sulfuretin and Dermatitis--Atopic

sulfuretin has been researched along with Dermatitis--Atopic* in 1 studies

Other Studies

1 other study(ies) available for sulfuretin and Dermatitis--Atopic

Article	Year
Sulfuretin alleviates atopic dermatitis-like symptoms in mice via suppressing Th2 cell activity. Immunologic research, 2018, Volume: 66, Issue:5 Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by uncontrolled Th2 cells response to environmental allergens. Long-term topical application of corticosteroids for treating AD may induce severe side effects. Sulfuretin is a major flavonoid found in Rhus verniciflua and carries antioxidant and anti-inflammatory properties. Its therapeutic effect on AD has not been characterized. We first studied the cytotoxic and regulatory effects of sulfuretin on differentiated Th2 cells. Next, we evaluated therapeutic effect of sulfuretin on AD-like damages caused by 2,4-dinitrochlorobenzene (DNCB) in a mouse model. Serum IgE level, overall symptomatic score, and cytokine accumulation at the lesions were measured. Lastly, we investigated the regulatory mechanism of sulfuretin on GATA3 pathway in primary mouse CD4 Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Cells, Cultured; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Models, Animal; Flavonoids; GATA3 Transcription Factor; Humans; Interleukin-4; Mice; Mice, Inbred BALB C; Skin; Th2 Cells	2018

Article

Year

Sulfuretin alleviates atopic dermatitis-like symptoms in mice via suppressing Th2 cell activity.

Immunologic research, 2018, Volume: 66, Issue:5

Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by uncontrolled Th2 cells response to environmental allergens. Long-term topical application of corticosteroids for treating AD may induce severe side effects. Sulfuretin is a major flavonoid found in Rhus verniciflua and carries antioxidant and anti-inflammatory properties. Its therapeutic effect on AD has not been characterized. We first studied the cytotoxic and regulatory effects of sulfuretin on differentiated Th2 cells. Next, we evaluated therapeutic effect of sulfuretin on AD-like damages caused by 2,4-dinitrochlorobenzene (DNCB) in a mouse model. Serum IgE level, overall symptomatic score, and cytokine accumulation at the lesions were measured. Lastly, we investigated the regulatory mechanism of sulfuretin on GATA3 pathway in primary mouse CD4

Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Cells, Cultured; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Models, Animal; Flavonoids; GATA3 Transcription Factor; Humans; Interleukin-4; Mice; Mice, Inbred BALB C; Skin; Th2 Cells

2018