sulindac and Pseudomonas-Infections

sulindac has been researched along with Pseudomonas-Infections* in 2 studies

Other Studies

2 other study(ies) available for sulindac and Pseudomonas-Infections

ArticleYear
Amelioration of pulmonary pathophysiology of adult respiratory distress syndrome by sulindac, a cyclo-oxygenase inhibitor.
    The Journal of trauma, 1987, Volume: 27, Issue:12

    The effects of sulindac, a cyclo-oxygenase inhibitor, were tested in a bacteremic porcine model of acute respiratory failure produced by a continuous infusion of live Pseudomonas aeruginosa. Control groups received either a single intravenous dose of sulindac (6 mg/kg) 20 minutes after baseline determinations or a continuous infusion of Ps. aeruginosa (10(7) CFU/kg/min) beginning at time 0. The experimental group received both. Sulindac alone had no effect on any hemodynamic or gas exchange parameter. Ps. aeruginosa infusion caused pulmonary hypertension, hypoxemia, increased intrapulmonary shunt fraction, systemic hypotension, and increased extravascular lung water. Sulindac treatment reversed the pulmonary hypertension, hypoxemia, and increased intrapulmonary shunting, prevented the systemic hypotension, but had no effect on the rising extravascular lung water.

    Topics: Animals; Blood Pressure; Extracellular Space; Indenes; Lung; Pseudomonas Infections; Pulmonary Circulation; Pulmonary Gas Exchange; Respiratory Distress Syndrome; Sulindac; Swine

1987
Neutropenia and pseudomonas septicemia after sulindac therapy: case report.
    Military medicine, 1982, Volume: 147, Issue:9

    Topics: Aged; Agranulocytosis; Female; Humans; Indenes; Neutropenia; Pseudomonas Infections; Sulindac

1982