Page last updated: 2024-11-04

sulfinpyrazone and Hyperlipemia

sulfinpyrazone has been researched along with Hyperlipemia in 11 studies

Sulfinpyrazone: A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

Research Excerpts

ExcerptRelevanceReference
"Preliminary data obtained in the ambit of Anturan Reinfarction Italian Study (ARIS) show that, in postmyocardial infarction, reduced platelet survival time occurred in hyperbetalipoproteinemic patients treated with placebo, but not in the group of patients treated with sulfinpyrazone (interaction between treatment and lipemic level is at p approximately equal to 0."9.04A controlled study of the effect of sulfinpyrazone on platelet survival and on platelet-bound 14C-serotonin release in patients with previous myocardial infarction. ( Basagni, M; Boschetti, C; Cortellaro, M; Fassio, G; Polli, EE, 1979)
"Preliminary data obtained in the ambit of Anturan Reinfarction Italian Study (ARIS) show that, in postmyocardial infarction, reduced platelet survival time occurred in hyperbetalipoproteinemic patients treated with placebo, but not in the group of patients treated with sulfinpyrazone (interaction between treatment and lipemic level is at p approximately equal to 0."5.04A controlled study of the effect of sulfinpyrazone on platelet survival and on platelet-bound 14C-serotonin release in patients with previous myocardial infarction. ( Basagni, M; Boschetti, C; Cortellaro, M; Fassio, G; Polli, EE, 1979)
"Gout is increasingly recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian data on the disease burden of gout are available."1.46The rising prevalence and incidence of gout in British Columbia, Canada: Population-based trends from 2000 to 2012. ( Aviña-Zubieta, JA; Choi, HK; De Vera, MA; McCormick, N; Rai, SK; Sayre, EC; Shojania, K, 2017)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-199010 (90.91)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rai, SK1
Aviña-Zubieta, JA1
McCormick, N1
De Vera, MA1
Shojania, K1
Sayre, EC1
Choi, HK1
Greco, R1
Siciliano, S1
Gentile, F1
Elia, L1
Murena, E1
Forni, N1
Boccalatte, A1
Marsico, F1
Paredero Del Bosque Martin, V1
Cortellaro, M1
Boschetti, C1
Fassio, G1
Basagni, M1
Polli, EE1
Mustard, JF1
Packham, MA1
Kinlough-Rathbone, RL1
Strano, A1
Novo, S1
Latour, JG1
Groulx, C1
Léger-Gauthier, C1
Nenci, GG1
Agnelli, G1
Berrettini, M1
Parise, P1
Ballatori, E1
Steele, P1
Battock, D1
Genton, E1
Renaud, S1
Lecompte, F1
Holländer, E1
Schwarczmann, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation in High Risk Primary Prevention (Patients With Metabolic Syndrome)[NCT00272311]Phase 470 participants (Actual)Interventional2006-10-31Completed
A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation & Endothelial Function in Secondary Prevention (Pts w/Chronic Stable Coronary Disease)[NCT00272337]Phase 437 participants (Actual)Interventional2006-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Nitric Oxide Formation From Baseline to 3 Months

Changes in Heme oxygenase (HO-1) a downstream target of nitric oxide (NO) formation. (NCT00272311)
Timeframe: Baseline to 3 Months (90-97 days)

Interventionng/mL (Mean)
Arm 1 of 5 Randomized Treatment Arms27.6
Arm 2 of 5 Randomized Treatment Arms27.0
Arm 3 of 5 Randomized Treatment Arms31.4
Arm 4 of 5 Randomized Treatment Arms25.7
Arm 5 of 5 Randomized Treatment Arms28.3

Change in Nitric Oxide Formation From Baseline to 3 Months.

