sulfinpyrazone and Blood Clot studies

Sulfinpyrazone: A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

Research Excerpts

Excerpt	Relevance	Reference
"We carried out a pilot study in 15 hemodialysis patients with recurrent vascular access thrombosis to examine whether the combination of low dose aspirin (85 mg once daily) and sulfinpyrazone (200 mg three times daily) is safe and effective in the prevention of vascular access thrombosis."	9.07	Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. ( Bauman, JE; Domoto, DT; Joist, JH, 1991)
"The effect of sulfinpyrazone on the incidence of thrombosis of arterio-venous shunts was investigated in a double-blind crossover study in 45 patients on chronic hemodialysis over a period of 12 months."	9.04	The role of sulfinpyrazone in the prevention of arterio-venous shunt thrombosis. ( Gent, M; Hirsh, J; Kaegi, A; Pineo, GF; Shimizu, A; Trivedi, H, 1975)
"We carried out a pilot study in 15 hemodialysis patients with recurrent vascular access thrombosis to examine whether the combination of low dose aspirin (85 mg once daily) and sulfinpyrazone (200 mg three times daily) is safe and effective in the prevention of vascular access thrombosis."	5.07	Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. ( Bauman, JE; Domoto, DT; Joist, JH, 1991)
"The effect of sulfinpyrazone on the incidence of thrombosis of arterio-venous shunts was investigated in a double-blind crossover study in 45 patients on chronic hemodialysis over a period of 12 months."	5.04	The role of sulfinpyrazone in the prevention of arterio-venous shunt thrombosis. ( Gent, M; Hirsh, J; Kaegi, A; Pineo, GF; Shimizu, A; Trivedi, H, 1975)
"Sulfinpyrazone1 has long been recognised as a potent uricosuric agent, but has more recently been studied extensively as a platelet inhibitor and antithrombotic agent."	3.75	Sulfinpyrazone: a review of its pharmacological properties and therapeutic use. ( Margulies, EH; Sherry, S; White, AM, 1980)
"Aspirin has been shown to reduce the number of transient ischemic attacks (TIA), stroke and death in patients with multiple TIA."	3.75	Antithrombotic effects of drugs which suppress platelet function: their potential in prevention growth of tumour cells. ( Turpie, AG, 1982)
"Two highly sensitive models of arterial and venous thrombosis forming with the test of endothelial stability a complementary system with a maximum stress on the role of vascular lesion were used to test a series of four antithrombotic drugs (heparin, acetylsalicylic acid, dipyridamole, sulfinpyrazone) and four drugs with other indications but with an antithrombotic activity in experiment (prenylamine, troxerutin, ketanserin and pizotifen)."	3.67	Antithrombotics in view of thrombosis models. ( Hladovec, J, 1986)
"Sulfinpyrazone treatment of patients with myocardial infarction (Killip--classification I and II), starting 25--35 days after the acute myocardial infarction, reduces cardiac mortality and incidence of sudden death for a period of two years."	1.26	[Action mechanism and clinical indications for thrombocyte aggregation inhibitors]. ( Oelz, O, 1979)
"Platelet adhesion and thrombus formation were compared after perfusion of native blood and of blood anticoagulated with citrate, heparin or heparin plus citrate."	1.26	Effects of acetylsalicylic acid, sulfinpyrazone and dipyridamole on platelet adhesion and aggregation in flowing native and anticoagulated blood. ( Baumgartner, HR, 1979)
"and sulfinpyrazone have been tested in several large scale clinical trials."	1.26	[Antiplatelet drugs (author's transl)]. ( Dechavanne, M; Follea, G; Trzeciak, MC, 1979)
