sulindac-sulfone and Liver-Neoplasms

This is the first report enumerating a superb antiproliferative effect of both sulindac and exisulind on hepatocellular cancer cell lines. The growth inhibition and cytotoxicity of sulindac in human hepatocellular carcinoma cell lines HepG2, Huh-7, and KYN-2 were investigated by studying cell growth, cell cycle distribution, and induction of apoptosis. In the presence of sulindac, there was a marked time- and dose-dependent decrease in cell proliferation and viability. Also, exisulind exhibited a similar growth-inhibitory effect on the KYN-2 cell line. The findings of this study suggest that sulindac exhibits a growth-inhibitory effect on human hepatocellular carcinoma cell lines; therefore, these drugs might serve as an effective tool for hepatocellular carcinoma chemoprevention.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Cyclooxygenase 2; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Interphase; Isoenzymes; Liver Neoplasms; Membrane Proteins; Necrosis; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulindac; Time Factors; Tumor Cells, Cultured