sulfasalazine has been researched along with Stevens-Johnson Syndrome in 20 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report two cases of Stevens-Johnson syndrome (SJS) associated with the use of sulfasalazine in two ulcerative colitis patients previously tolerant to mesalamine." | 7.77 | Stevens-Johnson syndrome with sulfasalazine treatment: report of two cases. ( Colombel, JF; Cortot, A; De Vroey, B; Delaporte, E; Lavogiez, C; Pineton de Chambrun, G; Tremblay, L, 2011) |
| "Photo-induced SJS associated with sulfasalazine therapy occurred in a 34-year-old white man diagnosed as having seronegative symmetrical polyarthritis with no predisposing factors." | 7.72 | Photo-induced Stevens-Johnson syndrome due to sulfasalazine therapy. ( Borrás-Blasco, J; Devesa, P; González-Delgado, M; Matarredona, J; Montesinos-Ros, A; Navarro-Ruiz, A, 2003) |
| " She was treated at the Allergology service of the San Juan de Dios Hospital of the Costa Rican Social Security Fund, and after 20 days of treatment with sulfasalazine she had a severe drug reaction on the skin, compatible with Stevens-Johnson syndrome." | 4.31 | [Stevens-Johnson syndrome in a patient with positive lymphocyte transformation test]. ( Carvajal-Elizondo, M; Chinchilla-Monge, R; Monge-Ortega, OP; Quiros, S, 2023) |
| "A young woman thought to have seronegative rheumatoid arthritis developed Stevens-Johnson syndrome after treatment with sulfasalazine; this resolved with prednisone." | 3.79 | Giant cell myocarditis in a patient with a spondyloarthropathy after a drug hypersensitivity reaction. ( Cooper, LT; Davies, RA; Grenon, J; Mesana, TG; Mielniczuk, LM; Mitoff, PR; Veinot, JP, 2013) |
| "We report two cases of Stevens-Johnson syndrome (SJS) associated with the use of sulfasalazine in two ulcerative colitis patients previously tolerant to mesalamine." | 3.77 | Stevens-Johnson syndrome with sulfasalazine treatment: report of two cases. ( Colombel, JF; Cortot, A; De Vroey, B; Delaporte, E; Lavogiez, C; Pineton de Chambrun, G; Tremblay, L, 2011) |
| "We report a 29-year-old white woman with conjunctival pigmentation after a Stevens-Johnson syndrome (SJS) episode triggered by sulfasalazine." | 3.74 | Conjunctival pigmentation in Stevens-Johnson syndrome. ( Calonge, M; Fuentes-Páez, G; Herreras, JM; Mendez, MC; Montañez, J; Saornil, MA, 2007) |
| "Photo-induced SJS associated with sulfasalazine therapy occurred in a 34-year-old white man diagnosed as having seronegative symmetrical polyarthritis with no predisposing factors." | 3.72 | Photo-induced Stevens-Johnson syndrome due to sulfasalazine therapy. ( Borrás-Blasco, J; Devesa, P; González-Delgado, M; Matarredona, J; Montesinos-Ros, A; Navarro-Ruiz, A, 2003) |
| "Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening and severe adverse cutaneous drug reactions characterized by epidermal detachment presenting as blisters and areas of denuded skin." | 1.42 | Stevens Johnson syndrome-Toxic Epidermal Necrolysis Overlap induced by sulfasalazine treatment: a case report. ( Alami, Z; Dikhaye, S; Elmrahi, A; Fihmi, N; Zizi, N, 2015) |