"Our results suggest that hypoxemia is associated with shortened platelet survival time and that platelets may, therefore, be involved in the thromboembolic complications that develop in patients with hypoxemia."	1.26	Platelet survival time in patients with hypoxemia and pulmonary hypertension. ( Ellis, JH; Genton, E; Steele, P; Weily, HS, 1977)

Research

Studies (102)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Change in Nitric Oxide Formation From Baseline to 3 Months

Timeframe	Studies, this research(%)	All Research%
pre-1990	98 (96.08)	18.7374
1990's	4 (3.92)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Mustard, JF	8
Rowsell, HC	1
Smythe, HA	1
Senyi, A	1
Murphy, EA	1
McNicol, GP	1
de Gaetano, G	2
Cerletti, C	1
Bertelè, V	1
Kelton, JG	3
Hirsh, J	8
Buckler, P	1
Douglas, AS	2
Kester, RC	2
Hansen, MS	2
Birgens, HS	2
Packham, MA	6
Lecompte, T	1
Kher, A	1
Gaillard, JL	1
Samama, M	1
Rhyner, K	1
Stenger, M	1
Block, LH	1
Lewis, GP	1
Smith, JR	1
McCollum, CN	2
Crow, MJ	1
Rajah, SM	1
Wizemann, V	1
Buddensiek, P	1
de Boor, J	1
Grebe, S	1
Schütterle, G	1
Gaspari, A	1
Ortensi, A	1
Lania, M	1
Ipri, D	1
Busatta, D	1
Stratton, JR	1
Ritchie, JL	2
Polli, EE	1
Cortellaro, M	1
Lindner, A	1
Hamilton, GW	1
Harker, LA	6
Gaudiani, VA	1
Miller, DC	1
Kosek, JC	1
Burg, J	1
Jamieson, SW	1
Kazmier, FJ	2
Littlejohn, GO	1
Deck, JH	1
Reynolds, WJ	1
Rüegg, M	1
Kinlough-Rathbone, RL	5
Mitchell, JR	1
Margulies, EH	1
White, AM	1
Sherry, S	1
Weston, MJ	1
Woods, HF	1
Turney, JH	1
Weiss, HJ	4
Fuster, V	6
Chesebro, JH	3
Turpie, AG	3
Bern, MM	1
Green, J	1
Vigdahl, RL	1
Ferber, RH	1
Parrish, SL	1
Villaverde, CA	1
Hernández, MR	1
Escolar, G	1
Almirall, L	1
Borruel, MT	1
Kahn, SB	1
Loo, J	1
Lagarde, M	1
Dechavanne, M	2
Newland, H	1
Rubegni, M	1
Provvedi, D	1
Bellini, PG	1
Bandinelli, C	1
De Mauro, G	1
Loeliger, EA	2
Didisheim, P	2
Latour, JG	2
Dmoszyńska-Giannopoulou, A	1
Pluta, A	1
Schott, G	1
Oelz, O	1
Haas, S	1
Fritsche, HM	2
Ketterl, R	2
Leimgruber, D	2
Blümel, G	2
Silvestri, G	1
Groulx, C	1
Léger-Gauthier, C	1
Baumgartner, HR	1
Follea, G	1
Trzeciak, MC	1
Yasunaga, K	1
Vera, JC	1
Rodvien, R	1
Salzman, EW	1
Jobin, F	2
Fernández B de Quirós, J	1
Dulp-Gollasch, I	1
Hess, H	1
Deykin, D	1
Gent, M	5
Genton, E	5
Köhler, H	1
Steele, P	1
Ellis, JH	1
Weily, HS	2
Moore, S	1
Kaegi, A	2
Pineo, GF	2
Shimizu, A	2
Trivedi, H	2
de Jonge, H	1
Janicki, K	1
Dmoszyńska, A	1
Janicka, L	1
Stettner, S	1
Jesipowicz, J	1
Ferlito, S	1
Domoto, DT	1
Bauman, JE	1
Joist, JH	1
Carter, G	1
Gavin, JB	1
Gelman, JS	1
Mehta, J	1
Hladovec, J	1
Goldman, M	1
Davì, G	1
Botindari, G	1
Catalano, I	1
Strano, A	1
Opatrný, K	2
Cepelák, V	1
Valenta, J	1
Cepeláková, H	1
Sefrna, F	1
Maekawa, T	1
Fujimoto, T	1
Yamazaki, H	1
Di Perri, T	1
Kumashiro, R	1
Piotrowski, JJ	1
Kholoussy, AM	1
Hashimoto, N	1
Matsumoto, T	1
Evans, G	1
Bove, LG	1
Forbes, CD	1
Prentice, CR	1
Steele, PP	1
Born, GV	1
Gagnon, FT	1
Renaud, S	1
Lecompte, F	1
Perlick, E	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation in High Risk Primary Prevention (Patients With Metabolic Syndrome)[NCT00272311]	Phase 4	70 participants (Actual)	Interventional	2006-10-31	Completed
A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation & Endothelial Function in Secondary Prevention (Pts w/Chronic Stable Coronary Disease)[NCT00272337]	Phase 4	37 participants (Actual)	Interventional	2006-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Changes in Heme oxygenase (HO-1) a downstream target of nitric oxide (NO) formation. (NCT00272311)
Timeframe: Baseline to 3 Months (90-97 days)

Change in Nitric Oxide Formation From Baseline to 3 Months.

