sulindac and Fever
sulindac has been researched along with Fever* in 5 studies
Reviews
1 review(s) available for sulindac and Fever
Article | Year |
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Flushing out the diagnosis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Eosinophilia; Fatigue; Female; Fever; Headache; Hepatomegaly; Humans; Nausea; Pain; Sulindac | 2009 |
Other Studies
4 other study(ies) available for sulindac and Fever
Article | Year |
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NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory, analgesic, antipyretic, anti-platelet, and anti-cancer properties.
Sulindac is chemopreventive and has utility in patients with familial adenomatous polyposis; however, side effects preclude its long-term use. NOSH-sulindac (AVT-18A) releases nitric oxide and hydrogen sulfide, was designed to be a safer alternative. Here we compare the gastrointestinal safety, anti-inflammatory, analgesic, anti-pyretic, anti-platelet, and anti-cancer properties of sulindac and NOSH-sulindac administered orally to rats at equimolar doses. Gastrointestinal safety: 6h post-administration, number/size of hemorrhagic lesions in stomachs were counted. Tissue samples were frozen for PGE2, SOD, and MDA determination. Anti-inflammatory: 1h after drug administration, the volume of carrageenan-induced rat paw edemas was measured for 5h. Anti-pyretic: fever was induced by LPS (ip) an hour before administration of the test drugs, core body temperature was measured hourly for 5h. Analgesic: time-dependent analgesic effects were evaluated by carrageenan-induced hyperalgesia. Antiplatelet: anti-aggregatory effects were studied on collagen-induced platelet aggregation of human platelet-rich plasma. Anti-cancer: We examined the effects of NOSH-sulindac on the growth properties of 12 human cancer cell lines of six different tissue origins. Both agents reduced PGE2 levels in stomach tissue; however, NOSH-sulindac did not cause any stomach ulcers, whereas sulindac caused significant bleeding. Lipid peroxidation induced by sulindac was higher than that from NOSH-sulindac. SOD activity was significantly lowered by sulindac but increased by NOSH-sulindac. Both agents showed similar anti-inflammatory, analgesic, anti-pyretic, and anti-platelet activities. Sulindac increased plasma TNFα whereas this rise was lower in the NOSH-sulindac-treated animals. NOSH-sulindac inhibited the growth of all cancer cell lines studied, with potencies of 1000- to 9000-fold greater than that of sulindac. NOSH-sulindac inhibited cell proliferation, induced apoptosis, and caused G2/M cell cycle block. These results demonstrate that NOSH-sulindac is gastrointestinal safe, and maintains the anti-inflammatory, analgesic, antipyretic, and antiplatelet properties of its parent compound sulinsac, with anti-growth activity against a wide variety of human cancer cells. Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antipyretics; Cell Line, Tumor; Cell Survival; Dinoprostone; Edema; Fever; Hydrogen Sulfide; Hyperalgesia; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Donors; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Sulindac; Superoxide Dismutase | 2015 |
Serious adverse reactions associated with sulindac.
Sulindac is a nonsteroidal anti-inflammatory agent that has been associated with serious adverse reactions. We saw four patients with reactions associated with sulindac. Our patients, one of whom died, had high temperatures and involvement of one or more organs, including the skin, liver, CNS, lymph nodes, bone marrow, and lungs. Eight similar previously reported cases also are summarized. In view of these cases of sulindac-induced toxicity, six of which were proved unequivocally by drug rechallenge, we suggest that physicians be cautious in prescribing this agent. Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Eruptions; Female; Fever; Humans; Indenes; Male; Middle Aged; Stevens-Johnson Syndrome; Sulindac | 1982 |
Sulindac causing a hypersensitivity reaction with peripheral and mediastinal lymphadenopathy.
Topics: Arthritis; Drug Hypersensitivity; Fever; Humans; Indenes; Lymphatic Diseases; Male; Middle Aged; Splenomegaly; Sulindac | 1982 |
Febrile reaction to sulindac.
Topics: Drug Hypersensitivity; Fever; Humans; Indenes; Male; Middle Aged; Sulindac | 1981 |