sulindac and Back-Pain

Forty-six patients (seventeen male, twenty-nine female) with musculo-skeletal disease were put on a controlled clinical study comparing sulindac with ibuprofen and soluble aspirin. Twenty patients were treated with sulindac 200 mg twice daily, twelve received sulindac 100 mg twice daily, eight had ibuprofen 400 mg thrice daily and six treated with soluble aspirin 600 mg thrice daily. All patients did well on these drugs, but the ones on sulindac 200 mg twice daily showed better response than sulindac 100 mg twice daily. It proved to have the same efficiency as ibuprofen and soluble aspirin; but had less side-effects and also patients required to take the drug only twice daily to get relief because of its prolonged duration of action.

Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Back Pain; Clinical Trials as Topic; Female; Humans; Ibuprofen; Indenes; Lumbosacral Region; Male; Middle Aged; Osteoarthritis; Random Allocation; Sulindac; Tenosynovitis

Topics: Auditory Perception; Back Pain; Female; Hallucinations; Humans; Middle Aged; Sulindac; Visual Perception

Diarrhea and a small bowel lesion similar to that reported in celiac sprue were observed in a patient who had been taking sulindac. Symptoms and biopsy abnormalities resolved completely after discontinuation of the medication and promptly recurred upon its re-administration. This report emphasizes the need to consider possible drug-related small bowel disease in the growing list of causes of the "flat" small intestinal mucosal lesion.

Topics: Back Pain; Biopsy; Diarrhea; Duodenal Diseases; Duodenum; Female; Humans; Indenes; Middle Aged; Sulindac

Topics: Back Pain; Carbidopa; Drug Combinations; Humans; Indenes; Levodopa; Male; Middle Aged; Parkinson Disease; Sulindac

We report 2 patients who had serious adverse effects after taking sulindac. One of these patients developed toxic hepatitis and Stevens-Johnson/toxic epidermal necrolysis syndrome which resulted in death. Such fatal reaction to sulindac therapy has not been reported previously. There was temporal relation of ingestion of sulindac to 2 episodes of acute pancreatitis in the 2nd patient, strongly suggesting drug induction. Recent reports of similar side effects with other nonsteroidal antiinflammatory drugs suggest that these drugs may have potentially more serious toxicity than has been recognized.

Topics: Acute Disease; Arthritis, Rheumatoid; Back Pain; Chemical and Drug Induced Liver Injury; Female; Humans; Indenes; Middle Aged; Pancreatitis; Stevens-Johnson Syndrome; Sulindac

Topics: Adult; Aged; Back Pain; Female; Humans; Ibuprofen; Indenes; Knee Joint; Lumbar Vertebrae; Male; Middle Aged; Osteoarthritis; Sulindac