Intervention	ng/mL (Mean)
Arm 1 of 5 Randomized Treatment Arms	27.6
Arm 2 of 5 Randomized Treatment Arms	27.0
Arm 3 of 5 Randomized Treatment Arms	31.4
Arm 4 of 5 Randomized Treatment Arms	25.7
Arm 5 of 5 Randomized Treatment Arms	28.3

Heme oxygenase a downstream target of nitric oxide formation (NCT00272337)
Timeframe: Baseline to 3 Months (90-97 days)

Article	Year
Antiplatelet agents: rationale and results. Clinics in haematology, 1983, Volume: 12, Issue:1 Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Animals; Arachidonic Acids; Aspirin; Blood Plate	1983
Bleeding associated with antithrombotic therapy. Seminars in hematology, 1980, Volume: 17, Issue:4 Topics: 4-Hydroxycoumarins; Aspirin; Dextrans; Dipyridamole; Dose-Response Relationship, Drug; Fibrinolytic	1980
Pharmacology of platelet-affecting drugs. Circulation, 1980, Volume: 62, Issue:6 Pt 2 Topics: Animals; Arachidonic Acids; Arteriosclerosis; Aspirin; Blood Platelets; Cyclic AMP; Dose-Response Re	1980
[Pharmacology of anti-platelet agents]. Journal des maladies vasculaires, 1983, Volume: 8, Issue:1 Topics: Animals; Anticoagulants; Aspirin; Blood Platelets; Cyclic AMP; Cyclooxygenase Inhibitors; Dipyridamo	1983
Present status of antiaggregating agents in coronary and cerebrovascular disease prevention. Haematologica, 1980, Volume: 65, Issue:3 Topics: Animals; Anticoagulants; Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Dise	1980
[Prevention of thrombosis by thrombocyte inhibition. 2. Clinical results]. Ugeskrift for laeger, 1980, Jan-28, Volume: 142, Issue:5 Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Cerebrovascular Disorders; Clofibrate; Dextrans;	1980
Prostaglandins and platelets. Annual review of medicine, 1980, Volume: 31 Topics: Arachidonic Acids; Aspirin; Blood Platelets; Epoprostenol; Fatty Acids; Humans; Oxygenases; Phosphol	1980
Sulfinpyrazone: a review of its pharmacological properties and therapeutic use. Drugs, 1980, Volume: 20, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Antibody Formation; Aspirin; Blood Platelets; Cardiovascular Diseas	1980
Platelet-active drugs in the secondary prevention of cardiovascular events: an overview. Circulation, 1980, Volume: 62, Issue:6 Pt 2 Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Coronary Disease; Dipyridamole; Sulfinpyrazone; T	1980
10. Antithrombotic therapy: role of platelet-inhibitor drugs. II. Pharmacologic effects of platelet-inhibitor drugs (second of three parts). Mayo Clinic proceedings, 1981, Volume: 56, Issue:3 Topics: Aspirin; Dipyridamole; Drug Therapy, Combination; Epoprostenol; Fibrinolytic Agents; Gastrointestina	1981
Antiplatelet therapy. Clinics in haematology, 1981, Volume: 10, Issue:2 Topics: Aspirin; Blood Platelets; Cerebrovascular Disorders; Clofibrate; Coronary Disease; Dipyridamole; Hea	1981
Antithrombotic effects of drugs which suppress platelet function: their potential in prevention growth of tumour cells. Progress in clinical and biological research, 1982, Volume: 89 Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Cell Division; Clinical Trials as Topic; Coronary	1982
[Prevention of thrombosis with coumarin, low doses of heparin, dextran and inhibitors of platelet function]. Nederlands tijdschrift voor geneeskunde, 1977, Oct-29, Volume: 121, Issue:44 Topics: Aspirin; Coumarins; Dextrans; Dipyridamole; Heart Valve Prosthesis; Heparin; Humans; Lipids; Platele	1977
Actions and clinical status of platelet-suppressive agents. Seminars in hematology, 1978, Volume: 15, Issue:1 Topics: Aspirin; Blood Platelets; Cerebrovascular Disorders; Coronary Disease; Dipyridamole; Heart Valve Dis	1978
Platelet suppressive therapy. British medical bulletin, 1978, Volume: 34, Issue:2 Topics: Arteriovenous Shunt, Surgical; Aspirin; Blood Platelets; Cerebrovascular Disorders; Clofibrate; Coro	1978
Platelets and thrombosis in the development of atherosclerosis and its complications. Advances in experimental medicine and biology, 1978, Volume: 102 Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Dipyridamole; Endothelium; Human	1978
Platelets and thrombosis in the development of atherosclerosis and its complications. Advances in experimental medicine and biology, 1978, Volume: 102 Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Dipyridamole; Endothelium; Human	1978
Platelets and thrombosis in the development of atherosclerosis and its complications. Advances in experimental medicine and biology, 1978, Volume: 102 Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Dipyridamole; Endothelium; Human	1978
Platelets and thrombosis in the development of atherosclerosis and its complications. Advances in experimental medicine and biology, 1978, Volume: 102 Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Dipyridamole; Endothelium; Human	1978
