sulindac and Drug-Hypersensitivity

sulindac has been researched along with Drug-Hypersensitivity* in 13 studies

Reviews

1 review(s) available for sulindac and Drug-Hypersensitivity

ArticleYear
Hepatocellular damage from non-steroidal anti-inflammatory drugs.
    QJM : monthly journal of the Association of Physicians, 2003, Volume: 96, Issue:11

    Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for the management of rheumatological disorders, and as analgesics and antipyretics. Hepatotoxicity is an uncommon, but potentially lethal complication, which usually occurs within 12 weeks of starting therapy. It can occur with all NSAIDs, but appears to be more common with diclofenac and particularly sulindac. Female patients aged >50 years, with autoimmune disease, and those on other potentially hepatotoxic drugs, appear to be particularly susceptible. Liver function test abnormalities generally settle within 4-6 weeks of stopping the causative drug. However, some patients may develop acute liver failure and successful orthotopic liver transplantation may be undertaken in such patients. Recent in vitro animal studies have shown that the mechanism of diclofenac toxicity relates both to impairment of ATP synthesis by mitochondria, and to production of active metabolites, particularly n,5-dihydroxydiclofenac, which causes direct cytotoxicity. Mitochondrial permeability transition (MPT) has also been shown to be important in diclofenac-induced liver injury, resulting in generation of reactive oxygen species, mitochondrial swelling and oxidation of NADP and protein thiols. Physicians and hepatologists must be vigilant to the hepatotoxic potential of any NSAID, as increased awareness, surveillance and reporting of these events will lead to a better understanding of the risk factors and the pathophysiology of NSAID-related hepatotoxicity.

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Injury; Diclofenac; Disease Susceptibility; Drug Hypersensitivity; Female; Humans; Liver Diseases; Liver Failure, Acute; Middle Aged; Mitochondria, Liver; Risk Factors; Sulindac

2003

Other Studies

12 other study(ies) available for sulindac and Drug-Hypersensitivity

ArticleYear
A severe multisystem reaction to sulindac.
    Archives of internal medicine, 1991, Volume: 151, Issue:2

    We present a case of a severe reaction to sulindac. A 30-year-old woman with quiescent systemic lupus erythematosus received sulindac for nonspecific migrating chest pain. An initial course of therapy produced an unrecognized sensitization to the drug with a febrile illness and rash. Readministration of the drug caused an anaphylactoid reaction as well as evidence of cardiovascular, hepatic, pulmonary, and hematologic dysfunction. The patient's illness had evidence of types I, II, and III hypersensitivity reactions.

    Topics: Adult; Anaphylaxis; Chest Pain; Drug Hypersensitivity; Female; Humans; Lupus Erythematosus, Systemic; Sulindac

1991
Pulmonary infiltrates associated with sulindac therapy.
    Chest, 1990, Volume: 97, Issue:1

    Pulmonary infiltrates, cough, dyspnea, and fever developed in a 62-year-old woman with chronic degenerative arthritis who had been receiving sulindac therapy for six months. Her pulmonary signs and symptoms resolved upon withholding the drug. Inadvertent rechallenge resulted in rapid recurrence of respiratory symptoms and pulmonary infiltrates. This constellation of clinical findings provides strong evidence of isolated pulmonary reactions as a complication of sulindac therapy.

    Topics: Drug Hypersensitivity; Female; Humans; Lung; Lung Diseases; Middle Aged; Radiography; Sulindac

1990
[A successfully treated case of splenic abscess due to candidiasis associated with drug induced myelosuppression].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1990, Volume: 87, Issue:2

    Topics: Abscess; Aged; Bone Marrow; Candidiasis; Drug Hypersensitivity; Female; Humans; Splenic Diseases; Sulindac

1990
Lymphadenopathy with sulindac therapy.
    Connecticut medicine, 1988, Volume: 52, Issue:2

    Topics: Adult; Drug Hypersensitivity; Female; Humans; Indenes; Lymphatic Diseases; Sulindac

1988
Hypersensitivity reaction to sulindac (Clinoril).
    Archives of internal medicine, 1984, Volume: 144, Issue:11

    Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease. To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration. A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy. The onset and duration of symptoms correlated directly to drug ingestion. This hypersensitivity response cannot be explained pathophysiologically by any mechanism. Repeated exposure and rechallenge of the subject to sulindac was deemed too dangerous, and precludes exact method to establish mechanisms to explain this transient, reproducible, idiosyncratic, adverse drug reaction.

