sulfasalazine has been researched along with Ulcer in 23 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "), which reduced mortality and pathology (including colon obstruction, ulceration, wall thickness, and myeloperoxidase release) more effectively than the clinically used drug sulfasalazine (100 mg/kg/day p." | 3.78 | Antagonism of protease-activated receptor 2 protects against experimental colitis. ( Cotterell, AJ; Do, AT; Fairlie, DP; Liu, L; Lohman, RJ; Suen, J; Vesey, DA, 2012) |
| " The prodrugs exhibited comparable ameliorating effect as that of sulfasalazine on trinitrobenzenesulfonic acid-induced experimental colitis in rats with a better safety profile." | 3.75 | Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease. ( Bhatt, L; Dhaneshwar, SS; Gairola, N; Kadam, SS; Kandpal, M; Rathi, B; Vadnerkar, G, 2009) |
| " In acetic acid-induced colitis in the rat, levels of malondialdehyde were found to be more markedly reduced with MED15 than with 5-aminosalicylic acid." | 3.72 | Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. ( Belogi, L; Bettelli, E; Mezzadri, CM; Tubaro, E, 2003) |
| "It is important to distinguish between ulcerative colitis and Crohn's colitis because response to treatment and prognosis are different." | 2.35 | Inflammatory disease of the colon: ulcerative colitis and Crohn's colitis. ( Ament, ME, 1975) |
| "Ulcerative proctitis is a non-specific inflammatory condition of a diffuse nature involving the mucosa of the rectum." | 1.26 | Ulcerative proctitis. ( Buls, J, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (39.13) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dhaneshwar, SS | 2 |
| Chail, M | 1 |
| Patil, M | 1 |
| Naqvi, S | 1 |
| Vadnerkar, G | 2 |
| Gairola, N | 1 |
| Kandpal, M | 1 |
| Bhatt, L | 1 |
| Rathi, B | 1 |
| Kadam, SS | 1 |
| Shenoy, P | 1 |
| Misra, R | 1 |
| Jain, M | 1 |
| Agarwal, V | 1 |
| Lohman, RJ | 1 |
| Cotterell, AJ | 1 |
| Suen, J | 1 |
| Liu, L | 1 |
| Do, AT | 1 |
| Vesey, DA | 1 |
| Fairlie, DP | 1 |
| Tubaro, E | 1 |
| Belogi, L | 1 |
| Mezzadri, CM | 1 |
| Bettelli, E | 1 |
| Wedemeyer, H | 1 |
| Kuipers, JG | 1 |
| Streetz, K | 1 |
| Mengel, M | 1 |
| Schedel, I | 1 |
| Kezmic, N | 1 |
| Meier, P | 1 |
| Zeidler, H | 1 |
| Manns, MP | 1 |
| Wagner, S | 1 |
| Düzgün, N | 1 |
| Ateş, A | 1 |
| Buls, J | 1 |
| McCarthy, CF | 1 |
| Kumar, M | 1 |
| Puri, AS | 1 |
| Srivastava, R | 1 |
| Yachha, SK | 1 |
| Takeshima, F | 1 |
| Makiyama, K | 1 |
| Doi, T | 1 |
| Ohta, M | 1 |
| Konno, H | 1 |
| Kamiya, K | 1 |
| Suwa, D | 1 |
| Baba, M | 1 |
| Tanaka, T | 1 |
| Nakamura, T | 1 |
| Nishino, N | 1 |
| Sugimura, H | 1 |
| Nakamura, S | 1 |
| Matsukawa, M | 1 |
| Kouda, T | 1 |
| Kane, SP | 1 |
| Boots, MA | 1 |
| Ament, ME | 1 |
| Oestreicher, P | 1 |
| Nielsen, ST | 1 |
| Rainsford, KD | 1 |
| Chan, SW | 1 |
| Scully, C | 1 |
| Prime, SS | 1 |
| Eveson, J | 1 |
| Tandon, RK | 1 |
| Atmakuri, SP | 1 |
| Mehra, NK | 1 |
| Malaviya, AN | 1 |
| Tandon, HD | 1 |
| Chopra, P | 1 |
| Del Soldato, P | 1 |
| Foschi, D | 1 |
| Varin, L | 1 |
| Daniotti, S | 1 |
| Psaila, JV | 1 |
| Myers, B | 1 |
| Jones, IR | 1 |
| Rhodes, J | 1 |
| Foster, GR | 1 |
| Fedotin, MS | 1 |
| Grimmett, GM | 1 |
| Shelburne, J | 1 |
| McKechnie, JC | 1 |
| Bynum, TE | 1 |
| Bentlif, PS | 1 |
| Lanza, FL | 1 |
3 reviews available for sulfasalazine and Ulcer
| Article | Year |
|---|---|
Erosive arthritis in a patient with Behçet's disease.