Platelet inhibitors in the treatment of thrombosis. Clinical and investigative medicine. Medecine clinique et experimentale, 1978, Volume: 1, Issue:3-4 Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Aspirin; Blood Platelets; Clinical Trials as Topic; Clof	1978
[Clinical prevention of thrombosis by antiplatelet agents]. L'union medicale du Canada, 1979, Volume: 108, Issue:10 Topics: Aspirin; Blood Platelets; Clofibrate; Dipyridamole; Humans; Hydroxychloroquine; Sulfinpyrazone; Thro	1979
[State of thrombosis risk: diagnostic and preventive possibilities]. Polskie Archiwum Medycyny Wewnetrznej, 1979, Volume: 62, Issue:6 Topics: Anticoagulants; Aspirin; Dipyridamole; Humans; Platelet Aggregation; Risk; Sulfinpyrazone; Thrombosi	1979
Critical evaluation of platelet-inhibiting drugs in thrombotic disease. Progress in hematology, 1975, Volume: 9 Topics: Arteriosclerosis; Aspirin; Blood Platelets; Cerebrovascular Disorders; Clinical Trials as Topic; Clo	1975
Antiplatelet drugs-a new pharmacologic approach to the prevention of thrombosis. American heart journal, 1976, Volume: 92, Issue:1 Topics: Anticoagulants; Aspirin; Blood Platelets; Brain; Clofibrate; Dextrans; Dipyridamole; Humans; Ischemi	1976
Platelet-inhibiting drugs in the prevention of clinical thrombotic disease (second of three parts). The New England journal of medicine, 1975, 12-11, Volume: 293, Issue:24 Topics: Aged; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Cardiac Catheterization; Clinical Tria	1975
[Platelet antiaggregants in the treatment of arterial thrombosis]. Minerva cardioangiologica, 1991, Volume: 39, Issue:10 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Cerebrovascular Disorders; Coronary Artery	1991
Pharmacology of platelet inhibitors. Journal of the American College of Cardiology, 1986, Volume: 8, Issue:6 Suppl B Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Blood Platelets; Dex	1986
Platelets and prostaglandins in sudden death: therapeutic implications. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Animals; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis; Aspirin	1985
Antiplatelet drugs in the management of patients with thrombotic disorders. Seminars in thrombosis and hemostasis, 1986, Volume: 12, Issue:2 Topics: Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Blood Coagulation Disorders; Blood Platelets	1986
[Antiplatelet drugs and prevention of aortocoronary bypass occlusion]. Cardiologia (Rome, Italy), 1988, Volume: 33, Issue:2 Topics: Aspirin; Coronary Artery Bypass; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Sulfinpyrazo	1988
[Antiplatelet therapy of thrombosis]. Nihon rinsho. Japanese journal of clinical medicine, 1986, Volume: 44, Issue:5 Topics: Animals; Aspirin; Cerebrovascular Disorders; Coronary Disease; Humans; Postoperative Complications;	1986
[Thrombosis in various diseases: arteriosclerosis and thrombosis]. Nihon rinsho. Japanese journal of clinical medicine, 1986, Volume: 44, Issue:5 Topics: Animals; Arteriosclerosis; Aspirin; Dipyridamole; Humans; Sulfinpyrazone; Thrombosis	1986
Management of thrombotic diseases. Seminars in hematology, 1971, Volume: 8, Issue:2 Topics: Anticoagulants; Aspirin; Blood Coagulation; Blood Platelets; Cerebrovascular Disorders; Coronary Dis	1971
The prevention of thrombosis. The Journal of the Maine Medical Association, 1974, Volume: 65, Issue:10 Topics: Anti-Inflammatory Agents; Anticoagulants; Aspirin; Coumarins; Dipyridamole; Heparin; Humans; Platele	1974
Platelet inhibition in the management of thrombosis. Thrombosis et diathesis haemorrhagica, 1974, Sep-30, Volume: 32, Issue:1 Topics: Aspirin; Blindness; Blood Platelets; Cell Survival; Cerebrovascular Disorders; Dextrans; Dipyridamol	1974
Anticoagulants. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Anticoagulants; Aspirin; Blood Platelet Disorders; Dipyridamole; Enzyme Therapy; Factor IX; Factor V	1974
Platelet pharmacology in relation to thrombosis. Advances in cardiology, 1970, Volume: 4 Topics: Adenine Nucleotides; Animals; Arteriosclerosis; Aspirin; Binding Sites; Blood Cells; Blood Coagulati	1970

Article	Year
Pharmacology of antiplatelet drugs and clinical trials on thrombosis prevention: a difficult link. Lancet (London, England), 1982, Oct-30, Volume: 2, Issue:8305 Topics: Acetylation; Aspirin; Blood Platelets; Blood Vessels; Clinical Trials as Topic; Dipyridamole; Humans	1982
Present status of antiaggregating agents in coronary and cerebrovascular disease prevention. Haematologica, 1980, Volume: 65, Issue:3 Topics: Animals; Anticoagulants; Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Dise	1980