| "An acute respiratory failure occurred 36 hours after from admission due to an obstructive and desquamative necrosis of the tracheobronchial epithelium." | 1.31 | [Fatal toxic respiratory epitheliolysis. Subacute tracheo-bronchial desquamation in Stevens-Johnson syndrome]. ( Hazouard, E; Machet, L; Martin, L; Maurage, C; Michalak-Provost, S, 2001) |
| "Sulfasalazine is an important therapeutic agent in the management of chronic inflammatory bowel disease (CIBD)." | 1.28 | Sulfasalazine desensitization in children and adolescents with chronic inflammatory bowel disease. ( Tolia, V, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carvajal-Elizondo, M | 1 |
| Monge-Ortega, OP | 1 |
| Chinchilla-Monge, R | 1 |
| Quiros, S | 1 |
| Nakamura, R | 1 |
| Ozeki, T | 1 |
| Hirayama, N | 1 |
| Sekine, A | 1 |
| Yamashita, T | 1 |
| Mashimo, Y | 1 |
| Mizukawa, Y | 1 |
| Shiohara, T | 1 |
| Watanabe, H | 1 |
| Sueki, H | 1 |
| Ogawa, K | 1 |
| Asada, H | 1 |
| Kaniwa, N | 1 |
| Tsukagoshi, E | 1 |
| Matsunaga, K | 1 |
| Niihara, H | 1 |
| Yamaguchi, Y | 1 |
| Aihara, M | 1 |
| Mushiroda, T | 1 |
| Saito, Y | 1 |
| Morita, E | 1 |
| Xiong, H | 1 |
| Chen, S | 1 |
| Luo, X | 1 |
| Viola, A | 1 |
| Caltagirone, AM | 1 |
| Campisi, G | 1 |
| Guarneri, G | 1 |
| Cappello, M | 1 |
| Mitoff, PR | 1 |
| Mesana, TG | 1 |
| Mielniczuk, LM | 1 |
| Grenon, J | 1 |
| Veinot, JP | 1 |
| Cooper, LT | 1 |
| Davies, RA | 1 |
| Zizi, N | 1 |
| Elmrahi, A | 1 |
| Dikhaye, S | 1 |
| Fihmi, N | 1 |
| Alami, Z | 1 |
| Tremblay, L | 1 |
| Pineton de Chambrun, G | 1 |
| De Vroey, B | 1 |
| Lavogiez, C | 1 |
| Delaporte, E | 1 |
| Colombel, JF | 1 |
| Cortot, A | 1 |
| Rachwał-Siek, K | 1 |
| Ponikowska, M | 1 |
| Wiland, P | 1 |
| Borrás-Blasco, J | 1 |
| Navarro-Ruiz, A | 1 |
| Matarredona, J | 1 |
| Devesa, P | 1 |
| Montesinos-Ros, A | 1 |
| González-Delgado, M | 1 |
| Iemoli, E | 1 |
| Piconi, S | 1 |
| Ardizzone, S | 1 |
| Bianchi Porro, G | 1 |
| Raimond, F | 1 |
| Fuentes-Páez, G | 1 |
| Mendez, MC | 1 |
| Montañez, J | 1 |
| Herreras, JM | 1 |
| Saornil, MA | 1 |
| Calonge, M | 1 |
| Maddocks, JL | 1 |
| Slater, DN | 1 |
| Hensen, EJ | 1 |
| Claas, FH | 1 |
| Vermeer, BJ | 1 |
| Hensen, E | 1 |
| Hessemer, CA | 1 |
| Schinagl, EF | 1 |
| Martin, L | 1 |
| Hazouard, E | 1 |
| Michalak-Provost, S | 1 |
| Maurage, C | 1 |
| Machet, L | 1 |
| Várkonyi, V | 1 |
| Török, I | 1 |
| Márta, D | 1 |
| Makovitzky, J | 1 |
| Tolia, V | 1 |
| Curley, RK | 1 |
| Macfarlane, AW | 1 |
| Ström, J | 1 |
20 other studies available for sulfasalazine and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
[Stevens-Johnson syndrome in a patient with positive lymphocyte transformation test].
Topics: Adult; Colitis, Ulcerative; Female; Humans; Lymphocyte Activation; Stevens-Johnson Syndrome; Sulfani | 2023 |
Association of HLA-A*11:01 with Sulfonamide-Related Severe Cutaneous Adverse Reactions in Japanese Patients.
Topics: Adult; Drug Hypersensitivity Syndrome; Female; Genetic Predisposition to Disease; HLA-A11 Antigen; H | 2020 |
Salazosulphapyridine-related Stevens-Johnson Syndrome Caused by Sulphapyridine and Confirmed by Enzyme-linked Immunospot Assay.
