sulfuretin and Alzheimer-Disease

sulfuretin has been researched along with Alzheimer-Disease* in 1 studies

Other Studies

1 other study(ies) available for sulfuretin and Alzheimer-Disease

Article	Year
Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry, 2015, Jan-01, Volume: 23, Issue:1 Alzheimer's disease (AD), a progressive and neurodegenerative disorder of the brain, is the most common cause of dementia among elderly people. To date, the successful therapeutic strategy to treat AD is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (AChE). In the present study, aurone derivatives were designed and synthesized as AChE inhibitors based on the lead structure of sulfuretin. Of those synthesized, compound 10d showed ca. 1700-fold and 6-fold higher AChE inhibitory activity than sulfuretin and galantamine, respectively. This compound also ameliorated scopolamine-induced memory deficit in mice when administered orally at the dose of 1 and 2mg/kg. Topics: Alzheimer Disease; Animals; Benzofurans; Cholinesterase Inhibitors; Male; Mice	2015

Article

Year

Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors.

Bioorganic & medicinal chemistry, 2015, Jan-01, Volume: 23, Issue:1

Alzheimer's disease (AD), a progressive and neurodegenerative disorder of the brain, is the most common cause of dementia among elderly people. To date, the successful therapeutic strategy to treat AD is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (AChE). In the present study, aurone derivatives were designed and synthesized as AChE inhibitors based on the lead structure of sulfuretin. Of those synthesized, compound 10d showed ca. 1700-fold and 6-fold higher AChE inhibitory activity than sulfuretin and galantamine, respectively. This compound also ameliorated scopolamine-induced memory deficit in mice when administered orally at the dose of 1 and 2mg/kg.

Topics: Alzheimer Disease; Animals; Benzofurans; Cholinesterase Inhibitors; Male; Mice

2015