Secondary prevention of myocardial infarction--the present state of the ART. British medical journal, 1980, May-03, Volume: 280, Issue:6223 Topics: Anticoagulants; Aspirin; Blood Platelets; Clinical Trials as Topic; Dipyridamole; Humans; Myocardial	1980
Sulfinpyrazone: a review of its pharmacological properties and therapeutic use. Drugs, 1980, Volume: 20, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Antibody Formation; Aspirin; Blood Platelets; Cardiovascular Diseas	1980
Series on pharmacology in practice. 10. Antithrombotic therapy: role of platelet-inhibitor drugs. III. Management of arterial thromboembolic and atherosclerotic disease (third of three parts). Mayo Clinic proceedings, 1981, Volume: 56, Issue:4 Topics: Anticoagulants; Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Coro	1981
Drug trials in prevention of occlusion of aorta--coronary artery vein grafts. The Journal of thoracic and cardiovascular surgery, 1982, Volume: 83, Issue:1 Topics: Angiography; Aspirin; Clinical Trials as Topic; Coronary Artery Bypass; Dipyridamole; Humans; Postop	1982
Antithrombotic effects of drugs which suppress platelet function: their potential in prevention growth of tumour cells. Progress in clinical and biological research, 1982, Volume: 89 Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Cell Division; Clinical Trials as Topic; Coronary	1982
[Possibilities and limits of controlled clinical therapy studies for the demonstration of the effectiveness of antithrombotic therapy]. Folia haematologica (Leipzig, Germany : 1928), 1975, Volume: 102, Issue:2 Topics: Adult; Anticoagulants; Aspirin; Clinical Trials as Topic; Dextrans; Dipyridamole; Dose-Response Rela	1975
Drug therapy: antiplatelet therapy (second of two parts). The New England journal of medicine, 1978, Jun-22, Volume: 298, Issue:25 Topics: Aged; Arteriovenous Shunt, Surgical; Aspirin; Blood Platelets; Cerebrovascular Disorders; Clinical T	1978
Platelet inhibitors in the treatment of thrombosis. Clinical and investigative medicine. Medecine clinique et experimentale, 1978, Volume: 1, Issue:3-4 Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Aspirin; Blood Platelets; Clinical Trials as Topic; Clof	1978
Critical evaluation of platelet-inhibiting drugs in thrombotic disease. Progress in hematology, 1975, Volume: 9 Topics: Arteriosclerosis; Aspirin; Blood Platelets; Cerebrovascular Disorders; Clinical Trials as Topic; Clo	1975
The role of sulfinpyrazone in the prevention of arterio-venous shunt thrombosis. Circulation, 1975, Volume: 52, Issue:3 Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Clinical Trials as Topic; Female; Humans; Male; Middle A	1975
Platelet-inhibiting drugs in the prevention of clinical thrombotic disease (second of three parts). The New England journal of medicine, 1975, 12-11, Volume: 293, Issue:24 Topics: Aged; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Cardiac Catheterization; Clinical Tria	1975
Platelet-inhibiting drugs in the prevention of clinical thrombotic disease (third of three parts). The New England journal of medicine, 1975, Dec-18, Volume: 293, Issue:25 Topics: Anticoagulants; Aspirin; Clinical Trials as Topic; Clofibrate; Dipyridamole; Drug Evaluation; Fibrin	1975
Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. Thrombosis research, 1991, Jun-15, Volume: 62, Issue:6 Topics: Aspirin; Blood Coagulation Tests; Blood Platelets; Catheters, Indwelling; Drug Evaluation; Drug Ther	1991
Platelet-inhibitory therapy in reconstructive arterial surgery. Advances in prostaglandin, thromboxane, and leukotriene research, 1985, Volume: 13 Topics: Aspirin; Blood Platelets; Clinical Trials as Topic; Coronary Artery Bypass; Dipyridamole; Double-Bli	1985
[Personal experience with the administration of sulfinpyrazone to patients with kidney failure]. Vnitrni lekarstvi, 1986, Volume: 32, Issue:7 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Kidney Failure, Chronic; Kinet	1986
Arteriovenous-shunt thrombosis. Prevention by sulfinpyrazone. The New England journal of medicine, 1974, Feb-07, Volume: 290, Issue:6 Topics: Adult; Anticoagulants; Arteriovenous Shunt, Surgical; Clinical Trials as Topic; Drug Evaluation; Hum	1974

Article	Year
The effect of sulfinpyrazone on platelet economy and thrombus formation in rabbits. Blood, 1967, Volume: 29, Issue:6 Topics: Animals; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Extracorporeal Circulation; Is	1967
Antiplatelet drugs in the secondary prevention of myocardial infarction. One view of the present position. Lancet (London, England), 1980, Oct-04, Volume: 2, Issue:8197 Topics: Aspirin; Blood Platelets; Coronary Disease; Dipyridamole; Humans; Myocardial Infarction; Recurrence;	1980
