sulindac and Tenosynovitis

Forty-six patients (seventeen male, twenty-nine female) with musculo-skeletal disease were put on a controlled clinical study comparing sulindac with ibuprofen and soluble aspirin. Twenty patients were treated with sulindac 200 mg twice daily, twelve received sulindac 100 mg twice daily, eight had ibuprofen 400 mg thrice daily and six treated with soluble aspirin 600 mg thrice daily. All patients did well on these drugs, but the ones on sulindac 200 mg twice daily showed better response than sulindac 100 mg twice daily. It proved to have the same efficiency as ibuprofen and soluble aspirin; but had less side-effects and also patients required to take the drug only twice daily to get relief because of its prolonged duration of action.

Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Back Pain; Clinical Trials as Topic; Female; Humans; Ibuprofen; Indenes; Lumbosacral Region; Male; Middle Aged; Osteoarthritis; Random Allocation; Sulindac; Tenosynovitis

A 67 year old female patient from the capital with acute onset of a severe symmetrical synovitis affecting the flexor digitorum tendon sheaths, wrists and hand joints with pitting edema of the dorsum of both hands is described. She was seronegative for latex test and improved with low doses of prednisone. This syndrome described previously went into complete remission although stopping therapy.

Topics: Aged; Edema; Female; Hand; Humans; Prednisone; Sulindac; Synovitis; Tenosynovitis