    Topics: Adult; Drug Hypersensitivity; Humans; Indenes; Male; Pain; Paresthesia; Peripheral Nervous System Diseases; Sulindac

1984
An expanded profile of cutaneous reactions to nonsteroidal anti-inflammatory drugs. Reports to a specialty-based system for spontaneous reporting of adverse reactions to drugs.
    JAMA, 1984, Sep-21, Volume: 252, Issue:11

    The nonsteroidal anti-inflammatory drugs are widely used in the United States and are a frequent cause of cutaneous reactions. Since December 1980, dermatologists have reported 135 of these drug reactions to a specialty-based Adverse Drug Reaction Reporting System. Reactions to piroxicam were most frequently reported; the majority of reactions to this drug were vesiculobullous and occurred most often in sun-exposed areas. Other reactions to nonsteroidal anti-inflammatory drugs not previously recognized include serum sickness, exfoliative erythroderma, and photosensitivity associated with sulindac; toxic epidermal necrolysis was reported with tolmetin, zomepirac sodium, and piroxicam. Fixed drug eruptions were noted with ibuprofen and naproxen, and photosensitivity was reported with sulindac and indomethacin. These findings illustrate the usefulness of a specialty-based system for spontaneous reporting of new and serious adverse reactions to drugs.

    Topics: Aged; Anaphylaxis; Anti-Inflammatory Agents; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Meclofenamic Acid; Photosensitivity Disorders; Piroxicam; Propionates; Stevens-Johnson Syndrome; Sulindac; Thiazines; Tolmetin

1984
Anaphylactic reaction associated with sulindac.
    Annals of emergency medicine, 1984, Volume: 13, Issue:6

    Reported is the case of an anaphylactic reaction following sulindac ingestion. A 64-year-old man developed marked shortness of breath following the ingestion of a 200-mg sulindac tablet. On admission he had a palpable blood pressure of 50 mm Hg and diffuse inspiratory and expiratory wheezes on auscultation. He demonstrated marked cardiovascular instability for 24 hours following the adverse reaction. He was treated successfully with a continuous intravenous infusion of epinephrine, a corticosteroid, and an antihistamine. Recovery was complete. This case demonstrates that caution is needed in prescribing sulindac and other nonsteroidal anti-inflammatory drugs.

    Topics: Anaphylaxis; Drug Hypersensitivity; Electrocardiography; Emergencies; Epinephrine; Humans; Hypotension; Indenes; Male; Middle Aged; Sulindac

1984
Sulindac-induced aseptic meningitis.
    Archives of internal medicine, 1982, Volume: 142, Issue:1

    A 22-year-old woman with systemic lupus erythematosus experienced generalized pruritus, shortness of breath, pleuritic chest pain, visual blurring, severe photophobia, a stiff neck, an occipital headache, and a temperature of 39.4 degrees C within one hour after taking sulindac (Clinoril). Findings from a CSF examination disclosed a notable elevation of protein and a polymorphonuclear pleocytosis. All symptoms disappeared within 24 hours. Inhibition of prostaglandin synthesis did not seem to be the mechanism of this adverse reaction, since the patient tolerated aspirin.

    Topics: Adult; Drug Hypersensitivity; Female; Humans; Indenes; Lupus Erythematosus, Systemic; Meningitis; Meningitis, Aseptic; Sulindac

1982
Sulindac causing a hypersensitivity reaction with peripheral and mediastinal lymphadenopathy.
    Annals of internal medicine, 1982, Volume: 97, Issue:4

    Topics: Arthritis; Drug Hypersensitivity; Fever; Humans; Indenes; Lymphatic Diseases; Male; Middle Aged; Splenomegaly; Sulindac

1982
Febrile reaction to sulindac.
    JAMA, 1981, Jul-17, Volume: 246, Issue:3

    Topics: Drug Hypersensitivity; Fever; Humans; Indenes; Male; Middle Aged; Sulindac

1981
Sulindac-induced anaphylaxis.
    Annals of emergency medicine, 1981, Volume: 10, Issue:3

    This communication describes the first known report of sulindac-induced anaphylaxis. A 17-year-old patient who ingested a single tablet of sulindac developed pruritus, hives, and dyspnea. Blood pressure was not detectable. The patient was treated with epinephrine, a corticosteroid, and an antihistamine. Recovery was complete. The ability of this class of drugs to produce dangerous reactions is discussed.

    Topics: Adult; Anaphylaxis; Arthritis, Juvenile; Drug Hypersensitivity; Female; Humans; Indenes; Sulindac

1981
Life-threatening hypersensitivity to sulindac.
    JAMA, 1980, Jul-18, Volume: 244, Issue:3

    Topics: Adolescent; Arthritis, Rheumatoid; Drug Hypersensitivity; Humans; Indenes; Leukopenia; Liver; Male; Pain; Pharyngitis; Pneumonia; Pruritus; Sulindac

1980
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