Antithrombotic treatment. British medical journal (Clinical research ed.), 1983, Jul-16, Volume: 287, Issue:6386 Topics: Ancrod; Aspirin; Cerebrovascular Disorders; Dextrans; Dipyridamole; Drug Administration Schedule; He	1983
The thrombogenicity of Dacron arterial grafts and its modification by platelet inhibitory drugs. Annals of the Royal College of Surgeons of England, 1984, Volume: 66, Issue:4 Topics: Arteries; Aspirin; Blood Platelets; Blood Vessel Prosthesis; Dipyridamole; Drug Therapy, Combination	1984
[Prevention of thrombosis by thrombocyte inhibitors. 1. Cell regulation mechanisms and pharmacological modification]. Ugeskrift for laeger, 1980, Jan-28, Volume: 142, Issue:5 Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cyclic AMP; Dextrans; Dipyridamole; Humans; Hydroxy	1980
[Divergence between the pharmacologic and clinical effects of inhibitors of prostaglandin synthesis]. Deutsche medizinische Wochenschrift (1946), 1984, Aug-03, Volume: 109, Issue:31-32 Topics: Aspirin; Blood Platelets; Dipyridamole; Drug Interactions; Epoprostenol; Humans; Platelet Aggregatio	1984
Prostaglandin endoperoxides and thromboxane A2 in thrombus formation in the hamster cheek pouch in vivo. Prostaglandins, 1984, Volume: 28, Issue:1 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cheek; Cricetinae; Cyclooxygenase Inhibitors;	1984
Antithrombotic therapy for vascular prosthesis: an experimental model testing platelet inhibitory drugs. Surgery, 1980, Volume: 87, Issue:6 Topics: Aspirin; Blood Circulation; Blood Platelets; Blood Vessel Prosthesis; Dipyridamole; Humans; Methods;	1980
Gastrointestinal blood loss in patients undergoing maintenance dialysis. Kidney international. Supplement, 1983, Volume: 16 Topics: Adult; Aged; Aluminum Hydroxide; Female; Heparin; Humans; Kidney Failure, Chronic; Male; Melena; Mid	1983
[Anti-platelet aggregation therapy in vascular microsurgery: experimental study with sulfinpyrazone]. Annali italiani di chirurgia, 1983, Volume: 55, Issue:1 Topics: Animals; Female; Femoral Artery; Male; Microsurgery; Platelet Aggregation; Rats; Rats, Inbred Strain	1983
The effects of antithrombotic drugs in patients with left ventricular thrombi: assessment with indium-111 platelet imaging and two-dimensional echocardiography. Circulation, 1984, Volume: 69, Issue:3 Topics: Adult; Aged; Anticoagulants; Aspirin; Dipyridamole; Echocardiography; Heart Ventricles; Humans; Indi	1984
111In-oxine platelet imaging in hemodialysis patients: detection of platelet deposition at vascular access sites. Nephron, 1982, Volume: 31, Issue:4 Topics: Adult; Aged; Blood Platelets; Humans; Hydroxyquinolines; Indium; Male; Middle Aged; Oxyquinoline; Ra	1982
Veno-venous allografts: patency, subendothelial proliferation, and the role of platelet-active agents. The Journal of surgical research, 1983, Volume: 34, Issue:3 Topics: Animals; Aspirin; Blood Platelets; Cell Division; Dipyridamole; Dogs; Female; Graft Survival; Male;	1983
Antithrombotic therapy. Cardiovascular clinics, 1983, Volume: 13, Issue:2 Topics: Anticoagulants; Aspirin; Blood Platelets; Dipyridamole; Fibrinolytic Agents; Humans; Sulfinpyrazone;	1983
Dermatomyositis associated with platelet thrombi formation and responsive to antiplatelet therapy. The Journal of rheumatology, 1983, Volume: 10, Issue:1 Topics: Adult; Aspirin; Blood Platelets; Dermatomyositis; Dipyridamole; Female; Humans; Sulfinpyrazone; Thro	1983
[The pharmacology of sulfinpyrazone (Anturan)]. Wiener medizinische Wochenschrift. Supplement, 1980, Volume: 61 Topics: Blood Platelets; Fibrinolysis; Humans; Prostaglandin Antagonists; Sulfinpyrazone; Thrombocytopenia;	1980
Non-steroidal anti-inflammatory agents and coronary heart disease. Acta medica Scandinavica. Supplementum, 1980, Volume: 642 Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Caroti	1980
Antiplatelet agents and extracorporeal circulation. The International journal of artificial organs, 1980, Volume: 3, Issue:3 Topics: Epoprostenol; Extracorporeal Circulation; Heparin; Humans; Platelet Aggregation; Prostaglandins; Sul	1980
Effect of sulfinpyrazone upon antithrombin III and platelet factor 4 in chronic renal failure. Thrombosis research, 1982, Aug-15, Volume: 27, Issue:4 Topics: Adult; Aged; Antithrombins; Blood Coagulation Factors; Female; Humans; Kidney Failure, Chronic; Male	1982
Comparison of sulfinpyrazone and BL-3459 with S - 20344, a potent new antithrombotic agent. Thrombosis research, 1981, Mar-15, Volume: 21, Issue:6 Topics: Animals; Fibrinolytic Agents; Humans; Imidazoles; Male; Oxazoles; Platelet Aggregation; Prostaglandi	1981
[Sulfinpyrazone and aspirin in experimental microthrombosis]. Archivos de farmacologia y toxicologia, 1981, Volume: 7, Issue:1 Topics: Animals; Aspirin; Blood Vessels; Endothelium; Platelet Aggregation; Rats; Rats, Inbred Strains; Sulf	1981