Topics: Adult; Antirheumatic Agents; Arthritis; Behcet Syndrome; Colchicine; Female; Genitalia, Female; Gluc | 2003 |
[Therapy and nutrition for intestinal Behçet disease and simple ulcer].
Topics: Adult; Anhydrides; Behcet Syndrome; Colectomy; Enteral Nutrition; Ethanol; Female; Humans; Intestina | 2001 |
Inflammatory disease of the colon: ulcerative colitis and Crohn's colitis.
Topics: Adrenal Cortex Hormones; Adult; Anus Diseases; Arthritis; Azathioprine; Child, Preschool; Colectomy; | 1975 |
20 other studies available for sulfasalazine and Ulcer
| Article | Year |
|---|---|
Colon-specific mutual amide prodrugs of 4-aminosalicylic acid for their mitigating effect on experimental colitis in rats.
Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Drug Delivery Systems; Drug Stability; Drug-Related S | 2009 |
Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease.
Topics: Aminosalicylic Acids; Animals; Arthritis; Colitis; Colon; Female; Inflammatory Bowel Diseases; Male; | 2009 |
Lymphoma-like presentation in suspected rheumatoid arthritis due to sulphasalazine hypersensitivity syndrome.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Eruptions; Drug Hy | 2008 |
Antagonism of protease-activated receptor 2 protects against experimental colitis.
Topics: Animals; Body Weight; Calcium Signaling; Colitis; Colon; Cytokines; Edema; HT29 Cells; Humans; Inden | 2012 |
Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug.
Topics: Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; | 2003 |
A rare manifestation of Behçet's syndrome: immunological correlates and successful treatment of an esophageal ulcer.
Topics: Aged; Anti-Inflammatory Agents; Behcet Syndrome; Esophageal Diseases; Female; Humans; Prednisone; Su | 2003 |
Ulcerative proctitis.
Topics: Colitis, Ulcerative; Diagnosis, Differential; Humans; Proctitis; Sulfasalazine; Ulcer | 1980 |
Drug management of inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Antidiarrheals; Azathio | 1983 |
Solitary rectal ulcer in a child treated with local sulfasalazine.
Topics: Child; Colonoscopy; Enema; Female; Humans; India; Rectal Diseases; Sulfasalazine; Ulcer | 1994 |
Hyperbaric oxygen as adjunct therapy for Crohn's intractable enteric ulcer.
Topics: Adolescent; Anti-Inflammatory Agents; Colonic Diseases; Crohn Disease; Female; Follow-Up Studies; Fo | 1999 |
Crohn's disease of the esophagus: report of a case.
Topics: Adult; Anti-Inflammatory Agents; Crohn Disease; Esophageal Diseases; Gastrointestinal Agents; Humans | 2000 |
Megaloblastic anaemia associated with sulphasalazine treatment.
Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Humans; Proctitis; Sulfasalazine; Ulcer | 1977 |
Sulphasalazine fails to prevent development of mucosal ulceration and 5-lipoxygenase activity in guinea-pigs with chronic inflammatory bowel disease induced by combined bacterial immunization and oral carrageenin.
Topics: Animals; Arachidonate 5-Lipoxygenase; Bacteroides; Carrageenan; Guinea Pigs; Immunization; Inflammat | 1992 |
Pyostomatitis vegetans: oral manifestation of ulcerative colitis.
Topics: Acantholysis; Adolescent; Adult; Betamethasone; Colitis, Ulcerative; Female; Ferrous Compounds; Huma | 1991 |
Is solitary rectal ulcer a manifestation of a systemic disease?
Topics: Adolescent; Adult; Aged; Arthritis; Female; Fibrosis; HLA-B27 Antigen; Humans; Male; Middle Aged; Pr | 1990 |
Indomethacin-induced intestinal ulcers in rats: effects of salicylazosulfapyridine and dexamethasone.
Topics: Animals; Dexamethasone; Female; Indomethacin; Inflammation; Intestinal Diseases; Rats; Sulfasalazine | 1985 |
Effect of prostaglandin PGE2 on alcohol-induced ulceration in the rat colon.
Topics: Animals; Colonic Diseases; Dinoprostone; Ethanol; Female; Intestinal Mucosa; Prednisolone; Prostagla | 1986 |
Behçet's colitis with oesophageal ulceration treated with sulphasalazine and cyclosporin.
Topics: Behcet Syndrome; Colitis; Cyclosporins; Drug Therapy, Combination; Esophagitis; Female; Humans; Midd | 1988 |
Crohn's disease of the mouth.
Topics: Administration, Topical; Adolescent; Anti-Inflammatory Agents; Barium Sulfate; Biopsy; Crohn Disease | 1974 |
Ulcerative proctitis.
Topics: Adolescent; Adult; Biopsy; Colitis, Ulcerative; Cortisone; Diagnosis, Differential; Diazepam; Female | 1974 |