sulfuretin and Leishmaniasis--Visceral

Up to date, there are still significantly unmet clinical needs for treatment of the fatal visceral leishmaniasis; a neglected tropical disease. Herein, a recently reported antileishmanial hit sulfuretin analog suffering from a low potency and a problematic aqueous solubility that hindered further development was used as a starting point. A mitigation rational via incorporation of O

Topics: Alkanes; Antiprotozoal Agents; Benzofurans; Flavonoids; Humans; Leishmania donovani; Leishmaniasis, Visceral