995 |
28 other studies available for sulmazole and Cardiac Failure
| Article | Year |
|---|---|
Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Chemical Phenomena; Chemistry, Physical; D | 1985 |
Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.
Topics: Animals; Cardiotonic Agents; Dogs; Guinea Pigs; Heart Failure; Myocardial Contraction; Phosphodieste | 1984 |
Improvement of cardiac performance by AR-L 115 BS, a new cardiotonic drug, in the experimental failing dog heart.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Do | 1984 |
Inotropic drugs in the treatment of heart failure.
Topics: Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiac Glycosides; Cardiotonic Agents; Cyclic A | 1984 |
Inotropic drugs of the future.
Topics: Aminopyridines; Amrinone; Cardiotonic Agents; Heart Failure; Humans; Imidazoles; Practolol; Prenalte | 1982 |
Hemodynamic and clinical response to three-day infusion of sulmazol (AR-L 115 BS) in severe congestive heart failure.
Topics: Aged; Carbon Dioxide; Diuresis; Drug Tolerance; Female; Heart Failure; Hemodynamics; Humans; Imidazo | 1983 |
[Hemodynamic effects of a new positive inotropic agent (AR-L 115 BS) in ischemic and nonischemic myocardiopathies].
Topics: Adult; Aged; Cardiac Catheterization; Cardiotonic Agents; Coronary Disease; Female; Heart Failure; H | 1984 |
[Hemodynamic effects of ARL 115 in left ventricular insufficiency].
Topics: Adult; Aged; Cardiotonic Agents; Female; Heart Failure; Heart Ventricles; Hemodynamics; Humans; Imid | 1984 |
Acute clinical benefits of a new inotropic agent AR-L 115 BS after i.v. and oral administration.
Topics: Administration, Oral; Blood Pressure; Cardiotonic Agents; Female; Heart; Heart Failure; Heart Rate; | 1984 |
The effect of AR-L 115 BS on left ventricular function in patients with coronary heart disease and dilated cardiomyopathy.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Cardiac Catheterization; Cardiac Volume; Cardiomyopath | 1983 |
The effective plasma concentrations of sulmazol (AR-L 115 BS) on haemodynamics in chronic heart failure.
Topics: Aged; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart Failure; Hemodynamics; Humans; Imi | 1983 |
[Hemodynamic effect of ARL-115 in congestive heart failure following acute myocardial infarction].
Topics: Aged; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Myocardial Infarct | 1983 |
[Heart failure and acute myocardial infarct. Current treatment].
Topics: Cardiotonic Agents; Dobutamine; Heart Failure; Humans; Imidazoles; Labetalol; Myocardial Infarction; | 1983 |
[Effect of sulmazol on left ventricular function in congestive cardiomyopathy].
Topics: Adult; Blood Pressure; Cardiotonic Agents; Female; Heart; Heart Failure; Heart Rate; Humans; Imidazo | 1983 |
Hemodynamic activity of different doses of sulmazole by infusion.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Cardiotonic Agents; Dose-Response Relationship, Drug; F | 1983 |
Cardiovascular effects of sulmazol administered intravenously to patients with severe heart failure.
Topics: Acute Disease; Adult; Aged; Cardiotonic Agents; Coronary Circulation; Female; Heart Failure; Hemodyn | 1984 |
Hemodynamic effects of the new inotropic agent sulmazol (AR-L115 BS) administered intravenously to patients with severe heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Child; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Inf | 1983 |
AR-L115BS in the treatment of heart failure.
Topics: Adult; Coronary Disease; Heart Failure; Hemodynamics; Humans; Imidazoles; Middle Aged; Myocardial Co | 1982 |
[Changes in hemodynamic parameters after parenteral administration of ARL-115 in patients with severe heart insufficiency (NYHA III-IV)].
Topics: Cardiotonic Agents; Heart Failure; Hemodynamics; Humans; Imidazoles | 1982 |
The hemodynamic effect of AR-L 115 BS, a new positive-inotropic agent, in patients with left ventricular failure.
Topics: Aged; Blood Pressure; Cardiac Output; Cardiotonic Agents; Female; Heart Failure; Heart Rate; Hemodyn | 1981 |
The acute effect of a new positive inotropic agent (AR-L 115 BS) on cardiac hemodynamics and contractility in patients with severe chronic congestive heart failure.
Topics: Adult; Cardiotonic Agents; Chronic Disease; Coronary Circulation; Dose-Response Relationship, Drug; | 1981 |
The comparison of the effects of AR-L 115 BS and dobutamine in patients with severe cardiac failure.
Topics: Blood Pressure; Cardiotonic Agents; Catecholamines; Dobutamine; Female; Heart Failure; Heart Rate; H | 1981 |
Study of the acute effect of AR-L 115 BS, a new positive-inotropic agent in patients with exercise-induced heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Male; Midd | 1981 |
Contrasting preload-dependent hemodynamic and neurohumoral effects of isomazole, a partial phosphodiesterase inhibitor and calcium sensitizer.
Topics: Adult; Aged; Cardiotonic Agents; Coronary Circulation; Female; Heart; Heart Failure; Hemodynamics; H | 1997 |
Effects of isomazole on force of contraction and phosphodiesterase isoenzymes I-IV in nonfailing and failing human hearts.
Topics: Adult; Calcium; Chromatography, DEAE-Cellulose; Electric Stimulation; Female; Heart; Heart Failure; | 1991 |
Antagonism of novel inotropic agents at A1 adenosine receptors and m-cholinoceptors in human myocardium.
Topics: Adult; Binding, Competitive; Cardiotonic Agents; Electric Stimulation; Guanylyl Imidodiphosphate; He | 1990 |
Blood gas and hemodynamic changes induced by the treatment of pulmonary congestion with vasodilators in the acute phase of myocardial infarction.
Topics: Adult; Aged; Carbon Dioxide; Female; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; I | 1986 |
Systemic and regional hemodynamic effects of isomazole in awake dogs with congestive heart failure.
Topics: Angiotensin II; Animals; Cardiac Output; Catecholamines; Dogs; Heart Failure; Heart Rate; Hemodynami | 1987 |