Prevention of thrombosis with antiplatelet drugs. American family physician, 1980, Volume: 21, Issue:5 Topics: Aspirin; Blood Platelets; Dipyridamole; Humans; Sulfinpyrazone; Thrombosis	1980
Increase of platelet prostaglandin cyclic endoperoxides in thrombosis. Lancet (London, England), 1977, Jan-08, Volume: 1, Issue:8002 Topics: Blood Platelets; Clofibrate; Collagen; Dipyridamole; Heparin; Humans; Peroxides; Prospective Studies	1977
Antithrombotic effect of sulphinpyrazone. Lancet (London, England), 1978, May-27, Volume: 1, Issue:8074 Topics: Animals; Humans; Rabbits; Rats; Sulfinpyrazone; Thrombosis; Uric Acid	1978
[Anti-platelet aggregating drugs in the prevention of thromboembolic diseases]. Minerva medica, 1975, May-12, Volume: 66, Issue:36 Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents; Cardiovascular Diseases; Cerebrovascular Diso	1975
[Therapy and prevention of acute phlebothrombosis with heparin, coumarins and inhibitors of platelet function]. Zeitschrift fur arztliche Fortbildung, 1979, Jan-01, Volume: 73, Issue:1 Topics: Coumarins; Dextrans; Dipyridamole; Dose-Response Relationship, Drug; Heparin; Humans; Platelet Aggre	1979
[Action mechanism and clinical indications for thrombocyte aggregation inhibitors]. Schweizerische medizinische Wochenschrift, 1979, Mar-10, Volume: 109, Issue:10 Topics: Anticoagulants; Aspirin; Coronary Disease; Dipyridamole; Humans; Ischemic Attack, Transient; Myocard	1979
[Effects of heparin, sulfinpyrazone and acetylsalicylic acid on the collagen-induced thromboyte aggregation]. Die Medizinische Welt, 1979, Jun-01, Volume: 30, Issue:22 Topics: Aspirin; Heparin; Humans; In Vitro Techniques; Platelet Aggregation; Sulfinpyrazone; Thrombosis	1979
[Medical therapy of thrombosis]. Giornale di clinica medica, 1979, Volume: 60, Issue:6 Topics: Anticoagulants; Antihypertensive Agents; Aspirin; Fibrinolytic Agents; Humans; Hypolipidemic Agents;	1979
Activation of the Hageman factor-prekallikrein system in the pathogenesis of the generalized Shwartzman reaction and of the hepatic vein thrombosis phenomenon in the rat. Laboratory investigation; a journal of technical methods and pathology, 1979, Volume: 41, Issue:3 Topics: Animals; Arginine; Bradykinin; Dexamethasone; Dimercaprol; Endotoxins; Esterases; Factor XII; Female	1979
Effects of acetylsalicylic acid, sulfinpyrazone and dipyridamole on platelet adhesion and aggregation in flowing native and anticoagulated blood. Haemostasis, 1979, Volume: 8, Issue:3-5 Topics: Animals; Aspirin; Blood Platelets; Blood Vessels; Citrates; Dipyridamole; Dose-Response Relationship	1979
[Antiplatelet drugs (author's transl)]. Anesthesie, analgesie, reanimation, 1979, Volume: 36, Issue:7-8 Topics: Aspirin; Blood Platelets; Clofibrate; Dipyridamole; Female; Humans; Hydroxychloroquine; Ischemic Att	1979
[Inhibition of platelet aggregation by platelet inhibitory agents and its relation to their clinical effects]. Rinsho byori. The Japanese journal of clinical pathology, 1979, Volume: Suppl 40 Topics: Depression, Chemical; Dipyridamole; Dose-Response Relationship, Drug; Humans; Phthalazines; Platelet	1979
Antiplatelet agents in the treatment of thrombotic complications of primary thrombocythemia. Canadian Medical Association journal, 1979, Jan-06, Volume: 120, Issue:1 Topics: Aged; Aspirin; Humans; Male; Sulfinpyrazone; Thrombocythemia, Essential; Thrombosis	1979
Thrombotic and hemorrhagic problems in surgery. Thrombosis and haemostasis, 1978, Apr-30, Volume: 39, Issue:2 Topics: Aspirin; Blood Coagulation Factors; Dextrans; Extracorporeal Circulation; Female; Hemostasis; Hepari	1978
[Platelet-inhibiting drugs]. L'union medicale du Canada, 1978, Volume: 107, Issue:2 Topics: Anti-Bacterial Agents; Aspirin; Dextrans; Dipyridamole; Hemorrhage; Humans; Indomethacin; Platelet A	1978
Antiplatelet therapy (first of two parts). The New England journal of medicine, 1978, Jun-15, Volume: 298, Issue:24 Topics: Animals; Anti-Inflammatory Agents; Aspirin; Blood Coagulation; Blood Platelets; Cell Survival; Clofi	1978
[Influence of Anturane on platelets aggregation. Comparative study with acetylsalicylic acid in patients with and without oral anticoagulant therapy]. Revista clinica espanola, 1978, Nov-15, Volume: 151, Issue:3 Topics: Administration, Oral; Anticoagulants; Aspirin; Coumarins; Drug Evaluation; Drug Interactions; Drug T	1978
Antithrombotic therapy. Rationale and application. Postgraduate medicine, 1979, Volume: 65, Issue:1 Topics: Anticoagulants; Arteries; Arteriosclerosis; Aspirin; Blood Coagulation; Blood Coagulation Factors; D	1979