Topics: Colitis, Ulcerative; Enzyme-Linked Immunospot Assay; Female; Gastrointestinal Agents; Humans; Middle | 2018 |
Stevens-Johnson syndrome on treatment with sulfasalazine for Crohn's disease: Need for a multidisciplinary approach.
Topics: Adult; Crohn Disease; Female; Gastrointestinal Agents; Humans; Medical Illustration; Patient Care Te | 2019 |
Giant cell myocarditis in a patient with a spondyloarthropathy after a drug hypersensitivity reaction.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Drug Hypersensitivity; Echocardiography; | 2013 |
Stevens Johnson syndrome-Toxic Epidermal Necrolysis Overlap induced by sulfasalazine treatment: a case report.
Topics: Adult; Female; Gastrointestinal Agents; Humans; Stevens-Johnson Syndrome; Sulfasalazine | 2015 |
Stevens-Johnson syndrome with sulfasalazine treatment: report of two cases.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Female; Humans; Stevens-Johnson | 2011 |
[Toxic epidermal necrolysis during therapy with sulphasalazine in a patient with arthritis. Case report].
Topics: Adult; Antirheumatic Agents; Arthritis; Female; Humans; Stevens-Johnson Syndrome; Sulfasalazine | 2011 |
Photo-induced Stevens-Johnson syndrome due to sulfasalazine therapy.
Topics: Adult; Antirheumatic Agents; Arthritis; Humans; Male; Stevens-Johnson Syndrome; Sulfasalazine; Sunli | 2003 |
Erythroderma and toxic epidermal necrolysis caused by to 5-aminosalacylic acid.
Topics: Colitis, Ulcerative; Dermatitis, Exfoliative; Exanthema; Humans; Male; Mesalamine; Stevens-Johnson S | 2006 |
Conjunctival pigmentation in Stevens-Johnson syndrome.
Topics: Adult; Chronic Disease; Conjunctival Diseases; Female; Humans; Pigmentation Disorders; Stevens-Johns | 2007 |
Toxic epidermal necrolysis, agranulocytosis and erythroid hypoplasia associated with sulphasalazine.
Topics: Adult; Agranulocytosis; Autopsy; Bone Marrow Diseases; Colitis, Ulcerative; Humans; Male; Stevens-Jo | 1980 |
Drug-dependent binding of circulating antibodies in drug-induced toxic epidermal necrolysis.
Topics: Adult; Antibody-Dependent Cell Cytotoxicity; Humans; Male; Skin; Stevens-Johnson Syndrome; Sulfasala | 1981 |
[Pathogenesis and treatment of toxic epidermal necrolysis].
Topics: Adult; Humans; Male; Patient Care Team; Patient Isolation; Stevens-Johnson Syndrome; Sulfasalazine | 1981 |
Desensitization to sulfasalazine.
Topics: Aminosalicylic Acids; Child; Drug Hypersensitivity; Humans; Inflammatory Bowel Diseases; Stevens-Joh | 1993 |
[Fatal toxic respiratory epitheliolysis. Subacute tracheo-bronchial desquamation in Stevens-Johnson syndrome].
Topics: Acute Disease; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Autopsy; Bronchial Diseases; Bro | 2001 |
[Lyell's syndrome caused by Salazopyrine].
Topics: Colitis, Ulcerative; Drug Hypersensitivity; Staphylococcal Infections; Stevens-Johnson Syndrome; Sul | 1976 |
Sulfasalazine desensitization in children and adolescents with chronic inflammatory bowel disease.
Topics: Adolescent; Aminosalicylic Acids; Child; Chronic Disease; Desensitization, Immunologic; Diarrhea; Do | 1992 |
Fatal multisystemic toxicity associated with prophylaxis with pyrimethamine and sulfadoxine.
Topics: Adult; Humans; Male; Stevens-Johnson Syndrome; Sulfasalazine; Tobramycin | 1985 |
Toxic epidermal necrolysis (Leyell's syndrome). A report on four cases with three deaths.
Topics: Adolescent; Amobarbital; Aniline Compounds; Autopsy; Child; Conjunctiva; Female; Humans; Kidney; Lun | 1969 |