sulindac has been researched along with Diabetes-Mellitus* in 1 studies
1 other study(ies) available for sulindac and Diabetes-Mellitus
| Article | Year |
|---|---|
Dual action spirobicycloimidazolidine-2,4-diones: antidiabetic agents and inhibitors of aldose reductase-an enzyme involved in diabetic complications.
The desired 3-(arylsulfonyl)spiroimidazolidine-2,4-diones were synthesized by reacting spiroiminoimidazolidine-2,4-dione with arylsulfonyl chlorides. Spiroimidazolidine-2,4-dione was in turn synthesized from norcamphor. Structures of the synthesized molecules were established by modern spectroscopic techniques. The synthesized compounds were screened for in vivo antidiabetic activity and aldose reductase inhibition. Compounds 2a, 2b and 2g exhibited excellent dual activity, compound 2a being most prominent. These results reveal that the synthesized compounds may serve as the molecule of choice to treat diabetes and diabetic complications using a single medication. Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Enzyme Activation; Humans; Hydantoins; Hypoglycemic Agents; Inhibitory Concentration 50 | 2013 |