Heme oxygenase a downstream target of nitric oxide formation (NCT00272337)
Timeframe: Baseline to 3 Months (90-97 days)

Interventionng/mL (Mean)
1 of 5 Randomized Treatment Arms10.0
2 of 5 Randomized Treatment Arms11.2
3 of 5 Randomized Treatment Arms10.0
4 of 5 Randomized Treatment Arms11.0
5 of 5 Randomized Treatment Arms9.6

Reviews

2 reviews available for sulfinpyrazone and Hyperlipemia

ArticleYear
Platelets and thrombosis in the development of atherosclerosis and its complications.
    Advances in experimental medicine and biology, 1978, Volume: 102

    Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Dipyridamole; Endothelium; Human

1978
Platelets and thrombosis in the development of atherosclerosis and its complications.
    Advances in experimental medicine and biology, 1978, Volume: 102

    Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Dipyridamole; Endothelium; Human

1978
Platelets and thrombosis in the development of atherosclerosis and its complications.
    Advances in experimental medicine and biology, 1978, Volume: 102

    Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Dipyridamole; Endothelium; Human

1978
Platelets and thrombosis in the development of atherosclerosis and its complications.
    Advances in experimental medicine and biology, 1978, Volume: 102

    Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Dipyridamole; Endothelium; Human

1978
[Prospects of antiaggregant therapy in prevention of atherosclerosis].
    Giornale italiano di cardiologia, 1979, Volume: 9, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Arteriosclerosis; Aspirin; Blood Coagulation Diso

1979

Trials

1 trial available for sulfinpyrazone and Hyperlipemia

ArticleYear
A controlled study of the effect of sulfinpyrazone on platelet survival and on platelet-bound 14C-serotonin release in patients with previous myocardial infarction.
    Acta haematologica, 1979, Volume: 61, Issue:2

    Topics: Adult; Aged; Blood Platelets; Cell Survival; Cholesterol; Clinical Trials as Topic; Female; Humans;

1979

Other Studies

8 other studies available for sulfinpyrazone and Hyperlipemia

ArticleYear
The rising prevalence and incidence of gout in British Columbia, Canada: Population-based trends from 2000 to 2012.
    Seminars in arthritis and rheumatism, 2017, Volume: 46, Issue:4

    Topics: Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; British Columbia; Colchicine; Comorbidit

2017
[Prevention of ischemic cardiopathy, with special reference to secondary prevention in the post-infarct period].
    Bollettino della Societa italiana di cardiologia, 1981, Volume: 26, Issue:8

    Topics: Adrenergic beta-Antagonists; Coronary Artery Bypass; Heart Failure; Humans; Hyperlipidemias; Hyperte

1981
[Indications for surgical treatment and medical treatment of atherosclerosis].
    Minerva medica, 1980, Oct-20, Volume: 71, Issue:40

    Topics: Arteriosclerosis; Aspirin; Cholestyramine Resin; Clofibrate; Dextrothyroxine; Dipyridamole; Humans;

1980
Activation of the Hageman factor-prekallikrein system in the pathogenesis of the generalized Shwartzman reaction and of the hepatic vein thrombosis phenomenon in the rat.
    Laboratory investigation; a journal of technical methods and pathology, 1979, Volume: 41, Issue:3

    Topics: Animals; Arginine; Bradykinin; Dexamethasone; Dimercaprol; Endotoxins; Esterases; Factor XII; Female

1979
Inhibition of spontaneous platelet aggregation by sulfinpyrazone.
    Thrombosis and haemostasis, 1979, Aug-31, Volume: 42, Issue:2

    Topics: Aged; Arteriosclerosis; Diabetes Mellitus; Double-Blind Method; Humans; Hyperlipidemias; Male; Middl

1979
Effects of clofibrate and sulfinpyrazone on platelet survival time in coronary artery disease.
    Circulation, 1975, Volume: 52, Issue:3

    Topics: Adult; Blood Platelets; Cell Survival; Cholesterol; Clofibrate; Coronary Disease; Humans; Hyperlipid

1975
Thrombosis prevention by coagulation and platelet aggregtion inhibitors, in hyperlipemic rats.
    Thrombosis et diathesis haemorrhagica, 1970, Dec-31, Volume: 24, Issue:3

    Topics: Acenocoumarol; Adenine Nucleotides; Aniline Compounds; Animals; Anticoagulants; Blood Coagulation; B

1970
[Gout in advanced age].
    Munchener medizinische Wochenschrift (1950), 1968, Mar-15, Volume: 110, Issue:11

    Topics: Age Factors; Aged; Allopurinol; Bone and Bones; Cardiovascular Diseases; Colchicine; Female; Gout; H

1968