[Effect of heparin, acetylsalicylic acid and sulfinpyrazone on thrombocyte morphology]. Die Medizinische Welt, 1979, Mar-09, Volume: 30, Issue:10 Topics: Aspirin; Blood Platelets; Heparin; Humans; Sulfinpyrazone; Thrombosis	1979
[Prophylaxis and therapy of shunt thrombosis in terminal renal insufficiency (author's transl)]. Klinische Wochenschrift, 1977, Jan-15, Volume: 55, Issue:2 Topics: Anticoagulants; Arteriovenous Shunt, Surgical; Aspirin; Dextrans; Dipyridamole; Hemorrhagic Disorder	1977
Platelet survival time in patients with hypoxemia and pulmonary hypertension. Circulation, 1977, Volume: 55, Issue:4 Topics: Blood Platelets; Cell Survival; Female; Humans; Hypertension, Pulmonary; Hypoxia; Male; Oxygen; Sulf	1977
Effect of drugs of platelets and complications of vascular disease. Advances in experimental medicine and biology, 1977, Volume: 82 Topics: Animals; Anticoagulants; Aspirin; Blood Coagulation; Blood Platelets; Clofibrate; Coronary Disease;	1977
Platelets, thrombosis and atherosclerosis. Progress in biochemical pharmacology, 1977, Volume: 13 Topics: Arteries; Arteriosclerosis; Aspirin; Blood Platelets; Cell Division; Cell Survival; Dipyridamole; En	1977
Platelets, thrombosis and atherosclerosis. Progress in biochemical pharmacology, 1977, Volume: 13 Topics: Arteries; Arteriosclerosis; Aspirin; Blood Platelets; Cell Division; Cell Survival; Dipyridamole; En	1977
Platelets, thrombosis and atherosclerosis. Progress in biochemical pharmacology, 1977, Volume: 13 Topics: Arteries; Arteriosclerosis; Aspirin; Blood Platelets; Cell Division; Cell Survival; Dipyridamole; En	1977
Platelets, thrombosis and atherosclerosis. Progress in biochemical pharmacology, 1977, Volume: 13 Topics: Arteries; Arteriosclerosis; Aspirin; Blood Platelets; Cell Division; Cell Survival; Dipyridamole; En	1977
Letter: Action of sulfinpyrazon. Thrombosis et diathesis haemorrhagica, 1975, Jun-30, Volume: 33, Issue:3 Topics: Blood Platelets; Humans; Sulfinpyrazone; Thrombosis	1975
Pharmacological properties of drug inhibiting platelet aggregation. Acta clinica Belgica, 1975, Volume: 30, Issue:3 Topics: Aspirin; Dipyridamole; Humans; In Vitro Techniques; Platelet Aggregation; Sulfinpyrazone; Thrombosis	1975
Influence of antiplatelet drugs on occlusion of arteriovenous fistula in uraemic patients. International urology and nephrology, 1992, Volume: 24, Issue:1 Topics: Arteriovenous Shunt, Surgical; Female; Graft Occlusion, Vascular; Humans; Isoindoles; Male; Middle A	1992
Sulphinpyrazone reduces endocardial injury and mural thrombosis. Cardiovascular research, 1990, Volume: 24, Issue:4 Topics: Animals; Endocardium; Endothelium; Heart Diseases; Lactates; Male; Microscopy, Electron, Scanning; M	1990
Antithrombotics in view of thrombosis models. Thrombosis research, 1986, Sep-01, Volume: 43, Issue:5 Topics: Animals; Anticoagulants; Arteries; Aspirin; Dipyridamole; Female; Hydroxyethylrutoside; Ketanserin;	1986
[Prevention and medical treatment of polyregional vascular lesions]. Cardiologia (Rome, Italy), 1985, Volume: 30, Issue:11 Topics: Adult; Anticoagulants; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Diet; Dipyridamole; D	1985
Antiplatelet aggregators inhibit development of stress ulcers in Sprague-Dawley rats. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1985, Volume: 17, Issue:1 Topics: Animals; Anticoagulants; Aspirin; Capillaries; Dipyridamole; Gastric Mucosa; Male; Platelet Aggregat	1985
Platelet-surface reaction and thrombosis. Surgery, 1968, Volume: 64, Issue:1 Topics: Animals; Aspirin; Blood Platelets; Blood Vessel Prosthesis; Carbon Isotopes; Endarterectomy; Extraco	1968
Platelet survival and adhesiveness in recurrent venous thrombosis. The New England journal of medicine, 1973, May-31, Volume: 288, Issue:22 Topics: Adult; Anticoagulants; Blood Platelets; Cell Survival; Chromium Isotopes; Female; Humans; Male; Midd	1973
Platelet reactions and immune processes. IV. The inhibition of complement by pyrazole compounds and other inhibitors of platelet reactions. Canadian journal of microbiology, 1970, Volume: 16, Issue:2 Topics: Animals; Blood Coagulation; Blood Platelets; Chloroquine; Complement Inactivator Proteins; Erythrocy	1970
Thrombosis prevention by coagulation and platelet aggregtion inhibitors, in hyperlipemic rats. Thrombosis et diathesis haemorrhagica, 1970, Dec-31, Volume: 24, Issue:3 Topics: Acenocoumarol; Adenine Nucleotides; Aniline Compounds; Animals; Anticoagulants; Blood Coagulation; B	1970
[Thrombophilia in early and late sclerosis]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1968, Feb-01, Volume: 23, Issue:3 Topics: Age Factors; Anticoagulants; Arteries; Arteriosclerosis; Dipyridamole; Humans; Lipid Metabolism; Nuc	1968

sulfinpyrazone and Blood Clot